Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Jens-Ulrich
Jens-Ulrich Prowe, Hamburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20110042516 | WINDOW ELEMENT FOR A DOUBLE-SHELL SKIN FIELD OF AN AIRCRAFT FUSELAGE CELL - A window element for a double-shell skin field of an aircraft fuselage cell includes a window frame having a window module disposed in the frame, wherein the frame is disposed in an opening of the double-shell skin field, and wherein the frame is connected to the double-shell skin field by a surrounding embrasure profile positioned against a core structure of the skin field at least in some regions, wherein the core structure includes an inner and an outer covering layer. | 02-24-2011 |
| 20120056037 | FUSELAGE CELL STRUCTURE FOR AN AIRCRAFT IN HYBRID DESIGN - A fuselage cell structure for an aircraft includes at least two skin panels including at least one double shell skin panel and at least one monolithic skin panel. At least one brace which is at least one of a longitudinal and a transverse brace is disposed so as to form at least one of a longitudinal seam and a transverse seam between the at least one double shell skin panel and the at least one monolithic skin panel. The fuselage cell structure includes at least one of a longitudinal bracket and a load transfer point. The longitudinal bracket is disposed in a region of the longitudinal seam and includes a first and a second longitudinal flange that are disposed offset with respect to one another and connected by a web. The load transfer point is disposed in a region of the transverse seam so as to connect the longitudinal brace disposed on the at least one monolithic skin panel to the at least one double shell skin panel. | 03-08-2012 |
Jens-Ulrich Rahfeld, Lieskau DE
| Patent application number | Description | Published |
|---|---|---|
| 20080249083 | NOVEL GENES RELATED TO GLUTAMINYL CYCLASE - Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes. | 10-09-2008 |
| 20100009337 | NOVEL GENES RELATED TO GLUTAMINYL CYCLASE - Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes. | 01-14-2010 |
| 20100021478 | DIAGNOSTIC ANTIBODY ASSAY - The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided. | 01-28-2010 |
| 20100028918 | GLUTAMINYL CYCLASE AS A DIAGNOSTIC/PROGNOSTIC INDICATOR FOR NEURODEGENERATIVE DISEASES - A method for predicting, diagnosing and prognosticating a neurodegenerative disease, such as Alzheimer's disease (AD), Mild Cognitive Impairment (MCI) and neurodegeneration in Down's syndrome (NDS) using glutaminyl cyclase (QC) as a diagnostic/prognostic indicator. The use of antibodies binding to QC and kits for performing said diagnostic method are also provided. | 02-04-2010 |
| 20100099721 | NOVEL COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS - Inhibitors of prolyl endopeptidase of formula 1 | 04-22-2010 |
| 20100119478 | ANTIBODIES DIRECTED AGAINST PYROGLUTAMATE MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1 N1pE) - Monoclonal antibodies which bind specifically to the proinflammatory cytokine pyroglutamate MCP-1 (MCP-1 N1pE) are described. | 05-13-2010 |
| 20100125086 | USE OF ISOQC INHIBITORS - The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinising polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation. | 05-20-2010 |
| 20120064547 | DIAGNOSTIC ANTIBODY ASSAY - Novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided. | 03-15-2012 |
Jens-Ulrich Rahfeld, Ot Roeblingen Am See DE
| Patent application number | Description | Published |
|---|---|---|
| 20110166035 | NOVEL DIAGNOSTIC METHOD - Provided herein are methods, compositions, and kits related to the detection and diagnosis of a neurodegenerative disorder, such as Alzheimer's disease. Various aspects use the oligomeric state of fragments of amyloid β as a biomarker and further concerns a novel method to determine the oligomeric state of fragments of amyloid β in biological samples. | 07-07-2011 |
| 20110212853 | NOVEL DIAGNOSTIC METHOD - A method of monitoring treatment of an inflammatory disease or an inflammatory associated disease with the use of the ratio of N-terminal pyroglutamate modified MCP-1 (MCP-1 N1pE):total concentration of MCP-1 within a biological sample as a biomarker, and a method for determining the proportion of N-terminal pyroglutamate modified MCP-1 in relation to the total concentration of MCP-1 in biological samples. Also disclosed are a diagnostic kit and a method for screening a glutaminyl cyclase (QC) inhibitor or measuring the effectiveness of a glutaminyl cyclase (QC) inhibitor. | 09-01-2011 |
Jens-Ulrich Rahfeld, Roblingen Am See DE
| Patent application number | Description | Published |
|---|---|---|
| 20120045815 | CRYSTAL STRUCTURE OF GLUTAMINYL CYCLASE - A novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase. | 02-23-2012 |
Jens-Ulrich Rahfeld, Mansfelder Land DE
| Patent application number | Description | Published |
|---|---|---|
| 20120108449 | CRYSTAL STRUCTURE OF ISOGLUTAMINYL CYCLASE - A crystal comprising human isoglutaminyl cyclase having a characterised space group of P1211 and unit cell dimensions of +/−5% of a=126.51 Å, b=109.68 Å, c=159.53 Å, α=90.0°, β=104.9° and γ=90.0°. | 05-03-2012 |