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| 20090049298 | System for remote electronic notarization and signatory verification and authentication/ interface/ interlinked with an advanced steganographic cryptographic protocol - A method for remote electronic verification and authentication and screening of potential signatories for remote electronic notary transactions via remote pc encrypted platform to a broadband digitally or WIFI cellular/PDA device or portable pc device. The system implements the following electronic components, but not limited to, electronic signature device, digital certificates, electronic document, electronic biometric devices, electronic audio/visual software/hardware, and electronic payment systems and devices, all electronically synchronized to afford capable notary publics in executing remote electronic notary transactions via a satellite kiosk network or on-line virtual kiosk application. | 02-19-2009 |
| 20090327144 | SYSTEM FOR EXECUTING REMOTE ELECTRONIC NOTARIZATION AND SIGNATORY VERIFICATION AND AUTHENTICATION - A system for remote electronic verification and authentication and screening of potential signatories for remote electronic notary transactions via remote pc encrypted platform to a broadband digitally or WIFI cellular/PDA device or portable pc device. The system implements the following electronic components, but not limited to, electronic signature device, digital certificates, electronic document, electronic biometric devices, electronic audio/visual software/hardware, and electronic payment systems and devices, all electronically synchronized to afford capable notary publics in executing remote electronic notary transactions via a satellite kiosk network or on-line virtual kiosk application. | 12-31-2009 |
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| 20100272779 | PROGESTERONE-CONTAINING COMPOSITIONS AND DEVICES - Progesterone-containing compositions and devices that can maintain opening of a body passageway are described. One aspect of the invention provides a therapeutically effective (e.g., relaxative, anti-oxidative, anti-restenotic, anti-angiogenic, anti-neoplastic, anti-cancerous, anti-precancerous and/or anti-thrombotic) composition or formulation containing progesterone and optionally vitamin E and/or conjugated linoleic acid. Another aspect of the invention provides a drug eluting device, such as a drug eluting stent, with at least one coating layer comprising a progesterone composition that can minimize or eliminate inflammation, thrombosis, restenosis, neo-intimal hyperplasia, rupturing of vulnerable plaque, and/or other effects related to device implantation, treatment, or interaction. Other aspects of the invention provide for methods of using such compositions, formulations, and devices. | 10-28-2010 |
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| 20080208265 | SYSTEM AND METHOD FOR PERCUTANEOUS PALATE REMODELING - Methods and devices are disclosed for manipulating the palatal tissue. An implant is positioned within at least a portion of the soft palate and may be secured to other surrounding, less mobile structures such as the hard palate or the mucosa overlying the hard palate. The implant may be manipulated to displace at least a portion of the soft palate in an anterior or lateral direction, or to alter the tissue tension or compliance of the soft palate. | 08-28-2008 |
| 20090088779 | Articulating Suturing Device and Method - A device for closing an opening in tissue includes a shaft having a proximal end, a distal end, and at least one pin associated with a distal end the shaft. A flexible guidebody extends from the distal end of the shaft, while a foot associated with the device is movable with respect to the shaft through the pin connected to at least one slot of the foot. Another device for closing an opening in tissue includes a shaft having a proximal end and a distal end. A plurality of feet are disposed proximate the distal end of the shaft, the plurality of feet being movable with respect to the shaft. The device further includes a flexible guidebody extending from the distal end of the shaft. | 04-02-2009 |
| 20090157105 | ARTICULATING SUTURING DEVICE AND METHOD - A method for closing an opening in tissue using a suturing device includes inserting at least a portion of a suture through a tissue tract and through a tissue wall. Following inserting at least a portion of the suture, the method includes advancing a first end of the suture through a bight of the suture, the bight pre-formed about a periphery of a knot tube of the suturing device. Once the first end is advanced, the method includes tensioning the first end of the suture and a second end of the suture adjacent the bight to form a knot affixing a loop of suture across the puncture. | 06-18-2009 |
| 20090264903 | APPARATUS AND METHODS FOR MINIMALLY INVASIVE VALVE REPAIR - A surgical fastening apparatus including at least one self-closing clip and a deployment device. The self-closing clip comprises a wire defining an intermediate portion interconnecting opposing, first and second side portions having a memory set loop shape. The deployment device includes a clip holding assembly and an actuator. The clip holding assembly includes first and second containment arms and a transfer rod. The containment arms have a distal segment defining a lumen extending from an open, distal end. The transfer rod is associated with at least one of the containment arms in an axially movable fashion and forms an engagement feature. The actuator is connected to the transfer rod for controlling movement of the rod. Upon final assembly in a pre-deployment state, the engagement feature of the transfer rod engages the intermediate portion of the clip, and the side portions are captured by the containment arms. | 10-22-2009 |
| 20110152738 | DEVICES AND METHODS FOR DRESSING APPLICATORS - Devices, kits and methods described herein may be for wound healing, including the treatment, amelioration, or prevention of scars and/or keloids by applying and/or maintaining a pre-determined strain in an elastic skin treatment device that is then affixed to the skin surface using skin adhesives to transfer a generally planar force from the bandage to the skin surface. Applicators are used to apply and/or maintain the strains, and some of the applicators are further configured to provide at least some mechanical advantage to the user when exerting loads onto the skin treatment device. | 06-23-2011 |
| 20110245850 | SUTURE PASSER SYSTEMS AND METHODS FOR TONGUE OR OTHER TISSUE SUSPENSION AND COMPRESSION - Suture passer systems for tissue suspension and tissue compression, and more particularly for tongue suspension, are described. The system can include at least a first elongate tubular body or shaft, a needle having a lateral bias carried by the elongate body, and a retrieval element operably connected to the elongate tubular body. The needle can have a substantially straight configuration when located within the elongate tubular body, and be configured to exit an opening at or near a distal end of the elongate tubular body and assume a laterally biased or curved shape to form a path through tissue. The needle is configured to carry a suture. The retrieval element can be configured to retrieve the suture carried by the needle after the needle has formed a curved or otherwise angled path through tissue. The system can also include one or more bone anchors to secure the suture loops. Methods of placing one or more suture loops into tissue, such as the base of the tongue, are also described. | 10-06-2011 |
| 20120035521 | SEGMENTED SKIN TREATMENT SYSTEMS AND METHODS - Devices, kits and methods described herein may be for wound healing, including the treatment, amelioration, or prevention of scars and/or keloids by applying and/or maintaining a pre-determined strain in an elastic skin treatment device that is then affixed to the skin surface using skin adhesives to transfer a generally planar force from the bandage to the skin surface. Applicators are used to apply and/or maintain the strains, and some of the applicators are further configured to provide at least some mechanical advantage to the user when exerting loads onto the skin treatment device. | 02-09-2012 |
| 20120041556 | METHODS AND DEVICES FOR RHINOPLASTY AND TREATING INTERNAL VALVE STENOSIS - Methods and devices for rhinoplasty and treating nasal valve stenosis are disclosed herein. The nasal valve acts as a flow-limiter and can contribute to airway obstruction if resistance within the nasal valve is excessive. In one embodiment, a system for treating nasal valve stenosis includes a first elongate implant and a second elongate implant configured to support the nasal valves when implanted. The implants can be coupled together by connecting elements, such as eyelets, tethers, complementary socket joints, and button-rivet supports. | 02-16-2012 |
| 20120046590 | SKIN STRAINING DEVICES AND METHODS - A skin frame or other skin straining device strains skin on each side of a wound where a wound has been closed to off load stresses at the wound site. A dressing may be applied to the strained skin. The dressing may be integral with one or more elements of the skin straining device. | 02-23-2012 |
| 20120083724 | SEGMENTED SKIN TREATMENT SYSTEMS AND METHODS - Devices, kits and methods described herein may be for wound healing, including the treatment, amelioration, or prevention of scars and/or keloids by applying and/or maintaining a pre-determined strain in an elastic skin treatment device that is then affixed to the skin surface using skin adhesives to transfer a generally planar force from the bandage to the skin surface. Applicators are used to apply and/or maintain the strains, and some of the applicators are further configured to provide at least some mechanical advantage to the user when exerting loads onto the skin treatment device. | 04-05-2012 |
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| 20110024043 | CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME - Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body | 02-03-2011 |
| 20110027127 | ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME - Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system | 02-03-2011 |
| 20110027453 | CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME - Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body | 02-03-2011 |
| 20110027458 | CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME - Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body | 02-03-2011 |
| 20110028815 | ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME - Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system | 02-03-2011 |
| 20110028816 | ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME - Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system | 02-03-2011 |
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| 20090306640 | Vein Therapy Device and Method - A vapor delivery and insulation device is provided that may include any of a number of features. One feature of the device is that it can deliver vapor to the veins of a patient. The vapor can be generated within the device, in a handle of the device, or external to the device. Another feature of the device is that it can actively insulate the vapor to minimize heat transfer from a vapor delivery lumen of the device to an exterior surface of the device. The active insulation can be a vacuum or a flowing gas. Methods associated with use of the device are also covered. | 12-10-2009 |
| 20100234840 | METHODS AND SYSTEMS FOR DETERMINING PHYSIOLOGIC CHARACTERISTICS FOR TREATMENT OF THE ESOPHAGUS - A method and apparatus for treating abnormal mucosa in the esophagus is disclosed, such that the depth of the treated tissue is controlled. The depth of ablation is controlled by monitoring the tissue impedance and/or the tissue temperature. A desired ablation depth is also achieved by controlling the energy density or power density, and the amount of time required for energy delivery. A method and apparatus is disclosed for measuring an inner diameter of a body lumen, where a balloon is inflated inside the body lumen at a fixed pressure. | 09-16-2010 |
| 20110112524 | Hollow body cavity ablation apparatus - An ablation apparatus places electrodes at the perimeter of a cavity. In an embodiment, the alternating electric field is used to expose the cavity to enough energy to ablate the cavity. In an embodiment, two modes are used to expose different regions of the cavity to different amounts of power for so that the thermal effect is more uniform. In an embodiment, the electrodes have a relatively large surface area so as to avoid charring the cavity, but are shaped so as to fit within a body orifice. For example, the diameter of the sheathed housing the electrodes during penetration may be only 5.5 mm. | 05-12-2011 |
| 20110178584 | VAGINAL REMODELING DEVICE AND METHODS - This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator. | 07-21-2011 |
| 20110264176 | HOT TIP VEIN THERAPY DEVICE - Methods and apparatus for generating vapor within a catheter are provided which may include any number of features. One feature is generating vapor with an electrode array within a catheter. Another feature is sensing an impedance of the electrode array, and adjusting the power delivered to the electrode array to fully generate vapor within the catheter. Another feature is delivering the vapor to a vein of a patient for vein reduction therapy. | 10-27-2011 |
| 20120004654 | Methods and Systems for Determining Physiologic Characteristics for Treatment of the Esophagus - A method and apparatus for treating abnormal mucosa in the esophagus is disclosed, such that the depth of the treated tissue is controlled. The depth of ablation is controlled by monitoring the tissue impedance and/or the tissue temperature. A desired ablation depth is also achieved by controlling the energy density or power density, and the amount of time required for energy delivery. A method and apparatus is disclosed for measuring an inner diameter of a body lumen, where a balloon is inflated inside the body lumen at a fixed pressure. | 01-05-2012 |
| 20120004656 | METHODS AND SYSTEMS FOR TREATMENT OF TISSUE IN A BODY LUMEN - A system for measuring physiologic characteristics or treating tissue in a body lumen. The system may be used for treating abnormal mucosa in the esophagus. The system comprises an energy delivery device, such as an ablation device including an electrode support and an electrode pattern on the support. The ablation device may expand in size from a pre-deployed state to a deployed state. The system may include a sizing device having an inflatable balloon on a distal end of a catheter that is inflated with an expansion medium to expand the balloon to engage the wall of the esophagus so that the internal cross-section can be calculated or measured. The sizing device may also a controller for delivering an expansion medium and measuring the amount and pressure of the expansion medium inside the catheter. Methods of treating or diagnosing tissue are also disclosed. | 01-05-2012 |
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| 20090010509 | Method and system for detection of deformable structures in medical images - A method and system for detection of deformable structures in medical images is disclosed. Deformable structures can represent blood flow patterns in images such as Doppler echocardiograms. A probabilistic, hierarchical, and discriminant framework is used to detect such deformable structures. This framework integrates evidence from different primitive levels via a progressive detector hierarchy, including a series of discriminant classifiers. A target deformable structure is parameterized by a multi-dimensional parameter, and primitives or partial parameterizations of the parameter are determined. An input image is received, and a series of primitives are sequentially detected using the progressive detector hierarchy, in which each detector or classifier detects a corresponding primitive. The final detector detects configuration candidates for the deformable structure. | 01-08-2009 |
| 20090310837 | Method and System for Automatic Detection and Measurement of Mitral Valve Inflow Patterns in Doppler Echocardiography - A method and system for segmentation of mitral valve inflow (MI) patterns in Doppler echocardiogram images is disclosed. Trained root detectors are used to detect left root candidates, right root candidates, and peak candidates in an input Doppler echocardiogram image. Two global structure detectors, a single triangle detector for non-overlapping E-waves and A-waves and a double triangle detector for overlapping E-waves and A-waves, are used to detect single triangle candidates and double triangle candidates based on the left root, right root, and peak candidates. A shape profile is used to determine a shape probability for each of the single triangle candidates and each of the double triangle candidates. The best single triangle candidate and the best double triangle candidate are selected based on shape probability and detection probability. One of the best single triangle candidate and the best double triangle candidate is selected as the final segmentation result based on a shape probability comparison. | 12-17-2009 |
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| 20090080292 | Microfabricated acoustic transducer with a multilayer electrode - In a capacitive membrane ultrasound transducer, one or more electrodes include multiple layers of conductive or semiconductive material. The layers may be positioned adjacent an insulator or cavity in an arrangement to reduce electrical degradation. For example, a conductive layer with less work function and less resistivity is spaced from an insulator by a conductive layer with more work function and more resistivity. The different layers of electrode material may provide for less electrical degradation due to the type of material used and relative location. | 03-26-2009 |
| 20100273329 | METHOD FOR PREPARING A DONOR SURFACE FOR REUSE - A donor wafer, for example of silicon, has an irregular surface following cleaving of a lamina from the surface, for example by exfoliation following implant of hydrogen and/or helium ions to define a cleave plane. Pinholes in the lamina leave column asperities at the exfoliated surface of the donor wafer, and the beveled edge may leave an edge asperity which fails to exfoliate. To prepare the surface of the donor wafer for reuse, mechanical grinding removes the column and edge asperities, and minimal additional thickness. Following cleaning, growth and removal of an oxide layer at the surface rounds remaining peaks. The smoothed surface is well adapted to bonding to a receiver element and exfoliation of a new lamina. A variety of devices may be fabricated from the lamina, for example a photovoltaic cell. | 10-28-2010 |
| 20100326510 | THIN SEMICONDUCTOR LAMINA ADHERED TO A FLEXIBLE SUBSTRATE - A semiconductor donor body such as a wafer is implanted with ions to form a cleave plane. The donor wafer is affixed to a polyimide receiver element, for example by applying polyimide in liquid form to the donor wafer, then curing, or by affixing the donor wafer to a preformed polyimide sheet. Annealing causes a lamina to cleave from the donor wafer at the cleave plane. The resulting adhered lamina and polyimide body are not adhered to another rigid substrate and can be jointly flexed. | 12-30-2010 |
| 20100330731 | METHOD TO FORM A THIN SEMICONDUCTOR LAMINA ADHERED TO A FLEXIBLE SUBSTRATE - A semiconductor donor body such as a wafer is implanted with ions to form a cleave plane. The donor wafer is affixed to a polyimide receiver element, for example by applying polyimide in liquid form to the donor wafer, then curing, or by affixing the donor wafer to a preformed polyimide sheet. Annealing causes a lamina to cleave from the donor wafer at the cleave plane. The resulting adhered lamina and polyimide body are not adhered to another rigid substrate and can be jointly flexed. | 12-30-2010 |
| 20120003775 | Formed Ceramic Receiver Element Adhered to a Semiconductor Lamina - A method is described to create a thin semiconductor lamina adhered to a ceramic body. The method includes defining a cleave plane in a semiconductor donor body, applying a ceramic mixture to a first face of the semiconductor body, the ceramic mixture including ceramic powder and a binder, curing the ceramic mixture to form a ceramic body, and cleaving a lamina from the semiconductor donor body at the cleave plane, the lamina remaining adhered to the ceramic body. Forming the ceramic body this way allows outgassing of volatiles during the curing step. Devices can be formed in the lamina, including photovoltaic devices. The ceramic body and lamina can withstand high processing temperatures. In some embodiments, the ceramic body may be conductive. | 01-05-2012 |
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| 20090202854 | SKIN SYSTEM WITH ELASTIC COMPONENTS HAVING DIFFERING HARDNESSES FOR USE WITH ROBOTICS - An artificial skin system for use with a robotic assembly such as to provide an animated robot head with realistic skin movement. The skin system includes a receiving component for contacting the manipulator mechanism of the robotic assembly and also includes an exterior skin component that extends over the receiving component. An inner surface of the exterior skin component is integrally bonded to the receiving component such that the exterior skin component moves with the receiving component when a manipulator mechanism or robotics anchored to the receiving component moves or applies a force. The exterior skin component is formed of an elastic material with a second hardness that differs from a first hardness of elastic material of the receiving component, e.g., is less than the first hardness. The skin system includes a backing component bonded to the other components with a third hardness less than the first and second hardnesses. | 08-13-2009 |
| 20090289391 | FABRICATING MULTI-COMPONENT SKIN SYSTEMS FOR ROBOTICS AND OTHER APPLICATIONS - A method for fabricating a product, such as an amimatronic character, with artificial skin. The method includes providing data defining an exterior surface geometry of the product. A base geometry model of the product is generated based on the exterior surface geometry data, which in turn is used to fabricate a prototype of the product. Then, an exterior skin mold is formed using the product prototype mounted on an alignment block. The method includes fabricating an inner support structure based on the base geometry model having an exterior geometry smaller than the 3D base geometry model by the thickness of the exterior skin. The inner support structure is positioned within the mold with the inner support structure mounted upon the alignment block, which is received in the mold. The product is formed by pouring material for an exterior skin layer into the mold and over the inner support structure. | 11-26-2009 |
| 20100222914 | FABRICATING MULTI-COMPONENT SKIN SYSTEMS FOR ROBOTICS AND OTHER APPLICATIONS - A method for fabricating a product, such as an amimatronic character, with artificial skin. The method includes providing data defining an exterior surface geometry of the product. A base geometry model of the product is generated based on the exterior surface geometry data, which in turn is used to fabricate a prototype of the product. Then, an exterior skin mold is formed using the product prototype mounted on an alignment block. The method includes fabricating an inner support structure based on the base geometry model having an exterior geometry smaller than the 3D base geometry model by the thickness of the exterior skin. The inner support structure is positioned within the mold with the inner support structure mounted upon the alignment block, which is received in the mold. The product is formed by pouring material for an exterior skin layer into the mold and over the inner support structure. | 09-02-2010 |
| 20110087354 | MODELING SKIN-COVERED ROBOTICS DEVICES INCLUDING ARTISTIC DIGITAL ITERATIVE DESIGN PROCESSES - A method for fabricating a product, such as an animatronic character, with artificial skin. The method includes providing data defining an exterior surface geometry of the product. A base geometry model of the product is generated based on the exterior surface geometry data, which in turn is used to fabricate a prototype of the product. Then, an exterior skin mold is formed using the product prototype mounted on an alignment block. The method includes fabricating an inner support structure based on the base geometry model having an exterior geometry smaller than the 3D base geometry model by the thickness of the exterior skin. The inner support structure is positioned within the mold with the inner support structure mounted upon the alignment block, which is received in the mold. The product is formed by pouring material for an exterior skin layer into the mold and over the inner support structure. | 04-14-2011 |
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| 20090142352 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 06-04-2009 |
| 20090326202 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 12-31-2009 |
| 20110027287 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 02-03-2011 |
| 20110117011 | NEUTRALIZING PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) VARIANTS AND USES THEREOF - Neutralizing PCSK9 variants that interact with low density lipoprotein receptor (LDLR) are described. Methods and compositions for treating disorders by administering a pharmaceutically effective amount of a neutralizing PCSK9 variant are described. | 05-19-2011 |
| 20120020975 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 01-26-2012 |
| 20120020976 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 01-26-2012 |
| 20120027765 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 02-02-2012 |
| 20120093818 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 04-19-2012 |
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| 20090024090 | UNIVERSAL CATHETER SECUREMENT DEVICE - A universal securing device for holding catheters of various shapes and sizes and the like in place includes a base and cover. The cover may be connected to the base by a hinge which allows the cover to be lifted open or pushed down into a closed position, over a catheter fitting. The base may have locating elements configured and arranged to fit around catheter fittings of various sizes, and the locating elements prevent substantial movement of a catheter fitting and catheter in various dimensions. The cover may include capture elements which act to grip and compress the catheter fitting when the securing device is in a closed position, thus preventing substantial movement of a catheter fitting and catheter in various dimensions. The base may be attached to a patient with an adhesive pad attached to the bottom surface of the base. | 01-22-2009 |
| 20090177121 | POSTURAL AWARENESS APPARATUS - A postural awareness apparatus includes a pad, a signal producing system, and an activator that activates the signal producing system when a compressive force applied to the apparatus exceed a predetermined compressive force. The activator includes a switch having an upper portion, a compressible element having defined therein an opening, the compressible element at least partially surrounding the upper portion of the switch, and a cap adapted to secure the compressible element in a position at least partially surrounding the upper portion of the switch. | 07-09-2009 |
| 20100179482 | UNIVERSAL CATHETER SECUREMENT DEVICE - A universal device for securing a catheter on a patient includes a base which optionally has one or more locating elements for positioning or securing a catheter or catheter fitting of various shapes or sizes. The base optionally includes a recessed or flat receiving area defined by locating elements arranged in any configuration suitable to hold or receive a catheter or catheter fitting, e.g., in a tapering or V shaped formation. Additional locating elements may be positioned elsewhere on the base for receiving or holding a flange or wing of a catheter fitting and preventing its movement in various directions. The base optionally has an angled surface to maintain the desired angle for catheters or catheter fittings in a patient. A cover is removably or permanently connected to the base and may optionally have one or more top openings for receiving tabs or extensions of a catheter fitting. | 07-15-2010 |
| 20100179483 | MEDICAL ARTICLE SECUREMENT DEVICE - A securement device ( | 07-15-2010 |
| 20110264050 | MEDICAL ARTICLE SECUREMENT SYSTEM - A medical article securement device holds a medical article such as a catheter in position upon the body of a patient and at least inhibits longitudinal movement of the medical article. The securement device includes a retainer, a pair of hinged actuators, and a pair of engagement members coupled with the hinged actuators. Movement of the actuators causes the engagement members to grip at least a portion of a medical article placed within the retainer so as to inhibit longitudinal movement of the medical article with respect to the retainer. The shape of the retainer inhibits lateral and transverse movement of the medical article with respect to a patient's skin. | 10-27-2011 |
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| 20090093769 | UNIVERSAL CATHETER SECUREMENT DEVICE - A universal securing device for holding catheters of various shapes and sizes and the like in place includes a base and cover. The cover may be connected to the base by a hinge which allows the cover to be lifted open or pushed down into a closed position, over a catheter fitting. The base may have locating elements configured and arranged to fit around catheter fittings of various sizes, and the locating elements prevent substantial movement of a catheter fitting and catheter in various dimensions. The cover may include capture elements which act to grip and compress the catheter fitting when the securing device is in a closed position, thus preventing substantial movement of a catheter fitting and catheter in various dimensions. The base may be attached to a patient with an adhesive pad attached to the bottom surface of the base. | 04-09-2009 |
| 20090314641 | METHODS AND APPARATUS FOR LOW RESISTANCE ELECTROPHORESIS OF PRIOR-CAST, HYDRATABLE SEPARATION MEDIA - Methods and apparatus are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips. The method exploits the swelling of prior-cast, hydratable separation media upon rehydration to help lodge the media in an enclosing member that permits spaced electrical communication with the enclosed separation media. The electrical communication permits a voltage gradient to be established in the enclosed separation medium sufficient to effect separation of analytes therein. Cassettes, buffer cores, electrophoresis systems and kits are presented for effecting the methods of the invention. | 12-24-2009 |
| 20100059380 | APPARATUS FOR CONCURRENT ELECTROPHORESIS IN A PLURALITY OF GELS - Apparatus and methods for conducting electrophoretic separation concurrently in a plurality of gels with improved reproducibility among the gels. | 03-11-2010 |
| 20100105576 | Three Frame cDNA Expression Libraries for Functional Screening of Proteins - Compositions and methods are provided for generating three frame cDNA expression libraries for functional screening of proteins. The invention includes sets of 5′ adapters for cloning cDNA molecules in which the sets include three adapters that can be used to clone a particular cDNA in all three reading frames. The libraries so generated have greater complexity of expressed open reading frames, and thus can improve the success of functional protein screens, such as two hybrid screens. The adapters also have recombination sites for efficient cloning and transfer between systems. | 04-29-2010 |
| 20100114034 | SECUREMENT DEVICE FOR CATHETERS - A system for securing a medical device such as a catheter or other medical article having various shapes or sizes in place on a patient includes a securing device. The securing device may optionally include a retainer having one or more receiving areas and one or more retention arms adjacent to the receiving areas. The securing device may also include a retention strap having a latching element that is removably connectable to a retention arm to securely hold a catheter in place. The retainer may optionally be connected to a base which may optionally be connected to an adhesive pad for easy attachment of the securing device to a patient. | 05-06-2010 |
| 20110132763 | SOLUTION PHASE ELECTROPHORESIS DEVICE, COMPONENTS, AND METHODS - A device for fluid phase electrophoresis, particularly solution phase isoelectric focusing, components thereof, and methods for use are presented. | 06-09-2011 |
| 20110172759 | AXIALLY NESTED SLIDE AND LOCK EXPANDABLE DEVICE - The invention relates generally to expandable medical implants for maintaining support of a body lumen and, in particular, to an axially nested, diametrically expandable, slide and lock vascular device for enlarging an occluded portion of a vessel. The axially nested vascular device desirably achieves both competitive crossing profiles while maintaining other key features, such as, for example, radial strength and luminal patency. The collapsed profile can also be made very thin without compromising radial strength. Thus, the vascular device can advantageously be deployed in small and difficult to reach areas or vessels. The axial nesting substantially eliminates radial overlap between mating structural elements thereby desirably allowing for a low, uniform profile. | 07-14-2011 |
| 20110288487 | UNIVERSAL CATHETER SECUREMENT DEVICE - A universal securing device for holding catheters of various shapes and sizes and the like in place includes a base and cover. The cover may be connected to the base by a hinge which allows the cover to be lifted open or pushed down into a closed position, over a catheter fitting. The base may have locating elements configured and arranged to fit around catheter fittings of various sizes, and the locating elements prevent substantial movement of a catheter fitting and catheter in various dimensions. The cover may include capture elements which act to grip and compress the catheter fitting when the securing device is in a closed position, thus preventing substantial movement of a catheter fitting and catheter in various dimensions. The base may be attached to a patient with an adhesive pad attached to the bottom surface of the base. | 11-24-2011 |
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| 20110093393 | Method and System for Obtaining Feedback for a Product - The embodiments disclosed herein include new, more efficient ways to request, create, send, and receive product reviews from the Internet. One aspect of the invention is an email message for a customer. The email message includes a request to review a product obtained by the customer in a transaction; a rating input area and/or a text input area; an authentication token that includes a transaction identifier corresponding to the transaction; and an HTTP form submission command to send a response to the request from the customer to a remote computer. The response includes a rating entered in the rating input area and/or text entered in the text input area, and the authentication token. | 04-21-2011 |
| 20110196932 | STATUS MESSAGE DE-DUPLICATION - In one aspect, a computer-implemented method of de-duplication of messages in a micro-blog includes receiving a first message and posting the first message to the micro-blog, receiving a second message, and classifying the second message as a new message or an edited version of the first message. | 08-11-2011 |
| 20110196933 | ACTIVE E-MAILS - A computer-implemented method can include accessing a micro-blog to retrieve a real-time copy of the micro-blog thread and delivering the real-time copy of the micro-blog thread for display in an e-mail message. | 08-11-2011 |
| 20110197146 | Assisting The Authoring Of Posts To An Asymmetric Social Network - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for assisting the authoring of posts to an asymmetric social network. In one aspect, a method performed by a system of one or more data processing devices includes receiving, at the system, an identification of an electronic document that is available on the Internet, the system identifying image content in the electronic document, the system filtering the identified image content, the system triggering presentation of the filtered image content to an author of a post to an asymmetric social network, the system receiving a selection of a first image from amongst the presented image content, and the system adding the first image to a post to the asymmetric social network. | 08-11-2011 |
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| 20100078640 | Thin Film Transistor Backplane - A fabrication process for a device such as a backplane for a flat panel display includes depositing thin film layers on a substrate, forming a 3D template overlying the thin film layers, and etching the 3D template and the thin film layers to form gate lines and transistors from the thin film layers. An insulating or passivation layer can then be deposited on the gate lines and the transistors, so that column or data lines can be formed on the insulating layer. | 04-01-2010 |
| 20110309365 | THIN FILM TRANSISTOR BACKPLANE - A fabrication process for a device such as a backplane for a flat panel display includes depositing thin film layers on a substrate, forming a 3D template overlying the thin film layers, and etching the 3D template and the thin film layers to form gate lines and transistors from the thin film layers. An insulating or passivation layer can then be deposited on the gate lines and the transistors, so that column or data lines can be formed on the insulating layer. | 12-22-2011 |
| 20110316798 | Tactile Display for Providing Touch Feedback - A tactile display has a contact surface that has multiple addressable pixels. Each pixel has a vibration element that is energizable to vibrate at a selected frequency and amplitude. The vibration of selected pixels of the tactile display provides tactile feedback to a user's finger touching the contact surface. | 12-29-2011 |
| 20120043470 | X-RAY IMAGING APPARATUS - An X-ray imaging apparatus includes a top transparent conductive layer and a bottom transparent conductive layer electrically connected to the top transparent conductive layer. The apparatus also includes an X-ray field modulator positioned adjacent to the bottom transparent conductive layer and an electro-optic layer positioned between the X-ray field modulator and the top transparent conductive layer. The X-ray field modulator is configured to modulate one of a resistance and a charge level therethrough when exposed to different X-ray levels to thereby create different levels of voltage drop across the electro-optic layer. In addition, the different levels of voltage drop causes varying optical properties to appear in the electro-optic layer. | 02-23-2012 |
| 20120074433 | ELECTRONIC APPARATUS - An electronic apparatus is provided that includes a number of first components on a first substrate and a number of second components on a second substrate. A lamination material that includes a conducting material is placed between the first components and the second components. Any one first component can couple to a varied subset of second components. | 03-29-2012 |
