Patent application number | Description | Published |
20090069391 | Benzothiophene hydroxamic acid derivatives - The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 03-12-2009 |
20090082308 | Benzothiophene derivatives - The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 03-26-2009 |
20110251379 | COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS - As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease. | 10-13-2011 |
20130060013 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
20130060019 | Compounds for Use in Treating Neurodegenerative Disorders, Synthesis Thereof, and Intermediates Thereto - The present invention provides methods of making a compound of formula II: | 03-07-2013 |
20130060020 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
20130060021 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
20130060022 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
20130060023 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |
20130060024 | Compounds useful for treating neurodegenerative disorders - The present invention provides compounds of formula I: | 03-07-2013 |