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Jianmin Fang
Jianmin Fang, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090270485 | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site - Cell specific replication-competent viral vectors comprising a self processing peptide cleavage sequence are provided. The targeted replication-competent viral vectors include two or more co-transcribed genes under transcriptional control of the same heterologous transcriptional regulatory element (TRE), wherein at least a second gene is under translational control of a self processing cleavage sequence or 2A sequence. Exemplary vector constructs may further include an additional proteolytic cleavage site which provides a means to remove the self processing peptide sequence from the viral vector. | 10-29-2009 |
| 20100151523 | REGULATED EXPRESSION OF RECOMBINANT PROTEINS FROM ADENO-ASSOCIATED VIRAL VECTORS - Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing cleavage site between the coding sequence for the first and second immunoglobulin coding sequence and a additional proteolytic cleavage site, which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo. | 06-17-2010 |
| 20110065779 | AAV VECTOR COMPOSITIONS AND METHODS FOR ENHANCED EXPRESSION OF IMMUNOGLOBULINS USING THE SAME - Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo. | 03-17-2011 |
Jianmin Fang, Foster City, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080280356 | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site - Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo. | 11-13-2008 |
| 20100317096 | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site - Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo. | 12-16-2010 |
| 20110028694 | METHODS TO EXPRESS RECOMBINANT PROTEINS FROM LENTIVIRAL VECTORS - Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo. | 02-03-2011 |
Jianmin Fang, Singapore CN
| Patent application number | Description | Published |
|---|---|---|
| 20100264512 | Semiconductor Device and Method of Forming High-Frequency Circuit Structure and Method Thereof - A semiconductor device is made by providing an integrated passive device (IPD). Through-silicon vias (TSVs) are formed in the IPD. A capacitor is formed over a surface of the IPD by depositing a first metal layer over the IPD, depositing a resistive layer over the first metal layer, depositing a dielectric layer over the first metal layer, and depositing a second metal layer over the resistive and dielectric layers. The first metal layer and the resistive layer are electrically connected to form a resistor and the first metal layer forms a first inductor. A wafer supporter is mounted over the IPD using an adhesive material and a third metal layer is deposited over the IPD. The third metal layer forms a second inductor that is electrically connected to the capacitor and the resistor by the TSVs of the IPD. An interconnect structure is connected to the IPD. | 10-21-2010 |
Jianmin Fang, Shanghai CN
| Patent application number | Description | Published |
|---|---|---|
| 20100215655 | ANGIOGENESIS-INHIBITING CHIMERIC PROTEINS AND THE USE - The present invention is directed to DNA sequence encoding angionenesis-inhibiting recombinant chimeric protein, the chimeric protein per se, the pharmaceutical use of the chimeric protein, and to the pharmaceutical composition containing the recombinant protein and the formulation thereof. | 08-26-2010 |
| 20120112340 | Semiconductor Device and Method of Forming Insulating Layer Disposed Over The Semiconductor Die For Stress Relief - A semiconductor device has a semiconductor die and conductive layer formed over a surface of the semiconductor die. A first channel can be formed in the semiconductor die. An encapsulant is deposited over the semiconductor die. A second channel can be formed in the encapsulant. A first insulating layer is formed over the semiconductor die and first conductive layer and into the first channel. The first insulating layer extends into the second channel. The first insulating layer has characteristics of tensile strength greater than 150 MPa, elongation between 35-150%, and thickness of 2-30 micrometers. A second insulating layer can be formed over the semiconductor die prior to forming the first insulating layer. An interconnect structure is formed over the semiconductor die and encapsulant. The interconnect structure is electrically connected to the first conductive layer. The first insulating layer provides stress relief during formation of the interconnect structure. | 05-10-2012 |
Jianmin Fang, Shandong Province CN
| Patent application number | Description | Published |
|---|---|---|
| 20100136008 | TACI-Fc Fusion Proteins, Methods of Making and Uses Thereof - The subject invention relates generally to novel biologically active TACI-Fc fusion proteins that bind to BLyS and/or APRIL and uses thereof. The invention also relates to methods for recombinant production of homogeneous TACI-Fc fusion proteins on a large scale. | 06-03-2010 |
Jianmin Fang, Guangdong Province CN
| Patent application number | Description | Published |
|---|---|---|
| 20120115532 | METHOD AND BASE STATION FOR DETERMINING AN INITIAL TRANSMISSION POWER - A method for determining an initial transmission power and a base station is provided. The method comprises: a base station acquiring a measurement result of a second cell reported by said user equipment, wherein a first cell in which a user equipment (UE) is located belongs to the base station, and said first cell and said second cell belong to different base stations; and determining an initial transmission power of said user equipment when initiating a random access in said second cell according to a reference signal power of said second cell, said measurement result and a random access initial received target power of said second cell. Success rate of handover of user equipment is improved. | 05-10-2012 |