Patent application number | Description | Published |
20090253183 | Amplicon Rescue Multiplex Polymerase Chain Reaction for Amplification of Multiple Targets - Disclosed is a method for amplifying and detecting polynucleotides which can provide sensitive, specific detection of multiple targets from a clinical specimen within a relatively short time. | 10-08-2009 |
20100021896 | Method for Evaluating and Comparing Immunorepertoires - Disclosed is a method for amplifying RNA and/or DNA from immune cell populations and using the amplified products to produce an immune response profile and evaluate the possible correlation between a normal or abnormal immune response and the development of a disease such as an autoimmune disease, cancer, diabetes, or heart disease. | 01-28-2010 |
20100190186 | Method for Pathogen Capture from Mammalian Blood - Disclosed is a method for isolating, and thereby concentrating, microorganisms from mammalian blood. The method may be used in conjunction with PCR amplification of the DNA/RNA of the microorganism(s) to identify pathogenic microorganisms within the blood without requiring that those organisms be cultured as a first step in the identification process. | 07-29-2010 |
20100240093 | Isolated Staphylococcus Pseudolugdunensis - Disclosed is an isolated strain of a previously unknown | 09-23-2010 |
20100291668 | Apparatus for Performing Amplicon Rescue Multiplex PCR - The present disclosure is a cassette for PCR amplification and detection of DNA amplicons, the cassette having a cassette pipette which may be moved vertically and horizontally within the cassette, at least one reagent chamber, and at least one detector, such as a microarray, for the detection of DNA amplified during the PCR amplification steps. | 11-18-2010 |
20120171725 | Amplicon Rescue Multiplex Polymerase Chain Reaction for Amplification of Multiple Targets - Disclosed is a method for amplifying and detecting polynucleotides which can provide sensitive, specific detection of multiple targets from a clinical specimen within a relatively short time. | 07-05-2012 |
20120183969 | Immunodiversity Assessment Method and Its Use - Disclosed is a method for distinguishing the immunorepertoires of normal, healthy individuals from those of individuals who have symptomatic and/or non-symptomatic disease. | 07-19-2012 |
20120303283 | Polymerase Preference Index - Disclosed is a method for calculating a Polymerase Preference Index (PPI) for potential primers for DNA sequencing and/or amplification, and thereby increasing the efficiency of DNA sequencing and/or amplification performed using primers selected according to their PPI number. | 11-29-2012 |
20130137594 | SYSTEMS AND METHODS FOR PERFORMING AMPLICON RESCUE MULTIPLEX POLYMERASE CHAIN REACTION (PCR) - Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data. The control element is further configured to analyze the test data received from the reader and to produce an output indicative of a comparison of the test data to predefined data. | 05-30-2013 |
20130210021 | Isolated Staphylococcus Pseudolugdunensis - Disclosed is an isolated strain of a previously unknown | 08-15-2013 |
20140094376 | MULTIPLEX PYROSEQUENCING USING NON-INTERFERING NOISE CANCELLING POLYNUCLEOTIDE IDENTIFICATION TAGS - The present disclosure generally pertains to a multiplex method for analyzing samples comprising using polynucleotide amplification to produce amplified products wherein one or more target sequences are tagged with a non-interfering, non-canceling target-specific polynucleotide identification tag, pyrosequencing the amplified products through the non-canceling target-specific polynucleotide identification tag sequence to detect the presence of one or more specific polynucleotide identification tags. The presence of a specific polynucleotide identification tag being correlated with the presence of a specific target sequence. | 04-03-2014 |
20140127699 | Method for Evaluating and Comparing Immunorepertoires - Disclosed is a method for amplifying RNA and/or DNA from immune cell populations and using the amplified products to produce an immune response profile and evaluate the possible correlation between a normal or abnormal immune response and the development of a disease such as an autoimmune disease, cancer, diabetes, or heart disease. | 05-08-2014 |
20140235497 | Identification of Antigen-Specific Adaptive Immune Responses Using ARM-PCR and High-Throughput Sequencing - Disclosed is a method for correlating at least one amino acid sequence from an antibody isolated from human or animal blood with at least one DNA sequence corresponding to the antibody in the immunorepertoire of the human or animal. The method also provides a means for pairing heavy and light chains to produce synthesized monoclonal antibodies. | 08-21-2014 |
20150080259 | SYSTEMS AND METHODS FOR PERFORMING AMPLICON RESCUE MULTIPLEX POLYMERASE CHAIN REACTION (PCR) - Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data. The control element is further configured to analyze the test data received from the reader and to produce an output indicative of a comparison of the test data to predefined data. | 03-19-2015 |