Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Isao Ishida
Isao Ishida, Isehara JP
| Patent application number | Description | Published |
|---|---|---|
| 20090222935 | Transgenic animals and uses thereof - In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein. | 09-03-2009 |
| 20110067122 | Expression of Xenogenous (Human) Immunoglobulins in cloned, transgenic ungulates - The present invention relates to the production of a transgenic ungulate which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies. | 03-17-2011 |
Isao Ishida, Kanagawa JP
| Patent application number | Description | Published |
|---|---|---|
| 20110003319 | Transgenic Trasnchromosomal Rodents for Making Human Antibodies - The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. | 01-06-2011 |
Isao Ishida, Hyogo JP
| Patent application number | Description | Published |
|---|---|---|
| 20100184176 | BIOMASS HYDROTHERMAL DECOMPOSITION APPARATUS, METHOD THEREOF, AND ORGANIC MATERIAL PRODUCTION SYSTEM USING BIOMASS MATERIAL - A biomass hydrothermal decomposition apparatus includes, a biomass feeder ( | 07-22-2010 |
Isao Ishida, Shibuya-Ku JP
| Patent application number | Description | Published |
|---|---|---|
| 20100011452 | CHIMERIC NON-HUMAN ANIMAL - The present invention relates to a method for producing a chimeric non-human animal expressing a desired protein, and a chimeric non-human animal or an offspring thereof expressing a desired protein. | 01-14-2010 |
Isao Ishida, Yokohama-Shi JP
| Patent application number | Description | Published |
|---|---|---|
| 20090253902 | Isolation of a rearranged human immunoglobulin gene from a chimeric mouse and recombinant production of the encoded immunoglobulin - The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided. | 10-08-2009 |
Isao Ishida, Isehara-Shi JP
| Patent application number | Description | Published |
|---|---|---|
| 20090165154 | Transgenic ungulates having reduced prion protein activity and uses thereof - The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and a safer source of agricultural products. | 06-25-2009 |
Isao Ishida, Gunma JP
| Patent application number | Description | Published |
|---|---|---|
| 20090007282 | METHOD FOR MODIFYING CHROMOSOMES - The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof. | 01-01-2009 |
| 20110151518 | METHOD FOR MODIFYING CHROMOSOMES - The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof. | 06-23-2011 |
Isao Ishida, Tokyo JP
| Patent application number | Description | Published |
|---|---|---|
| 20080317743 | Human Artificial Chromosome Containing Human Antibody Lambda Light Chain Gene And Non-Human Animal Containing The Human Artificial Chromosome Capable Of Genetic Transmission - The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome. | 12-25-2008 |