| Patent application number | Description | Published |
|---|
| 20080199930 | METHOD AND APPARATUS FOR THE RAPID DISRUPTION OF CELLS OR VIRUSES USING MICRO BEADS AND LASER - A method and apparatus for rapid disruption of cells or viruses using beads and a laser are provided. According to the method and apparatus for rapid disruption of cells or viruses using beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC. | 08-21-2008 |
| 20080226504 | PUMP UNIT AND CENTRIFUGAL MICROFLUIDIC SYSTEM HAVING THE SAME - Provided are a pump unit and a centrifugal microfluidic system including the pump unit. The pump unit includes a gas generating agent. The gas generating agent includes a plurality of heating particles generating heat by absorbing energy and one of a sublimation material, azide, and azo compound mixed with the heating particles. When energy is supplied to the gas generating agent, the gas generating agent generates gas due to heat emitted from the heating particles to increase an air pressure around the gas generation agent so that the fluid is moved by the increased air pressure. | 09-18-2008 |
| 20080252905 | CENTRIFUGAL FORCE BASED MICROFLUIDIC DEVICE, MICROFLUIDIC SYSTEM INCLUDING THE SAME, AND METHOD OF DETERMINING HOME POSITION OF THE MICROFLUIDIC DEVICE - Provided is a centrifugal force based microfluidic system including: a microfluidic device including a rotatable platform and an optical path formed to extend horizontally in a straight line from a circumference of the platform; a motor rotating so as to control the microfluidic device; a light emitting unit emitting light towards the microfluidic device; a light receiving unit detecting the light emitted from the light emitting unit; and a controller determining a home position to be the position of the microfluidic device at a point of time when the light emitted from the light emitting unit is detected by the light receiving unit, wherein the light emitted from the light emitting unit passes through the optical path to be incident on the light receiving unit only when the microfluidic device is located in a predetermined position. | 10-16-2008 |
| 20080273205 | OPTICAL DETECTION APPARATUS AND METHOD USING PHASE SENSITIVE DETECTION METHOD FOR DISK-TYPE MICROFLUIDIC DEVICE - An optical detection apparatus and method using a phase sensitive detection method for a disk-type microfluidic device are provided. The optical detection apparatus includes: a rotation driving unit stopping rotation of the microfluidic device when a detection area of the disk-type microfluidic device reaches a predetermined position; at least one light source turned on and off at a corresponding frequency to emit light to the detection area held at the predetermined position; an optical sensor disposed to face the detection area and generating an electrical signal according to intensity of incident light; and a signal processing unit receiving the electrical signal generated by the optical sensor and outputting only a signal having a same frequency as an on/off frequency of one of the at least one light source. | 11-06-2008 |
| 20080274015 | MICROFLUIDIC DEVICE AND MICROFLUIDIC SYSTEM WITH THE SAME - Provided is a microfluidic device and microfluidic system with the device. The microfluidic device includes a substrate; a channel formed in the substrate and in which a fluid can move; a valve controlling flow of a fluid flowing along the channel and including a phase transition material which can be melted by energy such as electromagnetic wave energy; and a lens disposed on the substrate and adjusting an irradiating region of the valve, onto which the energy is applied. | 11-06-2008 |
| 20080300148 | MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit. | 12-04-2008 |
| 20080305006 | MICROFLUIDIC APPARATUS HAVING FLUID CONTAINER - A microfluidic apparatus having a substrate including a channel through which a fluid is conveyed, a fluid container in which at least one kind of fluid is accommodated and which is disposed on the substrate so as to allow the fluid to flow toward the channel, and a fluid flow controller which controls a flow of the fluid toward the channel from the fluid container. | 12-11-2008 |
| 20080314465 | MICROFLUIDIC VALVE, METHOD OF MANUFACTURING THE SAME, AND MICROFLUIDIC DEVICE COMPRISING THE MICROFLUIDIC VALVE - Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves. | 12-25-2008 |
| 20080318279 | APPARATUS AND METHOD FOR PURIFICATION OF NUCLEIC ACIDS BY PHASE SEPARATION USING LASER AND BEADS - An apparatus and method for purification of nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples and magnetic beads are introduced; a vibrator attached to the capillary and mixing the samples and the magnetic beads in the capillary; a laser generator attached to the capillary and supplying a laser to the capillary; and a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall. According to the method and apparatus, PCR yield can be increased since PCR inhibitors can be readily removed by means of a phase separation in a capillary. The use of an electromagnet ensures the removal of the PCR inhibitors. In addition, since cell lysis and DNA purification process can be simultaneously performed, LOC steps can be reduced. | 12-25-2008 |
| 20090021741 | OPTICAL DETECTION APPARATUS, OPTICAL DETECTION METHOD, AND MICROFLUIDIC SYSTEM INCLUDING THE OPTICAL DETECTION APPARATUS - Provided are an optical detection apparatus, a microfluidic system including the same, and an optical detection method. The optical detection apparatus including: at least one light emission unit which emits light of a predetermined wavelength band; at least one light receiving unit which is disposed such that the light receiving unit receives the light emitted from the light emission unit and generates an electrical signal according to the intensity of the light received, wherein the number of light receiving units is the same as the number of light emission units; a rotation operating unit which rotates a disk-type microfluidic apparatus comprising at least one detection chamber in which a sample is to be loaded such that the detection chamber is disposed in a light pathway between the light emission unit and the light receiving unit; and a processor which measures a property of the sample contained in the detection chamber using the electrical signal generated by the light receiving unit. | 01-22-2009 |
| 20090022625 | BIOCHEMICAL ANALYZER AND METHOD OF CONTROLLING INTERNAL TEMPERATURE OF THE BIOCHEMICAL ANALYZER - Provided is a biochemical analyzer in which a microfluidic biochemical assay may be performed. The analyzer includes: a microfluidic device loading space including a microfluidic device supporting unit detachably supporting a microfluidic device including an energy application region in which an energy is applied; an energy source loading space including an energy source applying the energy to the radiation application region; and an isolation wall isolating the microfluidic device loading space and the energy source loading space to prevent heat transfer between the microfluidic device loading space and the energy source loading space and including a window through which the energy can be transmitted. A method of controlling an internal temperature of the biochemical analyzer is also provided. | 01-22-2009 |
| 20090035847 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR NUCLEIC ACID DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - Provided are a centrifugal force-based microfluidic device for separating and amplifying a nucleic acid of a target cell and a microfluidic system including the same. The microfluidic device includes a rotary platform; a target cell nucleic acid extraction unit; and a polymerase chain reaction (PCR) unit wherein in a microfluidic structure arranged in the platform and connected to the target cell nucleic acid extraction unit. | 02-05-2009 |
| 20090065734 | HEAT TRANSFER MEDIUM AND HEAT TRANSFER METHOD USING THE SAME - Disclosed are a heat transfer medium and a heat transfer method that uses the heat transfer medium. The heat transfer medium comprises a light-transparent substrate coated with a plurality of nano particles. The nano particles absorb light incident thereon to thereby produce heat, which is transferred to a target object to be heated. Nano particles can be applied onto a target object. After heating, the particles are removed by etching. Nano particles can be selectively applied to the light-transparent substrate or directly to a target object to be heat so as to localize heat-production and thus heat selective portions of the target object. | 03-12-2009 |
| 20090099782 | AUTOMATIC ANALYZING METHOD AND APPARATUS FOR MICROFLUIDIC SYSTEM - Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantitation of a test. | 04-16-2009 |
| 20090143250 | MICROFLUIDIC DEVICE USING MICROFLUIDIC CHIP AND MICROFLUIDIC DEVICE USING BIOMOLECULE MICROARRAY CHIP - Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure. | 06-04-2009 |
| 20090189932 | DROPLET EMITTING APPARATUS HAVING PIEZOELECTRIC VOLTAGE GENERATOR AND METHOD OF EMITTING A DROPLET USING THE SAME - Provided are a droplet emitting apparatus and a method of emitting droplets using the same. The apparatus includes a solution tank for containing a solution; a nozzle including an opening through which at least a droplet of the solution is emitted; and a voltage generator including a piezoelectric material for generating a voltage by instantaneous pressure application, wherein the voltage generated by the pressure to the piezoelectric material is applied to the solution in order for the at least a droplet of the solution to be emitted through the nozzle | 07-30-2009 |
| 20090322828 | DEVICE FOR PRINTING DROPLET OR INK ON SUBSTRATE OR PAPER - A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet. | 12-31-2009 |
| 20100044216 | METHOD FOR CONTROLLING THE CONTACT ANGLE OF A DROPLET IN ELECTROWETTING AND AN APPARATUS USING THE DROPLET FORMED THEREBY - A method for controlling the hydrophilic droplet using the electrowetting principle is disclosed. More specifically, the present invention provides a method for increasing the change of the contact angle in the interface that is formed between the hydrophilic droplet and the nonpolar fluid by adding a constant concentration of two-element electrolyte or three-element electrolyte to the hydrophilic droplet; and an apparatus for controlling the droplet having the change of the contact angle and velocity scope increased by the method. | 02-25-2010 |
| 20100081207 | ASSAY MATERIAL, METHOD OF DETECTING A TARGET USING THE SAME, AND METHOD OF PRODUCING THE SAME - One or more exemplary embodiments providing an assay material including an assay material that includes a substrate, a compound linked to the substrate wherein the compound is linkable specifically to a target, and a patterned region disposed on the substrate wherein the patterned region provides an optical output signal when an incident optical signal is irradiated thereto and wherein the optical output signal corresponds to a code on the substrate. | 04-01-2010 |
| 20100081213 | CENTRIFUGAL-BASED MICROFLUIDIC APPARATUS, METHOD OF FABRICATING THE SAME, AND METHOD OF TESTING SAMPLES USING THE MICROFLUIDIC APPARATUS - Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test. | 04-01-2010 |
| 20100092985 | SOLID SUPPORT WITH ENHANCED DENSITY OF SIGNAL MATERIAL, KIT CONTAINING THE SAME AND METHOD OF DETECTING TARGET MATERIAL USING THE SAME - A solid support on which a labeled nucleic acid including a high density of signal materials, a kit containing the same, and a method of detecting a target material are provided. | 04-15-2010 |
| 20100093105 | MICROFLUIDIC DEVICE USING CENTRIFUGAL FORCE, METHOD OF MANUFACTURING THE MICROFLUIDIC DEVICE AND SAMPLE ANALYZING METHOD USING THE MICROFLUIDIC DEVICE - Provided is a microfluidic device including: a sample chamber; at least one analyzing unit receiving a sample from the sample chamber and detecting components contained in the sample according to a reaction of the sample and a reagent; and a denaturation detection chamber determining the storage condition of the microfluidic device, wherein the denaturation detection chamber accommodates a material whose light absorption changes according to the temperature and the water thereof | 04-15-2010 |
| 20100175993 | DISC-SHAPED MICROFLUIDIC DEVICE CAPABLE OF DETECTING ELECTROLYTES INCLUDED IN SPECIMEN BY USING ELECTROCHEMICAL METHOD - Provided is a rotatable disc-shaped microfluidic device which can electrochemically detect electrolytes comprised in a specimen. The microfluidic device including: a specimen chamber which accommodates a specimen; a detection chamber which receives the specimen from the specimen chamber; and an ion sensor which is formed in the detection chamber to electrochemically detect electrolytes in the specimen and includes an indicator electrode, a standard electrode and an ion selective film formed on a portion of the indicator electrode. The standard specimen is accommodated in the detection chamber, and a standard potential is measured. Then, the specimen is accommodated in the detection chamber, and a measurement potential is obtained to detect the concentration of the electrolytes comprised in the specimen. | 07-15-2010 |
| 20100175994 | DISC-SHAPED MICROFLUIDIC DEVICE CAPABLE OF DETECTING ELECTROLYTES INCLUDED IN SPECIMEN BY USING ELECTROCHEMICAL METHOD - Provided is a rotatable disc-shaped microfluidic device which can electrochemically detect electrolytes comprised in a specimen. The microfluidic device including: a specimen chamber which accommodates a specimen; a detection chamber which receives the specimen from the specimen chamber; and an ion sensor which is formed in the detection chamber to electrochemically detect electrolytes in the specimen and includes an indicator electrode, a standard electrode and an ion selective film formed on a portion of the indicator electrode. The standard specimen is accommodated in the detection chamber, and a standard potential is measured. Then, the specimen is accommodated in the detection chamber, and a measurement potential is obtained to detect the concentration of the electrolytes comprised in the specimen. | 07-15-2010 |
| 20110020194 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR PROTEIN DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction. | 01-27-2011 |
| 20110049398 | VALVE UNIT AND APPARATUS HAVING THE SAME - A valve unit and an apparatus having the same include a plug which includes a phase change material in a solid state at a room temperature and a plurality of fine heat-dissipating particles dispersed in the phase change material. The fine heat-dissipating particles dispersed in the phase change material dissipate heat by absorbing an electromagnetic wave energy generated by electromagnetic wave radiation from the outside and block fluid flow in a path formed by a channel. As an external energy source irradiates an electromagnetic wave on the plug, the plurality of fine heat-dissipating particles dissipate heat and the phase change material becomes molten, thus opening the path to allow the fluid to flow. | 03-03-2011 |
| 20110085950 | CENTRIFUGAL FORCE BASED MICROFLUIDIC SYSTEM AND BIO CARTRIDGE FOR THE MICROFLUIDIC SYSTEM - A microfluidic system based on centrifugal force and a bio cartridge for the microfluidic system are provided. The system includes a spindle motor, a rotatable frame detachably mounted on the motor and having a plurality of cells separated by partition walls, and the bio cartridge detachably accommodated in one of the plurality of cells. The bio cartridge includes a chamber for storing a fluid, a channel for transporting the fluid, and a valve for controlling the flow of the fluid. The valve may include a phase transition material, and exothermic minute particles dispersed in the material and generating heat when energy is applied thereto. | 04-14-2011 |
