Patent application number | Description | Published |
20120283215 | PHARMACEUTICAL COMPOSITIONS WHICH INHIBIT FKBP52-MEDIATED REGULATION OF ANDROGEN RECEPTOR FUNCTION AND METHODS OF USING SAME - Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided. | 11-08-2012 |
20140171503 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER - Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R | 06-19-2014 |
20140350093 | METHODS OF TREATING OR PREVENTING INSULIN RESISTANCE AND ASSOCIATED DISEASES AND CONDITIONS - Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R | 11-27-2014 |
20150283111 | METHODS OF TREATING PATIENTS INFECTED WITH HIV AND HTLV - Disclosed is a method of activating protein kinase C theta (PKCθ) in an HIV or HTLV infected animal comprising administering to the animal an effective amount of a compound of formula (I): Formula (I), or an epimer thereof; wherein Ar and R | 10-08-2015 |
Patent application number | Description | Published |
20090025891 | COMPOSITION AND METHOD FOR IMPROVING RETENTION AND DRAINAGE IN PAPERMAKING PROCESSES BY ACTIVATING MICROPARTICLES WITH A PROMOTER-FLOCCULANT SYSTEM - A composition and method for improving retention and drainage in a papermaking process is disclosed. An unexpected synergistic effect has been observed when certain amounts of a promoter are used in conjunction with a microparticle. Optionally, a flocculent is also used to further improve the observed synergism. The microparticle includes an inorganic anionic or cationic siliceous material. The promoter includes a modified diallyl-N,N-disubstituted ammonium halide polymer. The flocculant includes one or more high molecular weight, water-soluble cationic, anionic, nonionic, zwitterionic, or amphoteric polymers. | 01-29-2009 |
20120216970 | COMPOSITION AND METHOD FOR IMPROVING RETENTION AND DRAINAGE IN PAPERMAKING PROCESSES BY ACTIVATING MICROPARTICLES WITH A PROMOTER-FLOCCULANT SYSTEM - A composition and method for improving retention and drainage in a papermaking process is disclosed. An unexpected synergistic effect has been observed when certain amounts of a promoter are used in conjunction with a microparticle. Optionally, a flocculent is also used to further improve the observed synergism. The microparticle includes an inorganic anionic or cationic siliceous material. The promoter includes a modified diallyl-N,N-disubstituted ammonium halide polymer. The flocculant includes one or more high molecular weight, water-soluble cationic, anionic, nonionic, zwitterionic, or amphoteric polymers. | 08-30-2012 |
20140251318 | LIGNIN SEPARATION FROM LIGNOCELLULOSIC HYDROLIZATES AND ACIDIFIED PULP MILL LIQUORS - The invention provides methods and compositions for the removal of lignin from water suspensions originating from lignocellulosic feedstocks. The method involves adding coagulants and flocculants to the suspension. While hydrolysis does remove some lignin, the pitch in many feedstocks prevents the hydrolysis from coming into contact with all of the lignin or so effectively blocks it that the lignin can re-condense. This is especially the case with low lignin grass based lignocellulosic feedstock. But wWith the addition of the inventive coagulants and flocculants, a phase separation substantially accelerates and lignin forms flocs that forms that physically separates the lignin from the pitch and the cellulose thereby makes removal the lignin from aqueous suspensions by decanting and filtration effective and easy. | 09-11-2014 |
20140251565 | PROCESS FOR PRODUCING HIGH SOLIDS COLLOIDAL SILICA - The invention provides a method for improving the effectiveness of colloidal silica. The method involves removing enough charged impurities from the colloid to prevent the charged particles from causing the colloid to become a viscous gel. The method however also involves not removing too many charged particles so the silica material doesn't gel by cross-linking with itself. This method is quite effective because it recognizes that materials that have accumulated during the formation of the colloid do perform an important function, but they can perform better at a lower concentration. | 09-11-2014 |