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Jacobson, MA

A. Brian Jacobson, Milford, MA US

Patent application numberDescriptionPublished
20090091938LAMP AND METHOD FOR SUPPORTING A LIGHT SOURCE - A lamp is provided. Generally, the lamp comprises light source means for providing illumination in a frontward direction, retainer means for applying a frontward-directed load to the light source, and housing means for mechanically supporting the light source means and the retainer means.04-09-2009

Alan Jacobson, Cambridge, MA US

Patent application numberDescriptionPublished
20110034521COMPOUNDS AND METHODS FOR TREATING ZINC MATRIX METALLOPROTEASE DEPENDENT DISEASES - The present invention provides compounds and methods for treating zinc matrix metalloprotease dependent diseases. In certain embodiments, the compounds of the present invention have the following formulas:02-10-2011

Arthur A. Jacobson, Centerville, MA US

Patent application numberDescriptionPublished
20080225008SYSTEM AND METHOD FOR DRIVING AND RECEIVING DATA FROM MULTIPLE TOUCH SCREEN DEVICES - In one embodiment, multiple touch screen devices are driven from a graphics signal. A general-purpose computer provides a graphics signal of a particular display resolution. A display segmentor is configured to divide each graphics frame of the graphics signal into a plurality of pixel groups, each pixel group associated with a particular touch screen device of the plurality of touch screen devices. The display segmentor is further configured to generate an individual graphics signal from each pixel group, each individual graphics signal having a display resolution that is lower than the particular display resolution. One or more interfaces transmit each individual graphics signal to a different touch screen device of the plurality of touch screen devices.09-18-2008
20110167348PROGRAMMING ENVIRONMENT FOR CONFIGURING A SYSTEM OF AUDIO/VIDEO COMPONENTS - In one embodiment, a component library stores representations of audio/video components, the representations of audio/video components corresponding to physical audio/video components that are available for inclusion in a system. A configuration workspace is provided into which a selected plurality of representations of audio/video components from the component library are placed to indicate their inclusion in the system. A drawing tool may be used to draw connections between particular ones of the selected plurality of audio/video components in the configuration workspace. Further, a configuration compiler may determine one or more realized services that the system is capable of providing based on the selected plurality of audio/video components and the drawn connections between particular ones of the selected plurality of audio/video components, and may display to the user indications of the one or more realized services that the system is capable of providing.07-07-2011

Boris Jacobson, Westford, MA US

Patent application numberDescriptionPublished
20100231284Dynamic grounding system and method - Dynamic grounding including monitoring the floating DC outputs of a power amplifier, detecting an imbalance in the floating DC outputs, generating a compensation signal in response to a detected imbalance, and adjusting the power amplifier to re-balance the floating DC outputs and suppress transients.09-16-2010

Boris S. Jacobson, Westford, MA US

Patent application numberDescriptionPublished
20090021081METHODS AND APPARATUS FOR THREE-PHASE INVERTER WITH REDUCED ENERGY STORAGE - Methods and apparatus for a circuit including first and second energy sources, a rectifier coupled to the first and second energy sources, first and second energy storage devices coupled end-to-end across the positive and negative rails, and a single three-level inverter coupled to the rectifier for providing three-phase sinusoidal output voltages.01-22-2009
20090021966METHODS AND APPARATUS FOR A CASCADE CONVERTER USING SERIES RESONANT CELLS WITH ZERO VOLTAGE SWITCHING - A method of providing power to a load is provided. A first series resonant converter is provided. A second SRC is operably coupled to the first SRC in a cascade connected arrangement. First and second zero voltage switching (ZVS)-assistance networks are operably coupled between the first SRC and the second SRC, such that the first and second ZVS-assistance networks are providing first and second ZVS-assistant currents flowing from each ZVS-assistance network to the cascade connected arrangement of SRCs. Power from a power source is received at the cascade connected arrangement of first and second SRCs, power from a power source. The cascade connected arrangement of first and second SRCs supplies an output voltage to the load in response to receiving power from the power source.01-22-2009
20100289610Planar magnetic structure - An improved planar magnetic structure in which the voltage gradient between core and windings is reduced by shields disposed between the one or more legs of the core and the windings and extending through the PWB layers; vias are offset to permit them to be contained within the path of the winding; and the induced magnetic and eddy currents intrinsic to interstitial shield layers are reduced by configuring the shield conductors with pairs of courses with opposite and offsetting current propagation.11-18-2010
20100314937Reconfigurable multi-cell power converter - A reconfigurable multi-cell power converter and method wherein a set of cells are connected between an input bus and a load in an input series output parallel configuration or in an input parallel output series configuration. Each cell includes a primary side reconfigurable between series and parallel operation and a secondary side also reconfigurable between series and parallel operation. Switching circuitry is configured to reconfigure the primary side of each cell between series and parallel operation and vice versa and also to reconfigure the secondary side of each cell between series and parallel operation and vice versa. A controller is configured to actuate the switching circuitry depending a voltage on the input bus and/or cell condition to reconfigure all the cell primary sides and/or secondary sides while maintaining a desired input series output parallel or input parallel output series connection for the set of cells.12-16-2010
20110018341INTELLIGENT POWER SYSTEM - An intelligent power system includes one or more common power sources and one or more subsystem components interconnected with the common power sources. Each common power source includes an unregulated bus, a plurality of power source regulated buses, each regulated bus originating at a common power source and terminating at a respective one of k load subsystems, a power source, first, second, third and fourth groups of switches, a regulator having a plurality of outputs and an energy storage element. The regulator is configured to provide a time-shared mode of operation to provide power sequentially to one or more of the k load subsystems, such that the time intervals when the regulator is connected to any one of the k load subsystems do not overlap, and where the regulator is configured to switch in supplemental power from the energy storage, if necessary, to ensure that an average power delivered by the regulator does not exceed the average power consumed by all of the k load subsystems.01-27-2011
20110050324INTEGRATED SMART POWER SWITCH - A device including a controllable semiconductor, sensor, and controller is provided. The controllable semiconductor is associated with a first operating parameter and a second operating parameter, wherein at least the first operating parameter is controllable. The sensor is in communication with the controllable semiconductor device and acquires data relating to the second operating parameter of the controllable semiconductor device. The controller is in communication with the controllable semiconductor device and the sensor, and the controller is configured to access device data associated with the controllable semiconductor, control the first operating parameter of the controllable semiconductor, and receive data from the first sensor relating to the second operating parameter. The controller determines a first predicted value dependent on the device data, compares the data relating to the second operating parameter with the first predicted value, and, if a first condition is detected based on this comparison, dynamically modifies the first operating parameter.03-03-2011

Patent applications by Boris S. Jacobson, Westford, MA US

Bruce Jacobson, Framingham, MA US

Patent application numberDescriptionPublished
20090274705IL-13 BINDING AGENTS - Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.11-05-2009
20110262435IL-13 BINDING AGENTS - Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.10-27-2011

Bruce A. Jacobson, Framingham, MA US

Patent application numberDescriptionPublished
20090274696METHODS FOR TREATING INFLAMMATION - Provided are methods and compositions for reducing airway hyperresponsiveness and other inflammatory diseases, disorders and conditions in a mammal by decreasing FIZZ1 (Found in Inflammatory Zone 1) activity. Also provided are methods and compositions for identifying modulators of airway inflammation and/or inhibitors of FIZZ1. The present invention encompasses modulators of airway inflammation and/or inhibitors of FIZZ1 and uses thereof. In addition, the present invention provides methods and compositions for enhancing an immune response based on FIZZ1 protein.11-05-2009

Eric Jacobson, Northborough, MA US

Patent application numberDescriptionPublished
20100068174COMBINATION WITH BIS (THIOHYDRAZIDE AMIDES) FOR TREATING CANCER - Disclosed herein are methods of treating an immunosensitive cancer with bis(thio-hydrazide amides) or pharmaceutically-acceptable salts thereof and an immunotherapy.03-18-2010

John Carl Jacobson, Melrose, MA US

Patent application numberDescriptionPublished
20080209728METHODS AND APPARATUS FOR ATTACHING SWIRLERS TO TURBINE ENGINE COMBUSTORS - A method facilitates assembling a combustor for a gas turbine engine, wherein the combustor includes a swirler assembly. The method comprises machining material to form a domeplate, positioning a sealplate including an overhanging portion against the domeplate, securing the sealplate in position relative to the domeplate with a welding process, and welding the swirler assembly to the domeplate.09-04-2008

Patent applications by John Carl Jacobson, Melrose, MA US

Joseph Jacobson, Newton, MA US

Patent application numberDescriptionPublished
20090219261Touch-Sensitive Illuminated Display Apparatus and Method of Operation Thereof - A touch-sensitive system, and apparatus, and method of operation of the apparatus, are provided. In one embodiment, the apparatus includes a light source module configured to emit light; and a deformable waveguide coupled to the light source module and configured to transmit the light or a deflected version of the light at a situs at which pressure external to the deformable waveguide is applied. The deformable waveguide may also be illuminated by the light. The apparatus may also include one or more sensors configured to detect information indicative of the light or the deflected version of the light at the situs, and output a signal in response to the detected information.09-03-2009
20110172127Methods and Devices for High Fidelity Polynucleotide Synthesis - Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.07-14-2011
20110217738Methods and Devices for Nucleic Acid Synthesis - Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features. Each feature contains a plurality of oligonucleotides. Within each feature, each of the plurality of oligonucleotides includes an identical predetermined subunit sequence of X nucleosides and a degenerate sequence of Y nucleosides. A predetermined combination of a subset of the features can be used to produce a polynucleotide having a predetermined sequence of Z nucleosides.09-08-2011
20110297084Apparatus for Direct Fabrication of Nanostructures - An all-additive apparatus for direct fabrication of nanometer-scale planar and multilayer structures that performs “pick-and-place” retrieval and deposition of materials comprises a tip and a controller and transport mechanism configured for causing the tip to acquire a transferable material and deposit at least a portion of the acquired transferable material at a predetermined location onto a substrate, without the use of a bridging medium, in order to directly assemble a structure. The tip may be submillimeter-scale, may comprise a plurality of sub-tips disposed in a predetermined arrangement, and/or may mechanically vibrate. Mechanical vibration of the tip may be monitored. The tip may acquire the transferable material from a reservoir. The assembled structure may be cured on the substrate.12-08-2011
20120028843Methods and Apparatuses for Chip-Based DNA Error Reduction - Methods and apparatus relate to reduction of sequence errors generated during synthesis of nucleic acids on a microarray chip. The error reduction can include synthesis of complementary stands (to template strands), using a short universal primer complementary to the template strands and polymerase. Heteroduplex can be formed be melting and re-annealing complementary stands and template strands. The heteroduplexes containing a mismatch can be recognized and cleaved by a mismatch endonuclease. The mismatch-containing cleaved heteroduplexes can be removed from the microarray chip using a global buffer exchange. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.02-02-2012

Patent applications by Joseph Jacobson, Newton, MA US

Joseph M. Jacobson, Newton Center, MA US

Patent application numberDescriptionPublished
20090066625Electronic newspaper - We describe an electronic newspaper system which comprises an electronic newspaper device further comprising a low power flexible display, a radio for receiving information, a processor for processing said information for display and manipulation, memory for storing information and a battery for storing power in communication with a remote computer server capable of aggregating newspaper content and transmitting said content to said device. Additional aspects may include input means for inputting information, a back channel radio for sending information out and tracking means for tracking the position of the newspaper device. A further additional aspect of the invention comprises a business means comprising an electronic marketplace for electronic newspaper content.03-12-2009
20100063264NUCLEOTIDE SEQUENCING VIA REPETITIVE SINGLE MOLECULE HYBRIDIZATION - Methods of obtaining sequence information about target oligonucleotides by repetitive single molecule hybridization are disclosed. The methods include exposing a target oligonucleotide to one or more copies of a test oligonucleotide; measuring hybridization; dehybridizing the test oligonucleotide; and repeating until the information content from the hybridization trials equals or exceeds the information content of the target oligonucleotide.03-11-2010

Patent applications by Joseph M. Jacobson, Newton Center, MA US

May Jacobson, Sudbury, MA US

Patent application numberDescriptionPublished
20080213743Method for adjusting sedimentation rates - One or more chemicals are added to a physiological fluid to alter the density and/or shape of cells in the fluid to provide a desired sedimentation rate of the cells. In a preferred embodiment, the chemical to be added is an anticoagulant, preferably ACD.09-04-2008

Michael David Jacobson, Cambridge, MA US

Patent application numberDescriptionPublished
20100035848THERAPY FOR DISORDERS OF THE PROXIMAL DIGESTIVE TRACT - A method for managing or treating an inflammatory, erosive, dyspeptic or reflux disorder of the proximal digestive tract of a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor. A therapeutic combination, useful to treat any disease or condition in which an NSAID is indicated, comprises an NSAID in an anti-inflammatory, analgesic or antipyretic effective amount and a gastroprotective agent that comprises an ACE2 inhibitor in an amount effective to protect mucosal surfaces of the proximal digestive tract from erosion or ulceration induced by the NSAID.02-11-2010

Neil Jacobson, Acton, MA US

Patent application numberDescriptionPublished
20120102505DYNAMIC PROCESS VIRTUALIZATION - Access to virtual application resources can be regulated at runtime. More specifically, a process can be provided with access to at least one virtual application resource as a function of context. By way of example, process events can be monitored and analyzed during execution to determine whether access should be provided to the process.04-26-2012

Neil Jacobson, Arlington, MA US

Patent application numberDescriptionPublished
20090199175Dynamic Allocation of Virtual Application Server - A management system for virtual applications may deploy sets of virtual applications to many client devices, dynamically allocate virtual application servers to individual clients, manage updates to the virtual applications, and provide other high level management to deployments of virtual applications. A client device may include a virtual application management client that may communicate with a management server. The management client may add or remove virtual applications to the client device based on a policy received from the management server, and may query the management server to determine a currently available virtual application distribution server when a virtual application is requested. The management server may distribute and manage versions of applications across one or more virtual application distribution servers.08-06-2009
20090199178Virtual Application Management - A management system for virtual applications may deploy sets of virtual applications to many client devices by defining and distributing policies. The polices may define which client devices and/or users may permitted to access a virtual application from a server and how the virtual application may be used. A client device may include a virtual application management client that may communicate with a management server to retrieve and implement the policies. The management client may add or remove virtual applications to the client device based on a policy received from the management server. In some embodiments, policies may also be distributed and implemented on a virtual application server.08-06-2009
20100251236In-Process Intermediary To Create Virtual Processes - In one embodiment, the tools and techniques can include intercepting with an intermediary module in a running non-virtual process a request from the running non-virtual process to create a requested non-virtual process. In response to the request being intercepted, an appropriate virtual process corresponding to the requested non-virtual process can be identified. In addition, a virtual environment that is configured to host the virtual process can be prepared and the virtual process can be added to the virtual environment. Finally, the request can be fulfilled with the virtual process.09-30-2010
20110219146VIRTUAL SOFTWARE APPLICATION DEPLOYMENT CONFIGURATIONS - Configuration items for a software application can be automatically and/or manually discovered, and the application can be packaged to form a virtual application package. A deployment configuration can include settings for the configuration items. The deployment configuration can be set after packaging the software application. For example, a selected configuration item in the deployment configuration may be changed in response to user input. The virtual application package can be deployed to instantiate the application one or more times, and the deployment configuration can be applied in the instantiated application.09-08-2011
20110219365HIGH AND LOW VALUE APPLICATION STATE - A set of high value state in application state for a software application can be distinguished from a set of low value state in the application state. For example, a set of heuristics can be run on the application state to distinguish between the set of high value state and the set of low value state. A set of designations that designate the set of high value state in the application state as high value and that designate the set of low value state in the application state as low value can be generated. When processing the application, the high value state can be processed differently than the low value state. The application may be packaged as a virtual application.09-08-2011

Patent applications by Neil Jacobson, Arlington, MA US

Neil A. Jacobson, Arlington, MA US

Patent application numberDescriptionPublished
20090007139Running Add-On Components in Virtual Enviroments - Systems and methods for running add-on components in virtual environments are described. An add-on component can be executed in a virtual environment by setting up a communication link between a component proxy in the host operating system and a server process running in the virtual environment. The server process executes the add-on component based on commands forwarded by the component proxy forwards the commands from the operating system.01-01-2009
20110191788EXTENSIBLE APPLICATION VIRTUALIZATION SUBSYSTEMS - An extensible virtualization system provides an object model and manages a virtual application lifecycle in a way that allows new virtualization subsystems to be added to extend a virtualization product without reworking the product itself. Virtualizing an application generally involves three steps: metadata extraction, metadata storage and reconstitution, and runtime management of requests. The extensible virtualization system receives notification of an application preparation session and allows virtualization subsystems to monitor the session to collect configuration information specific to each subsystem that the application uses to run on a client. Each subsystem provides collected information to the extensible virtualization system, which stores the collected information until the application to be virtualized is deployed. When the application is deployed, the system invokes the same virtualization subsystem and provides the subsystem with the stored information.08-04-2011
20110219385VIRTUAL ENVIRONMENT FOR SERVER APPLICATIONS, SUCH AS WEB APPLICATIONS - An application virtualization system enables server applications, such as web applications to be easily deployable, separates an application and its state from the system, and allows applications to be easily moved to another server. The application virtualization system provides a way to isolate conflicts and allow multiple applications that provide conflicting information to run independently and avoid conflicts. The application virtualization system receives notification of an application preparation session and monitors the session to collect configuration information that the application uses to run on a client. The application virtualization system stores the collected information until the application to be virtualized is deployed. When an administrator later deploys the application, the system retrieves the stored information and uses the information and information from the client to reconstitute the metadata and virtualize the application.09-08-2011

Neil A. Jacobson, Acton, MA US

Patent application numberDescriptionPublished
20120102103RUNNING LEGACY APPLICATIONS ON CLOUD COMPUTING SYSTEMS WITHOUT REWRITING - Embodiments of the invention enable an application configured to store certain information (e.g., state information) locally to be deployed to a cloud computing environment in which local storage of such information is not permitted. For example, some embodiments create a “package” of resources that the application expects to be available to it during execution, and makes the package available to the application during execution in the cloud computing environment. The package may provide the application with resources it expects to have available during execution, such as the ability to store state information locally. As a result, the application need not be substantially modified to execute in the cloud computing environment.04-26-2012

Steven W. Jacobson, Millbury, MA US

Patent application numberDescriptionPublished
20080278351Primary flight display (PFD) including weather information and terrain awareness - The present invention provides a method and system for displaying critical navigational data on a primary flight display to a pilot of an aircraft. The method includes providing an image representative of weather information on a primary fight display and superimposing an image representative of a terrain warning indicator over at least part of the image representative of weather information.11-13-2008
20090112381Method and apparatus for a crash survivable flight data recorder - Common practice in the aviation industry is to place a single Flight Data Recorder (FDR) in an aircraft for the purpose of aiding an investigation of an aircraft accident or incident. In contrast, a system employing ‘an example’ embodiment of the invention uses multiple flight data recorders by having a primary node or first FDR, and one or more secondary nodes or one or more additional FDRs configured to store flight data. Each FDR is placed in a different location so as to ensure backup of the recorded and stored data. In this way, the invention system provides redundancy of information for an aircraft accident or incident and more reliable data storage.04-30-2009
20090265088SYMBOLOGY FOR A FLIGHT DISPLAY - Flight display systems are provided that present a pilot with a three dimensional view of an area within a potential flight path of an aircraft. The three dimensional view may include representations of potential obstacles and avoidance zones surrounding the potential obstacles. The view may also include cardinal compass representation aligned with the visual horizon. Aircraft traffic obstacle symbols may be variable based on the type of aircraft represented.10-22-2009

Stuart A. Jacobson, Lexington, MA US

Patent application numberDescriptionPublished
20100170660HEAT EXCHANGERS AND RELATED METHODS - Heat exchangers and related methods, e.g., methods of reducing heat from a load, are disclosed. In some embodiments, a device includes a stationary element defining a cavity, a movable element, and a first heat pipe in fluid communication with the cavity defined by the stationary element.07-08-2010
20110151507Solar Biofactory, Photobioreactors, Passive Thermal Regulation Systems and Methods for Producing Products - The invention described herein relates to photobioreactors, methods, assembly and use of such apparatus for culturing light-capturing organisms in a cost-effective manner. Various embodiments provide for a passive thermal regulation system employing selected microorganisms in a photobioreactor apparatus and methods for biological production of various fuel and chemical products from these organisms. Additional embodiments provide a solar biofactory system capable of culturing light capturing organisms to an areal productivity of 3.3 g/m2/hr. Further embodiments are directed to a photobioreactor capable of culturing light capturing organisms to an OD06-23-2011
20110217692Photobioreactors, Solar Energy Gathering Systems, And Thermal Control Methods - The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a prototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor.09-08-2011