Patent application number | Description | Published |
20090172655 | System, method and article of manufacture for using shadow installations of software modules during distributed system upgrade - A method, system and article of manufacture for upgrade of a software module executed in a distributed software computer system using shadow installations of software modules for minimum downtime. A first software module is executed on a first host and a second software module is executed on a second host, the two software modules in communication with each other. Target release of the first software module and a local release of the second software module are installed and deployed on the first host during the execution of the first software module. The first software module is switched to the target release in communication with the local release of the second software module. The communication with the second software module is reestablished after the upgrade. | 07-02-2009 |
20090208452 | Inhibitor of Endogenous Human Interferon-Gamma - The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods. | 08-20-2009 |
20100158865 | Inhibitor of endogenous human interferon-gamma - The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ, where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ, inactivated by physical or chemical methods. | 06-24-2010 |
20110135602 | SUPPERSSOR OF THE ENDOGENOUS INTERFERON-GAMMA - The invention relates to suppressor of the endogenous human interferon-gamma (hlFN-γ) applicable in treatment of diseases associated with impaired activity of endogenous hlFN-γ, especially autoimmune diseases and for prevention of graft arteriosclerosis and rejection of organs in allograft transplanted patients. It is based on inactive analogues of the hlFN-γ with pre-served affinity to the hlFN-γ receptor, genetically modified in the domain responsible for triggering the signal transduction pathway. | 06-09-2011 |
20110218325 | Inhibitor of Endogenous Human Interferon-Gamma - Inactivated protein derivatives of the hIFN-γ that preserve affinity to the hIFN-γ receptor are useful in the treatment of autoimmune diseases, especially multiple sclerosis. | 09-08-2011 |
20110286966 | Inhibitor of Endogenous Human Interferon-gamma - Modified endogenous human interferon-gamma (hIFN-γ), biologically inactive but preserving binding affinity to the hIFN-γ receptor, has applicability in the treatment of autoimmune diseases, especially multiple sclerosis. | 11-24-2011 |
20140212383 | SUPPRESSOR OF THE ENDOGENOUS INTERFERON-GAMMA - The invention relates to suppressors of endogenous human interferon-gamma (INF-γ) applicable in treatment of diseases associated with impaired activity of endogenous IFN-γ. The suppressors of the invention are useful in treating autoimmune diseases and for prevention of graft arteriosclerosis and rejection of organs in allograft transplanted patients. The invention includes inactive analogues or variants of IFN-γ having preserved affinity to the IFN-γ receptor, genetically modified in the domain responsible for triggering the signal transduction pathway. | 07-31-2014 |
20150106802 | REPLICATING VIRTUAL MACHINES ACROSS DIFFERENT VIRTUALIZATION PLATFORMS - A first virtual machine executing in a first computer server is replicated to a second virtual machine executing in a second computer server, where the first computer server and the second computer server are connected over a network and are each connected to one or more disk storage units capable of storing files in a file system. Virtual disks of the first virtual machine on the first server are transmitted to the second server, where each transmitted virtual disk is stored as a file in a storage unit connected to the second server and corresponds to one of a plurality of virtual disks of the second virtual machine running in the second server, and where the virtual disks of the first virtual machine have a first format and the virtual disks of the second virtual machine have a second format that is different from the first format. A plurality of updates to the virtual disks of the first virtual machine is captured, and contiguous data blocks from the virtual disks of the first virtual machine that are subject to the captured updates are identified. The identified contiguous data blocks are then transmitted to the second server for storage in the virtual disks of the second virtual machine. | 04-16-2015 |