Patent application number | Description | Published |
20130212722 | TRANSGENIC ANIMALS WITH CUSTOMIZABLE TRAITS - Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with, red fluorescent protein in the loxp cassette, dominant black (ΔG23) beta defensin 103 in the pigment cassette, and an SV40 (with intron) polyadenylation sequence. When Cre recombinase (or HTNCre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to turn black in the shape in which it was applied. | 08-15-2013 |
20130212723 | TRANSGENIC ANIMALS WITH CUSTOMIZABLE TRAITS - Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with red fluorescent protein in the loxp cassette, dominant black (ΔG23) beta defensin 103 in the pigment cassette, and an SV40 (with intron) polyadenylation sequence. When Cre recombinase (or HTNCre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to turn black in the shape in which the HTNCre was applied. | 08-15-2013 |
20130298268 | TRANSGENIC ANIMALS WITH CUSTOMIZABLE TRAITS - Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with, red fluorescent protein in the loxp cassette, dominant black (ΔG23) beta defensin 103 in the pigment cassette, and an SV40 (with intron) polyadenylation sequence. When Cre recombinase (or HTNCre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to turn black in the shape in which it was applied. | 11-07-2013 |
20150064149 | MATERIALS AND METHODS FOR CORRECTING RECESSIVE MUTATIONS IN ANIMALS - The present invention provides materials and methods for correcting an undesirable nucleic acid sequence (such as a deleterious recessive mutation) in the genome of animals (such as cattle) using site-specific nucleases to facilitate gene correction. In certain embodiments, the present invention can be used to correct mutations associated with a heritable disease selected from alpha-mannosidosis, beta-mannosidosis, arthrogryposis multiplex (AM), contractural arachnodactyly (CA), developmental duplication (DD), neuropathic hydrocephalus (NH), idiopathic epilepsy, osteopetrosis, protoporphyria, pulmonary hypoplasia and anasarca (PHA), titbial hemimelia (TH), Spider Lamb Syndrome (SLS), and Brisket Disease. | 03-05-2015 |
20150135346 | MATERIALS AND METHODS FOR MAKING A RECESSIVE GENE DOMINANT - The subject invention provides materials and method for making a recessive gene dominant. This is accomplished by interfering with the natural mechanisms that inhibit expression of the recessive gene and/or by interfering with the expression of the naturally dominant gene. In a preferred embodiment, the method of the subject invention comprises both reducing inhibition of expression of the recessive gene and increasing inhibition of the dominant gene. | 05-14-2015 |
20150275231 | Method of Preventing or Reducing Virus Transmission in Animals - The subject invention provides materials and methods for improving animal resistance to infection by intestinal viruses. This is accomplished by interfering with intestinal virus uptake employing methods that (1) reduce virus binding to receptors in the intestinal lining; (2) introduce decoy receptors expressed in the mammary gland leading to decoy secretion in milk; (3) produce decoy receptors by a variety of protein synthesis methods to provide decoy receptors to non-genetically modified animals, including humans; and/or (4) administer a vector to a non-genetically modified animal which vector has been genetically modified to produce a decoy receptor. | 10-01-2015 |
20150320019 | TRANSGENIC ANIMALS WITH CUTOMIZABLE TRAITS - Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with red fluorescent protein in the loxp cassette, dominant black (ΔG23) beta defensin 103 in the pigment cassette, and an SV40 (with intron) polyadenylation sequence. When Cre recombinase (or HTNCre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to turn black in the shape in which the HTNCre was applied. | 11-12-2015 |