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Jamieson, CA
Andrew Jamieson, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093838 | REGULATION OF ANGIOGENESIS WITH ZINC FINGER PROTEINS - Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided. | 04-15-2010 |
Andrew C. Jamieson, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080242847 | Position dependent recognition of GNN nucleotide triplets by zinc fingers - The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5′-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity. | 10-02-2008 |
Andrew T. Jamieson, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110159411 | Phase-shift photomask and patterning method - A phase shift photomask blank has a quartz substrate, a lower chrome layer, a light-absorbing MoSi layer, and an upper chrome layer. This mask can be patterned in various ways to form a patterned photomask with both phase shift and binary areas. | 06-30-2011 |
Catriona H. Jamieson, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100203113 | WNT SIGNALLING INHIBITORS, AND METHODS FOR MAKING AND USING THEM - The invention provides dBHD-based compositions and dBHD analog compositions, and pharmaceutical compositions comprising them, e.g., in the form of liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these dBHD analogs are used to inhibit a dysfunctional stem cell and/or a cancer (tumor) stem cell. | 08-12-2010 |
| 20110059448 | COMPOSITIONS AND METHODS FOR DETERMINING CANCER STEM CELL SELF-RENEWAL POTENTIAL - In alternative embodiments, the invention provides compositions and methods for determining the self-renewal potential of a cancer stem cell (CSC) through analysis of the cross-talk between cell self-renewal pathways leading to deregulation and enhanced self-renewal of the CSC, or for predicting the drugability (susceptibility to a drug) of a CSC, and/or for predicting the progression of a cancer that corresponds to the CSC, the method comprising detecting and quantifying in CSCs one or more B-cell lymphoma-2 (Bcl-2) family protein isoform(s) or transcripts (mRNAs, messages) encoding one or more Bcl-2 family protein(s) or protein isoform(s) thereof. In alternative embodiments, the invention provides compositions and methods to determine and measure the levels of Wnt, glycogen synthase kinase-3 beta (GSK-3 beta), glycogen synthase kinase-3 alpha (GSK-3 alpha), and/or Sonic Hedgehog Homolog (SHH or Shh) family proteins and alternatively spliced transcripts (mRNAs), and Wnt, GSK3beta, GSK3alpha and/or Shh family protein and alternatively spliced transcript ratios in cancer cells, e.g., stem cells, e.g., CSCs, for diagnostic, drug discovery and prognostic purposes. | 03-10-2011 |
Catriona Helen M. Jamieson, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090191202 | Methods for manipulating phagocytosis mediated by CD47 - Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable. | 07-30-2009 |
| 20100287631 | WNT PATHWAY MUTATIONS IN CANCER STEM CELLS - Cancer specific splicing events in the Wnt/β-catenin signaling pathway are associated with progression of myelogenous leukemia. Misspliced genes of interest include GSK3β. In some embodiments of the invention, polynucleotides are provided that correspond to misspliced GSK3β transcripts associated with cancer. Such transcripts are characterized by a deletion of exon (8), and particularly in exon (8) and (9). Detection of such transcripts in cells is indicative of the presence of leukemia, and particularly of the presence of leukemia stem cells. In other embodiments, polypeptides are provided that are encoded by misspliced GSK3β transcripts associated with cancer. Such polypeptides are useful as diagnostic markers for cancer, and as a target for screening of therapeutic agents. Animal models comprising a human LSC having a misspliced GSK3b transcript provide a useful model for leukemia, for drug/gene screening in the prevention and treatment of leukemia in humans, etc. | 11-11-2010 |
| 20110076683 | Identification, Isolation and Elimination of Cancer Stem Cells - Isolated populations of leukemic stem cells are provided. The cells are useful for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery of factors or molecules that can affect them. Detection of leukemic stem cells is useful in predicting disease progression, relapse, and development of drug resistance. Proliferation of LSC may be inhibited through interfering with activation of the β-catenin pathway. Methods are provided for the clinical staging of pre-leukemia and leukemias by differential analysis of hematologic samples for the distribution of one or more hematopoietic stem or progenitor cell subsets. | 03-31-2011 |
Catriona Helen M. Jamieson, Lajolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110243853 | MODELS OF ERYTHROPOIESIS - Non human animal models are provided for diseases involving erythroid function, particularly myeloproliferative disease. The models are useful for testing and screening of biologically active agents that affect erythropoiesis, and erythroid function. In the animal models of the invention, a hematopoietic stem or progenitor cell (HSC) population that has been genetically altered by the introduction of a mutant JAK2 coding sequence is transplanted into an immunocompromised, xenogeneic, non-human recipient. The recipient animal is engrafted with the cell population at a high frequency, and develops a myeloproliferative disorder characterized by polycythemia. | 10-06-2011 |
Eric Jamieson, Los Angeles, CA US
Gene C. Jamieson, Boulder Creek, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110184069 | METHODS AND COMPOSITIONS FOR ADMINISTRATION OF TRPV1 AGONISTS - Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided. | 07-28-2011 |
| 20110196043 | METHODS AND COMPOSITIONS FOR ADMINISTRATION OF TRPV1 AGONISTS - Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided. | 08-11-2011 |
Gene Curtis Jamieson, Boulder Creek, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100269858 | COMPOSITIONS AND KITS FOR THE REMOVAL OF IRRITATING COMPOUNDS FROM BODILY SURFACES - The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble. | 10-28-2010 |
John E. Jamieson, Pleasanton, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100187195 | Bottle With Directed Pour Spout - Described is a bottle having bottle central part having a bottle base, a handle, and a bottle top with a bottle filling fitment. A snap-on spout has a nozzle fitment with a forward directed pouring orifice and attached child-resistant nozzle. The snap-on spout is attached to the bottle central part with a non-circular snap-fit attachment surface. | 07-29-2010 |
| 20100213211 | Bottle Cap With Dosing and Pretreatment - Described is a bottle having a bottle base, a transition fitment with a pouring spout and a measuring cup closure, where the measuring cup in multifunctional, for example, serving as a measuring cup, a bottle closure, and a pretreatment applicator. | 08-26-2010 |
Jon Jamieson, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090290967 | End Effector - An apparatus for transporting a substrate is provided. The apparatus includes an upper portion housing an electric motor, the electric motor having a drive shaft. A motor housing encloses the electric motor. A pivot bracket having a first end and a second end, where the first end of the pivot bracket is coupled to the drive shaft. The apparatus includes a lower portion having a top surface affixed to the second end of the pivot bracket. The lower portion includes a plurality of paddle assemblies each having support extensions extending though a bearing assembly of the lower portion. Each of the paddle assemblies has an independent drive assembly disposed between corresponding support extensions, wherein the lower portion translates between a vertical and horizontal orientation by pivoting around an axis of the drive shaft. | 11-26-2009 |