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Jimeno
Antonio Jimeno, Englewood, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090099218 | SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS - This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines. | 04-16-2009 |
| 20090221522 | METHODS TO CORRECT GENE SET EXPRESSION PROFILES TO DRUG SENSITIVITY - The present invention comprises a treatment approach based on gene set-expression signatures that systematically connects a sample to a profile from a reference database to extrapolate the most effective therapeutic agent. Further disclosed are methods to optimize combination treatments. | 09-03-2009 |
| 20100113491 | SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS - A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6n was more effective than compound 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC50 of 2.1 μM. | 05-06-2010 |
Antonio Jimeno, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080293069 | RAPID PROGNOSTIC ASSAY FOR MALIGNANCIES TREATED WITH EPIDERMAL GROWTH FACTOR RECEPTOR - A molecular assay for determining the sensitivity or resistance of malignancies to chemotherapy prior to initiation of chemotherapy and which also allows for monitoring the therapeutic effects of the chemotherapy during treatment. The molecular assay measures tumor response to therapy with EGFR modulators and utilizes tumor mRNA as a starting material and a quantitative measurement of c-fos expression as an analytical endpoint. | 11-27-2008 |
José Jimeno, Madrid ES
| Patent application number | Description | Published |
|---|---|---|
| 20100041594 | Use of Aplidine for the Treatment of Pancreatic Cancer - Aplidine is active against cancer of the pancreas, including metastatic pancreatic cancer. | 02-18-2010 |
José Jimeno, Madrid ES
| Patent application number | Description | Published |
|---|---|---|
| 20100041594 | Use of Aplidine for the Treatment of Pancreatic Cancer - Aplidine is active against cancer of the pancreas, including metastatic pancreatic cancer. | 02-18-2010 |