Patent application number | Description | Published |
20090162421 | DRUGS AS WELL AS THEIR PRODUCTION AND USE IN THE TREATMENT OF PAIN-ASSOCIATED NEUROPATHIES - The present invention relates to the use of tarenflurbil and/or a pharmaceutically tolerable salt or derivative thereof in enantiomerically-pure and/or essentially enantiomerically-pure form or a form that is enriched with respect to flurbiprofen racemate and/or a racemate of said salt or derivative, for the production of a drug for the treatment of pain-associated neuropathy, pain-associated neuropathy that is simultaneously accompanied by states of nociceptive pain, peripheral and/or predominantly peripheral neuropathic pain or central and/or predominantly central neuropathic pain. | 06-25-2009 |
20100261657 | Use of a Granulin or a Granulin-Like Compound in the Therapy or Prophylaxis of Chronic Pains - The invention relates to the use of a granulin or a granulin-like compound for producing a pharmaceutical composition for the therapy or prophylaxis of chronic pain, in particular for neuropathic pain. | 10-14-2010 |
20110105405 | METHOD FOR ALLEVIATING PAIN USING PROTEIN ASSOCIATED WITH MYC AND RELATED COMPOUNDS, AND ASSAYS FOR IDENTIFYING SUCH COMPOUNDS - Use of PAM or functional fragments or derivatives thereof for the preparation of pharmaceutical compounds. | 05-05-2011 |
20110200994 | Method for Diagnosing a Genetic Predisposition for Vascular Disease - The invention relates to a method for diagnosing a genetic predisposition for a vascular disease, in particular for a coronary artery disease (CAD). According to the invention, the method has the following steps: Providing a sample containing a nucleic acid derived from the gene GCH1; and determining the presence or absence of a nucleotide polymorphism (SNP) of the gene GCH1 in the nucleic acid, wherein the SNP is selected from the group consisting of rs8007267 G>A, rs3783641 A>T, and rs10483639 C>G, wherein the presence of at least one of said SNPs indicates a genetic predisposition for a vascular disease. | 08-18-2011 |
20110207753 | METHODS FOR TREATING PAIN - The present invention features methods and compositions for preventing, reducing, or treating a traumatic, metabolic or toxic peripheral nerve lesion or pain including, for example, neuropathic pain, inflammatory and nociceptive pain by administering to a mammal in need thereof a compound that reduces the expression or activity of BH4. According to this invention, this reduction may be achieved by reducing the enzyme activity of any of the BH4 synthetic enzymes, such as GTP cyclohydrolase (GTPCH), sepiapterin reductase (SPR), or dihydropteridine reductase (DHPR); by antagonizing the cofactor function of BH4 on BH4-dependent enzymes; or by blocking BH4 binding to membrane bound receptors. The compounds of the invention may be administered alone or in combination with a second therapeutic agent. | 08-25-2011 |
20130102656 | USE OF A GRANULIN OR A GRANULIN-LIKE COMPOUND FOR THE THERAPY OR PROPHYLAXIS OF CHRONIC PAIN - The invention relates to the use of a granulin or a granulin-like compound for producing a pharmaceutical composition for the therapy or prophylaxis of chronic pain, in particular for neuropathic pain. | 04-25-2013 |
20130210826 | METHODS FOR TREATING PAIN - The present invention features methods and compositions for preventing, reducing, or treating a traumatic, metabolic, or toxic peripheral nerve lesion or pain including neuropathic pain, inflammatory, and nociceptive pain by administering to a mammal a compound that reduces expression or activity of BH4. This reduction may be achieved by reducing activity of a BH4 synthetic enzyme, including GTP cyclohydrolase, sepiapterin reductase, or dihydropteridine reductase; antagonizing the cofactor function of BH4 or BH4-dependent enzymes; or blocking BH4 binding to membrane bound receptors. The invention provides methods for diagnosing pain or a peripheral nerve lesion in a mammal by measuring levels of BH4 or its metabolites in biological sample or the levels or activity of any one of the BH4 synthetic enzyme in tissue samples of a mammal. Disclosed are screening methods that use BH4 or BH4 synthetic enzymes, BH4-dependent enzymes, and BH4-binding receptors to identify therapeutics for the treatment, prevention, or reduction of pain. | 08-15-2013 |
20130309199 | Novel Treatment of Multiple Sclerosis (MS) - The present invention relates to the use of an R-enantiomer of a compound according to the following formula (I) (I), wherein R | 11-21-2013 |