| Patent application number | Description | Published |
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| 20090036668 | MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS - Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber. | 02-05-2009 |
| 20090308490 | PARTICULATE SUBSTANCE COLLECTOR - The particulate substance collector described herein comprises a conductive material completely or partially encased in one or more types of non-conductive material(s). The collector can be mounted on a particulate substance collection system, which provides the collector with electrostatic charge. The charged collector is used to attract a measurable amount of particulate substances to the collector. The present invention broadens the range of substances that can be collected to include both conductive and non-conductive particulate materials. Previously, with collectors composed solely of a single material, conductive materials could not be collected. The present invention also broadens the type of receptacle that the particulate substance can be held in, to include both conductive and non-conductive receptacles. The present invention further provides the benefit of minimizing electric shock to the operator who inadvertently contacts the collector during operation. | 12-17-2009 |
| 20100113762 | Apparatus and Method Using Rotary Flow Distribution Mechanisms - Methods and apparatus for facilitating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is critical to the synthesis of radiolabeled biomarkers. | 05-06-2010 |
| 20100145630 | Apparatus and Method for Automated Quality Control - Methods and apparatus to assess current aspects of Quality Control useful for release of radioactive compounds for imaging, such as PET tracers as injectables, in an automated manner, without user interference, and in compliance with regulatory guidelines. The present method and system relates to an integrated automated quality control analysis of a substance utilizing a single sample injection for a plurality of inline quality control tests. A quantitative analysis of the sample via the plurality of quality control tests is conducted. A measurement value of each of the plurality of quality control parameters is determined and a comparison of each measurement value of the plurality of quality control parameters with a predetermined corresponding criterion value is made. A cumulative quality rating for the sample is determined and the validated sample is released based on the quality rating. | 06-10-2010 |
| 20110008215 | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure - Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components. | 01-13-2011 |
| 20110097245 | Portable Microfluidic Radiosynthesis System for Positron Emission Tomography Biomarkers and Program Code - Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber. | 04-28-2011 |
| 20110150714 | Modular System for Radiosynthesis with Multi-Run Capabilities and Reduced Risk of Radiation Exposure - Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components. | 06-23-2011 |
| Patent application number | Description | Published |
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| 20080293037 | Sequences Diagnostic For Shrimp Pathogens - Primers have been isolated that are diagnostic for the detection of the infectious hypodermal and hematopoietic necorsis virus (IHHNV). The primers are based on a new portion of the IHHNV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods. | 11-27-2008 |
| 20090061415 | Sequences Diagnostic For Shrimp Pathogens - Primers have been isolated that are diagnostic for the detection of the taura syndrome virus (TSV). The primers are based on a new portion of the TSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods. | 03-05-2009 |
| 20090117609 | USE OF TETRACYSTEINE TAGS IN FLUORESCENCE-ACTIVATED CELL SORTING ANALYSIS OF PROKARYOTIC CELLS PRODUCING PEPTIDES OR PROTEINS - A process of in vivo labeling and identifying recombinantly produced peptides or proteins within an unpermeabilized prokaryotic host cell. Recombinant prokaryotic cells expressing a fusion peptide comprising at least one tetracysteine tag were labeled in vivo using a biarsenical labeling reagent. A fluorescent activated cell sorter was used to identify and select subpopulations of fluorescent cells wherein the amount of fusion peptide in the cell was proportional to the amount of fluorescence detected. | 05-07-2009 |
| 20100063260 | Whitefly Ecdysone Receptor Antibody - The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity. | 03-11-2010 |
| 20100159513 | GENES THAT INCREASE PEPTIDE PRODUCTION - Several endogenous genes have been identified in | 06-24-2010 |
| 20100167303 | SEQUENCES DIAGNOSTIC FOR SHRIMP PATHOGENS - Primers have been isolated that are diagnostic for the detection of | 07-01-2010 |
| 20110097794 | Whitefly Ecdysone Receptor Nucleic Acids, Polypeptides, and Uses Thereof - The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity. | 04-28-2011 |
