Patent application number | Description | Published |
20090192041 | SYSTEMS, DEVICES, AND METHODS FOR CONTROLLABLY COUPLING QUBITS - A transverse coupling system may include a first qubit, a second qubit, a first conductive path capacitively connecting the first qubit and the second qubit, a second conductive path connecting the first qubit and the second qubit, and a dc SQUID connecting the first and the second conductive paths wherein the compound junction loop is threaded by an amount of magnetic flux. | 07-30-2009 |
20110057169 | SYSTEMS, METHODS AND APPARATUS FOR ACTIVE COMPENSATION OF QUANTUM PROCESSOR ELEMENTS - Apparatus and methods enable active compensation for unwanted discrepancies in the superconducting elements of quantum processor. A qubit may include a primary compound Josephson junction (CJJ) structure, which may include at least a first secondary CJJ structure to enable compensation for Josephson junction asymmetry in the primary CJJ structure. A qubit may include a series LC-circuit coupled in parallel with a first CJJ structure to provide a tunable capacitance. A qubit control system may include means for tuning inductance of a qubit loop, for instance a tunable coupler inductively coupled to the qubit loop and controlled by a programming interface, or a CJJ structure coupled in series with the qubit loop and controlled by a programming interface. | 03-10-2011 |
20130313526 | SYSTEMS, METHODS AND APPARATUS FOR ACTIVE COMPENSATION OF QUANTUM PROCESSOR ELEMENTS - Apparatus and methods enable active compensation for unwanted discrepancies in the superconducting elements of a quantum processor. A qubit may include a primary compound Josephson junction (CJJ) structure, which may include at least a first secondary CJJ structure to enable compensation for Josephson junction asymmetry in the primary CJJ structure. A qubit may include a series LC-circuit coupled in parallel with a first CJJ structure to provide a tunable capacitance. A qubit control system may include means for tuning inductance of a qubit loop, for instance a tunable coupler inductively coupled to the qubit loop and controlled by a programming interface, or a CJJ structure coupled in series with the qubit loop and controlled by a programming interface. | 11-28-2013 |
20150379418 | SYSTEMS, METHODS AND APPARATUS FOR ACTIVE COMPENSATION OF QUANTUM PROCESSOR ELEMENTS - Apparatus and methods enable active compensation for unwanted discrepancies in the superconducting elements of a quantum processor. A qubit may include a primary compound Josephson junction (CJJ) structure, which may include at least a first secondary CJJ structure to enable compensation for Josephson junction asymmetry in the primary CJJ structure. A qubit may include a series LC-circuit coupled in parallel with a first CJJ structure to provide a tunable capacitance. A qubit control system may include means for tuning inductance of a qubit loop, for instance a tunable coupler inductively coupled to the qubit loop and controlled by a programming interface, or a CJJ structure coupled in series with the qubit loop and controlled by a programming interface. | 12-31-2015 |
Patent application number | Description | Published |
20090075892 | Synthetic pulmonary surfactant peptides - The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B. The invention is also directed to the pharmaceutical compositions thereof and to a use thereof in the treatment or prophylaxis of RDS and other respiratory disorders. | 03-19-2009 |
20100130431 | DISCORDANT HELIX STABILIZATION FOR PREVENTION OF AMYLOID FORMATION - The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the α-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders. | 05-27-2010 |
20120041177 | METHOD OF PRODUCING POLYMERS OF SPIDER SILK PROTEINS - A method of producing polymers of an isolated spider silk protein involves providing a solution of said spider silk protein in a liquid medium at pH 6.4 or higher and/or an ion composition that prevents polymerisation of the spider silk protein. The properties of the liquid medium are adjusted to a pH of 6.3 or lower and an ion composition that allows polymerisation of the spider silk protein. The spider silk protein is allowed to form polymers in the liquid medium, and the resulting spider silk protein polymers are isolated from the liquid medium. The resulting polymers are useful as fibers, films, foams, nets or meshes. | 02-16-2012 |
20120122794 | Compound And Method For Treatment Of Alzheimer's Disease - An isolated protein selected from the group consisting of (i) proteins comprising an amino acid sequence having at least 70% identity to the C-terminal domain of lung surfactant protein C precursor (CTproSP-C, “CTC”) from a mammal; and (ii) proteins comprising an amino acid sequence having at least 70% identity to the Brichos domain of CTproSP-C from a mammal, is disclosed for treatment of Alzheimer's disease in a mammal, including man. | 05-17-2012 |
20120264914 | SPIDER SILK PROTEINS AND METHODS FOR PRODUCING SPIDER SILK PROTEINS - The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof. | 10-18-2012 |
20120329992 | SPIDER SILK PROTEINS AND METHODS FOR PRODUCING SPIDER SILK PROTEINS - The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof. | 12-27-2012 |
20130065278 | PRODUCTION OF PROTEINS AND POLYPEPTIDES - A method of producing a desired non-spidroin protein or polypeptide is comprising the steps of expressing in a suitable host a fusion protein, obtaining a mixture containing the fusion protein, and optionally isolating the fusion protein. The fusion protein is comprising at least one solubility-enhancing moiety which is derived from the N-terminal (NT) fragment of a spider silk protein. It is further comprising at least one moiety which is a desired non-spidroin protein or polypeptide. Each solubility-enhancing moiety is linked directly or indirectly to the desired protein or polypeptide moiety. | 03-14-2013 |
20130115698 | METHODS AND COMBINATION - A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein. | 05-09-2013 |
20130172262 | COMPOUND AND METHOD FOR TREATMENT OF ALZHEIMER'S DISEASE AND FAMILIAL DEMENTIA - An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal, including man. The isolated protein is selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of Bri2 from human; and proteins comprising an amino acid sequence having at least 70% identity to any one of the Brichos domains of Bri2 from human, chimpanzee, bovine, pig, mouse and rat. | 07-04-2013 |
20130176841 | Method and Apparatus for Receiving Physical Uplink Control Channel in LTE System - The present document discloses an apparatus for receiving Physical Uplink Control Channel (PUCCH) in Long Term Evolution (LTE) system, comprising: blocks of system FFT performing system FFT on data from a plurality of antennas, blocks of PUCCH RB processing units receiving the allocated logic resource index table and the local base sequence and output of the blocks of system FFT, and generating DMRS despread outputs and data values; a block of SR detection for receiving the data values and the DMRS despread outputs, and for generating SR detection results; blocks of user data extraction receiving data values and DMRS despread outputs, and performing user data extraction; blocks of PUCCH user processing units receiving an orthogonal sequence index, the data values and an output from blocks of user data extraction, and generating a ACK/NAK/CQI signal for a concerned UE. | 07-11-2013 |
20130316376 | SPIDER SILK FUSION PROTEIN STRUCTURES FOR BINDING TO AN ORGANIC TARGET - A protein structure capable of selective interaction with an organic target is provided. The protein structure is a polymer comprising as a repeating structural unit a recombinant fusion protein that is capable of selective interaction with the organic target. The fusion protein is comprising the moieties B, REP and CT, and optionally NT. B is a non-spidroin moiety of more than 30 amino acid residues, which provides the capacity of selective interaction with the organic target. REP is a moiety of from 70 to 300 amino acid residues and is derived from the repetitive fragment of a spider silk protein. CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein. NT is an optional moiety of from 100 to 160 amino acid residues and is derived from the N-terminal fragment of a spider silk protein. The fusion protein and protein structure thereof is useful as an affinity medium and a cell scaffold material. | 11-28-2013 |
20130336721 | FLUID STORAGE IN COMPRESSED-GAS ENERGY STORAGE AND RECOVERY SYSTEMS - In various embodiments, lined underground reservoirs and/or insulated pipeline vessels are utilized for storage of compressed fluid in conjunction with energy storage and recovery systems. | 12-19-2013 |
20140030274 | AMYLOIDOSIS TARGET USEFUL IN METHODS OF TREATMENT AND FOR SCREENING OF COMPOUNDS - A method involves screening a candidate compound for activity in the treatment of a condition associated with formation of amyloid protein fibrils in a mammal, such as Alzheimer's disease. It is determined whether the trimer/monomer ratio of a chaperone protein is decreased in the presence of the candidate compound. The chaperone protein is or has a high identity to the Brichos domains of Bri2, Bri3 or proSP-C from human. Monomers of the chaperone proteins and/or compounds that promote formation of these monomers are useful for medical treatment of the condition. | 01-30-2014 |
20140079674 | SPIDER SILK PROTEINS AND METHODS FOR PRODUCING SPIDER SILK PROTEINS - The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula REP-CT. REP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having from 70 to 120 amino acid residues. The invention further provides an isolated fusion protein consisting of a first protein fragment, which is a major ampullate spidroin protein, and a second protein fragment comprising a fusion partner and a cleavage agent recognition site. The first protein fragment is coupled via said cleavage agent recognition site to the fusion partner. The invention also provides a method of producing a major ampullate spidroin protein and polymers thereof. | 03-20-2014 |
20140187747 | Discordant Helix Stabilization For Prevention of Amyloid Formation - The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the α-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders. | 07-03-2014 |
20140243272 | COMPOUND AND METHOD FOR TREATMENT OF ALZHEIMER'S DISEASE - An isolated protein selected from the group consisting of (i) proteins comprising an amino acid sequence having at least 70% identity to the C-terminal domain of lung surfactant protein C precursor (CTproSP-C, “CTC”) from a mammal; and (ii) proteins comprising an amino acid sequence having at least 70% identity to the Brichos domain of CTproSP-C from a mammal, is disclosed for treatment of Alzheimer's disease in a mammal, including man. | 08-28-2014 |
20140288005 | COMPOUND FOR TREATMENT OF ALZHEIMER'S DISEASE AND FAMILIAL DEMENTIA - An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal, including man. The isolated protein is selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of Bri2 from human; and proteins comprising an amino acid sequence having at least 70% identity to any one of the Brichos domains of Bri2 from human, chimpanzee, bovine, pig, mouse and rat. | 09-25-2014 |
20150119554 | SPIDER SILK FUSION PROTEIN STRUCTURES INCORPORATING IMMUNOGLOBULIN FRAGMENTS AS AFFINITY LIGANDS - A recombinant fusion protein comprising the moieties Band CT, and optionally REP, wherein B is comprising at least one immunoglobulin fragment, which provides the capacity of selective interaction with an organic target; CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein; and REP is a moiety of from 70 to 300 amino acid residues and is derived from the repetitive fragment of a spider silk protein. | 04-30-2015 |
20150291674 | SPIDER SILK FUSION PROTEIN STRUCTURES FOR BINDING TO AN ORGANIC TARGET - A protein structure capable of selective interaction with an organic target is provided. The protein structure is a polymer comprising as a repeating structural unit a recombinant fusion protein that is capable of selective interaction with the organic target. The fusion protein is comprising the moieties B, REP and CT, and optionally NT. B is a non-spidroin moiety of more than 30 amino acid residues, which provides the capacity of selective interaction with the organic target. REP is a moiety of from 70 to 300 amino acid residues and is derived from the repetitive fragment of a spider silk protein. CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein. NT is an optional moiety of from 100 to 160 amino acid residues and is derived from the N-terminal fragment of a spider silk protein. The fusion protein and protein structure thereof is useful as an affinity medium and a cell scaffold material. | 10-15-2015 |
20160024464 | METHODS AND COMBINATION COMPRISING EUKARYOTIC CELLS AND RECOMBINANT SPIDER SILK PROTEIN - A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein. | 01-28-2016 |
Patent application number | Description | Published |
20100003992 | Finding Hidden Cells in a Mobile Communication System - A weaker cell is discovered in a mobile communication system that also includes a stronger cell. Discovery involves ascertaining a slot timing of a received signal that has passed through a channel. The slot timing is used to ascertain a stronger secondary synchronization vector contained in the received signal. A channel estimate is generated, and used with the stronger secondary synchronization vector to generate a cancellation signal that is an estimate of a stronger secondary synchronization vector component of the received signal. Removing the cancellation signal from the received signal yields a residual signal. The slot timing is used to ascertain a weaker secondary synchronization vector contained in the residual signal. The weaker secondary synchronization vector is used to ascertain a group identifier (ID) of the weaker cell. The group ID of the weaker cell and the residual signal are used to ascertain the weaker cell's scrambling code ID. | 01-07-2010 |
20100079244 | Robust Paging Indicator Detection - A robust method of page indication (PI) detection improves the probability of detecting a transmitted PI under conditions that decrease the probability of accurate PI detection. The method includes choosing a standard value of a PI threshold against which to compare accumulated PI bits when the probability of correctly detecting the PI is high, and choosing a derived value of the PI threshold lower than the standard value when the probability of correctly detecting the PI is low. The derived PI threshold value determination includes a factor indicative of a desired probability of accurate PI detection. | 04-01-2010 |
20140064211 | METHODS AND APPARATUS FOR USING A GEOMETRY INDICATOR IN HETNET DEPLOYMENTS - In a heterogeneous network deployment that includes a macro base station and a low power node, a geometry indicator is transmitted by the low power node to facilitate the calculation of a path loss difference value at a user equipment using power estimates of the received synchronization signal from the macro base station and received geometry indicator signal from the low power node. Using the estimated path loss difference value, the user equipment adjusts the power level of an initial preamble signal transmission to the macro base station. | 03-06-2014 |
20140092861 | WIRELESS COMMUNICATIONS BASED ON IDENTIFYING LOWER POWER NODES IN HETEROGENEOUS NETWORK DEPLOYMENTS - In a heterogeneous network deployment that includes one or more macro base stations and one or more low power nodes, a technique can be provided to encode network operational information using phase differences in synchronization signals transmitted by a network node. The synchronization signals may be one of the first signals that a user equipment (UE) attempts to locate when attempting to join a wireless network. The phase-encoded network operational information indicates to the UE where to locate a geometry indicator transmission from a low power node that is a part of the network, but is not the node that transmits the synchronization signals. The geometry indicator transmission may include identity information for the transmitting node and may be transmitted at a pre-determined nominal transmit power. | 04-03-2014 |
20140092879 | DOWNLINK TRANSMISSION POINT SELECTION IN A WIRELESS HETEROGENEOUS NETWORK - A heterogeneous wireless communication network comprises a macrocell base station that includes a first transmission point, at least one microcell base station that includes a second transmission point and a controller configured to enable transmission of wireless data from the macrocell base station and the at least one microcell base station to a user equipment (UE). The controller is configured to determine a set of transmission point combinations for providing downlink data, determine, using a statistics of ACKs and NACKs received for previous downlink transmissions from the transmission point combinations, a sequence of downlink transmissions to the UE from the transmission point combinations in the set. | 04-03-2014 |
20140126553 | PROCESSING UPLINK DATA TRANSMISSIONS IN A HETEROGENEOUS WIRELESS NETWORK - In a heterogeneous wireless network that includes a macro base station and one or more micro base stations, a wireless device to wirelessly transmit, in a first time slot at a first position in a first transmission subframe, data over a first physical communication channel. An ACK/NACK control message is received over a backhaul network connection a first time period after the first time slot. A response message is transmitted to the wireless device such that when the control message is received prior to the second time slot, then the response message uses data reception information from the control message and when the control message is not received prior to the second time slot, then the response message indicates that the data was successfully received. | 05-08-2014 |
20140200009 | OPERATION OF A HETEROGENEOUS WIRELESS NETWORK BY DETERMINING LOCATION OF A WIRELESS DEVICE - A heterogeneous wireless communication network includes a macrocell base station that one or more low power nodes. The location of a wireless device is estimated based on feedback reports received from the wireless device in response to downlink transmissions of a reference signal. Based on the estimated location, a schedule for future transmissions of the reference signal to the wireless device are determined. The schedule specifies a frequency of transmission of the reference signals. The schedule specifies downlink transmission antenna configuration to be used for the reference signal transmissions. | 07-17-2014 |
20160088495 | USING A GEOMETRY INDICATOR IN HETNET DEPLOYMENTS - In a heterogeneous network deployment that includes a macro base station and one or more low power nodes, a geometry indicator signal is transmitted to facilitate the determination of geometry or location at a user equipment. The geometry indicator, in general, is transmitted on the same or different frequency as the data signal transmission and is transmitted over a range that is same or different from that of the data signal transmission. The geometry indicator signal may be transmitted by the macro base station, the low power nodes or both. | 03-24-2016 |
Patent application number | Description | Published |
20080273930 | Milling Tool, a Cutting Insert for Milling Tool as Well as a Solid Milling Tool - The invention relates to a milling tool intended for chip-removing machining, comprising a basic body rotatable around a geometrical centre axis and a plurality of peripherically spaced-apart, detachable cutting inserts, which separately are securable in insert pockets adjacent to chip channels formed in the basic body, the individual cutting insert having at least one edge formed between a chip surface on the top side of the cutting insert and a clearance surface along the periphery side of the cutting insert, the tool geometry being markedly positive so far that the individual insert pocket is arranged to secure the individual cutting insert in a position in which the chip surface is inclined in relation to the centre axis while forming a positive angle of inclination. Characteristics of the invention is the combination that the angle of inclination between the chip surface and the centre axis is within the range of 25-28°, that the cutting edge cross section-wise has an arc-shape having a radius of curvature (ER) within the range of 5-20 μm, that the clearance surface of the cutting insert is formed with a clearance bevel, which extends from the cutting edge in the direction of the bottom side of the cutting insert and transforms into a main clearance portion, that the clearance angle (γ) of the clearance bevel is larger than 0°, but smaller than 3°, that the clearance angle (γ) of the main clearance portion is larger than the clearance angle (γ) of the clearance bevel, that the extension of the clearance bevel from the cutting edge to the main clearance portion is within the range of 0.05-0.30 mm, that the chip surface is formed with a reinforcement bevel, which extends from the cutting edge in the direction of the centre of the cutting insert and transforms into a main chip portion, the angle of inclination of the reinforcement bevel in relation to the centre axis being larger than −5°, but smaller than +5°, and that the extension of the reinforcement bevel from the cutting edge to the main chip portion is within range of 0.05-0.15 mm. The invention also separately relates to a milling insert as well as a solid milling tool. | 11-06-2008 |
20100003090 | INDEXABLE MILLING INSERT - An indexable milling insert, including an upperside, an underside parallel to an imaginary reference plane, and two cutting edges. Each cutting edge includes a cutting edge line and is formed between a chip surface included in the upperside and a first clearance surface extending between the upperside and the underside, the first clearance surface forming an acute, nominal first clearance angle (α) with a normal to the reference plane. Each cutting edge includes a main edge, which is at least partly convexly curved as viewed in plane elevation from above, and which extends from an initial end, which determines the maximal cutting depth of the milling insert, to a corner edge having a radius of curvature that is smaller than the radius of curvature of the main edge, the main edge rising in the direction from the initial end toward the corner edge such that the distance thereof to the underside successively increases in the direction. A second clearance surface is formed between the cutting edge line and the first clearance surface, the second clearance surface having a width of at most 0.3 mm and a nominal second clearance angle (λ) that is smaller than the first clearance angle. The second clearance surface is of uniform width and the second clearance angle decreases successively in the direction from the initial end toward the corner edge. | 01-07-2010 |
20120076595 | GEAR MILLING CUTTER AS WELL AS A REPLACEABLE MILLING INSERT THEREFOR - A gear milling cutter, including a basic body being rotatable around a center axis and having a rotationally symmetrical basic shape, which includes two opposite flank sides that extend radially inward from a periphery of the basic body, and a plurality of replaceable milling inserts, which are mounted on the flank sides and individually comprise a cutting edge that is formed between a chip surface and a clearance surface and extends between a pair of opposite and radially separated ends of the milling insert. Some of the plurality of milling inserts are root inserts, which are placed in tangentially spaced-apart positions along the periphery of the basic body. Others of the plurality of milling inserts are flank inserts, which are tangentially spaced-apart and placed in at least one ring formation located radially inside the root inserts. Sweep areas of radially separated milling inserts overlap each other in a ring-shaped overlapping zone by radially inner ends of at least the root inserts being situated nearer the center axis of the basic body than the radially outer ends of the flank insert next inside. The cutting edge of each milling insert includes a straight main edge, and a part edge that is located between the straight main edge and one of the ends of the milling insert and is shorter than the main edge, the part edge deviating from a straight reference line in the extension of the main edge in the direction of an end of the milling insert at a deviation angle (α) of at most 10°. The cutting edges of the root inserts overlap the cutting edges of the flank inserts in a point of intersection situated between end points of the part edges. | 03-29-2012 |
Patent application number | Description | Published |
20080242589 | SYNTHETIC LIPID MIXTURES FOR THE PREPARATION OF A RECONSTITUTED SURFACTANT - The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants comprising special phospholipid mixtures and artificial peptides which are analogues of the natural surfactant SP-C protein for the treatment of respiratory distress syndrome (RDS) and other diseases relating to pulmonary surfactant dysfunctions. | 10-02-2008 |
20090088379 | RECONSTITUTED SURFACTANTS HAVING IMPROVED PROPERTIES - The present invention is directed to a reconstituted surfactant containing a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide comprising a sequence comprised of repeated units where each unit contains between 3 and 8 hydrophobic amino acid residues and one basic amino acid residue. The invention is also directed to the pharmaceutical compositions thereof and to its use for the prophylaxis and/or treatment of RDS and other respiratory disorders. | 04-02-2009 |
20090170758 | COMPOSITIONS COMPRISING PULMONARY SURFACTANTS AND A POLYMYXIN HAVING IMPROVED SURFACE PROPERTIES - Pulmonary surfactants comprising additives, such as polymyxins, that improve their surface tension lowering properties. A method for improving the resistance to inactivation of a modified natural surfactant, such as one containing a lipid extract of minced mammalian lung comprising administering a surfactant in combination with a polymyxin. | 07-02-2009 |
20100004173 | RECONSTITUTED SURFACTANTS HAVING IMPROVED PROPERTIES - Reconstituted surfactants comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B are useful for the treatment and/or prophylaxis of RDS and other respiratory disorders. | 01-07-2010 |
20130079275 | RECONSTITUTED SURFACTANTS HAVING IMPROVED PROPERTIES - Reconstituted surfactants comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B are useful for the treatment and/or prophylaxis of RDS and other respiratory disorders. | 03-28-2013 |
20140142021 | RECONSTITUTED PULMONARY SURFACTANTS - The present invention is directed to a reconstituted surfactant comprising a phospholipid mixture, and a combination of particular analogues of the native surfactant protein SP-C with analogues of the native surfactant protein SP-B. The invention is also directed to pharmaceutical compositions and kits thereof and to its use for the treatment or prophylaxis of RDS and other respiratory disorders. | 05-22-2014 |
Patent application number | Description | Published |
20130123173 | CREATION OF OXIDATION-RESISTANT HDL MIMETIC PEPTIDES - The present invention provides non-naturally occurring polypeptides that are oxidation resistant and have cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABACI that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation; and diagnostic methods employing the peptides to evaluated cholesterol efflux activity. | 05-16-2013 |
20140287994 | PEPTIDES HAVING REDUCED TOXICITY THAT STIMULATE CHOLESTEROL EFFLUX - The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation. | 09-25-2014 |
20160031951 | PEPTIDES HAVING REDUCED TOXICITY THAT STIMULATE CHOLESTEROL EFFLUX - The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia. | 02-04-2016 |
Patent application number | Description | Published |
20150296394 | METHOD AND APPARATUS FOR A MODIFIED OUTER LOOP AFTER A RECEIVER OUTAGE EVENT - A method, system and non transitory, tangible computer readable storage medium provides for controlling the BLER (block error rate) in a digital communication system. The outer loop control of the system discounts responses sent by a receiver to data transmission from a transmitter that were sent during a receiver outage event. Either the NACKs or both the ACKs and NACKs sent by the receiver during receiver outage are discounted by the outer loop control which adapts subsequent transmissions by either directly adjusting transmission parameters or by adjusting the selection of transmission parameters. The adapting may be based on individual NACKs and ACKs or after establishing a BLER. | 10-15-2015 |
20150319678 | METHOD AND APPARATUS FOR ANTI-BLOCKING HETNET DEPLOYMENT - A new approach to anti-blocking cellularcommunication for HetNet deployment is proposed. First, a block detector sends a block indicator from an LPN to a scheduler in a macro base station. The scheduler then collects the block indicator statistics of each LPN on a sub-frame basis and updates the statistics in each sub-frame. If the statistics of received block indicators for one sub-frame during an observation period of a specific LPN exceeds a first predefined threshold, then the scheduler will not schedule any more uplink transmission to the LPN during the sub-frame for those UEs which are connected to the LPN. When the statistics of received block indicators becomes less than a second predefined threshold, which is less than the first threshold, the scheduler removes the limitation on uplink transmission to the LPN and allocates the sub-frame of the LPN as usual. | 11-05-2015 |
20150333876 | METHOD AND APPARATUS FOR A MODIFIED HARQ PROCEDURE AFTER A RECEIVER OUTAGE EVENT - A system and method of responding to a receiver outage event, which includes: determining if a receiver outage event has occurred; if a receiver outage event has occurred, discarding soft bits that were corrupted due to the outage event; and if a received first redundancy version (RV) of coded bits corrupted by the outage event was decoded incorrectly, sending a message to a transmitter in response to the outage event, and thereafter receiving a second RV of coded bits retransmitted by the transmitter in response to the message. | 11-19-2015 |
20160037552 | METHOD AND APPARATUS TO ADAPT THE NUMBER OF HARQ PROCESSES IN A DISTRIBUTED NETWORK TOPOLOGY - A system includes a downlink transmitter unit, a downlink scheduler unit, and an uplink receiver unit. At least one of the units is located at a physically separate location from others of the units, and the at least one of the units communicates with the others of the units over a backhaul. A controller that allocates a number of hybrid automatic repeat request (HARQ) processes according to any communication delays caused by the backhaul. | 02-04-2016 |
20160135146 | USER EQUIPMENT GROUPING AND COMMON CONTROL SIGNALING TO USER EQUIPMENT GROUPS - A cellular telecommunications system and method of scheduling a group of user equipments is provided. The system includes a macro cell with a macro base station and multiple associated low power nodes (LPN's). The macro base station and the LPN's share the same cell ID. The system and method provide for scheduling a group of UE's by grouping a plurality of the UE's together, assigning a group identifier to the group, notifying the group and encoding a control channel with the group identifier. A single control channel is delivered to each UE in the group of UE's. The UE's of the group of UE's may be processed by different LPN's. The transmitted control channel may be included in a DCI (downlink control information) and delivers uplink scheduling grants to the UE's. Based on the transmitted control channel, the UE's are scheduled for uplink transmission. | 05-12-2016 |