| Patent application number | Description | Published |
|---|
| 20080207880 | Reduction of the Content of Protein Contaminents in Compositions Comprising a Vitamin K-Dependent Protein of Interest - The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides. | 08-28-2008 |
| 20090017557 | FVII Specific Antibodies and Use Thereof - The present invention relates to novel antibodies against FVII, use for determining amount of correctly folded and intact FVII in a sample, as well as for purification and process optimization. | 01-15-2009 |
| 20090042784 | Purification of a Drug Substance of a Factor VII Polypeptide by Removal of DesGla-Factor VII Polypeptide Structures - The present invention relates to a purification process for drug substances of a Factor VII polypeptide having an impurity in the form of desGla-Factor VII polypeptide structures. The process utilizes an anion-exchange material and includes washing and/or elution with a buffer of a predetermined pH. | 02-12-2009 |
| 20100136622 | Method for the Production of Proteins - The present invention relates to a process for the purification of a protease. | 06-03-2010 |
| 20110003363 | Reduction of Dimer Content in Factor VII Polypeptide Compositions by Heat Treatment - The present application relates to a method of reducing the content of dimers in Factor VII polypeptide composition by heat treatment. | 01-06-2011 |
| 20110064719 | HYDROPHOBIC INTERACTION CHROMATOGRAPHY PURIFICATION OF FACTOR VII POLYPEPTIDES - The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern. | 03-17-2011 |
| 20110081702 | Method for the Production of Proteins - The present invention relates to a process for the purification of a protease. | 04-07-2011 |
| 20110177580 | Method of Controlling a Polypeptide Modification Reaction - The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions comprising said polypeptides. | 07-21-2011 |
