Patent application number | Description | Published |
20090011519 | DEVICE AND METHOD FOR MICRO SORBENT EXTRACTION AND DESORPTION - This invention relates to a micro cartridge and to a method of using the micro cartridge to sample and extract components of interest from a gas or a liquid. The cartridge contains a sorbent and has passages through which a pressure drop can be created to permit access between the gas or liquid and the sorbent. The micro cartridge is elongated and has one pointed end to fit into the injection port of a suitable analysis instrument where the components of interest are desorbed. The cartridge has two ends that are covered by removable closures and preferably has a diameter of less than 1 millimeter. The cartridge can be used with micro machine components and components made using nano technology. | 01-08-2009 |
20090026122 | BIOCOMPATIBLE SOLID-PHASE MICROEXTRACTION COATINGS AND METHODS FOR THEIR PREPARATION - A biocompatible coating for solid phase microextraction (SPME) of a small molecule from a biological matrix. The coating comprises SPME particles and a biocompatible polymer. The biocompatible polymer (e.g. polyacrylonitrile) reduces adsorption of proteins or macromolecules onto the SPME particles and allows the SPME particles to extract the small molecule from the matrix. A process for coating a flexible fiber with a biocompatible coating. The process comprises: coating the fiber with a suspension of SPME particles, the SPME particles being suspended in a solution of a biocompatible polymer and a solvent, the biocompatible polymer can comprise polyacrylonitrile (PAN); drying the coated fiber to remove the solvent; and curing the dried coated fiber at an elevated temperature. | 01-29-2009 |
20120164286 | SOLID-PHASE MICROEXTRACTION COATINGS AND METHODS FOR THEIR PREPARATION - There is described a coated solid phase microextraction (SPME) fibre for use in direct immersion SPME of a food matrix that includes carbohydrates. The coated SPME fibre includes a SPME fibre for absorbing a small molecule from the food matrix; and a protective coating which has a surface that is substantially uniform and substantially smooth, the protective coating reducing adsorption of the carbohydrates onto the SPME fibre and allowing the SPME fibre to extract the small molecule from the food matrix. A process for producing the coated SPME fibre and a method of performing solid phase microextraction are also described. | 06-28-2012 |
20120228228 | Methods of Preparation and Manufacture of Biocompatible Solid-Phase Microextraction Coatings and Coated Devices - A process for manufacturing a fiber or other device with a biocompatible coating for using the fiber in solid phase microextraction (SPME) of a small molecule of interest from a matrix. The process includes the step of coating the fiber/device with a coating of a biocompatible polymer and a solvent having solid phase microextraction (SPME) particles with pores dimensioned to absorb the small molecule of interest from the matrix suspended therein. The process also includes the steps of drying the coated fiber/device to remove the solvent and curing the dried coated fiber at an elevated temperature. | 09-13-2012 |
20150231602 | METHODS OF PREPARATION AND MANUFACTURE OF BIOCOMPATIBLE SOLID-PHASE MICROEXTRACTION COATINGS AND COATED DEVICES - Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the investigation of living systems. A number of interfaces to analytical instrumentation are disclosed including mass spectrometry, LC/MS, MALDI and CE as well as direct spectroscopic on-fibre measurement. | 08-20-2015 |
20150318158 | PROBE FOR EXTRACTION OF MOLECULES OF INTEREST FROM A SAMPLE - The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs a molecule of interest from a matrix, or a polymer and solid phase microextraction (SPME) particles having pores dimensioned to absorb a molecule of interest from a matrix, where the mesh substrate has a sufficiently open structure to allow fluid to flow through the mesh substrate; and a solid substrate connected to the mesh substrate to provide stability to the coated mesh substrate. Mass spectrometry systems that include such a device are also described. Methods of analyzing an analyte previously extracted from a matrix onto the device are also described. | 11-05-2015 |
20150318160 | PROBE FOR EXTRACTION OF MOLECULES OF INTEREST FROM A SAMPLE - A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer. The solid substrate may have at least two edges that meet at an angle from about 8° to about 180°. Mass spectrometry systems that include such a device are also described. Methods of analyzing a molecule previously extracted from a sample onto the device are also described. | 11-05-2015 |