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Jan Jezek
Jan Jezek, Wellingborough GB
| Patent application number | Description | Published |
|---|---|---|
| 20090136538 | Stable vaccine formulation - An aqueous vaccine composition comprises a protein adsorbed on a solid and one or more stabilising agents, further characterized in that | 05-28-2009 |
| 20090148406 | Stable Aqueous Systems Comprising Proteins - An aqueous system comprises a protein and one or more stabilising agents, characterised in that (i) the one or more stabilising agents have ionisable groups capable of exchanging protons with the protein and with the ionised products of water dissociation; (ii) the ionisable groups include first groups that are positively charged when protonated and uncharged when deprotonated, and second groups that are uncharged when protonated and negatively charged when deprotonated; and (v) the pH of the composition is within a range of protein stability that is at least 50% of the maximum stability of the protein with respect to pH. | 06-11-2009 |
| 20110033549 | Stabilisation of Proteins - A dry composition for use in therapy or diagnosis, obtainable by drying an aqueous composition comprising a protein and one or more displacement buffers, wherein the pH of the aqueous composition is such that the protein is stable, wherein the or each displacement buffer has a pKa that is at least 1 unit greater or less than the pH of the aqueous composition, and wherein the aqueous composition is substantially free of a conventional buffer having a pKa that is within one pH unit of the pH of the aqueous composition. | 02-10-2011 |
| 20110034898 | Stable Formulation of a Therapeutic Protein - An aqueous composition comprising a therapeutic protein further characterized in that | 02-10-2011 |
| 20110097348 | Protein Formulation - A composition comprises a biological molecule that is susceptible to aggregation, dimerisation or hydrolysis, wherein the ionic strength is less than 40 mM. | 04-28-2011 |
| 20110171264 | Protein Formulation - An aqueous composition which comprises a protein or other biological molecule and also (i) optionally comprises one or more metal ions at a concentration of 0.01 to 20 mM; (ii) comprises excipients which are weak ligands; and (iii) is substantially free of excipients which are medium-strength ligands or strong ligands. | 07-14-2011 |
Jan Jezek, Northamptonshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20100197802 | SKIN DRESSINGS - Improvements relating to skin dressing A skin dressing adapted, on activation, to generate one or more S-nitrosothiols by reaction between a thiol and a nitrate salt in the dressing, the skin dressing comprising a source of Cu | 08-05-2010 |
| 20110070318 | SKIN DRESSINGS - A skin dressing is provided comprising a first component comprising a source of protons, a second component comprising a nitrite salt, the dressing comprising a non-thiol reductant, such that, when the first and second components are brought together and applied to a skin site the nitrite reacts to generate nitric oxide, increasing the pH of the dressing in contact with the skin from an acidic value to a more neutral value. | 03-24-2011 |
Jan Jezek, Northants GB
| Patent application number | Description | Published |
|---|---|---|
| 20090081279 | Skin Dressings - A skin dressing is adapted, on activation, to release one or more S-nitrosothiols, preferably S-nitroso-L-glutathione. S-nitrosothiols decompose spontaneously to produce nitric oxide, which has beneficial effects on tissues, particularly in wound healing. | 03-26-2009 |
| 20100183701 | Wound Dressings comprising hydrated hydrogels and enzymes - A skin dressing comprises a hydrated hydrogel material including a source of lactate ions and a supply of glucose, optionally also including a source of zinc ions and a source of iodide ions. The dressing has beneficial effects on skin. | 07-22-2010 |
Jan Jezek, Bedfordshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20090036350 | Method for Stabilisation of a Protein Solution by Addition of Hydroxyl Radical Quenchers and its Sterilisation by Ionising Radiation - A method of sterilising a protein in an aqueous environment, comprises exposing to ionising radiation an aqueous composition comprising the protein with a protective compound or combination of protective compounds having the following characteristics: (i) a rate of reaction with hydroxyl radicals greater than 5×10 | 02-05-2009 |
| 20100028372 | STABILIZATION OF AQUEOUS COMPOSITIONS OF PROTEINS WITH DISPLACEMENT BUFFERS - An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least one displacement buffer wherein the displacement buffer has a pKa that is at least 1 unit greater or less than the pH of step (a); and c. adjusting the pH of the composition to the pH of step (a); wherein the aqueous composition does not comprise a conventional buffer at a concentration greater than about 2 mM and wherein the conventional buffer has a pKa that is within 1 unit of the pH of step (a). | 02-04-2010 |
| 20100029542 | PROTEIN STERILISATION BY RADIATION AND ADDITION OF A STABILISING COMPOSITION - A method of sterilising a protein, comprises exposing to ionising radiation an at least substantially dry composition comprises a protein and a protective compound or combination of protective compounds having both of the following characteristics: (i) a rate of reaction with singlet oxygen greater than 1×10 7 L mol−1 S−1; (ii) being a reducing agent whilst at the same time containing a proton dissociable group with a pKa no more than 3 units from the pH of the composition. The compound having characteristic (i) is selected from histidine, thiamine and tryptophan, the compound having characteristic (ii) is selected from methionine, malate, citrate, lactate and tiron. The radiation is gamma radiation or electron beam, whereby the preferred dose is 15-40 kGy. | 02-04-2010 |
Jan Jezek, Stanwick GB
| Patent application number | Description | Published |
|---|---|---|
| 20110287113 | TREATMENT OF PSORIASIS - The invention relates to an aqueous composition capable of delivering nitric oxide for use in the treatment of psoriasis, particularly plaque psoriasis, e.g. by application of a skin dressing. | 11-24-2011 |