| Patent application number | Description | Published |
|---|
| 20080287650 | High purity peptides - The invention relates to methods for the preparation of highly purified peptides. The peptides are prepared in high optical purity of at least about 98.5%, and preferably at least about 99%. Specifically, Nesiritide (SEQ. ID NO. 1) having a purity of at least 99% as measured by HPLC and containing about 0.05% to about 0.5% [D-His]-Nesiritide (SEQ. ID NO. 1) as measured by chiral GC/MS. | 11-20-2008 |
| 20100029916 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 02-04-2010 |
| 20100273982 | PROCESS FOR PRODUCTION OF BIVALIRUDIN - The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp | 10-28-2010 |
| 20110160431 | PRODUCTION OF PEPTIDES CONTAINING POLY-GLY SEQUENCES USING FMOC CHEMISTRY - A peptide containing a poly-Gly sequence, such as bivalirudin, can be prepared in a purified form in which low amounts of GIy deletion or GIy addition byproducts are present. A protected poly-Gly-containing peptide is attached to a resin using Fmoc-Gly-GIy-OH units for assembly of the poly-Gly segment. The protected peptide is then cleaved from the resin with an acidic composition to produce an unprotected or semi-protected crude peptide, which can then be isolated from acidic composition. | 06-30-2011 |
| Patent application number | Description | Published |
|---|
| 20080287692 | Synthesis of cyclopentadiene derivatives - A compound of formula (X): | 11-20-2008 |
| 20090062491 | Metallocene Compounds - A bridged metallocene compound of formula (I) wherein: M is an atom of a transition metal; X, is a hydrogen atom, a halogen atom, or a hydrocarbon-based group; R1 is a C1-C40 hydrocarbon radical; R2 and R3, form together a condensed 3-7 membered ring; R4 is a hydrogen atom or a C1-C40 hydrocarbon radical; W is an aromatic 5 or 6 membered ring. | 03-05-2009 |
| 20090171047 | Metallocene Compounds - A bridged metallocene compound of formula (I) | 07-02-2009 |
| 20090221772 | Metallocene Compounds - A bridged metallocene compound of formula (I) wherein: M is a transition metal; X, is a hydrogen atom, a halogen atom, or a hydrocarbon group optionally containing hetematoms; L is a divalent bridging group; R | 09-03-2009 |
| 20090275712 | Metallocene Compounds - A bridged metallocene compound of formula (I) | 11-05-2009 |
| 20110021344 | Method for preparing non-metallocene ligands - A method of preparing supported catalysts useful for olefin polymerization is described. The catalysts comprise a Group 4 metal complex that incorporates a tridentate dianionic ligand. An activator mixture is first made from a boron compound having Lewis acidity and an excess of an alumoxane. The activator mixture is then combined with a support and the Group 4 metal complex to give a supported catalyst. The method provides an active, supported catalyst capable of making high-molecular-weight polyolefins. | 01-27-2011 |
| 20110021727 | Catalysts based on 2-(2-aryloxy)quinoline or 2-(2-aryloxy)dihydroquinoline ligands - Catalysts useful for polymerizing olefins are disclosed. The catalysts comprise an activator and a Group 4 metal complex that incorporates a dianionic, tridentate 2-(2-aryloxy)quinoline or 2-(2-aryloxy)dihydroquinoline ligand. In one aspect, supported catalysts are prepared by first combining a boron compound having Lewis acidity with excess alumoxane to produce an activator mixture, followed by combining the activator mixture with a support and the tridentate, dianionic Group 4 metal complex. The catalysts are easy to synthesize, support, and activate, and they enable facile production of high-molecular-weight polyolefins. | 01-27-2011 |
