Patent application number | Description | Published |
20090076268 | Facile assembly of fused benzofuro-heterocycles - This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization. | 03-19-2009 |
20090099157 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S - Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. | 04-16-2009 |
20090156599 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 - Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease. | 06-18-2009 |
20110105752 | PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES - The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor. | 05-05-2011 |
20110160451 | 2-Aminopyrimidine modulators of the histamine H4 receptor - 2-Aminopyrimidine compounds are described, which are useful as H | 06-30-2011 |
20110160452 | 2-Aminopyrimidine modulators of the histamine H4 receptor - 2-Aminopyrimidine compounds are described, which are useful as H | 06-30-2011 |
20110218338 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - 2-Aminopyrimidine compounds are described, which are useful as H | 09-08-2011 |
20130005687 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 - Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease. | 01-03-2013 |
20130053398 | MODULATORS OF FATTY ACID AMIDE HYDROLASE - 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). A method of synthesizing 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is also disclosed. | 02-28-2013 |
20130158258 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - 2-Aminopyrimidine compounds are described, which are useful as H | 06-20-2013 |
20130158259 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - 2-Aminopyrimidine compounds are described, which are useful as H | 06-20-2013 |
20140107098 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 - Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease. | 04-17-2014 |
20140221310 | FLAP MODULATORS - The present invention relates to compounds of Formula (I), | 08-07-2014 |
20140221311 | FLAP MODULATORS - The present invention relates to compounds of Formula (I), | 08-07-2014 |
20140275028 | 1,2,5-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS - The present invention relates to compounds of Formula (I), | 09-18-2014 |
20140275029 | 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS - The present invention relates to compounds of Formula (I), | 09-18-2014 |