Patent application number | Description | Published |
20090209458 | Cell-penetrating socs polypeptides that inhibit cytokine-induced signaling - Disclosed are compositions and methods related to cell-penetrating suppressor of cytokine signaling (SOCS) proteins that inhibit cytokine-induced signaling. | 08-20-2009 |
20130089528 | COMPOSITIONS AND METHODS FOR PRESERVING INSULIN-PRODUCING CELLS AND INSULIN PRODUCTION AND TREATING DIABETES - Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of blood glucose levels and may reducing insulin resistance, the compositions, methods and cells described herein can also be used for treating Type 2 diabetes (T2D). | 04-11-2013 |
20140309159 | COMPOSITIONS AND METHODS FOR TARGETING NUCLEAR IMPORT SHUTTLES AND TREATING INFLAMMATORY DISORDERS - The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation. | 10-16-2014 |
20140336113 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERLIPIDEMIA, FATTY LIVER, ATHEROSCLEROSIS AND OTHER DISORDERS ASSOCIATED WITH METABOLIC SYNDROME - The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function. | 11-13-2014 |
20150191522 | COMPOSITIONS FOR PRESERVING INSULIN-PRODUCING CELLS AND INSULIN PRODUCTION AND TREATING DIABETES - Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of fasting blood glucose levels and may ameliorate (e.g., reduce, eliminate) insulin resistance, the compositions, methods and cells described herein can also be used for treating Type 2 diabetes (T2D). | 07-09-2015 |
Patent application number | Description | Published |
20100163232 | GAS SEPARATOR - A combination liquid and gas separator and jetting tool includes a housing containing a rotatable drum, a stator in the inlet end of the housing for swirling a liquid/gas mixture, a rotor attached to the drum for rotation by the mixture; whereby the gas and liquid are separated. The liquid and gas are discharged through separate restricted orifices downstream of the drum. Orifices can be located in a rotating head for cleaning, cutting or other downhole operations. | 07-01-2010 |
20110100715 | CENTER DISCHARGE GAS TURBODRILL - A compact gas turbine motor and a speed reduction transmission capable of providing the speed and torque required for drilling with center discharge bits. The transmission includes two sun gears of different pitch diameters, keyed to the turbine shaft. Upper planet gears, whose carrier is fixed in place, drive an outer ring gear, which engages lower planet gears having a different pitch diameter. The lower planet gears engage the lower sun gear. Due to the different pitch diameters of the sun gears and planet gears, the gear carrier for the lower planet gears rotates in the same direction as the turbine shaft, but at a much slower rate. Exhaust gas from the turbine can be directed through one or more flow restriction elements to increase gas density in the turbine, further reducing turbine speed. The flow restriction element can comprise a venturi, to provide a vacuum assist to remove cuttings. | 05-05-2011 |
20120160493 | METHOD AND APPARATUS FOR MILLING A ZERO RADIUS LATERAL WINDOW IN CASING - A flexible milling assembly for milling an orifice through a well casing. One embodiment includes a drive yoke, and a plurality of straight and split yoke assemblies—all linked together and to a cutter head with universal blocks that enable the components to pivot relative to each other. A string of joint tubing connected to a prime mover on the surface is used to lower the milling assembly into a well and supply the driving torque. A split shoe coupled to a guide tube is positioned within the well casing where the orifice is to be milled. The milling assembly is guided through a curved passage within the split shoe to bring the cutter head into contact with the well casing. A protector assembly can be provided to enclose and protect the milling assembly when it is tripping into and out of the well casing. | 06-28-2012 |
20120160567 | METHOD AND APPARATUS FOR DRILLING A ZERO-RADIUS LATERAL - A jet drill coupled to a distal end of a flexible jet lance is lowered into a well casing and advanced through a curved passage formed in a deflection shoe oriented to direct the jet drill through an orifice milled in the well casing. The jet drill is actuated with a pressurized fluid produced by a pump on the surface that is conveyed through a high pressure hose that runs through the flexible jet lance. Force transmitted through a thrust liner of the jet lance advances the jet drill while the lateral bore is being drilled. The thrust liner comprises helical coils of steel wire providing a high elastic modulus and buckling resistance, even while passing through the curved passage. Tension cables in the jet lance maintain tension on the thrust liner and enable the assembly to be pulled from the lateral bore and well. | 06-28-2012 |
20130112427 | Split Ring Shift Control for Hydraulic Pulse Valve - A hydraulic pulse valve for use in downhole tools includes a split ring seal to limit the fluid flow available to shift a poppet in the valve from an open position to a closed position. The split ring seal provides relatively long and repeatable pressure pulses, which improve the effectiveness of the hydraulic pulse valve for borehole applications. | 05-09-2013 |
20130286787 | Low-Frequency Seismic-While-Drilling Source - A bottom hole assembly is configured with a drill bit section connected to a pulse generation section. The pulse generation section includes a relatively long external housing, the particular housing length being selected for the particular drilling location. The long external housing is positioned closely adjacent to the borehole sidewalls to thereby create a high speed flow course between the external walls of the housing and the borehole sidewalls. The long external housing includes a valve cartridge assembly and optionally a shock sub decoupler. While in operation, the valve cartridge assembly continuously cycles and uses downhole pressure to thereby generate seismic signal pulses that propagate to geophones or other similar sensors on the surface. The amount of bypass allowed through the valve assembly is selectable in combination with the long external housing length and width to achieve the desired pulse characteristics. The bottom hole assembly optionally includes an acoustic baffle to attenuate wave propagation going up the drill string. | 10-31-2013 |
20130292180 | Steerable Gas Turbodrill - A gas turbodrill with an adjustable bent housing for use in a spur lateral drilling application. The gas turbodrill includes a high-speed gas turbine, a gearbox assembly, a pivoting shaft connection point, a gimbal assembly comprising a hollow ball and socket joint, a bearing assembly and drill bit assembly. The gas turbodrill gimbal assembly enabling a bend through an angle of up to 5 degrees while drilling. Springs and the application of pressure will lock the bend in place once drilling commences to facilitate lateral drilling of the spur. | 11-07-2013 |
20130299196 | Extended Reach Placement of Wellbore Completions - A self-actuated cyclical flow interruption valve on a deployment tool is positioned at a proximal end of a well completion assembly. Fluid is pumped though the self-actuated cyclical flow interruption valve and vented immediately distal of the valve, to return to surface of the well. A water hammer pulse is generated each time the self-actuated cyclical flow interruption valve closes, thereby generating an impact force that acts to push the completion equipment distally into the well. The continuous cyclic force of the impact facilitates placement of the completion equipment where desired in the well, including within a horizontal extension of the well. Fluid discharged through the self-actuated cyclical flow interruption valve circulates up to the surface through a vertical and inclined section of the well. | 11-14-2013 |
20130306319 | Hydraulic Pulse Valve With Improved Pulse Control - Hydraulic pulses are produced each time that a pulse valve interrupts the flow of a pressurized fluid through a conduit. The pulse valve includes an elongate housing having an inlet configured to couple to the conduit to receive the pressurized fluid, and an outlet configured to couple to one or more tools. In the housing, a valve assembly includes a poppet reciprocating between open and closed positions, and a poppet seat, in which the poppet closes to at least partially block the flow of pressurized fluid through the valve. A pilot within the poppet moves between disparate positions to modify fluid paths within the valve. When the valve is open, a relatively lower pressure is produced by a Venturi effect as the fluid flows through a throat in the poppet seat, to provide a differential pressure used to move the pilot and poppet. An optional bypass reduces the pulse amplitude. | 11-21-2013 |
20140028078 | Hyper-Pressure Pulse Excavator - A hyper-pressure water cannon, or pulse excavator, is able to discharge fluid pulses at extremely high velocities to fracture a rock face in excavation applications. A compressed water cannon can be used to generate hyper-pressure pulses by discharging the pulse into a straight nozzle section which leads to a convergent tapered nozzle. The hyper-pressure water cannon design is relatively compact, and the pulse generator can readily be maneuvered to cover the face of an excavation as part of a mobile mining system. | 01-30-2014 |
20140102802 | CENTER DISCHARGE GAS TURBODRILL - A compact gas turbine motor and a speed reduction transmission capable of providing the speed and torque required for drilling with center discharge bits. The transmission includes two sun gears of different pitch diameters, keyed to the turbine shaft. Upper planet gears, whose carrier is fixed in place, drive an outer ring gear, which engages lower planet gears having a different pitch diameter. The lower planet gears engage the lower sun gear. Due to the different pitch diameters of the sun gears and planet gears, the gear carrier for the lower planet gears rotates in the same direction as the turbine shaft, but at a much slower rate. Exhaust gas from the turbine can be directed through one or more flow restriction elements to increase gas density in the turbine, further reducing turbine speed. The flow restriction element can comprise a venturi, to provide a vacuum assist to remove cuttings. | 04-17-2014 |
20150101824 | ACTUATION MECHANISM FOR WATER HAMMER VALVE - The present invention discloses an actuation mechanism for a water hammer valve. The water hammer valve is initially prevented from operating, and an actuation mechanism for the water hammer valve is actuated by dropping one or more balls or other objects onto the valve. Once actuated, the pilot and piston mechanism in the water hammer valve operate to produce hydraulic pulses from an upstream pressurized fluid. | 04-16-2015 |
Patent application number | Description | Published |
20130207465 | APPARATUS AND METHOD FOR DIRECTLY POWER NON-MOBILE COMPUTERS BY SOLAR PV ARRAY WITHOUT DC-AC AND AC-DC CONVERSIONS - An apparatus and method for non-mobile computer's solar power input interface and corresponding multiple DC outputs from solar PV panels is disclosed. In one embodiment, the invention requires no AC-DC or DC-AC conversions between solar PV panels natural DC power outputs and the power consuming computers. In another embodiment, non-mobile digital devices and equipments such as a network router or a digital TV which need low voltage DC power, can also directly use solar PV panel DC power outputs described in this invention. | 08-15-2013 |
20130257157 | APPARATUS AND METHOD FOR SOALR COMPATIBLE GREEN POWER SUPPLY - An apparatus and method for green power supply unit (gPSU) that uses solar PV power as primary input source and grid utility power as backup source, provides seamless power to load is disclosed. In one embodiment, the invention can be retrofitted or mounted easily for a system such as non-mobile computer, and ultimately utilize clean energy, and aim to reduce the consumption of traditional grid power which usually involves environmental concerns. | 10-03-2013 |
20130297949 | HYBRID BLADE WEBSERVER WITH SOLAR AS PRIMARY POWER SOURCE - An apparatus and method for green hybrid blade webserver that directly uses solar PV as primary power source at ultimate efficiency, with grid utility power (wall power) as backup source, is disclosed. In one embodiment, the invention can be retrofitted or mounted easily into a data center rack, plug in solar lines from PV panel on roof and run. | 11-07-2013 |
20150095405 | SELF-ADAPTIVE WORKLOAD SOLAR MODE COMPUTING OPTIMIZER SYSTEM FRAMEWORK FOR GREEN HYBRID SERVERS - An apparatus and method for self-adaptive software workload and service green power mode computing optimizer system framework at data center, and a companion “Green Flag” mechanism for general consumer or computing device end users that are coupled with green hybrid servers, to enable software executions to directly utilize solar PV power as much as possible, and so help deliver the environmentally sustainable way of cloud computing. | 04-02-2015 |