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Jiang, US
Aixiang Jiang, Nashville, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20110097423 | Gene Prognosis Predictor Signature for Colorectal Carcinoma - The present invention is drawn to methods of assessing colorectal cancer prognosis by examining the expression of particular genes disregulated in this disease state. Subjects exhibiting disregulation in one or more of these genes will have a higher risk of cancer recurrence and death. | 04-28-2011 |
Delu Jiang, Westfield, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100087431 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS - The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer. | 04-08-2010 |
| 20100130466 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS - The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer. | 05-27-2010 |
Gengwei Jiang, Lake Oswego, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20100308463 | INTERFACIAL CAPPING LAYERS FOR INTERCONNECTS - Adhesive layers residing at an interface between metal lines and dielectric diffusion barrier (or etch stop) layers are used to improve electromigration performance of interconnects. Adhesion layers are formed by depositing a precursor layer of metal-containing material (e.g., material containing Al, Ti, Ca, Mg, etc.) over an exposed copper line, and converting the precursor layer to a passivated layer (e.g., nitridized layer). For example, a substrate containing exposed copper line having exposed Cu—O bonds is contacted with trimethylaluminum to form a precursor layer having Al—O bonds and Al—C bonds on copper surface. The precursor layer is then treated to remove residual organic substituents and to form Al—N, Al—H bonds or both. The treatment can include direct plasma treatment, remote plasma treatment, UV-treatment, and thermal treatment with a gas such as NH | 12-09-2010 |
Guang L. Jiang, Irvine, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120136011 | COMPOUNDS AND METHODS FOR SKIN REPAIR - The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles. | 05-31-2012 |
Hualin Jiang, Granger, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20090025898 | Process for molding a friction wafer - A process and apparatus for making die-dried friction wafers collects friction particulates in a mold defining a wafer. The mold includes at least one perforate wall portion against which an aqueous slurry including the particulates is passed to form at least one layer on the wall as the particulates collect in the mold. The collection is dried followed by curing, and may be cured in the mold by heating. | 01-29-2009 |
| 20110056848 | ELECTROCHEMICAL TEST SENSOR - An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit. | 03-10-2011 |
Jutao Jiang, Tigard, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20110220971 | PHOTOSENSITIVE IMAGING DEVICES AND ASSOCIATED METHODS - Backside illuminated photosensitive devices and associated methods are provided. In one aspect, for example, a backside-illuminated photosensitive imager device can include a semiconductor substrate having multiple doped regions forming a least one junction, a textured region coupled to the semiconductor substrate and positioned to interact with electromagnetic radiation, and a passivation region positioned between the textured region and the at least one junction. The passivation region is positioned to isolate the at least one junction from the textured region, and the semiconductor substrate and the textured region are positioned such that incoming electromagnetic radiation passes through the semiconductor substrate before contacting the textured region. Additionally, the device includes an electrical transfer element coupled to the semiconductor substrate to transfer an electrical signal from the at least one junction. | 09-15-2011 |
| 20110227138 | Photosensitive Imaging Devices And Associated Methods - Photosensitive devices and associated methods are provided. In one aspect, for example, a photosensitive imager device can include a semiconductor substrate having multiple doped regions forming at least one junction, a textured region coupled to the semiconductor substrate and positioned to interact with electromagnetic radiation, and an electrical transfer element coupled to the semiconductor substrate and operable to transfer an electrical signal from the at least one junction. In one aspect, the textured region is operable to facilitate generation of an electrical signal from the detection of infrared electromagnetic radiation. In another aspect, interacting with electromagnetic radiation further includes increasing the semiconductor substrate's effective absorption wavelength as compared to a semiconductor substrate lacking a textured region. | 09-22-2011 |
| 20110260059 | PHOTOSENSITIVE IMAGING DEVICES AND ASSOCIATED METHODS - A monolithic sensor for detecting infrared and visible light according to an example includes a semiconductor substrate and a semiconductor layer coupled to the semiconductor substrate. The semiconductor layer includes a device surface opposite the semiconductor substrate. A visible light photodiode is formed at the device surface. An infrared photodiode is also formed at the device surface and in proximity to the visible light photodiode. A textured region is coupled to the infrared photodiode and positioned to interact with electromagnetic radiation. | 10-27-2011 |
Jutao Jiang, Boise, ID US
| Patent application number | Description | Published |
|---|---|---|
| 20080239111 | Method and appratus for dark current compensation of imaging sensors - Disclosed embodiments provide methods and apparatuses for dark current compensation of imager pixels signals. A row-wise dark offset is calculated and then subtracted from the imaging pixel signals, a row-wise dark offset for at least one row being different from a row-wise dark offset for at least another row. | 10-02-2008 |
Longzhi Jiang, Florence, SC US
| Patent application number | Description | Published |
|---|---|---|
| 20100244824 | APPARATUS FOR SUPPORTING AND METHOD FOR FORMING A SUPPORT FOR A MAGNETIC RESONANCE IMAGING (MRI) MAGNET - An apparatus and method for supporting a magnetic resonance imaging magnet are provided. The apparatus includes a magnet coil support structure having a main former body with a plurality of channels and an end flange at each end of the main former body. The end flanges are reinforced with a strengthening material at least at corner regions of the end flanges. | 09-30-2010 |
| 20110148416 | APPARATUS AND METHOD TO IMPROVE MAGNET STABILITY IN AN MRI SYSTEM - An MRI apparatus and method comprises an MRI system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly to acquire MR images. The magnet comprises a main coil former and a shield coil former arranged radially around the bore of the magnet, wherein a radius of the shield coil former is greater than a radius of the main coil former. The magnet also includes at least one main coil affixed to the main coil former, at least one shield coil affixed to the shield coil former, and at least one structural member affixed to the main coil former and to the shield coil former to provide structural support and enable longitudinal alignment adjustment between the main coil former and the shield coil former. | 06-23-2011 |
| 20110271693 | SYSTEM AND METHOD FOR REMOVING HEAT GENERATED BY A HEAT SINK OF MAGNETIC RESONANCE IMAGING SYSTEM - Systems and methods from removing heat generated by a heat sink of a magnetic resonance imaging (MRI) system are provided. One system includes a coldhead sleeve cooling arrangement for a coldhead of the MRI system. The coldhead sleeve cooling arrangement includes a coldhead sleeve configured to receive therein a coldhead of an MRI system and a cooling system surrounding an outer surface of the coldhead sleeve. The cooling system uses helium gas to remove heat from the coldhead sleeve. | 11-10-2011 |
| 20110284191 | THERMAL SHIELD AND METHOD FOR THERMALLY COOLING A MAGNETIC RESONANCE IMAGING SYSTEM - A thermal shield and method for thermally cooling a magnetic resonance imaging (MRI) system are provided. One thermal shield includes a cooling tube forming a frame. The cooling tube is configured to receive therethrough cryogen fluid from a cryogen vessel of an MRI system. The thermal shield further includes at least one thermal control layer surrounding the frame and together with the frame is configured to provide thermal shielding of the MRI system. | 11-24-2011 |
| 20120062231 | RADIO FREQUENCY (RF) COIL FOR MRI HAVING HIGH THERMAL CONDUCTIVITY - An MRI apparatus and method is disclosed comprising a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly to acquire MR images. The RF coil assembly comprises an RF tube, a plurality of electrically conductive members disposed around the RF tube and configured to transmit RF excitation pulses, a plurality of electrical components coupled to the electrically conductive members, and at least one thermally conductive substrate mounted upon the RF tube, wherein one of the plurality of electrically conductive members and the plurality of electrical components is mounted to the at least one thermally conductive substrate and is in thermal contact therewith. | 03-15-2012 |
| 20120081117 | SYSTEM AND METHOD FOR SELF-SEALING A COLDHEAD SLEEVE OF A MAGNETIC RESONANCE IMAGING SYSTEM - Systems and methods for self-sealing a coldhead sleeve of a magnetic resonance imaging system are provided. One coldhead sleeve arrangement includes a coldhead sleeve configured to receive therein a coldhead of an MRI system and having an open end. The coldhead sleeve arrangement also includes a sealing member coupled at the open end of the coldhead sleeve and configured in a normally closed position covering the open end. | 04-05-2012 |
| 20120082357 | SYSTEM AND METHOD FOR MODELING GRADIENT COIL OPERATION INDUCED MAGNETIC FIELD DRIFT - A system and method for modeling gradient coil operation induced magnetic field drift include a computer programmed to acquire a pulse sequence to be applied during an MR scan and determine a power spectrum of a plurality of gradient pulses of the pulse sequence. The computer is also programmed to calculate a drift of the magnetic field attributable to application of the plurality of gradient pulses by the plurality of gradient coils during application of the pulse sequence and apply the pulse sequence during the MR scan. The computer is further programmed to acquire MR data based on application of the pulse sequence, correct the acquired MR data based on the calculated drift of the magnetic field, and reconstruct an image based on the corrected MR data. | 04-05-2012 |
| 20120108433 | SUPERCONDUCTING MAGNET COIL SUPPORT WITH COOLING AND METHOD FOR COIL-COOLING - A superconducting magnet coil support with cooling and a method for coil cooling are provided. One superconducting coil support arrangement includes a superconducting coil and at least one support beam supporting the superconducting coil and defining a tank for storing a cooling fluid therein. The superconducting coil support arrangement further includes a plurality of cooling tubes coupled to the superconducting coil and connected to the at least one support beam, wherein the plurality of cooling tubes are configured to transfer the cooling fluid therethrough. | 05-03-2012 |
| 20120118630 | APPARATUS AND METHOD FOR PROVIDING ELECTRIC CABLES WITHIN A MAGNETIC RESONANCE IMAGING SYSTEM - An apparatus and method for mounting cables within a magnetic resonance imaging (MRI) system are provided. One apparatus includes a cable assembly having a rigid support structure defining a channel with a cross-section and an electrical cable having a cross-section smaller than the cross-section of the channel. The electrical cable is secured within the channel of the rigid support structure, with the rigid support structure configured for coupling to a stationary component of the MRI system to resist movement from a movable component to which the electrical cable is connected. | 05-17-2012 |
Majiong Jiang, St. Louis, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20120034550 | Palladium-Platinum Nanostructures And Methods For Their Preparation - Palladium-seeded, dendritic platinum nanostructures that are useful as electrocatalysts and methods for preparing such nanostructures. The palladium-platinum nanostructures may be incorporated into fuel cell electrodes including fuel cells that include a proton exchange membrane (PEM). | 02-09-2012 |
Qin Jiang, Memphis, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20110256546 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER RESISTANT TO ANAPLASTIC LYMPHOMA KINASE (ALK) KINASE INHIBITORS - Compositions and methods for the diagnosis and treatment of a cancer that is resistant to at least one anaplastic lymphoma kinase (ALK) kinase inhibitor are provided herein. The present invention is based on the discovery of mutations within ALK that confer resistance to at least one ALK kinase inhibitor. Polynucleotides and polypeptides having at least one ALK inhibitor resistance mutation are provided and find use in methods and compositions useful in the diagnosis, prognosis, and/or treatment of diseases associated with aberrant ALK activity, more particularly, those that are resistant to at least one ALK kinase inhibitors. Methods and compositions are also provided for the identification of agents that can inhibit the kinase activity and/or reduce the expression level of the ALK resistance mutants. | 10-20-2011 |
Qing Jiang, West Lafayette, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110207808 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS - Provided are long-chain carboxychromanol compounds useful for treating conditions associated with the need to inhibit cyclooxygenase-1, cyclooxygenase-2, and/or 5-lipoxygenase, and pharmaceutical formulations containing the compounds. | 08-25-2011 |
Ryan Hsin-Chin Jiang US
| Patent application number | Description | Published |
|---|---|---|
| 20120056238 | BIDIRECTIONAL SILICON-CONTROLLED RECTIFIER - A bidirectional silicon-controlled rectifier, wherein the conventional field oxide layer, which separates an anode structure from a cathode structure, is replaced by a field oxide layer having floating gates, a virtual gate or a virtual active region. Thus, the present invention can reduce or escape from the bird's beak effect of a field oxide layer, which results in crystalline defects, a concentrated current and a higher magnetic field and then causes abnormal operation of a rectifier. Thereby, the present invention can also reduce signal loss. | 03-08-2012 |
Shudong Jiang, Hanover, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20090247847 | SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGE RECONSTRUCTION - Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images. | 10-01-2009 |
| 20100265493 | Pulsed Lasers in Frequency Domain Diffuse Optical Tomography and Spectroscopy - A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described. | 10-21-2010 |
Xiaomo Jiang, Greenville, SC US
| Patent application number | Description | Published |
|---|---|---|
| 20110196593 | SYSTEM AND METHOD FOR MONITORING A GAS TURBINE - A system for monitoring a gas turbine includes a memory containing information from comparable gas turbines and an input device that generates a unit data signal and a risk signal. A processor in communication with the memory and the input device incorporates the unit data signal into the database, projects information for the gas turbine, and calculates a conditional risk that the gas turbine will reach a limit. An output signal includes repair or maintenance schedules. A method for monitoring a gas turbine includes receiving information from comparable gas turbines, adding information from the gas turbine to the information from comparable gas turbines, and projecting information for the gas turbine. The method further includes calculating a conditional risk that the gas turbine will reach a limit and generating an output signal containing repair or maintenance schedules. | 08-11-2011 |
Xiaoning Jiang, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20120119620 | Multistage Force Amplification of Piezoelectric Stacks - Embodiments of the disclosure include an apparatus and methods for using a piezoelectric device, that includes an outer flextensional casing, a first cell and a last cell serially coupled to each other and coupled to the outer flextensional casing such that each cell having a flextensional cell structure and each cell receives an input force and provides an output force that is amplified based on the input force. The apparatus further includes a piezoelectric stack coupled to each cell such that the piezoelectric stack of each cell provides piezoelectric energy based on the output force for each cell. Further, the last cell receives an input force that is the output force from the first cell and the last cell provides an output apparatus force In addition, the piezoelectric energy harvested is based on the output apparatus force. Moreover, the apparatus provides displacement based on the output apparatus force. | 05-17-2012 |
Xiaoyan Jane Jiang, Columbia, SC US
| Patent application number | Description | Published |
|---|---|---|
| 20100322371 | OPTIMIZED FLOWER TUBES AND OPTIMIZED ADVANCED GRID CONFIGURATIONS - A support grid for a nuclear fuel assembly, the fuel rod assembly having a generally cylindrical fuel rod with a diameter, wherein the support grid includes a frame assembly having a plurality of outer straps and a plurality tubular members and/or helical frame members. The tubular members/helical frame members have a contact portion structured to contact an adjacent helical frame member and at least one helical fuel rod contact portion with a lesser diameter. The lesser diameter is generally equivalent to the fuel rod diameter such that a fuel rod disposed in the helical frame member would engage the inner helical frame member at helical fuel rod contact portion. The helical fuel rod contact portion may have a variable pitch. | 12-23-2010 |
| 20110002435 | NUCLEAR FUEL ASSEMBLY SUPPORT GRID - A nuclear fuel assembly support grid formed from an array of a plurality of orthogonally arranged straps in an egg-crate configuration with angled trailing and/or leading edges that are designed to break the correlation of vortices shed from the edges of the grid straps by varying the phase of the vortices to avoid resonant vibration of the straps. | 01-06-2011 |
| 20110002436 | NUCLEAR FUEL ASSEMBLY SUPPORT GRID - A nuclear fuel assembly support grid formed from an array of a plurality of orthogonally arranged straps in an egg-crate configuration with angled trailing and/or leading edges that are designed to break the correlation of vortices shed from the edges of the grid straps by varying the phase of the vortices to avoid resonant vibration of the straps. | 01-06-2011 |
| 20110033020 | HELICALLY FLUTED TUBULAR FUEL ROD SUPPORT - A support grid for a nuclear fuel assembly, the fuel rod assembly having a generally cylindrical fuel rod with a diameter, wherein the support grid includes a frame assembly having a plurality of outer straps and a plurality of helical frame members. The helical frame members have a contact portion structured to contact an adjacent helical frame member and at least one helical fuel rod contact portion with a lesser diameter. The lesser diameter is generally equivalent to the fuel rod diameter such that a fuel rod disposed in the helical frame member would engage the inner helical frame member at helical fuel rod contact portion. The helical frame members are coupled to each other at the contact portions thereby forming a grid. The plurality of outer straps are disposed about the perimeter of the helical frame members. | 02-10-2011 |
Xingmao Jiang, Albuquerque, NM US
| Patent application number | Description | Published |
|---|---|---|
| 20080210053 | HOLLOW SPHERE METAL OXIDES - In accordance with invention, there are methods for fabricating hollow spheres and nanofoams. The method for making hollow spheres can include providing a homogeneous precursor solution including a first solvent and one or more anhydrous precursor species and forming aerosol droplets having a first size distribution using the homogeneous precursor solution in an anhydrous carrier gas. The method can also include transporting the aerosol droplets through an aerosol reactor including a reactant to form a plurality of hollow spheres, wherein each of the plurality of hollow spheres can be formed by one or more chemical reactions occurring at a surface of the aerosol droplet. The method can further include controlling size and thickness of the hollow spheres by one or more of the precursor solution concentration, aerosol droplet size, temperature, residence time of the aerosol droplets in the aerosol reactor, and the reactant distribution in the aerosol reactor. | 09-04-2008 |
| 20090175948 | AEROSOL METHOD FOR NANO SILVER-SILICA COMPOSITE ANTI-MICROBIAL AGENT - A method of forming and resulting nano-structured composite includes atomizing a mixture of an amount of each of aminopropyltriethoxysilane, AgNO | 07-09-2009 |
Xuwei Jiang, Albany, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120136087 | PHOSPHORYLCHOLINE-BASED AMPHIPHILIC SILICONES FOR MEDICAL APPLICATIONS - Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings. | 05-31-2012 |
Ying Jiang, Eugene, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20120028257 | Modified luciola cruciata luciferase gene and protein - A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from | 02-02-2012 |
Ying-Bing Jiang US
| Patent application number | Description | Published |
|---|---|---|
| 20110186971 | METHOD OF MAKING DENSE, CONFORMAL, ULTRA-THIN CAP LAYERS FOR NANOPOROUS LOW-K ILD BY PLASMA ASSISTED ATOMIC LAYER DEPOSITION - Barrier layers and methods for forming barrier layers on a porous layer are provided. The methods can include chemically adsorbing a plurality of first molecules on a surface of the porous layer in a chamber and forming a first layer of the first molecules on the surface of the porous layer. A plasma can then be used to react a plurality of second molecules with the first layer of first molecules to form a first layer of a barrier layer. The barrier layers can seal the pores of the porous material, function as a diffusion barrier, be conformal, and/or have a negligible impact on the overall ILD k value of the porous material. | 08-04-2011 |
Ying-Bing Jiang, Albuquerque, NM US
| Patent application number | Description | Published |
|---|---|---|
| 20100178468 | ULTRA-THIN MICROPOROUS/HYBRID MATERIALS - Ultra-thin hybrid and/or microporous materials and methods for their fabrication are provided. In one embodiment, the exemplary hybrid membranes can be formed including successive surface activation and reaction steps on a porous support that is patterned or non-patterned. The surface activation can be performed using remote plasma exposure to locally activate the exterior surfaces of porous support. Organic/inorganic hybrid precursors such as organometallic silane precursors can be condensed on the locally activated exterior surfaces, whereby ALD reactions can then take place between the condensed hybrid precursors and a reactant. Various embodiments can also include an intermittent replacement of ALD precursors during the membrane formation so as to enhance the hybrid molecular network of the membranes. | 07-15-2010 |
Yinglu Jiang US
| Patent application number | Description | Published |
|---|---|---|
| 20110318650 | Inorganic Solid Electrolyte Glass Phase Composite and a Battery Containing an Inorganic Solid Electrolyte Glass Phase Composite - An inorganic solid electrolyte glass phase composite is provided comprising a substance of the general formula La | 12-29-2011 |
Yinglu Jiang, Morgantown, WV US
| Patent application number | Description | Published |
|---|---|---|
| 20090101522 | High Temperature Electrochemical Characterization of Molten Metal Corrosion - A system and method for the high temperature in-situ determination of corrosion characteristics of a molten metal on an alloy under study is provided which takes place within an insulated furnace. A graphite crucible provided in the furnace contains an electrolyte formed from a molten salt of a metal halide. A reference electrode formed from the same metal as the electrolyte is immersed in the electrolyte solution in the graphite crucible. A beta-alumina crucible containing a molten metal is also provided within the furnace and preferably within the graphite crucible. A measuring electrode formed from the alloy under study is immersed in the molten metal. Standard electrochemical techniques are used to measure and analyze the electrochemical effects of corrosion of the molten metal on the alloy. | 04-23-2009 |
Yuan Jiang, Londonderry, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20120014936 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF HEPARAN N-SULFATASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A. | 01-19-2012 |
Yuqiu Jiang US
| Patent application number | Description | Published |
|---|---|---|
| 20080219988 | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER - Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer. | 09-11-2008 |
Zhong-Xing Jiang, Salt Lake City, UT US
| Patent application number | Description | Published |
|---|---|---|
| 20100099845 | PROTECTED ENANTIOPURE TRIFLUOROTHREONINES AND METHODS OF MAKING AND USING SAME - Disclosed are processes for preparing a protected trifluorothreonine, or salt thereof or carboxylate derivative thereof, the process comprising: dihydroxylation of an alkene to yield a dihydroxyl compound; conversion of the dihydroxyl compound to a monohydroxyl compound; protection of the monohydroxyl compound to yield an azide compound; transformation of the azide compound to yield an amino compound; protection of the amino compound to yield a protected amine compound; and oxidation of the protected amine compound to yield the protected trifluorothreonine. Also disclosed are compounds having the structure: | 04-22-2010 |