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Johannes
Charles W. Johannes, Singapore SG
| Patent application number | Description | Published |
|---|---|---|
| 20120083607 | Enzymatic Transamination of Cyclopamine Analogs - Provided are processes for the synthesis of amino analogues from ketone starting materials. | 04-05-2012 |
Erik Paul Johannes, Burnaby CA
| Patent application number | Description | Published |
|---|---|---|
| 20080209891 | METHOD OF OPERATING A SYNGAS GENERATOR - A method of operating a syngas generator within a desired temperature range, despite a need for intermittent syngas output, involves switching between operating the syngas generator in a rich mode and a lean mode. Operation of the syngas generator in both the rich mode and the lean mode sustains the operating temperature of the syngas generator within that desired temperature range, particularly for non-catalytic reactors. The method of switching from the lean mode to the rich mode of operation can include decreasing the oxygen-to-carbon ratio of reactants supplied to the syngas generator. The flow rate of one or more of the reactant streams supplied to the syngas generator can be actively controlled in order to switch operation of the syngas generator between the rich and lean modes. | 09-04-2008 |
Erik Paul Johannes, Vancouver CA
| Patent application number | Description | Published |
|---|---|---|
| 20080314032 | Segmented Particulate Filter For An Engine Exhaust Stream - A particulate filter is fluidly connected to and disposed downstream from a diesel engine exhaust stream outlet. The filter has a plurality of filter segments that have differing physical properties or structural characteristics such that the engine exhaust stream to fuel stream ratio is maintained substantially consistent among segments during their regeneration. A method for regenerating a segmented filter comprises maintaining the engine exhaust stream to fuel stream ratio substantially consistent among segments during their regeneration. | 12-25-2008 |
Jochemus Gildenhuys Johannes, Johannesburg ZA
| Patent application number | Description | Published |
|---|---|---|
| 20100222612 | Method and Apparatus for Producing Purified Methyl Isobutyl Ketone - This invention relates to a method of producing purified methyl isobutyl ketone (MIBK) comprising subjecting a feed stream containing MIBK and impurities to a first distillation procedure from which acetone is recovered and a bottom product containing MIBK and impurities is withdrawn. This bottom product is fed to a second distillation column, where a vapour overhead product is withdrawn, condensed and fed to an overhead liquid-liquid separator. Part of an organic phase from the overhead liquid-liquid separator is fed to the second distillation column and part is fed to a third distillation column. A vapour overhead product is withdrawn from the third column which is condensed in the same said condensor. The condensed product is fed to the same said overhead liquid-liquid separator, and purified MIBK is withdrawn from the third distillation column. This invention also relates to an apparatus used in such a method. | 09-02-2010 |
Ludger Johannes, Courbevoie FR
| Patent application number | Description | Published |
|---|---|---|
| 20090214438 | METHODS AND COMPOSITIONS FOR THE PREPARATION AND USE OF TOXIN CONJUGATES - The present invention relates to methods for the preparation of toxin conjugates that are useful in vaccination and other therapies and diagnostics. In particular, methods are provided that involve a [3+2] cycloaddition between a first reactive unsaturated group on a toxin moiety and a second reactive unsaturated group on a bioactive moiety. Also provided are conjugates that are formed through this conjugation method, pharmaceutical compositions comprising these conjugates, and methods of using these pharmaceutical compositions for the treatment or diagnostic of antigen-related conditions, including tumors and infections. | 08-27-2009 |
| 20100196418 | UNIVERSAL CARRIER FOR TARGETING MOLECULES TO Gb3 RECEPTOR EXPRESSING CELLS - The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: | 08-05-2010 |
| 20100329992 | SHIGA TOXIN B-SUBUNIT AS A VECTOR FOR TUMOR DIAGNOSIS AND DRUG DELIVERY TO GB3 EXPRESSING TUMORS - The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb | 12-30-2010 |
| 20110152252 | SHIGA TOXIN B-SUBUNIT/CHEMOTHERAPEUTICS CONJUGATES - The present invention relates to the use of a Shiga toxin B-subunit moiety as carrier for therapeutic agents, for example, anti-cancer agents such as anti-cancer agents that require intracellular uptake to exert their anti-cancer effects. In particular, the present invention provides conjugates comprising a Shiga toxin moiety covalently linked to an anti-cancer agent through a self-immolative spacer, and methods of using such conjugates to increase cellular uptake and/or specificity for cancer cells of the anti-cancer drug. Also provided are methods of treatment involving administration of such conjugates, and pharmaceutical compositions and kits useful for carrying out such methods of treatment. | 06-23-2011 |
| 20110201601 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY - The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins. | 08-18-2011 |
| 20110243914 | SHIGA TOXIN B-SUBUNIT AS A VECTOR FOR TUMOR DIAGNOSIS AND DRUG DELIVERY TO GB3 EXPRESSING TUMORS - The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb | 10-06-2011 |
Ludger Johannes, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20100322913 | CHIMERIC POLYPEPTIDE COMPRISING THE FRAGMENT B OF SHIGA TOXIN AND PEPTIDES OF THERAPEUTIC INTEREST - The invention pertains to methods for using chimeric polypeptides of the formula: | 12-23-2010 |
Siegmund Johannes, Gauteng ZA
| Patent application number | Description | Published |
|---|---|---|
| 20100191330 | HUMAN MAMMARY PROSTHETIC SUPPORT AND METHOD OF IMPLANTING - A human mammary prosthetic support ( | 07-29-2010 |
Van Amelsvoort Netherlands Johannes, At Vlaardingen NL
| Patent application number | Description | Published |
|---|---|---|
| 20100297261 | Food Product and Fortification System Therefor - A food product comprising a source of at least one metal ion selected from Fe and Cu ions and an ascorbic acid derivative substituted in the 2-position, wherein the molar ratio of the metal ion or metal ions in the source of metal ions to the ascorbic acid derivative is from 1:0.5 to 1:15. | 11-25-2010 |