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Johannes C.

Johannes C. Clevers, Huis Ter Heide NL

Patent application numberDescriptionPublished
20100275280METHOD FOR IDENTIFYING, EXPANDING AND REMOVING ADULT STEM CELLS AND CANCER STEM CELLS - The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue.10-28-2010

Johannes C. Laffra, Raleigh, NC US

Patent application numberDescriptionPublished
20080301140Method, Apparatus and Computer Program Product for Optimizing File Accesses for an Application Executing in a Virtual Container - Disclosed is a method, apparatus and a computer program of a virtual execution environment. In one aspect thereof a data processor includes a disk-based storage system and a virtual machine monitor configured to execute a program in a virtual container. The virtual machine monitor is responsive, prior to execution of the application, to record a set of files accessed during a phase change in the disk-based storage system in a manner predetermined to minimize the time needed to retrieve the set of files. The virtual machine monitor is further responsive, at the occurrence of the phase change, or prior to the occurrence of a phase change if the files are prefetched, to retrieve the files from the disk-based storage system. In a further aspect thereof there is provided a server of the virtual execution environment that includes a unit, responsive to receiving notification from the at least one virtual machine monitor of an occurrence of contemporaneous file accesses not associated with a known phase change of a virtual container, for evaluating the occurrence as a candidate phase change and, responsive to the evaluation indicating a presence of a previously unknown phase change, for adding a list of the files accessed to a phase change template for use by the same or a different virtual machine monitor during another instance of execution of the application.12-04-2008
20080301205Method, Apparatus And Computer Program Product For Optimizing Access To The Content Of A Virtual Application Container On A Fixed, Read-Only Medium - Disclosed is a method, apparatus and a computer program of a virtual execution environment. In one aspect thereof a data processor includes a read-only storage medium and a virtual machine monitor configured to execute a program in a virtual container. Prior to execution of the application a set of application components accessed during a phase change are recorded in the read-only storage medium in a manner predetermined to minimize the time needed to retrieve the set of components. At the occurrence of the phase change, or prior to the occurrence of a phase change if the files are prefetched, the virtual machine monitor retrieves the components from the read-only storage medium. In a further aspect thereof there is provided a packager of an application to be executed in a virtualization environment by a virtual machine monitor. The packager is responsive to receiving notification from a virtual machine monitor of an occurrence of contemporaneous file accesses, not associated with a known phase change of a virtual container, to evaluate the occurrence as a candidate phase change, and responsive to the evaluation indicating a presence of a previously unknown phase change, for recording the files accessed on a new read-only storage medium in the order accessed for use by the same or a different virtual machine monitor during another instance of execution of the application.12-04-2008
20100023644INSPECTING WEB BROWSER STATE INFORMATION FROM A SYNCHRONOUSLY-INVOKED SERVICE - The present invention provides a browser-independent method to inspect the state of any Web Browser from a service that has been invoked synchronously. The remote agent responds to the service request with instructions for the browser to synchronously and recursively invoke another service request with a specific portion of the browser state as the arguments. This allows the browser to continue operating in a synchronous manner, while appearing to behave like a multi-threaded application that is responsive to state inspection requests.01-28-2010

Johannes C. Van Der Spuy, Pretoria ZA

Johannes C. Van Groeninghen, Dortmund DE

Patent application numberDescriptionPublished
20100190692METHODS FOR REDUCING GNRH-POSITIVE TUMOR CELL PROLIFERATION - A method for recognizing and evaluating the presence and function of GnRH receptors on tumor cells originating in the brain and/or nervous system and/or the meninges and/or reactive neuroglia cells and/or primitive neuroectodermal tumor cells and/or on Kaposi sarcoma is provided. Furthermore a method for reducing degenerate GnRH-positive tumor cells and/or for decreasing cellular replication of the above GnRH-positive tumor cells comprising administering to a cell or to a subject a replication decreasing amount of a GnRH agonist and/or GnRH antagonist and/or an erythropoietin agonist, and/or a thrombopoietin agonist, and/or a endothelin antagonist and/or a gonadotropin inhibiting hormone agonist is also provided. Furthermore, a diagnostic kit for detecting GnRH receptors on tumor cells according to the present methods is disclosed.07-29-2010

Johannes C. Vleghert, Dg Dordrecht NL

Patent application numberDescriptionPublished
20090023525MANUFACTURE OF POLYURETHANE FOAM BALL - The present invention relates to a novel method for manufacturing a cellular elastomeric polyurethane foam ball. The product polyurethane foam ball may be used as a core for a tennis ball which meets ITF specifications for tennis balls, including weight, diameter, bound, forward deformation and return deformation.01-22-2009