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Jiang, CT

Aimin Jiang, New Haven, CT US

Patent application numberDescriptionPublished
20090306045Inhibition of Glycogen Synthase Kinase and Methods of Treating Autoimmune or Immune Inflammatory Disease - The present invention relates to the use of glycogen synthase kinase 3(GSK3) inhibitors, especially inhibitors of GSK-3α, GSK-3β and GSK-3β2, preferably, inhibitors of GSK-3β, in patients having autoimmune diseases and/or immune dysfunction/dysregulation to induce immune tolerance. Inhibition of GSK leads to activation of a pathway of dendritic cell maturation which leads to a dendritic phenotype which attenuates, rather than induces, immune responses. The immune responses and mature dendritic cells produced by the method of the present invention redirect or attenuate the immune response in individuals, thus leading to effective therapies for a number of autoimmune diseases and/or diseases of immune dysfunction/dysregulation (immune inflammatory diseases), including systemic lupus erythematosus (SLE), autoimmune diabetes (type I diabetes mellitus), asthma, rheumatoid arthritis, inflammatory bowel disease, among numerous others.12-10-2009

Huiping Jiang, Ridgefield, CT US

Patent application numberDescriptionPublished
20100107263C-REACTIVE PROTEIN (CRP) KNOCKOUT MOUSE - The instant invention relates to a transgenic, non-human animal that carries a mutation in the gene encoding C-reactive protein (CRP). Preferably, the invention relates to an animal comprising a homozygous CRP-deficient mouse and techniques for producing such animals. The invention also relates to organs, tissues, cells, cell lines and sub-cellular fractions derived from such animals. Techniques for generating total or tissue-specific CRP knockout animals are also described. The invention further relates to the use of such knockout animals for the study of the role of CRP proteins in vivo or ex vivo, particularly in relation to its role in inflammatory pathway and in the etiology human diseases.04-29-2010

John Jiang, Milford, CT US

Patent application numberDescriptionPublished
20090052111HIGH VOLTAGE CAPACITORS - A capacitor includes a ceramic capacitor body having opposite ends and comprised of a plurality of electrode layers and dielectric layers and first and second external terminals attached to the ceramic capacitor body. The internal active electrodes within the ceramic capacitor body are configured in an alternating manner. Internal electrode shields within the ceramic capacitor body are used to assist in providing resistance to arc-over. The shields may include a top internal electrode shield and an opposite bottom internal electrode shield wherein the top internal electrode shield and the opposite bottom internal electrode shield are on opposite sides of the plurality of internal active electrodes and each internal electrode shield extends inwardly to or beyond a corresponding external terminal to thereby provide shielding. Side shields are used. The capacitor provides improved resistance to arc-over, high voltage breakdown in air, and allows for small case size. To further increase voltage breakdown, a coating on the ceramic capacitor may be used.02-26-2009
20090052112HIGH VOLTAGE CAPACITORS - A capacitor includes a ceramic capacitor body having opposite ends and comprised of a plurality of electrode layers and dielectric layers and first and second external terminals attached to the ceramic capacitor body. The internal active electrodes within the ceramic capacitor body are configured in an alternating manner. Internal electrode shields within the ceramic capacitor body are used to assist in providing resistance to arc-over. The shields can include a top internal electrode shield and an opposite bottom internal electrode shield wherein the top internal electrode shield and the opposite bottom internal electrode shield are on opposite sides of the plurality of internal active electrodes and each internal electrode shield extends inwardly to or beyond a corresponding external terminal to thereby provide shielding. Side shields are used. The capacitor provides improved resistance to arc-over, high voltage breakdown in air, and allows for small case size.02-26-2009
20100033894HIGH VOLTAGE CAPACITORS - A multilayer ceramic capacitor component includes a ceramic capacitor body having opposite ends and comprised of a plurality of electrode layers and dielectric layers, first and second external terminals attached to the ceramic capacitor body. The plurality of electrode layers include a plurality of alternating layers of active electrodes extending inwardly from alternating ends of the ceramic capacitor body. The capacitor may include a plurality of side shields disposed within the plurality of alternating layers of active electrodes to provide shielding with the alternating layers of active electrodes having a pattern to increase overlap area to provide higher capacitance without decreasing separation between the alternative layers of active electrodes. The capacitor may have a voltage breakdown of 3500 volts DC or more in air. The capacitor may have a coating. The capacitor provides improved resistance to arc-over, high voltage breakdown in air, and allows for small case size.02-11-2010

Patent applications by John Jiang, Milford, CT US

Yirong Jiang, Manchester, CT US

Patent application numberDescriptionPublished
20100037652MULTI-CHANNEL HEAT EXCHANGER WITH MULTI-STAGE EXPANSION - An expansion device for a heat exchanger having a manifold and a plurality of mini- and or micro-channels. The expansion device has an outer element having a plurality of orifices therethrough that is received in the manifold, and an inner element telescopically received in the outer element having at least one orifice therethrough and being in fluid communication with the plurality of orifices. Fluid passing through the at least one orifice and through the plurality of orifices is expanded and reduced in pressure prior to entering the manifold.02-18-2010
20100089095MULTI-PASS HEAT EXCHANGERS HAVING RETURN MANIFOLDS WITH DISTRIBUTING INSERTS - A multi-pass heat exchanger having a return manifold with a partition, a front wall, and a rear wall is provided. The partition separates the return manifold into a collection chamber and a distribution chamber. The front and rear walls define a fluid channel. The front wall has a plurality of perforations placing the fluid channel in separate fluid communication with the collection chamber and the distribution chamber.04-15-2010
20100089559METHOD AND APPARATUS FOR IMPROVING DISTRIBUTION OF FLUID IN A HEAT EXCHANGER - A mini-channel heat exchanger or a micro-channel heat exchanger includes an insert (04-15-2010

Patent applications by Yirong Jiang, Manchester, CT US

Yirong Jiang, Ellington, CT US

Patent application numberDescriptionPublished
20100282454MINICHANNEL HEAT EXCHANGER HEADER INSERT FOR DISTRIBUTION - An inlet header of a microchannel heat exchanger is provided with a first insert disposed within the inlet header and extending substantially the length thereof, and having a plurality of openings for the flow of refrigerant into the internal confines of the inlet header and then to the channels. A second insert, disposed within the first insert, extends substantially the length of the first insert and is of increasing cross sectional area toward its downstream end such that annular cavity is formed between the first and second insert. The annular cavity of decreasing cross sectional area provides for the maintenance of a substantially constant mass flux of the refrigerant along the length of the annulus so as to thereby maintain an annular flow regime of the liquid and thereby promote uniform flow distribution to the channels.11-11-2010
20110030934Integrated Flow Separator and Pump-Down Volume Device for Use in a Heat Exchanger - A phase separator and fluid storage volume device for a heat exchanger comprises a vessel, a vapor tube, a liquid tube, an access tube and a flow regulating device. The vessel comprises a first chamber, a second chamber, and a divider separating the first chamber from the second chamber. The vapor tube extends from within the second chamber, through the divider and the first chamber to outside the first chamber. The vapor tube also includes holes between an inlet and an outlet of the tube within the first chamber. The liquid tube extends from within the second chamber to outside of the second chamber. The access tube connects to the second chamber. The flow regulating device is disposed within the vapor tube to provide phase separation between refrigerant traveling between the first chamber and the second chamber within the vapor tube.02-10-2011
20110127023DESIGN CHARACTERISTICS FOR HEAT EXCHANGERS DISTRIBUTION INSERT - A heat exchanger includes heat exchange tubes, a manifold, and a distribution insert incorporating orifices that communicate a fluid into the manifold for distribution into the heat exchange tubes. A design characteristic of the distribution insert and another design characteristic of at least one of the distribution insert, the manifold and the heat exchange tubes are employed to determine an essential design relationship. The essential design relationship defines a design parameter, the value of which falls within a determined range of values.06-02-2011
20110132585HEAT EXCHANGER TUBE CONFIGURATION FOR IMPROVED FLOW DISTRIBUTION - A microchannel heat exchanger includes for each channel, a serpentine shaped tube for providing a plurality of parallel flow passes for successively conducting fluid flow therethrough, and being fluidly interconnected between an inlet and an outlet manifold. Multiple circuits are obtained by the individual serpentine shaped tubes. Various methods are provided for forming the serpentine shaped tubes.06-09-2011

Zaoli Jiang, Woodbridge, CT US

Patent application numberDescriptionPublished
20100166892HERBAL COMPOSITION PHY906 AND ITS USE IN CHEMOTHERAPY - This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.07-01-2010
20100255129HERBAL COMPOSITION PHY906 AND ITS USE IN CHEMOTHERAPY - This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.10-07-2010

Zhaozong Jiang, New Haven, CT US

Patent application numberDescriptionPublished
20090047717ENZYME-CATALYZED POLYCARBONATE AND POLYCARBONATE ESTER SYNTHESIS - An enzymatic process for preparing aliphatic polycarbonates via terpolymerization or transesterification using a dialkyl carbonate, an aliphatic diester, and an aliphatic diol or triol reactant. A catalyst having an enzyme capable of catalyzing an ester hydrolysis reaction in an aqueous environment is subsequently added to the reaction mixture. Next, polymerization of the reaction proceeds for an allotted time at a temperature ≦100° C. Finally, the copolymer is isolated from an the catalyst via filtration.02-19-2009
20100041856ENZYME-CATALYZED POLYCARBONATE AND POLYCARBONATE ESTER SYNTHESIS - An enzymatic process for preparing aliphatic polycarbonates via terpolymerization or transesterification using a dialkyl carbonate, an aliphatic diester, and an aliphatic diol or triol reactant. A catalyst having an enzyme capable of catalyzing an ester hydrolysis reaction in an aqueous environment is subsequently added to the reaction mixture. Next, polymerization of the reaction proceeds for an allotted time at a temperature≦100° C. Finally, the copolymer is isolated from an the catalyst via filtration.02-18-2010

Zhi-Xing Jiang, Southbury, CT US

Patent application numberDescriptionPublished
20080299237PERSONAL CARE COMPOSITION WITH COCOA BUTTER AND DIHYDROXYPROPYL AMMONIUM SALTS - A personal care composition is provided that when the composition is applied to the skin provides improved translucency to reveal a healthy skin color. The composition is based upon a mixture of dihydroxypropyl quaternary ammonium salt and cocoa butter.12-04-2008
20090155321COMPOSITIONS WITH ENCAPSULATED COLORING AGENTS AND METHOD TO IMPART A HEALTHY SKIN APPEARANCE - A cosmetic composition and method of imparting a healthy appearance to skin is provided which includes using a composition formed with about 0.1 to about 20% by weight of the composition of beads, from about 1 to about 80% by weight of the beads of a first coloring agent incorporated within a matrix of the beads, and a cosmetically acceptable carrier, the composition having a hue less than 25°, the beads being coated and having an exterior color other than that of the first coloring agent.06-18-2009
20090155322SELF-TANNING EFFECTS - A cosmetic composition and method is herein described for sunless tanning to impart a glow/shiny effect on skin. The composition includes a sunless tanning agent and coated beads incorporating tan colored pigment. A colorant which imparts a color other than tan to the beads is distributed within the coating. The cosmetic composition provides to the skin an immediate tan via the disintegrated beads. Sunless tanning agent acts more slowly and eventually will replace the pigment effect. The coating with colorant prevents the formula undesirably from appearing tan. Instead a color such as white renders the formula more aesthetically pleasing and more in line with the visuals paradigm of a moisturizer rather than a foundation.06-18-2009
20090155373COSMETIC COMPOSITIONS AND METHOD WHICH IMPART A HEALTHY APPEARANCE TO SKIN - A cosmetic product and method of imparting a healthy appearance to skin is provided which includes using a composition formed with about 0.1 to about 20% by weight of the composition of beads, from about 1 to about 80% by weight of the beads of a coloring agent incorporated within a matrix of the beads, and a cosmetically acceptable carrier, the composition being delivered from a package with instructions being printed on or associated with the package indicating topical use on skin to impart a healthy appearance, and wherein the skin with the applied composition has a reflectance in the range from 510 to 600 nm, and reflectance amplitude ratios at wavelength 510/540 nm ranging from 1.10 to 1.20 and at wavelength 600/580 nm ranging from 1.35 to 1.65.06-18-2009
20100145886Evaluation and Selection Process for Consumer Products - A product evaluation and selection process for consumer products is described. The process includes demonstrating the effectiveness of consumer product on consumer skin by comparing actual images of skin treated with product to images of skin that were artificially transformed. The process also includes the assignment of a symbol associated with a difference in product performance where the symbol may be used to aid consumers in selecting product.06-10-2010
20110091396SUNLESS TANNING COMPOSITION INSURING EFFECTIVE APPLICATION TO SKIN - A sunless tanning composition is provided with from 0.1 to 40% of a C04-21-2011
20110142305TARGETED IMAGE TRANSFORMATION OF SKIN ATTRIBUTE - Targeted attribute transformation involves obtaining a digital image of the skin, selecting an individual skin attribute (an imperfection, such as a blemishes, pores, or wrinkles), extracting the individual skin attribute from the digital image by linear digital filtering on all the color channels, to obtain a contrast map in all three channels of the individual attribute, and adding or subtracting a fraction of the contrast map to the initial image, to obtain the skin image with transformed selected skin attribute.06-16-2011

Patent applications by Zhi-Xing Jiang, Southbury, CT US