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| 20100138384 | Policy-based management of a redundant array of independent nodes - An archive cluster application runs in a distributed manner across a redundant array of independent nodes. Each node preferably runs a complete archive cluster application instance. A given nodes provides a data repository, which stores up to a large amount (e.g., a terabyte) of data, while also acting as a portal that enables access to archive files. Each symmetric node has a set of software processes, e.g., a request manager, a storage manager, a metadata manager, and a policy manager. The request manager manages requests to the node for data (i.e., file data), the storage manager manages data read/write functions from a disk associated with the node, and the metadata manager facilitates metadata transactions and recovery across the distributed database. The policy manager implements one or more policies, which are operations that determine the behavior of an “archive object” within the cluster. The archive cluster application provides object-based storage. Preferably, the application permanently associates metadata and policies with the raw archived data, which together comprise an archive object. Object policies govern the object's behavior in the archive. As a result, the archive manages itself independently of client applications, acting automatically to ensure that all object policies are valid. | 06-03-2010 |
| 20110106770 | Fixed content storage within a partitioned content platform using namespaces, with versioning - Archive cluster management is enhanced by logically partitioning a physical cluster that comprises a redundant array of independent nodes. Using a web-based interface, an administrator defines one or more “tenants” within the archive cluster, wherein a tenant has a set of attributes: namespaces, administrative accounts, data access accounts, and a permission mask. A namespace is a logical partition of the cluster that serves as a collection of objects typically associated with at least one defined application. Each namespace has a private file system with respect to other namespaces. This approach enables a user to segregate cluster data into logical partitions. Using the administrative interface, a namespace associated with a given tenant is selectively configured without affecting a configuration of at least one other namespace in the set of namespaces. One configuration option is “versioning,” by which an administrator can elect to enable multiple versions of a same data object to be stored in association with a given namespace. Each version of the data object has associated therewith a time of storage attribute that uniquely identifies the version in the archive. Once versioning is enabled for a namespace, the administrator can set a configuration parameter identifying a time period for maintaining a version in the archive cluster, as well as a parameter for a time period for maintaining a version of the data object on a replica associated with the archive cluster. A current version of the data object is freely accessible in the archive, and a prior version may be browsed via an API. Preferably, versioning is disabled for a data object under retention. | 05-05-2011 |
| 20110106802 | Fixed content storage within a partitioned content platform using namespaces - Content platform management is enhanced by logically partitioning a physical cluster that comprises a redundant array of independent nodes. Using an interface, an administrator defines one or more “tenants” within the archive cluster, wherein a tenant has a set of attributes including, for example, namespaces, administrative accounts, data access accounts, and a permission mask. A namespace is a logical partition of the cluster that serves as a collection of objects typically associated with at least one defined application. Each namespace has a private file system such that access to one namespace (and its associated objects) does not enable a user to access objects in another namespace. A namespace has capabilities (e.g., read, write, delete, purge, and the like) that a namespace administrator can choose to enable or disable for a given data account. Using the interface, an administrator for the tenant creates and manages namespaces such that the cluster then is logically partitioned into a set of namespaces, wherein one or more namespaces are associated with a given tenant. This approach enables a user to segregate cluster data into logical partitions. Using the administrative interface, a namespace associated with a given tenant is selectively configured without affecting a configuration of at least one other namespace in the set of namespaces. This architecture enables support for many top level tenants, with multiple namespaces per tenant, and wherein configuration is effected at the level of a namespace. | 05-05-2011 |
| 20110191300 | Metadata management for fixed content distributed data storage - An archival storage cluster of preferably symmetric nodes includes a metadata management system that organizes and provides access to given metadata, preferably in the form of metadata objects. Each metadata object may have a unique name, and metadata objects are organized into regions. Preferably, a region is selected by hashing one or more object attributes (e.g., the object's name) and extracting a given number of bits of the resulting hash value. The number of bits may be controlled by a configuration parameter. Each region is stored redundantly. A region comprises a set of region copies. In particular, there is one authoritative copy of the region, and zero or more backup copies. The number of backup copies may be controlled by a configuration parameter. Region copies are distributed across the nodes of the cluster so as to balance the number of authoritative region copies per node, as well as the number of total region copies per node. Backup region copies are maintained synchronized to their associated authoritative region copy. | 08-04-2011 |
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| 20090233285 | SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR - The present invention relates, in general, to prostate cancer. More specifically, the present invention relates to a method to diagnose prostate cancer in a patient by detecting a PCA3 sequence, and more particularly a PCA3 RNA, the PCA3 sequence detected in a sample from the patient being specifically associated with prostate cancer. In a particular embodiment the method and kit enables an amplification of a PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA. The invention also relates to methods and kits to detect such an amplified PCA3 RNA, using a probe which spans the amplified exon-exon junction. In particular the methods and kits are designed to detect a PCA3 RNA which lacks one intron or more, and in particular case is intron-less. The invention further relates to a method of detecting PCA3 RNA expressed in non-prostate tissue or cells of the urinary tract, that comprises PCA3 intron 3. | 09-17-2009 |
| 20100021884 | mRNA Ratios in Urinary Sediments and/or Urine as a Prognostic and/or Theranostic Marker for Prostate Cancer - Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the subject. Kits for prognosing prostate cancer are also described. More particularly, the present invention features a method for prognosing prostate cancer in a biological sample of a patient comprising: assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of PSA in the biological sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of PSA; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value. | 01-28-2010 |
| 20110165178 | DIAGNOSIS OF PROSTATE CANCER - The present invention relates to vitro diagnosis methods of prostate cancer from a test biological sample, comprising measuring the expression level of KIAA0153 in said test biological sample, as well as to methods for screening compounds inhibiting KIAA0153 gene expression or biological activity and uses of such KIAA0153 inhibiting compounds. | 07-07-2011 |
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| 20090031855 | POROUS BODIES AND METHODS - Systems and methods for treating a fluid with a body are disclosed. Various aspects involve treating a fluid with a porous body. In select embodiments, a body comprises ash particles, and the ash particles used to form the body may be selected based on their providing one or more desired properties for a given treatment. Various bodies provide for the reaction and/or removal of a substance in a fluid, often using a porous body comprised of ash particles. Computer-operable methods for matching a source material to an application are disclosed. Certain aspects feature a porous body comprised of ash particles, the ash particles have a particle size distribution and interparticle connectivity that creates a plurality of pores having a pore size distribution and pore connectivity, and the pore size distribution and pore connectivity are such that a first fluid may substantially penetrate the pores. | 02-05-2009 |
| 20100133106 | Porous Bodies and Methods - Systems and methods for treating a fluid with a body are disclosed. Various aspects involve treating a fluid with a porous body. In select embodiments, a body comprises ash particles, and the ash particles used to form the body may be selected based on their providing one or more desired properties for a given treatment. Various bodies provide for the reaction and/or removal of a substance in a fluid, often using a porous body comprised of ash particles. Computer-operable methods for matching a source material to an application are disclosed. Certain aspects feature a porous body comprised of ash particles, the ash particles have a particle size distribution and interparticle connectivity that creates a plurality of pores having a pore size distribution and pore connectivity, and the pore size distribution and pore connectivity are such that a first fluid may substantially penetrate the pores. | 06-03-2010 |
| 20100298124 | Porous Bodies and Methods - Systems and methods for treating a fluid with a body are disclosed. Various aspects involve treating a fluid with a porous body. In select embodiments, a body comprises ash particles, and the ash particles used to form the body may be selected based on their providing one or more desired properties for a given treatment. Various bodies provide for the reaction and/or removal of a substance in a fluid, often using a porous body comprised of ash particles. Computer-operable methods for matching a source material to an application are disclosed. Certain aspects feature a porous body comprised of ash particles, the ash particles have a particle size distribution and interparticle connectivity that creates a plurality of pores having a pore size distribution and pore connectivity, and the pore size distribution and pore connectivity are such that a first fluid may substantially penetrate the pores. | 11-25-2010 |
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| 20090256067 | Electron capture dissociation in radiofrequency ion traps - A system and method that includes injecting low-energy electrons in a radiofrequency (RF) ion trap in order to dissociate positive ions by electron capture. The system includes an ion trap, a controller to provide RF that can be switched on and off rapidly, and a source of low-energy electrons that can be turned on and off synchronously with the radiofrequency on/off periods. | 10-15-2009 |
| 20110154918 | SURFACE SAMPLING MOBILE CHEMICAL DETECTION PROBE - A sampling device that contains a heated porous inlet and a transfer line. The device provides sample compounds present as vapor, liquid, or solid, in air, or on surfaces such as soil. The sample device can collect and deliver the sample to an analyzer in real time and can operate while in motion such as on a moving vehicle. The sampling device is especially useful to screen toxic and hazardous compounds that might be contaminating an inhabited area. | 06-30-2011 |
| 20110181288 | Trace explosives personnel screening system - A detector system with a portal including a plurality of output ports that direct a plurality of output airstreams in an essentially horizontal direction, and a plurality of intake ports that pull in air. The system also includes at least one concentrator coupled to at least one of the intake ports, and a detector coupled to the concentrator. The horizontally oriented output airstreams and multiple intake ports provide a system that can rapidly screen multiple people for explosives and other substances. | 07-28-2011 |
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| 20080232663 | SYSTEM AND METHOD FOR REMOTE NAVIGATION OF A SPECIMEN - A method of providing remote navigation of a specimen includes receiving a command to remotely control a microscope and a camera coupled with the microscope to view a portion of a specimen disposed on the microscope, capturing a digital image of the portion with the camera in response to the command, representing the digital image as a plurality of digital image components, each of the digital image components providing a different level of detail of the image, and transmitting the components in sequential order of increasing level of detail from least detailed to most detailed. | 09-25-2008 |
| 20090074284 | SYSTEM AND METHOD FOR CREATING MAGNIFIED IMAGES OF A MICROSCOPE SLIDE - A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z | 03-19-2009 |
| 20100034437 | System and method for reconstructing a diagnostic trajectory - A system and method for reconstructing a diagnostic trajectory. | 02-11-2010 |
| 20100067759 | System and Method for Remote Navigation of a Specimen - A method of providing remote navigation of a specimen includes receiving a command to remotely control a microscope and a camera coupled with the microscope to view a portion of a specimen disposed on the microscope, capturing a digital image of the portion with the camera in response to the command, representing the digital image as a plurality of digital image components, each of the digital image components providing a different level of detail of the image, and transmitting the components in sequential order of increasing level of detail from least detailed to most detailed. | 03-18-2010 |
| 20100073472 | Intergrated virtual slide and live microscope system - A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view. | 03-25-2010 |
