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| 20090087903 | Temperature control device with a flexible temperature control surface - A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber. | 04-02-2009 |
| 20100178697 | SYSTEM, APPARATUS AND METHOD FOR MATERIAL PREPARATION AND/OR HANDLING - Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency. | 07-15-2010 |
| 20100331522 | CAPTURE AND ELUTION OF BIO-ANALYTES VIA BEADS THAT ARE USED TO DISRUPT SPECIMENS - Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Heating may be used. Lysing may be performed in a flow through apparatus. | 12-30-2010 |
| 20110207180 | TEMPERATURE CONTROL DEVICE WITH A FLEXIBLE TEMPERATURE CONTROL SURFACE - A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber. | 08-25-2011 |
| 20110207632 | TEMPERATURE CONTROL DEVICE WITH A FLEXIBLE TEMPERATURE CONTROL SURFACE - A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber. | 08-25-2011 |
| 20120252008 | COMPOSITIONS AND METHODS FOR CAPTURE AND ELUTION OF BIOLOGICAL MATERIALS VIA PARTICULATES - Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content. | 10-04-2012 |
| 20130090267 | TEMPERATURE CONTROL DEVICE WITH A FLEXIBLE TEMPERATURE CONTROL SURFACE - A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber. | 04-11-2013 |
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| 20090258057 | Synthetically Functionalized Living Cells - Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs). | 10-15-2009 |
| 20100323018 | Branched DNA/RNA monomers and uses thereof - The invention provides compositions and methods relating to delivery of agents in vivo or in vitro. More specifically, the invention provides nanoparticles synthesized from crosslinked nucleic acids, optionally having a lipid shell or coating, and may further comprise for example small molecule or high molecular weight compounds as therapeutic or diagnostic agents. | 12-23-2010 |
| 20100324124 | Compositions and methods relating to DNA-based particles - The invention provides compositions and methods relating to delivery of agents in vivo or in vitro. More specifically, the invention provides nanoparticles synthesized from crosslinked nucleic acids, optionally having a lipid shell or coating, and may further comprise for example small molecule or high molecular weight compounds as therapeutic or diagnostic agents. | 12-23-2010 |
| 20110033522 | REAGENTS FOR INDUCING AN IMMUNE RESPONSE - The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell. | 02-10-2011 |
| 20110171689 | ARTIFICIAL IMMUNE SYSTEM: METHODS FOR MAKING AND USE - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system. | 07-14-2011 |
| 20110229529 | LIPID VESICLE COMPOSITIONS AND METHODS OF USE - The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents. | 09-22-2011 |
| 20110229556 | LIPID-COATED POLYMER PARTICLES FOR IMMUNE STIMULATION - The invention provides delivery systems comprised of lipid coated polymer core particles, as well as compositions, methods of synthesis, and methods of use thereof. The particles can be used to carry antigen and adjuvant, resulting in enhanced immune responses. | 09-22-2011 |
| 20110293705 | METHODS AND COMPOSITIONS FOR LOCALIZED AGENT DELIVERY - The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively. | 12-01-2011 |
| 20120027837 | MULTILAYER COATING COMPOSITIONS, COATED SUBSTRATES AND METHODS THEREOF - The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a first plurality of first units, each first unit comprising a protamine polypeptide. In some embodiments, a structure comprising a microneedle substrate and a multilayer film coated on at least portion of the microneedle substrate, wherein the multilayer film comprises an agent for release and a first plurality of first unit; each first unit comprising a first layer and a second layer, wherein the first layer and the second layer are associated with one another. | 02-02-2012 |
| 20120177724 | LIPID VESICLE COMPOSITIONS AND METHODS OF USE - The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally. | 07-12-2012 |
| 20130078656 | ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system. | 03-28-2013 |
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| 20090188180 | INTEGRATED WALL SYSTEM - A composite wall system includes a foundationless wall substructure such as a sheet piling wall with a base portion embedded in the ground and an exposed portion extending above the ground, and one or more fascia panels or sheets such as synthetic simulated stonework panels applied over the foundationless wall substructure. Components of the wall system prevent debris from entering between the wall substructure and the fascia panels, and in seawall applications prevent water incursion and resist wave action. | 07-30-2009 |
| 20100290843 | SYSTEM AND METHOD FOR INSTALLING SHEET PILES - A system for installation of sheet pile including a sheet pile installation apparatus having a substantially rigid elongate beam with an upper end and a lower end, and at least one drive finger proximal the lower end of the substantially rigid elongate beam; and a sheet pile having an elongate member with an upper end and a lower end, and a first side and a second side, the first side having a male profile lock and the second side having a female profile lock, the sheet pile further including at least one receiver proximal the lower end for receiving the at least one drive finger of the sheet pile installation apparatus. | 11-18-2010 |
| 20110280670 | ACTIVE GRIPPING SHEET PILING INSTALLATION SYSTEM AND METHOD - A system and method for installing sheet piles using active gripping along side portions of the sheet piles. A sheet pile profile including first and second locking profiles and a gripping flange enables engagement of the sheet piles onto a mandrel for installation. Double engagement flanges on the locking profiles and an expandable connection between adjacent sheet piles provide improved resistance to fluid passage. | 11-17-2011 |
| 20130014453 | SHEET PILING WITH AVERSIVE ADDITIVE - A sheet piling member comprising including a base construction material forming a rigid shape and an aversive agent incorporated with respect to the base construction material. The aversive agent deters contact with the base construction material by living rodents. | 01-17-2013 |
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| 20080277126 | METHOD AND APPARATUS FOR SUPPRESSING SPARKS - A spark suppression device includes a plurality of blades or vanes that are mounted transversely in a duct of an air handling/dust collection system communicating with a spark source. A controlled flow of air carries sparks from the spark source through the spark suppression device. Sparks are suppressed by turbulence created in the airstream from the blades that have a downstream curvature. The turbulence strips away a hot air bubble surrounding a spark ember, thereby effectively cooling the spark and significantly reducing combustion at the spark ember. Other attributes of the invention contributing to spark suppression include an overlapping arrangement of the blades that results in high-velocity impact of the sparks against the blades, thereby breaking up the spark embers into smaller embers, and creation of rapid increased pressure within the spark suppression device that also helps to strip away the spark ember from the surrounding hot air bubble. | 11-13-2008 |
| 20080308501 | Liquid/Solid Separator and Method - A liquid/solid separator system mounted on a mobile cart and connected to a process tank for reducing the rate at which fluids are consumed in manufacturing processes. The system may include automation and also may include a shear-stepped screen including tilted wire wedge wires arranged at varying cant angles. The system may include a fine screen basket received in a settling box. | 12-18-2008 |
| 20110030951 | INTEGRATED FLUID FILTRATION AND RECIRCULATION SYSTEM AND METHOD - An integrated fluid filtration and recirculation system and method are provided for re-circulating and filtering fluid that is used in well cleaning operations. The system is incorporated within an enclosure, which is transportable, such as on a vehicle trailer. The system has power generation capability, thereby making the system capable of operating as a stand-alone unit. Chemicals may be infused into the filtered fluid from an integral chemical supply allowing the system to also function as a treatment facility for the fluid. The components of the system are arranged in a linear fashion that enables the system to maintain a minimum profile for transport upon a conventional trailer, yet the system provides enough room within the enclosure to allow operators to repair/inspect each of the system components. The enclosure may be climate controlled, and the enclosure may include removable panels for operation of the system in temperate conditions when climate control is unnecessary. | 02-10-2011 |
