| Patent application number | Description | Published |
|---|
| 20080241877 | Immobilised Enzymes - The present invention relates to a method for immobilizing enzymes in a solid porous support, and to enzymes immobilized in solid porous supports. Specifically, the present invention uses a fluid containing the enzyme under high pressure (such as 25 to 50 Mpa) to immobilize the enzyme (such as CALB) on the porous support (such as silica). The resulting porous support contain more immobilized enzyme than would otherwise have been obtained by a process carried out at atmospheric pressures. | 10-02-2008 |
| 20080246006 | Cdte/Gsh Core-Shell Quantum Dots - Quantum dots, each having a core comprising CdTe and a shell comprising GSH covering the core, are provided. The Quantum dots can be formed in a solution comprising a telluride (Te) precursor and a cadmium (Cd) precursor for forming the cores, and glutathione (GSH) for forming shells covering the cores. The cores can comprise CdTe nanocrystals grown in the solution. The growth of the nanocrystals can be limited. The quantum dots can have high fluorescence emission quantum yield such as up to about 45%, and small sizes such as from about 3.8 nm to about 6 nm. | 10-09-2008 |
| 20080287288 | Mesoporous Nanoparticles - The present invention provides a process for making mesoporous nanoparticles. The process comprises providing an acidic mixture comprising a fluorocarbon surfactant, a second surfactant and a silica precursor. The silica precursor is then reacted to form the mesoporous nanoparticles. | 11-20-2008 |
| 20090012625 | Porous biomaterial-filler composite and method for making the same - A porous biomaterial-filler composite comprising a biomaterial, such as collagen, interspersed with a calcium phosphate-type filler material. The porosity of the composite is similar to that of natural bone and can feature a pore size ranging from a few nanometres to greater than 100 microns. Scaffolds prepared from the biomaterial-filler composite are suitable for resorbable bone substitute materials. | 01-08-2009 |
| 20090035855 | THREE-DIMENSIONAL RECONSTITUTED EXTRACELLULAR MATRICES AS SCAFFOLDS FOR TISSUE ENGINEERING - A biomaterial scaffold comprising: a) reconstituted extracellular matrix; and b) polyelectrolyte complex fibers; wherein the matrix and the fibers are functionally associated. | 02-05-2009 |
| 20090069825 | Scaffold and Method of Forming Scaffold by Entangling Fibres - A porous scaffold is provided, which comprises tangled fibres. A porous scaffold can be formed by applying a fluid to fibres to entangle them. The fibres comprise a polyelectrolyte complex and a cross-linker. The cross-linker links polyelectrolytes within individual fibres and inhibits secondary polyelectrolyte complication between adjacent fibres. | 03-12-2009 |
| 20090170692 | CATALYSTS FOR RING-CLOSING METATHESIS - A catalyst composition is provided, which may be used for ring closing metathesis. In the composition, a catalyst is immobilized on a siliceous mesocellular foam support. A suitable catalyst for use in the composition is a Grubbs-type catalyst or a Hoveyda-Grubbs-type catalyst. | 07-02-2009 |
| 20090186419 | Luminescent Metal Oxide Films - The present invention relates to articles and methods involving luminescent films which may be useful in various applications. Luminescent films of the present invention may comprise a layer of metal oxide nanoparticles and, in some cases, may interact with an analyte to generate a detectable signal, whereby the presence and/or amount of analyte can be determined. In some embodiments, fluorescence resonance energy transfer (FRET) may occur between the luminescent film and the analyte. Such articles and methods may be useful in, for example, biological assays or in sensors. | 07-23-2009 |
| 20090280327 | COATED COMPOSITES OF MAGNETIC MATERIAL AND QUANTUM DOTS - Composites and methods associated with the same are provided. The composite structures are formed of quantum dots and magnetic nanoparticles. The structures may be coated, for example, with a non-organic shell such as silica. In some cases, the shell may be functionalized or derivatized to include compounds, atoms, or materials that can alter or improve properties such as water solubility, water stability, photo-stability and biocompatibility. A reverse microemulsion process can be used to form the coated composites. The composition and other characteristics of the composites may be controlled to provide desired magnetic and optical properties. The structures may be used in a variety of applications including biological labeling, magnetic resonance imagine (MRI) and drug targeting, amongst others. | 11-12-2009 |
| 20090281358 | HETEROGENEOUS CHIRAL CATALYST - The invention provides a heterogeneous catalyst comprising a catalytic group coupled to a mesocellular siliceous foam support. The catalytic group is capable of catalysing a reaction selected from the group consisting of a Friedel-Craft reaction and a Diels-Alder reaction. | 11-12-2009 |
| 20090305412 | MECHANICALLY REVERSIBLE GEL - The present invention relates to a process for making a gel comprising combining a silanol species comprising at least two silanol groups per molecule and a hydrophilic hydroxyl species comprising at least two hydroxyl groups per molecule. The gel is capable of being converted to a liquid by application of a mechanical shear force and the liquid is capable of being converted to the gel in the absence of said mechanical shear force. | 12-10-2009 |
| 20100016621 | Hydrosilylation - The present invention relates to a process for converting a substrate to a product comprising exposing the substrate to a hydrosilane in the presence of a carbene catalyst. | 01-21-2010 |
| 20100048390 | MESOCELLULAR FOAM PARTICLES - The present invention provides a process for making regular shaped particles of solid foam. A first mixture, comprising water, an acid, a surfactant and a hydrophobic material, is combined with a hydrolysable silicon species to form a second mixture. The second mixture is maintained under conditions and for a sufficient time to form regular shaped precursor particles. The second mixture is then aged at a temperature and for a time effective to produce the regular shaped particles of solid foam. | 02-25-2010 |
| 20100048755 | POROUS POLYMERIC MATERIAL WITH CROSS-LINKABLE WETTING AGENT - A porous material is provided which comprises a transparent polymer matrix defining interconnected pores and a wetting agent. At least a portion of the wetting agent is cross-linked with the polymer matrix. A process for forming a porous polymeric material is also provided. A bicontinuous microemulsion comprising water, a wetting agent, a monomer, and a surfactant copolymerizable with the monomer is polymerized, to form a polymer defining interconnected pores. The wetting agent comprises a cross-linkable wetting agent such that after polymerization, at least a portion of the cross-linkable wetting agent is cross-linked with the polymer. The wetting agent may comprise acrylated hyaluronic acid (AHA) such as methacrylated hyaluronic acid (MeHA). The wetting agent may also comprise a hyaluronic acid (HA). The wetting agent may include an unbonded portion that this releasable from the material. A contact lens may be made from the porous material. | 02-25-2010 |
| 20100048815 | Electrically Conducting Polymers - The present invention provides a polymer for use in detecting or quantifying an analyte Exposure of the polymer to the analyte is capable of causing a shift in the onset potential for conductivity or semiconductivity of the polymer. A sensor for an analyte comprising the polymer is also described. | 02-25-2010 |
| 20100105544 | CATALYST IMMOBILIZATION ON SILICEOUS MESOCELLULAR FOAM VIA CLICK CHEMISTRY - The present invention relates to a method for preparing a heterogenised catalyst, comprising grafting a catalyst or catalyst precursor, via click chemistry, to a siliceous mesocellular foam (MCF). The invention also relates to a heterogenised catalyst comprising a catalyst species grafted onto a siliceous mesocellular foam (MCF) via a 1,2,3-triazole | 04-29-2010 |
| 20100111917 | CELL-ADHESIVE POLYELECTROLYTE MATERIAL FOR USE AS MEMBRANE AND COATING - A multilayer polyelectrolyte support material is provided that includes a polyelectrolyte layer and a polyelectrolyte-polyethylene glycol layer adjacent to the polyelectrolyte layer. The support material also includes a ligand conjugated to the polyelectrolyte-polyethylene glycol layer, allowing for attachment of a protein or a cell to the support material with controlled orientation. | 05-06-2010 |
| 20100113832 | PALLADIUM CATALYSTS - The invention relates to a particulate substance comprising a particulate porous support coupled to a palladium species. The palladium species may comprise palladium nanoclusters. The particulate substance may be used as a catalyst for conducting a carbon-carbon coupling reaction or a reduction. | 05-06-2010 |
| 20100116682 | ELECTROCHEMICAL SENSOR WITH INTERDIGITATED MICROELECTRODES AND CONDUCTED POLYMER - The present invention generally relates to electronic devices and methods. In some cases, the invention provides a sensor device comprising a pair of interdigitated microelectrodes ( | 05-13-2010 |
| 20100126880 | DNA COMPLEXING AGENTS - The invention provides a compound of structure (I): wherein X is S, O or NR | 05-27-2010 |
| 20100167057 | MAGNETIC NANOPARTICLES, MAGNETIC AND FLUORESCENT NANOCOMPOSITE, AND FORMATION OF MAGHEMITE BY OXIDIZING IRON STEARATE WITH METHYLMORPHOLINE N-OXIDE - Maghemite (γ-Fe | 07-01-2010 |
| 20100197920 | N-HETEROCYCLIC CARBENE METALLACYCLE CATALYSTS AND METHODS - The present invention generally relates to materials and methods for catalytic reactions, including transition metal-catalyzed cross-coupling reactions. The materials may be stable metal complexes that do not require special handling or processing conditions. In some cases, materials of the invention advantageously may be synthesize in one synthetic step without the need for isolation of intermediate compounds. Also, materials of the invention may be synthesized from inexpensive and readily available starting materials, under relatively mild reaction conditions that do not require the exclusion of air, water, and the like. In some embodiments, the material is a N-heterocyclic carbene metallacycle complex. Such materials and methods may be useful in the production of fine chemicals, advanced materials and specialty polymers. | 08-05-2010 |
| 20100210744 | Mesoporous Polymer Colloids - The invention provides a particulate material comprising porous polymeric microparticles having a mesoporous structure. A process for making the particles is also presented. The process comprises impregnating a porous microparticulate template material with a liquid comprising one or more monomers. The one or more monomers are then polymerised in and/or on the template material to form a polymer, and the template material is then removed to produce the particulate material. | 08-19-2010 |
| 20100248245 | INTEGRATED APPARATUS FOR CONDUCTING AND MONITORING CHEMICAL REACTIONS - Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles. | 09-30-2010 |
| 20100272997 | DENSIFICATION OF METAL OXIDES - The present invention relates to methods for manufacturing of fully densified nanocrystalline metal oxide ceramic materials at low sintering temperature. Methods of the invention involve dry compaction of a product resulting from hydrothermal treatment of metal ion suspensions and subsequent sintering. The present invention may produce ceramic bodies that exhibit nanocrystalline structural features with measured densities that are found to be extremely similar to the theoretical density. | 10-28-2010 |
| 20100285573 | Apparatus for processing a sample in a liquid droplet and method of using the same - The invention provides an apparatus and a method of processing a biological and/or chemical sample in a liquid droplet. The apparatus comprises a processing compartment, which is defined by a reservoir and an immobilisation member. The processing compartment is further adapted to accommodate a medium, which is immiscible with the liquid droplet, and of a lower surface energy than the liquid of the liquid droplet. The reservoir is defined by a circumferential wall and a base. The immobilisation member is arranged within the reservoir and comprises a surface that is patterned in such a way that it comprises at least one predefined immobilisation area. The predefined immobilisation area within the patterned surface is of a higher surface energy than the medium. Furthermore the at least one predefined area is of a higher surface energy than the remaining surface and of a sufficient width in the plane of the surface to allow, in said hydrophobic medium, the immobilisation of the liquid droplet on the hydrophilic area via hydrophilic-hydrophilic or hydrophobic-hydrophobic interactions. The remaining surface is of at most about the same surface energy as the medium. In the method of the invention the medium is disposed into the apparatus, such that the predefined immobilisation area is entirely covered by the medium. The liquid droplet is disposed onto the predefined immobilisation area, whereby the liquid droplet is immobilised thereon via hydrophilic-hydrophilic or hydrophobic-hydrophobic interactions. A process is performed on the biological and/or chemical sample in said liquid droplet. | 11-11-2010 |
| 20100285585 | METHOD FOR EXTRACELLULAR MATRIX MEDIATED DIFFERENTIATION AND PROLIFERATION OF STEM CELLS - There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells | 11-11-2010 |
| 20100316797 | FORMING GLUTATHIONE-CAPPED AND METAL-DOPED ZINC SELENIDE/ZINC SULFIDE CORE-SHELL QUANTUM DOTS IN AQUEOUS SOLUTION - In a process of forming a capped crystal structure, a precursor solution is heated. The solution comprises a mixture of zinc (Zn) precursor, selenium (Se) precursor, precursor for a dopant, glutathione (GSH), and water. The dopant comprises a transition metal (M). The molar ratio of Zn:Se in the solution may be about 10:3 to about 10:5. The solution is heated for a first period sufficient to allow Zn(M)Se crystal core to form. After the first period of heating, more zinc precursor and GSH are added to the heated solution, and the solution is heated for a second period sufficient to form ZnS crystal shell on the Zn(M)Se crystal core. GSH is added in a sufficient amount to form a GSH layer around the Zn(M)Se/ZnS quantum dot. | 12-16-2010 |
| 20110006453 | HYDRODYNAMIC SPINNING OF POLYMER FIBER IN COAXIAL LAMINAR FLOWS - A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer. | 01-13-2011 |
| 20110014473 | POLYMER-COATED NANOPARTICLES - Polymers for coating nanoparticles (e.g., colloid nanoparticles and quantum dots) and methods associated therewith are provided. Such polymers may be derived from amino acids comprising suitable functional groups for associating the polymer to the nanoparticle. For example, in some embodiments, the polymer includes a polypeptide backbone (e.g., polyaspartic acid) with amino acid side groups (e.g., cysteine and/or methionine). Such a polymer can enable strong binding of the polymer to the nanoparticle surface via its multiple thiol groups, which can lead to excellent colloidal stability. Moreover, the carboxylic acid and amine functional groups of the polymer can facilitate attachment of binding partners (e.g., antibodies) to the polymer, which can allow the polymer-coated nanoparticle to be used in a variety of applications including protein detection and cell labeling. | 01-20-2011 |
| 20110015402 | RECIRCULATING REACTOR - The invention provides a recirculating reactor for converting a substrate to a product. The reactor comprises a reaction chamber and a recirculation system, said recirculation system comprising a separator. The reaction chamber contains a catalyst, and comprises a chamber body, a chamber inlet and a chamber outlet. The recirculation system is adapted for recirculating liquid from the chamber outlet to the chamber inlet, and the separator is used for separating a by-product from the liquid. | 01-20-2011 |
| 20110028513 | METHOD FOR TREATING NEUROLOGICAL DISORDERS WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS - There is presently provided methods for delivering a neuroprotective agent to a neural cell. The methods comprise contacting a neural cell with an imidazolium or imidazolinium compound as described herein, including an imidazolium or imidazolinium salt. | 02-03-2011 |
| 20110030809 | FLUID PROCESSING AND TRANSFER USING INTER-CONNECTED MULTI-CHAMBER DEVICE - A micro-fluidic device comprises a body. The body defines pneumatic ports, chambers for receiving liquids, and a connecting conduit. Each port is sealed with a seal and is shaped to couple to a pneumatic conduit through the seal. At least some of the chambers each have a top opening and a bottom opening. The top openings are in fluid communication with corresponding ports. The bottom openings are in fluid communication with one another through the connecting conduit, which is above the bottom openings. Selective application of pneumatic pressures to the chambers through the pneumatic conduits can transfer a liquid from one chamber to another through the connecting conduit, for example, for processing bio-samples within the device. | 02-10-2011 |
| 20110044992 | METHOD OF DELIVERING AN ANTI-CANCER AGENT TO A CELL - There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell. | 02-24-2011 |
| 20110070280 | METHOD FOR DIFFERENTIATING EMBRYONIC STEM CELLS INTO CELLS EXPRESSING AQP-1 - The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis. | 03-24-2011 |
| 20110073811 | COATED WATER SOLUBLE NANOPARTICLES - Nanoparticles and methods of making nanoparticles are provided. The nanoparticles may include semiconductor nanocrystals. A shell may encapsulate a nanoparticle core, and the shell may include non-organic material and may be silica. The shell may also include additional species such as PEG. In some embodiments, a passivation layer is in contact with the core. | 03-31-2011 |
| 20110112310 | AZIRIDINE SYNTHESIS - The invention relates to a process for making an aziridine. wherein an aldehyde, a nitroso compound and a Michael acceptor are reacted in the presence of an N-heterocyclic carbene (NHC) catalyst. | 05-12-2011 |
| 20110124049 | INTEGRATED MICROFLUIDIC DEVICE FOR GENE SYNTHESIS - We report making an integrated micro-fluidic device for synthesizing double stranded DNA from short oligo-nucleotides. We demonstrate successful synthesis of a 760 bp gene segment from a pool of 39 oligonucleotides on a micro-fluidic device using both the one-step and two-step synthesis processes. We also describe purifying the double stranded DNA PCR product and filtering out sequence errors in the double stranded DNA product, all on the same device. | 05-26-2011 |
| 20110124755 | Polyisocyanurates - The invention relates to a polyisocyanurate comprising isocyanurate rings linked by linker groups coupled to the nitrogen atoms of said rings. The polyisocyanurate may be microporous or mesoporous or both microporous and mesoporous. | 05-26-2011 |
| 20110129924 | Porous Polymeric Articles - Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three-dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores. In some embodiments, the porous structure is constructed and arranged for use as a template for ultrafiltration, cell growth, and/or for forming complex, biomimetic, porous biohybrid organs, where living cells can be immobilized and perform their normal physiological functions. | 06-02-2011 |
| 20110136929 | TRAPPING GLUCOSE PROBE IN PORES OF POLYMER - A polymer matrix defining pores is formed by polymerizing polymer precursors in a precursor solution. The precursor solution comprises a bicontinuous microemulsion of a first fluid in a first continuous phase and a second fluid in a second continuous phase. The first fluid comprises the polymer precursors. The second fluid comprises the glucose probe. Some internal pores are connected to surface pores in the matrix through openings sized to allow passage of glucose molecules but restrict passage of the glucose probe. As the glucose probe is dispersed in the precursor solution prior to polymerization, some glucose probe molecules are trapped in the internal pores after polymerization. The formed polymer may be used in an ophthalmic device such as contact lens, for detecting the presence of glucose in an ocular fluid. | 06-09-2011 |
| 20110146449 | METHODS AND COMPOSITIONS COMPRISING POLYOXOMETALATES - The present invention generally relates to compositions and methods comprising polyoxometalates (POMs). In some cases, a reduced form of a POM may be formed via electrolysis in the presence of essentially no supporting electrolyte. The reduced POMs may be used for various applications, for example, for the formation of metallic nanoparticles. Some embodiments of the present invention provide compositions and methods comprising reduced forms of the polyoxometalate, [alpha-SiW | 06-23-2011 |
| 20110165689 | METHODS, COMPOSITIONS, AND ARTICLES COMPRISING STABILIZED GOLD NANOCLUSTERS - The invention relates generally to gold nanoclusters, and in particular, fluorescent gold nanoclusters. The gold nanoclusters may be stabilized, for example, with a protein or stabilizing agent. In some cases, the gold nanoclusters may be used in methods or articles to determine the presence, absence, and/or concentration of mercuric ions in a sample. | 07-07-2011 |
