Patent application number | Description | Published |
20110098725 | DEVICES AND METHODS FOR ENDOLUMENAL WEIGHT LOSS TREATMENTS - Devices and methods for forming and securing tissue folds, elongated invaginations, and tissue appositions in stomach tissue are used as a treatment for obesity. In a first embodiment, a plurality of tissue folds is formed in the fundus region of the stomach. In a second embodiment, one or more elongated invaginations are formed in the body region and/or antrum of the stomach. In a third embodiment, a plurality of tissue folds is formed in the fundus region of the stomach and one or more elongated invaginations is formed in the body region and/or antrum of the stomach. In other embodiments, a plurality of tissue folds is formed in the fundus region of the stomach and one or more tissue appositions are formed in the body region and/or antrum of the stomach. Additional embodiments include various combinations of tissue folds, elongated invaginations, tissue appositions, and other reconfigurations of stomach tissue. | 04-28-2011 |
20140128668 | DEVICES AND METHODS FOR ENDOLUMENAL WEIGHT LOSS TREATMENTS - Devices and methods for forming and securing tissue folds, elongated invaginations, and tissue appositions in stomach tissue are used as a treatment for obesity. In a first embodiment, a plurality of tissue folds is formed in the fundus region of the stomach. In a second embodiment, one or more elongated invaginations are formed in the body region and/or antrum of the stomach. In a third embodiment, a plurality of tissue folds is formed in the fundus region of the stomach and one or more elongated invaginations is formed in the body region and/or antrum of the stomach. In other embodiments, a plurality of tissue folds is formed in the fundus region of the stomach and one or more tissue appositions are formed in the body region and/or antrum of the stomach. Additional embodiments include various combinations of tissue folds, elongated invaginations, tissue appositions, and other reconfigurations of stomach tissue. | 05-08-2014 |
Patent application number | Description | Published |
20110088194 | SURFACE TREATING APPLIANCE - An upright surface treating appliance includes a main body and a stand pivotable relative to the main body between a supporting position and a retracted position. A stand retaining mechanism is provided for releasably retaining the stand in the supporting position, and which includes a locking member pivotably moveable about a first axis to release the stand as it is moved from the supporting position to the retracted position, and about a second axis spaced from the first axis to retain the stand as it is returned to the supporting position. At least one biasing member applies a relatively large first force to the locking member which resists movement thereof about the first axis. To facilitate the return of the stand to its supporting position, the biasing member is arranged to apply a relatively small second force to reset the locking member following movement thereof about the second axis. | 04-21-2011 |
20110088196 | SURFACE TREATING APPLIANCE - An upright surface treating appliance includes a main body having a user operable handle, a surface treating head connected to a yoke moveable relative to the main body, a stand moveable relative to both the main body and the yoke between a supporting position for supporting the main body in an upright position, and a retracted position, and a stand retaining mechanism for releasably retaining the stand in the supporting position and from which the stand is releasable upon application of a force to one of the main body and the stand. The yoke is moveable relative to the main body in response to an impact on the surface treating head to apply said force to the stand. This allows the force of the impact on the surface treating head to be transferred through the stand to the stand retaining mechanism, which, depending on the magnitude of the impact, can release both the stand and the yoke for movement relative to the main body. This avoids the need to provide separate releasing mechanisms for both the yoke and the stand. | 04-21-2011 |
20110088198 | SURFACE TREATING APPLIANCE - An upright surface treating appliance includes a main body, a surface treating head connected to a yoke, and a stand. To provide a compact appliance the yoke and the stand are pivotable independently relative to the main body about a common pivot axis. This can also enable the yoke and the stand to be rotatably connected to the main body using one or more common connectors or bearings. | 04-21-2011 |
20110088200 | SURFACE TREATING APPLIANCE - An upright surface treating appliance includes a main body having a user operable handle, and a stand moveable relative to the main body between a supporting position for supporting the main body in an upright position, and a retracted position. The stand includes at least one surface-engaging rolling member for allowing the appliance to be rolled along a surface using the handle when, with the stand in its supporting position, the main body is reclined rearwardly from its upright position. The appliance further includes a stand retaining mechanism for releasably retaining the stand in the supporting position and from which the stand is releasable upon application of a force to the main body. The stand retaining mechanism includes a system for increasing the force required to release the stand when the main body is reclined rearwardly from its upright position. This can reduce the risk of the stand being released accidentally from the supporting position when the main body is reclined rearwardly from its upright position and rolled along a surface. | 04-21-2011 |
20110088208 | SURFACE TREATING APPLIANCE - A surface treating appliance includes a surface treating head rotatably connected to a yoke, and a main body including a casing housing a fan unit for creating a fluid flow through the appliance. The main body is moveable relative to the yoke between an upright position and a reclined position. A retaining mechanism is provided for inhibiting rotation of the head relative to the yoke when the main body is in the upright position. The retaining mechanism includes a locking member which is moveable between a stowed position and a deployed position for inhibiting rotation of the head relative to the yoke, and an actuator for urging the locking member towards its deployed position. To provide a compact appliance, the actuator is carried by the casing so as to move therewith and urge the locking member towards its deployed position as the main body is moved to the upright position. | 04-21-2011 |
20110088210 | SURFACE TREATING APPLIANCE - A surface treating appliance includes a surface treating head rotatably connected to a yoke, and a main body pivotably moveable relative to the yoke about a pivot axis between an upright position and a reclined position. A retaining mechanism is provided for inhibiting rotation of the head relative to the yoke when the main body is in the upright position. The retaining mechanism includes a locking member which is moveable between a stowed position and a deployed position for inhibiting rotation of the head relative to the yoke, and an actuator for urging the locking member towards its deployed position. To provide a compact appliance, the actuator moves with the main body about the pivot axis to urge the locking member towards its deployed position as the main body is moved to the upright position. | 04-21-2011 |
20110088212 | SURFACE TREATING APPLIANCE - An upright surface treating appliance includes a main body having a user operable handle, and a support assembly for allowing the appliance to be rolled along a surface using the handle. The support assembly includes a pair of dome-shaped wheels rotatably connected to a yoke, and a stand pivotable relative to the main body. The appliance also includes a surface treating head having at least one support member. A stand retaining mechanism is provided for releasably retaining the stand in a supporting position relative to the main body in which the wheels are raised above the surface and the main body is supported by the stand and the support member of the surface treating head. The stand is moveable relative to the main body from the supporting position to a retracted position in which the main body is supported by at least the wheels to allow the appliance to be maneuvered over the surface during treatment thereof. | 04-21-2011 |
20120233808 | SURFACE TREATING APPLIANCE - A surface treating appliance includes a surface treating head, a hose, and a fan unit for generating a flow of fluid. A flexible duct assembly has a first end and a second end moveable relative to the first end between a first position allowing fluid flow between the hose and the fan unit, and a second position allowing fluid flow between the surface treating head and the fan unit. The duct assembly is connected to a first support which is pivotable about a first axis, and to a second support which is pivotable about a second axis spaced from the first axis. A drive mechanism effects the pivoting movement of the supports about their axes to move the second end of the duct assembly between the first and second positions. | 09-20-2012 |
Patent application number | Description | Published |
20110229877 | ENZYME-PORE CONSTRUCTS - The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing. | 09-22-2011 |
20120064599 | HYBRIDIZATION LINKERS - The invention provides method of covalently coupling two or more moieties, the method comprising: (a) providing a first moiety having covalently attached thereto (i) at least one first linker comprising a first hybridizable region and (ii) at least one first group capable of forming a covalent bond; (b) providing a second moiety having covalently attached thereto (i) at least one second linker comprising a second hybridizable region capable of hybridizing to the first hybridizable region and (ii) at least a second group capable of forming a covalent bond with the first group; (c) contacting the first and second moieties under conditions that allow the first and second hybridizable regions to hybridize and link the moieties; and (d) exposing the linked moieties to conditions that allow the formation of a covalent bond between the first and second groups. | 03-15-2012 |
20120100530 | ENZYME MUTANT - The invention relates to constructs comprising a nucleic acid binding protein and a surface. At least one native accessible cysteine residue is removed from the binding protein. The binding protein is attached to the surface via one or more accessible cysteine residues. The removal of other accessible cysteine residues from the protein allows control attachment to the surface. The constructs can be used to generate transmembrane pores having a nucleic acid binding protein attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect each of its component nucleotides by stochastic sensing. | 04-26-2012 |
20140051069 | ENZYME-PORE CONSTRUCTS - The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing. | 02-20-2014 |
20140186823 | MUTANT PORES - The invention relates to mutant forms of Msp. The invention also relates to nucleic acid characterisation using Msp. | 07-03-2014 |
20140262784 | COUPLING METHOD - The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing. | 09-18-2014 |
20150031020 | ENZYME-PORE CONSTRUCTS - The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing. | 01-29-2015 |
20150057948 | ANALYSIS OF MEASUREMENTS OF A POLYMER - A time-ordered series of measurements of a polymer made during translocation of the polymer through a nanopore are analysed. The measurements are dependent on the identity of k-mers in the nanopore, a k-mer being k polymer units of the polymer, where k is a positive integer. The method involves deriving, from the series of measurements, a feature vector of time-ordered features representing characteristics of the measurements; and determining similarity between the derived feature vector and at least one other feature vector. | 02-26-2015 |
20150177237 | APTAMER METHOD - The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores. | 06-25-2015 |
20150197796 | SSB METHOD - The invention relates to a method of characterising a target polynucleotide using a single-stranded binding protein (SSB). The SSB is either an SSB comprising a carboxy-terminal (C-terminal) region which does not have a net negative charge or a modified SSB comprising one or more modifications in its C-terminal region which decreases the net negative charge of the C-terminal region. | 07-16-2015 |
20160076092 | ENZYME-PORE CONSTRUCTS - The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing. | 03-17-2016 |
Patent application number | Description | Published |
20130310756 | DOSE MEASUREMENT SYSTEM AND METHOD - Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors. | 11-21-2013 |
20150085286 | DOSE MEASUREMENT SYSTEM AND METHOD - Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors. | 03-26-2015 |
20150144793 | DOSE MEASUREMENT SYSTEM AND METHOD - Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors. | 05-28-2015 |
20160030673 | LIQUID MEASUREMENT SYSTEMS, APPARATUS, AND METHODS OPTIMIZED WITH TEMPERATURE SENSING - An apparatus for measuring liquid volume in a container includes a plurality of light sources for emitting electromagnetic radiation (EMR) toward the container, a plurality of sensors optically coupleable to the plurality of light sources, each sensor of the plurality of sensors for detecting the EMR emitted by at least a portion of the plurality of light sources, a temperature sensor for measuring at least one temperature associated with a liquid in the container, and at least one processor for receiving data representative of the portion of the detected EMR from each of the plurality of sensors, comparing the at least one measured temperature to a temperature guideline to identify any temperature events associated with the received data; normalizing the received data based on any temperature events associated with the received data; and converting the normalized data into a signature representative of the EMR detected by the plurality of sensors. | 02-04-2016 |
Patent application number | Description | Published |
20150182086 | CLEANING APPLIANCE - A cleaning appliance of the cylinder type comprises a separating apparatus for separating dirt from a dirt-bearing fluid flow, and a floor-engaging rolling assembly. The separating apparatus comprises a first cyclonic separation unit having a low efficiency cyclone and a second cyclonic separation unit having a plurality of second cyclones. The rolling assembly comprises a main body and a pair of floor-engaging wheels. The main body comprises a recess in which the separating apparatus is received such that when the cleaning appliance is viewed from either side at least one fifth of the width of the low efficiency cyclone is hidden from view by a portion of the rolling assembly at the point of maximum depth of the recess. | 07-02-2015 |
20150190025 | SELF-RIGHTING CLEANING APPLIANCE - A self-righting cleaning appliance of the cylinder type comprises a cyclonic separating apparatus for separating dirt from a dirt-bearing fluid flow, and a floor-engaging rolling assembly. The cleaning appliance is arranged so that it is urged to return to an upright position if it is tipped onto its side. | 07-09-2015 |
20150190026 | SELF-RIGHTING CLEANING APPLIANCE - A self-righting cleaning appliance of the cylinder type comprises a separating apparatus for separating dirt from a dirt-bearing fluid flow, and a floor-engaging rolling assembly having a recess in which the separating apparatus is received. At least a portion of the separating apparatus is visible as a portion of the outer surface of the cleaning appliance when the separating apparatus is received in the recess, and the cleaning appliance is arranged so that it is urged to return to an upright position if it is tipped onto its side. | 07-09-2015 |
20150265116 | CLEANER APPLIANCE - A cleaning appliance having a cleaner head rotatably attached to a duct. The cleaner head includes a main body having an agitator chamber, an agitator rotatably mounted within the agitator chamber, and a drive assembly coupled to the agitator such that torque generated by the drive assembly is transmitted to the agitator. The drive assembly is located within the agitator such that the centre of gravity of the cleaner head is located on or near a vertical plane containing the rotational axis about which the cleaner head rotates relative to the duct. | 09-24-2015 |
20150265117 | CLEANER HEAD - A cleaner head that includes a main body having an agitator chamber, an axle that extends into the chamber, a bearing assembly mounted on the axle, a biasing member, and an agitator mounted on the bearing assembly. The bearing assembly is moveable along the axle between a first position and a second position. The biasing member then biases the bearing assembly towards the first position, and the agitator pushes the bearing assembly against the biasing member towards the second position. | 09-24-2015 |
20150320271 | CLEANING APPLIANCE - A cleaning appliance of the cylinder type comprises a separating apparatus for separating dirt from a dirt-bearing fluid flow, and a floor-engaging rolling assembly comprising a main body and a pair of floor-engaging wheels. The most rearward point of the separating apparatus is arranged in line with or rearward of the centre point of the wheels. | 11-12-2015 |
20150320272 | CLEANING APPLIANCE - A cleaning appliance of the cylinder type comprises a separating apparatus for separating dirt from a dirt-bearing fluid flow, and a floor-engaging rolling assembly. The separating apparatus comprises a first cyclonic separation unit having a low efficiency cyclone and a second cyclonic separation unit having a plurality of second cyclones. The rolling assembly comprises a main body and a pair of floor-engaging wheels. The main body comprises a recess in which the separating apparatus is received such that when the cleaning appliance is viewed from either side there is no gap between the first cyclonic separation unit and the rolling assembly along at least 50 to 100% of the full length of the low efficiency cyclone. | 11-12-2015 |
20150320273 | CLEANING APPLIANCE - A cleaning appliance of the cylinder type comprises a separating apparatus for separating dirt from a dirt-bearing fluid flow, and a floor-engaging rolling assembly. The separating apparatus comprises a first cyclonic separation unit having a low efficiency cyclone and a second cyclonic separation unit having a plurality of second cyclones. The rolling assembly comprises a main body having a recess in which the separating apparatus is received, and a plurality of floor-engaging wheels rotatably connected to the main body. The recess in the main body comprises a plurality of shaped recesses, each of which corresponds to the shape of at least a portion of a second cyclone. When the separating apparatus is received in the recess, a second cyclone is located at least partially in each shaped recess. | 11-12-2015 |