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James M. Coull, Westford US

James M. Coull, Westford, MA US

Patent application numberDescriptionPublished
20080206747Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation - This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.08-28-2008
20080220987Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation - This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.09-11-2008
20080269074Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation - This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.10-30-2008
20090005256Analysis of Encoded Chemical Libraries - The invention provides methods and compositions for analysis of a mixture of DNA sequences. More particularly, the invention provides methods and compositions for analysis of encoded chemical libraries having encoding nucleic acid tags (e.g., encoded chemical libraries prepared by nucleic acid-mediated chemistry) through analyzing the nucleic acid templates.01-01-2009
20090131662Compositions And Methods Pertaining To PNA Synthons And Oligomers Comprising A Universal Base - This invention is related to compositions and methods pertaining to PNA synthons, PNA oligomers and/or PNA/DNA Chimeras comprising a universal base.05-21-2009
20090136941METHODS, KITS AND COMPOSITIONS PERTAINING TO LINEAR BEACONS - This invention is directed to methods for determining amplified nucleic acid using Linear Beacons05-28-2009
20090163381Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation - This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.06-25-2009
20090176984Isotopically Enriched N-Substituted Piperazine Acetic Acids And Methods For The Preparation Thereof - In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids.07-09-2009
20090270602Compositions comprising a linked acceptor moiety - This invention is directed to compositions comprising a linked acceptor moiety.10-29-2009
20090275142COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY - The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.11-05-2009
20090280477Turn Over Probes and Use Thereof for Nucleic Acid Detection - The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.11-12-2009
20100120632Methods and Compositions For Sorting and/or Determining Organisms - This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to selectively stain the organisms or cells in combination with the use of binding partners to selectively immobilize the stained organisms or cells to a solid carrier. By combining the selectivity of both molecular probes and binding partners in an orthogonal method for staining and immobilization, these methods and compositions increase both the discriminating power of the assays and/or the certainty of the result obtained therefrom.05-13-2010
20100129842ISOBARICALLY LABELED ANALYTES AND FRAGMENT IONS DERIVED THEREFROM - This invention pertains to isobarically labeled analytes and fragment ions thereof.05-27-2010
20100159455RECEPTOR FAMILY PROFILING - The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics.06-24-2010
20100190660Methods, Compositions And Libraries Pertaining To PNA Dimer And PNA Oligomer Synthesis - This invention pertains to the field of PNA dimer and PNA oligomer synthesis.07-29-2010
20100196887COMPOSITIONS AND METHODS FOR MULTIPLEX ANALYSIS OF POLYNUCLEOTIDES - Provided herein are compositions and methods for the multiplex analysis and/or detection of polynucleotides having one or more distinguishable target sequences. The methods employ signal-quencher probe pairs having specific relative differential thermal melting temperatures that permit the detection of one or more target sequences on one or more polynucleotides.08-05-2010
20110003712Methods, Kits and Compositions for the Identification of Nucleic Acids Electrostatically Bound to Matrices - This invention pertains to methods, kits and compositions suitable for the detection, identification and/or quantitation of nucleic acids which are electrostatically immobilized to matrices using non-nucleotide probes which sequence specifically hybridize to one or more target sequences of the nucleic acid but do not otherwise substantially interact with the matrix. Once the nucleic acid is immobilized, the detectable non-nucleotide probe/target sequence complex, formed before or after the immobilization of the nucleic acid, can be detected, identified or quantitated under a wide range of assay conditions as a means to detect, identify or quantitate the target sequence in the sample. Because it is reversibly bound, the non-nucleotide probe/target sequence can optionally be removed from the matrix for detecting, identifying or quantitating the target sequence in the sample. Because the non-nucleotide probe/target sequence is protected against degradation, it is another advantage of this invention that the sample can be treated with enzymes which degrade sample components, either before or after the nucleic acid is bound to the matrix, in order to “clean up” the sample (e.g. a complex biological sample such as a cell lysate) and thereby improve the detection, identification or quantitation of the target sequence in the sample. The methods, kits and compositions of this invention are therefore particularly well suited for the analysis, and particularly single point mutation analysis, in a particle assay, in an array assay, in a nuclease digestion/protection assay and/or in a line assay format. When utilized in combination with non-nucleotide “Beacon” probes, the invention is particularly well suited for use in a self-indicating assay format.01-06-2011
20110059458COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY - The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications.03-10-2011

Patent applications by James M. Coull, Westford, MA US