Patent application number | Description | Published |
20080214825 | Method For Producing Substituted Halopyridines - Methods for producing substituted halopyridines (II) by reacting a β-hydroxy-y-acyl butyronitrile (I) or a suitable acyl-protected derivative with hydrogen halides, or substances or mixtures that can release hydrogen halides. In the formulae (I) and (II): R, R | 09-04-2008 |
20080306260 | Method for Producing Aryl Amines, Aryl Ethers and Aryl Thioethers - The invention relates to a method for producing aryl or heteroaryl amines, ethers or thioethers (III) by cross-coupling primary or secondary amities, alcohols or thioalcohols with substituted aryl or heteroaryl compounds (I) in the presence of a Brønsted base and a catalyst or a pre-catalyst containing a) a transition metal, a complex, a salt, or a compound of a transition metal from the group V, Mn, Fe, Co, Ni, Rh, Pd, Ir, Pt, and b) at least one sulfonated phosphane ligand in a solvent or a solvent mixture corresponding to Scheme 1 wherein Hal represents fluorine, chlorine, bromine, iodine, alkoxy, trifluoromethane sulfonate, nonafluorotrimethyl-methane sulfonate, methane sulfonate, 4-nitrobenzene sulfonate, benzene sulfonate, 2-naphthalene sulfonate, 3-nitrobenzene sulfonate, 4-nitrobenzene sulfonate, 4-chlorobenzene sulfonate, 2,4,6-triisopropylbenzene sulfonate or any other sulfonate, and X represents O, S or NR″. The invention also relates to novel phosphane ligands. | 12-11-2008 |
20100178678 | Method for producing cyclopent-4-ene-1,3-diol or cyclopent-4-ene-1,3-diol derivatives - The invention relates to a method for producing cis-cyclopent-4-ene-1,3-diol and cis-cyclopent-4-ene-1,3-dialkanoates by selective cis-1,2-reduction of 4-hydroxycyclopent-2-enone by means of a hydroboron, in the presence of substoichiometric quantities of a trivalent rare earth metal compound, to form cyclopent-4-ene-1,3-diol which can then be optionally reacted with an acylation agent to form cis-cyclopent-4-ene-1,3-dialkanoates, in order to simplify the reprocessing and without intermediate isolation. | 07-15-2010 |
20100234607 | Process for preparing 2-amino-4- (haloalkyl) pyridine derivatives by cyclizing suitable nitrile precursors with nitrogen compounds - A process in which a 2-aminopyridine derivative of the general formula II is obtained from open-chain nitrile precursor I or III by reaction with a nitrogen compound in a cyclization reaction is described. | 09-16-2010 |
20110288294 | Preparation process for an inhibitor of a blood clotting factor - The invention relates to a process for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide (I) from 5-chlorothiophene-2-carboxylic acid and 4-[4-((S)-5-aminomethyl-2-oxooxazolidin-3-yl)phenyl]morpholin-3-one (II) | 11-24-2011 |
20110319649 | Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide - The invention relates to ((R)-1-Benzylcarbamoyl-2-hydroxy-ethyl)-carbamic acid tert-butyl ester (compound III) with an ee of greater than 90%. | 12-29-2011 |
20120095251 | Process for Producing Lacosamide - The present invention relates to a method for producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide), by methylation of (R)-2-acetamino-2-N-benzyl-3-hydroxy-propionamide (V), in which the methylation is carried out at a temperature below 20° C. | 04-19-2012 |
20140039203 | Process for preparing spiro[2.5]octane-5,7-dione - Disclosed is a method for the synthesis of spiro[2.5]octane-5,7-dione useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed are novel intermediates used in the synthesis of this compound. | 02-06-2014 |
20140336405 | Process for preparing spiro[2.5]octane-5,7-dione - Disclosed is a method for the synthesis of spiro[2.5]octane-5,7-dione useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed are novel intermediates used in the synthesis of this compound. | 11-13-2014 |