| Patent application number | Description | Published |
|---|
| 20090170192 | METHODS AND DNA CONSTRUCTS FOR HIGH YIELD PRODUCTION OF POLYPEPTIDES - The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell. | 07-02-2009 |
| 20100125129 | Thermostable Fusion Proteins and Thermostable Adjuvant - Fusion proteins including maltodextrin-binding protein (MBP) domains that are thermally stable and soluble are provided. Methods for forming and using the fusion proteins are also provided. | 05-20-2010 |
| 20100167358 | COMPOSITIONS AND PROCESSES FOR IMPROVED PLASMID DNA PRODUCTION - Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity. These processes feature RNA based inducers of plasmid copy number. | 07-01-2010 |
| 20100167405 | PROCESSES FOR IMPROVED STRAIN ENGINEERING - Improvements in strain engineering technology are needed to insure the economic feasibility of future engineered recombinant organisms for industrial biotechnology. Disclosed herein are rapid, efficient methods (Genome Mass Transfer) that facilitate introduction of new selectable traits into a target microbial host. In one preferred embodiment, methods for high efficiency electroporation mediated transfer of donor DNA into a recipient microbial cell are disclosed. | 07-01-2010 |
| 20100184157 | E. COLI PLASMID DNA PRODUCTION - General methods and strains of bacteria are described, that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined with flocculation mediated removal of cell debris and host nucleic acids achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus reducing production costs. | 07-22-2010 |
| 20100233814 | Bacterial strains with improved plasmid stability - The present invention relates to the propagation of covalently closed circular recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly is strain modifications that improve strain viability, plasmid stability, plasmid production yield, and plasmid-directed protein production yield, using said DNA molecules in fermentation culture. | 09-16-2010 |
| 20100303859 | VECTORS AND METHOD FOR GENETIC IMMUNIZATION - Improved DNA vaccine plasmids are disclosed that contain novel immunostimulatory RNA compositions. The improved plasmids eliminate all extraneous sequences, incorporate a novel antibiotic free short RNA based selectable marker, increase eukaryotic expression using a novel chimeric promoter, improve yield and stability during bacterial production, and improve immunostimulation. These vectors are utilized in immunization to elicit improved immune responses or therapy to induce type 1 interferon production. | 12-02-2010 |
