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Irina A.
Irina A. Afonina, Mill Creek, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090048427 | HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS - Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI | 02-19-2009 |
| 20100228017 | OLIGONUCLEOTIDES CONTAINING PYRAZOLO[3,4-D] PYRIMIDINES FOR HYBRIDIZATION AND MISMATCH DISCRIMINATION - Oligonucleotides in which one or more purine residues are substituted by pyrazolo[3,4-d]pyrimidines exhibit improved hybridization properties. Oligonucleotides containing pyrazolo[3,4-d]pyrimidine base analogues have higher melting temperatures than unsubstituted oligonucleotides of identical sequence. Thus, in assays involving hybridization of an oligonucleotide probe to a target polynucleotide sequence, higher signals are obtained. In addition, mismatch discrimination is enhanced when pyrazolo[3,4-d]pyrimidine-containing oligonucleotides are used as hybridization probes, making them useful as probes and primers for hybridization, amplification and sequencing procedures, particularly those in which single- or multiple-nucleotide mismatch discrimination is required. | 09-09-2010 |
Irina A. Ivanter, Sayrevill, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20110120956 | METHOD AND SYSTEM FOR TREATING BALLAST WATER - Ballast and/or cooling water biocidal treatment and disinfection systems and techniques are provided. The systems utilize oxidation reduction potential control to regulate addition, or concentration of an electrocatalytically generated biocidal agent to disinfection levels in ship buoyancy and to biofouling levels in ship cooling water systems. The disinfection and biofouling control systems provide suitable treatment while reducing the potential for corrosion of ship components and, in some cases, undesirable disinfection byproducts. | 05-26-2011 |
Irina A. Pikuleva, Lyndhurst, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100075991 | Post-translational regulation of catalytic activities of cytochrome P450 46A1 and uses thereof - Provided herein are methods and compounds for post-translational regulation of cytochrome P450 46A1 (CYP46A1) enzyme activity in the brain and retina. Also, a method for identifying a potential regulator of a CYP46A1 enzyme using crystal structures of the enzyme and a subsequent method for screening for a regulatory activity in the presence of CYP46A1 enzyme are provided. In addition, the regulator compounds that either inhibit or stimulate cholesterol hydroxylation by the CYP46A1 enzyme are provided. Further provided is a method of treating a pathoneurological condition associated with increased cholesterol levels in the brain and retina using the stimulatory compounds. | 03-25-2010 |
Irina A. Sokolova, Villa Park, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20090269768 | DETECTION OF HIGH GRADE DYSPLASIA IN CERVICAL CELLS - Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture. | 10-29-2009 |
| 20090298087 | METHODS AND PROBES FOR THE DETECTION OF CANCER - Probe sets and methods of using probes and probe sets for the detection of cancer are described. Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if cancer cells are present the sample. Also included are methods of selecting a combination of probes for the detection of cancer. | 12-03-2009 |
Irina A. Zamulaeva, Obninsk RU
| Patent application number | Description | Published |
|---|---|---|
| 20090131391 | INHIBITOR FOR DIFFERENTIATION OF HEMATOPOIETIC PRECURSOR CELLS - The invention relates to medicine and can be used for treating persons with diseases associated with a differentiation of hematopoietic precursor cells. The inventive inhibitor for differentiation of hematopoietic precursor cells is embodied in the form of an organic compound of selen-9-phenyl-symmetrical-octahydro-selenoxanten. Said agent makes it possible to more efficiently protect normal tissues. | 05-21-2009 |