Patent application number | Description | Published |
20080233143 | Adjuvanting Material - The present invention provides an adjuvanting material, the adjuvanting material comprising a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group. Further, the present invention provides an immunogenic composition comprising (a) a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group; (b) an antigen comprising a metal affinity tag; and optionally (c) metal ions, whereby the antigen is linked to the lipid dendritic cell targeting moiety via the interaction between the metal affinity tag and the metal chelating group. | 09-25-2008 |
20100129385 | IMMUNOGENIC MOLECULES - The present invention relates generally to the field of immunology and more particularly to molecules capable of stimulating a cellular immune response. More particularly, the present invention provides self-adjuvanting immunogenic molecules capable of stimulating an immune response to epitopes of a polypeptide irrespective of a subjects HLA type. The present invention further contemplates methods for the production and use of the self-adjuvanting immunogenic molecules and compositions comprising same useful in the vaccination of subjects against specific polypeptides. | 05-27-2010 |
20110200632 | ADJUVANTING MATERIAL - The present invention provides an adjuvanting material, the adjuvanting material comprising a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group. Further, the present invention provides an immunogenic composition comprising (a) a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group; (b) an antigen comprising a metal affinity tag; and optionally (c) metal ions, whereby the antigen is linked to the lipid dendritic cell targeting moiety via the interaction between the metal affinity tag and the metal chelating group. | 08-18-2011 |
20140079728 | ADJUVANTING MATERIAL - The present invention provides an adjuvanting material, the adjuvanting material comprising a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group. Further, the present invention provides an immunogenic composition comprising (a) a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group; (b) an antigen comprising a metal affinity tag; and optionally (c) metal ions, whereby the antigen is linked to the lipid dendritic cell targeting moiety via the interaction between the metal affinity tag and the metal chelating group. | 03-20-2014 |
20150307545 | ADJUVANTING MATERIAL - The present invention provides an adjuvanting material, the adjuvanting material comprising a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group. Further, the present invention provides an immunogenic composition comprising (a) a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group; (b) an antigen comprising a metal affinity tag; and optionally (c) metal ions, whereby the antigen is linked to the lipid dendritic cell targeting moiety via the interaction between the metal affinity tag and the metal chelating group. | 10-29-2015 |
Patent application number | Description | Published |
20090105155 | TRUNCATED LHRH FORMULATIONS - The present invention provides a peptide useful for raising an antiLHRH response in an animal. The peptide comprises a first and second region, the first region consisting of a sequence of less than 60 amino acids which comprises at least one T helper cell epitope and the second region consisting of the sequence SYGLRPG. | 04-23-2009 |
20100310595 | METHOD OF TRANSFECTION AND COMPOSITIONS THEREFOR - The present invention relates to the targeted delivery of molecules to cells expressing toll-like receptors (TLRs). Aspects of the invention provide compounds comprising a positively charged group linked to a TLR ligand. These compounds are useful for in vitro and in vivo methods of transfection of TLR-expressing cells. Other aspects of the invention relate to the use of such compounds for repression of gene expression and DNA vaccination approaches. | 12-09-2010 |
20110262473 | SYNTHETIC VACCINE COMPONENT - The present invention relates generally to the field of synthetic vaccines, components thereof and methods for producing same. More particularly, the present invention provides a component of synthetic vaccines and its use in a modular approach to vaccine production. | 10-27-2011 |
20120064109 | IMMUNOGENIC COMPOSITION AND USES THEREOF - The present invention provides an immunogenic composition comprising an antigen and a dendritic cell targeting component. A charged group is covalently attached to a dendritic cell ligand and is electrostatically associated with the dendritic cell targeting component. | 03-15-2012 |
20120251536 | BIOPOLYMER HYBRID GEL-DEPOT DELIVERY SYSTEM - The invention relates to biopolymer-gel based depot systems for prolonged and/or controlled release delivery of biologically active agents, methods for the manufacture of the biopolymer based gel-depots which include a biologically active agent, and uses of such biopolymer gel-depots in therapy. The biopolymer-gel based depot systems comprise a biocompatible polyaminosaccharide and/or protein; a biocompatible phosphate and/or sulphonamide compound; a biologically active agent; an aqueous insoluble alkaline earth metal phosphate; and a biocompatible glycan and/or proteoglycan. | 10-04-2012 |
20150150966 | IMMUNOGENIC COMPOSITION AND USES THEREOF - The present invention provides an immunogenic composition comprising an antigen and a dendritic cell targeting component. A charged group is covalently attached to a dendritic cell ligand and is electrostatically associated with the dendritic cell targeting component. | 06-04-2015 |
Patent application number | Description | Published |
20120254791 | INTERACTIVE MENU ELEMENTS IN A VIRTUAL THREE-DIMENSIONAL SPACE - The present technology includes a digital content authoring tool for authoring digital content without the need to understand or access computer code. The present technology further includes creating digital content that is compatible with a diverse population of end user devices without the need for separate versions of the completed content. Instead, the digital authoring tool can manage versions of assets, which individually, can be compatible with different device criteria. Additionally, the present technology contemplates methods of delivering packages of the digital content that are configured to be compatible with the hardware configuration of each requesting device, despite the diverse capabilities of end user devices. Accordingly, the technology described herein provides a simple method for creating and delivering digital content that is configured for presentation on a user's specific device. | 10-04-2012 |
20140365794 | BROWSER-DRIVEN POWER SAVING - The embodiments disclosed herein describe ways that a browser application or other process can reduce power usage by a computing device. Methods include the process suspending one or more plug-ins on a web page by replacing them with a snapshot taken from the plug-in, and reducing processing on non-media plug-ins and non-visible portions of web pages running in the browser, but not currently in focus, such as when a tab is in the background behind a different tab, when a browser window is minimized, or when the web page is entirely or partially occluded. | 12-11-2014 |
20150234568 | Interactive Menu Elements in a Virtual Three-Dimensional Space - The present technology includes a digital content authoring tool for authoring digital content without the need to understand or access computer code. The present technology further includes creating digital content that is compatible with a diverse population of end user devices without the need for separate versions of the completed content. Instead, the digital authoring tool can manage versions of assets, which individually, can be compatible with different device criteria. Additionally, the present technology contemplates methods of delivering packages of the digital content that are configured to be compatible with the hardware configuration of each requesting device, despite the diverse capabilities of end user devices. Accordingly, the technology described herein provides a simple method for creating and delivering digital content that is configured for presentation on a user's specific device. | 08-20-2015 |
20150347198 | WEB BROWSER FOR SPOOFING SUPPORTED FEATURES - Emulating a supported web browser feature when a webpage is merely testing for web browser support of various features. Frequently a web page may test for support of various features of a web browser. The present technology prevents the unnecessary and premature initiation of supported features saving a user time from having to authorize its use, in addition to saving the valuable system resources (e.g. memory, power, etc.) before the supported features are actually needed by the webpage. By emulating or spoofing support of various features of a web browser, the user of a computing device can be spared authorizing use of the various features, and spared the extra power consumption of initializing the various features that may not be used. | 12-03-2015 |
Patent application number | Description | Published |
20140160202 | PAGEWIDTH PRINTHEAD ASSEMBLY HAVING INK DISTRIBUTION MEMBER - A pagewidth printhead assembly for an inkjet printer includes: a plurality of channels for distributing the ink along a length of the printhead assembly; a plurality of printhead integrated circuits; and an ink distribution member upon which the printhead integrated circuits are fixed and which distributes ink from the channels to the printhead integrated circuits. The ink distribution member has a plurality of ink supply holes and a plurality of ink supply conduits defined in a surface thereof and the printhead integrated circuits are fixed to the ink distribution member via a bonding film. The bonding film includes a plurality of through-holes coinciding with the ink supply holes and end portions of the ink supply conduits. | 06-12-2014 |
20140184707 | INK DISTRIBUTION MEMBER FOR MOUNTING PRINTHEAD INTEGRATED CIRCUIT - An elongate ink distribution member for mounting a printhead integrated circuit. The ink distribution member includes a plurality of longitudinally extending ink supply channels and a mounting surface having a plurality of ink supply conduits defined therein. The ink supply conduits are arranged in sets with each set of ink supply conduits being in fluid communication with a respective one of the ink supply channels. The ink supply conduits extend generally transversely from an upstream outer region towards a downstream inner region of the mounting surface. | 07-03-2014 |
20150070439 | REMOVABLE PRINTHEAD ASSEMBLY FOR SINGLE-PASS INKJET PRINTER - A removable printhead assembly for a single-pass inkjet printer, the printhead assembly including: a body adapted for user removal and insertion in the printer; an elongate ink manifold assembly mounted in the body, the ink manifold assembly having a plurality of longitudinally extending ink channels, a plurality of outlets defined in a mounting surface; and a plurality of ink conduits connecting each ink channel to a corresponding set of outlets; a plurality of printhead chips mounted on the mounting surface; a plurality of pressure regulator assemblies for delivering ink to the printhead chips at a negative pressure; a plurality of electrical connectors; and a plurality of ink ports. | 03-12-2015 |
20150266303 | REMOVABLE PRINTHEAD CARTRIDGE HAVING PLURALITY OF PRINTHEAD CHIPS - A removable printhead cartridge for a single-pass inkjet printer, the printhead assembly including: a body adapted for user removal and insertion in the printer; an elongate ink manifold assembly mounted in the body, the ink manifold assembly having a plurality of longitudinally extending ink channels, a plurality of outlets defined in a mounting surface; and a plurality of ink conduits connecting each ink channel to a corresponding set of outlets; a plurality of printhead chips mounted on the mounting surface; a plurality of ink storage modules, each containing a device for delivering ink to the printhead chips at a negative pressure; and a plurality of electrical connectors. | 09-24-2015 |
Patent application number | Description | Published |
20080230468 | HIGH FLOWRATE FILTER FOR INKJET PRINTHEAD - A filter for an inkjet printer that has a chamber divided into an upstream section and a downstream section by a filter membrane. An inlet conduit establishes fluid communication between an ink supply and the upstream section. An outlet conduit establishes fluid communication between the downstream section and a printhead. During use at least part of the inlet conduit is elevated relative to the filter membrane. By elevating the inlet conduit relative to the filter membrane, it acts as a bubble trap to retain bubbles that would otherwise obstruct the filter. This allows the filter size to be reduced for a more compact overall design. | 09-25-2008 |
20080303881 | INK SUPPLY ARRANGEMENT FOR INKJET PRINTHEAD HAVING LARGE NOZZLE NUMBER - An ink supply arrangement for an inkjet printhead is provided having at least one collapsible ink bag containing ink for distribution to nozzles of the printhead via a fluid path between the ink bag and nozzles, a body for housing the ink bag and the printhead, and a biasing member in the ink bag. The ink is primed in the fluid path and nozzles so as to be ejected by the nozzles, in use, thereby depleting the ink contained in the ink bag. The ink bag is attached to the body at a wall opposite a wall of the ink bag facing the printhead. The biasing member applies outwardly directed force on the wall of the ink bag facing the printhead thereby maintaining substantially constant negative pressure at the nozzles as the ink is depleted. The fluid path connects the ink bag to at least 6400 nozzles of the printhead. | 12-11-2008 |
20120062664 | INK CARTRIDGE WITH HIGH FLOW RATE SUPPLY TO PRINTHEAD - An ink cartridge supplies an inkjet printhead by forming a sealed engagement with an inlet on the printhead. The ink cartridge has an ink storage volume, an outlet opening in fluid communication with the ink storage volume, an outlet valve for connection to an inlet on the inkjet printhead, the outlet valve having a radially extending flange portion fixed within the outlet opening and, an annular skirt of resilient material extending from the outlet opening to the flange portion. The resilient material elastically biases part of the annular skirt into sealing engagement with the flange portion to close the outlet valve. Engagement with the inlet on the printhead during installation of the ink cartridge, compresses the annular skirt to open the outlet valve such that ink flows from the ink storage volume around the radially extending flange portion to the printhead. | 03-15-2012 |
Patent application number | Description | Published |
20150154022 | Soft-Partitioning of a Register File Cache - Soft-partitioning of a register file cache is implemented by renaming registers associated with an instruction based on which thread, in a multi-threaded out-of-order processor, the instruction belongs to. The register renaming may be performed by a register renaming module and in an embodiment, the register renaming module receives an instruction for register renaming which identifies the thread associated with the instruction and one or more architectural registers. Available physical registers are then allocated to each identified architectural register based on the identified thread. In some examples, the physical registers in the multi-threaded out-of order processor are logically divided into groups and physical registers are allocated based on a thread to group mapping. In further examples, the thread to group mapping is not fixed but may be updated based on the activity level of one or more threads in the multi-threaded out-of-order processor. | 06-04-2015 |
20150160981 | Global Register Protection In A Multi-Threaded Processor - Global register protection in a multi-threaded processor is described. In an embodiment, global resources within a multi-threaded processor are protected by performing checks, before allowing a thread to write to a global resource, to determine whether the thread has write access to the particular global resource. The check involves accessing one or more local control registers or a global control field within the multi-threaded processor and in an example, a local register associated with each other thread in the multi-threaded processor is accessed and checked to see whether it contains an identifier for the particular global resource. Only if none of the accessed local resources contain such an identifier, is the instruction issued and the thread allowed to write to the global resource. Otherwise, the instruction is blocked and an exception may be raised to alert the program that issued the instruction that the write failed. | 06-11-2015 |
20150205611 | Stack Pointer Value Prediction - Methods and apparatus for predicting the value of a stack pointer which store data when an instruction is seen which grows the stack. The information which is stored includes a size parameter which indicates by how much the stack is grown and one or both of: the register ID currently holding the stack pointer value or the current stack pointer value. When a subsequent instruction shrinking the stack is seen, the stored data is searched for one or more entries which has a corresponding size parameter. If such an entry is identified, the other information stored in that entry is used to predict the value of the stack pointer instead of using the instruction to calculate the new stack pointer value. Where register renaming is used, the information in the entry is used to remap the stack pointer to a different physical register. | 07-23-2015 |
20150205612 | Stack Saved Variable Pointer Value Prediction - Methods of predicting stack pointer values of variables stored in a stack are described. When an instruction is seen which stores a variable in the stack in a position offset from the stack pointer, an entry is added to a data structure which identifies the physical register which currently stores the stack pointer, the physical register which stores the value of the variable and the offset value. Subsequently when an instruction to load a variable from the stack from a position which is identified by reference to the stack pointer is seen, the data structure is searched to see if there is a corresponding entry which includes the same offset and the same physical register storing the stack pointer as the load instruction. If a corresponding entry is found the architectural register in the load instruction is mapped to the physical register storing the value of the variable from the entry. | 07-23-2015 |
20150220450 | Return Stack Buffer Having Multiple Address Slots Per Stack Entry - A return stack buffer (RSB) is modified such that each entry comprises two or more address slots. When a function is called, the address following the function call is pushed to the RSB and stored in a selected one of the address slots in a top entry in the RSB. One or more pointer bits within the entry are set to indicate which slot the address was stored in. | 08-06-2015 |
20150220451 | Storing Look-Up Table Indexes in a Return Stack Buffer - A return stack buffers (RSB) is modified to store index values instead of addresses. When a function is called, the address following the function call is stored in a look-up table and the index at which the address is stored is pushed to the RSB. When a function returns, an index is popped from the RSB and used to identify an address in the look-up table. In another embodiment, the RSB is modified such that each entry comprises two or more address slots. When a function is called, the address following the function call is pushed to the RSB and stored in a selected one of the address slots in a top entry in the RSB. One or more pointer bits within the entry are set to indicate which slot the address was stored in. | 08-06-2015 |
20150301863 | Allocating Resources to Threads Based on Speculation Metric - Methods, reservation stations and processors for allocating resources to a plurality of threads based on the extent to which the instructions associated with each of the threads are speculative. The method comprises receiving a speculation metric for each thread at a reservation station. Each speculation metric represents the extent to which the instructions associated with a particular thread are speculative. The more speculative an instruction, the more likely the instruction has been incorrectly predicted by a branch predictor. The reservation station then allocates functional unit resources (e.g. pipelines) to the threads based on the speculation metrics and selects a number of instructions from one or more of the threads based on the allocation. The selected instructions are then issued to the functional unit resources. | 10-22-2015 |
20150339123 | Restoring a Register Renaming Map - A technique for restoring a register renaming map is described. In one example, a restore table having a number of storage locations saves a copy of the register renaming map whenever a flow-risk instruction is passed to a re-order buffer. When all storage locations are full, further instructions still pass to the re-order buffer, but a copy of the map is not saved. A storage location subsequently becomes available when its associated flow-risk instruction is executed. A register renaming map state for an unrecorded flow-risk instruction passed to the re-order buffer whilst the storage locations were full is generated and stored in the available location. This is generated using the restore table entry for a previous flow-risk instruction and re-order buffer values for intervening instructions between the previous and unrecorded flow-risk instructions. The restore table can be used to restore the map if an unexpected change in instruction flow occurs. | 11-26-2015 |
20150370574 | REPLICATING LOGIC BLOCKS TO ENABLE INCREASED THROUGHPUT - A datapath pipeline which uses replicated logic blocks to increase the throughput of the pipeline is described. In an embodiment, the pipeline, or a part thereof, comprises a number of parallel logic paths each comprising the same logic. Input register stages at the start of each logic path are enabled in turn on successive clock cycles such that data is read into each logic path in turn and the logic in the different paths operates out of phase. The output of the logic paths is read into one or more output register stages and the logic paths are combined using a multiplexer which selects an output from one of the logic paths on any clock cycle. Various optimization techniques are described and in various examples, register retiming may also be used. In various examples, the datapath pipeline is within a processor. | 12-24-2015 |
Patent application number | Description | Published |
20100005122 | DYNAMIC INFORMATION SYSTEMS - This invention discloses the concept of a dynamic metasystem managing a dynamic system, achieved through the use of, and an environment (i.e., tools and ontologies) supporting dynamic artifacts. A system for generating a dynamic information system comprises a persistent dynamic repository of data and an integration metasystem. The repository forms an asymmetric navigational database, and the database includes an ontology model. The ontology model has an abstract model framework that supports creation and use of multi-dimensional and asymmetric abstract models of data, and views which define the content and form of presentation of that data using a computer. The integration metasystem includes components that describe components of shared infrastructure and services of an enterprise architecture, and a dynamic information system software tool generating artifacts representing information and views that define the presentation of data. The artifacts are provided to the ontology model, and have interfaces to the abstract model framework that permit creation, reading and modification of the contents of the asymmetric navigational database. | 01-07-2010 |
20100332542 | METHOD, SYSTEM, AND PROGRAM PRODUCT FOR DISCOVERING RELEVANT INFORMATION IN A DYNAMIC INFORMATION SYSTEM - The invention provides a method, system, and program product for discovering relevant information in a dynamic information system (DIS). An illustrative method according to the invention includes comparing information provided by the user to information in a network, determining whether the network contains information relevant to the information provided by the user, and displaying to the user an object containing the relevant information. | 12-30-2010 |
Patent application number | Description | Published |
20080206312 | Therapeutic Morpholino-Substituted Compounds - Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation. The compounds are useful in treating PI 3-kinase-dependent conditions including cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, vascular restenosis, atherosclerosis, and unstable angina; respiratory diseases such as asthma, chronic obstructive pulmonary diseases (COPD), and bronchitis; inflammatory disorders; neoplasms including cancers such as glioma, prostate cancer, small cell lung cancer, and breast cancer; and diseases linked to disordered white blood cell function, such as autoimmune and inflammatory diseases. | 08-28-2008 |
20080312233 | Therapeutic Morpholino-Substituted Compounds - Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation. The compounds are useful in treating PI 3-kinase-dependent conditions including cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, vascular restenosis, atherosclerosis, and unstable angina; respiratory diseases such as asthma, chronic obstructive pulmonary diseases (COPD), and bronchitis; inflammatory disorders; neoplasms including cancers such as glioma, prostate cancer, small cell lung cancer, and breast cancer; and diseases linked to disordered white blood cell function, such as autoimmune and inflammatory diseases. | 12-18-2008 |
Patent application number | Description | Published |
20090175819 | MOLECULE AND CHIMERIC MOLECULES THEREOF - The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule that comprises a dimeric 4-helix bundle, such as IFN-a2B, IFN-b1, IFN-g, IL-10 or its receptor, such as IFNAR2, IL-10Ra or chimeric molecules thereof comprising at least a portion of the protein molecule, such as IFN-a2B-Fc, IFN-b1-Fc, IFN-g-Fc, IFNAR2-Fc, IL-IO-Fc, IL-10Ra-Fc; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications. | 07-09-2009 |
Patent application number | Description | Published |
20100036089 | Methods for the Synthesis of Dicarba Bridges in Organic Compounds - The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis. | 02-11-2010 |
20120238693 | CROSSLINKING METHOD - The invention provides a method of preparing a crosslinked polymer, which method comprises polymerising branched polyunsaturated monomers by a metathesis polymerisation reaction, wherein the branched polyunsaturated monomers contain acyclic ethylenically unsaturated groups that are capable of undergoing polymerization by a metathesis reaction such that the metathesis polymerisation produces a crosslinked polymer and substantially no non-volatile ethylenically unsaturated by-products. | 09-20-2012 |
20120259094 | AFFINITY LIGANDS AND METHODS FOR PROTEIN PURIFICATION - The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilise the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R | 10-11-2012 |
20130023645 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS - The present invention related to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds containing a turn-induced group between the pair of cross metathesisable groups to facilitate the cross-metathesis. | 01-24-2013 |
20150148524 | AMINO ACID ANALOGUES AND METHODS FOR THEIR SYNTHESIS - A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (I) or (II): (Formulae (I), (II)) wherein R | 05-28-2015 |
20150315243 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS - The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis. | 11-05-2015 |