Patent application number | Description | Published |
20090018177 | Propane-1,3-Dione Derivative or Salt Thereof - Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene or thiophene ring substituted with a group derived from 1-hydroxymethyl, shows excellent availability, in addition to its excellent GnRH receptor antagonism, thereby accomplishing the invention. Since the compound of the invention shows excellent availability, in addition to its strong GnRH receptor antagonism, it can be expected that it exerts superior drug effect in the living body, and it is useful for the treatment of sex hormone dependent diseases such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma, benign prostatic hypertrophy and the like. In addition, since the compound of the invention is excellent in metabolic stability in human and also is less in drug interaction, it has more desirable properties as a medicament to be used for the aforementioned diseases. | 01-15-2009 |
20090181964 | Propane-1,3-Dione Derivative or Salt Thereof - It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by —SO | 07-16-2009 |
20100324017 | ACYLGUANIDINE DERIVATIVE - An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia and the like, based on the 5-HT | 12-23-2010 |
20110207729 | BICYCLIC ACYLGUANIDINE DERIVATIVE - An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia, and the like, based on the serotonin 5-HT | 08-25-2011 |
20110306621 | ACYLGUANIDINE DERIVATIVES - An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT | 12-15-2011 |
20120041036 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) - An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on serotonin 5-HT | 02-16-2012 |
20120142727 | NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE - [Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT | 06-07-2012 |
20130317010 | TETRAHYDROISOQUINOLINE DERIVATIVE - To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT | 11-28-2013 |