Patent application number | Description | Published |
20080267989 | Hiv Gp-41-Membrane Proximal Region Arrayed On Hepatitis B Surface Antigen Particles as Novel Antigens - Recombinant HBsAg-gp120 has been used to present approximately amino acids 1-500 gp120. However, this presentation of gp120 in this form has not successfully been used to produce neutralizing antibodies. The use of the immunogenic Hepatitis B surface antigen (HBsAg) particulate platform to array specific epitopes from the conserved, neutralization-sensitive membrane proximal region (MPR) of HIV-1, and the use of these monomeric fusion proteins, polymeric forms of these fusion proteins, and nucleic acids encoding these fusion proteins to induce an immune response to HIV-1 are disclosed. | 10-30-2008 |
20100215682 | DELETION OF THE BETA 20-21 LOOP IN HIV GP120 EXPOSES THE CD4 BINDING SITE FOR IMPROVED ANTIBODY BINDING AND ANTIBODY INDUCTION - Disclosed herein are isolated immunogens including variant gp120 polypeptides. In an example, a variant gp120 polypeptide includes a deletion of at least 8 consecutive residues of the fourth conserved loop (C4) between residues 419 and 434 of gp120 according to HXB2 numbering. Also provided are isolated nucleic acid molecules encoding the disclosed isolated immunogens. In an example, an isolated nucleic acid molecule further includes a nucleic acid molecule encoding a hepatitis B surface antigen or a variant thereof. Compositions including the isolated immunogens including variant gp120 polypeptides are also disclosed. In some examples, a composition further includes a carrier protein, such as a hepatitis B surface antigen or a variant thereof (natural or recombinant). Viral-like particles are also provided including any of the disclosed isolated immunogens or compositions. Also disclosed are uses of these variant gp120 polypeptides and nucleic acids encoding variant polypeptides, such as to induce an immune response to HIV-1. | 08-26-2010 |
20110142869 | MEMBRANE PROXIMAL REGION OF HIV GP41 ANCHORED TO THE LIPID LAYER OF A VIRUS-LIKE PARTICLE VACCINE - Disclosed herein are isolated immunogens including variant hepatitis B surface antigens (HBsAgs). In an example, a variant HBsAg includes a HBsAg with one or more transmembrane domains of the HBsAg replaced with a gp41 antigenic insert. The antigenic insert can include an antigenic polypeptide fragment of gp41 including the membrane proximal region of gp41 and a transmembrane membrane region of gp41. The replacement of a membrane spanning domain of HBsAg with a membrane spanning domain of gp41 anchors gp41 into HBsAg in virtually the identical orientation as on HIV virions and correctly orients the nearby MPR on the lipid layer. Thus, the disclosed variant HBsAgs display the neutralization-sensitive MPR in association with a lipid layer, while presenting it at the most immunogenic site on HBsAg. Also disclosed are uses of these variant HBsAgs, and nucleic acids encoding variant HBsAgs, such as to induce an immune response to HIV-1. | 06-16-2011 |
20120207784 | INSERTION OF FOREIGN GENES IN RUBELLA VIRUS AND THEIR STABLE EXPRESSION IN A LIVE, ATTENUATED VIRAL VACCINE - Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) with an in-frame deletion, a rubella structural protein ORF, and a heterologous antigenic insert. In one example, the in-frame deletion within the rubella non-structural protein ORF is an in-frame deletion between two NotI restriction enzyme sites. In some examples, the heterologous antigenic insert is positioned within the rubella non-structural protein ORF. In other examples, the heterologous antigenic insert is positioned within the rubella structural protein ORF. Exemplary antigenic inserts include a Gag antigenic insert, a gp41 antigenic insert or a gp120 antigenic insert. Also disclosed are uses of the isolated rubella viral vector, such as to induce an immune response to HIV-1, testing sensitivity to neutralizing antibodies, or screening antiviral drugs (such as protease inhibitors). | 08-16-2012 |
20140093528 | DELETION OF THE BETA 20-21 LOOP IN HIV GP120 EXPOSES THE CD4 BINDING SITE FOR IMPROVED ANTIBODY BINDING AND ANTIBODY INDUCTION - Disclosed herein are isolated immunogens including variant gp120 polypeptides. In an example, a variant gp120 polypeptide includes a deletion of at least 8 consecutive residues of the fourth conserved loop (C4) between residues 419 and 434 of gp120 according to HXB2 numbering. Also provided are isolated nucleic acid molecules encoding the disclosed isolated immunogens. In an example, an isolated nucleic acid molecule further includes a nucleic acid molecule encoding a hepatitis B surface antigen or a variant thereof. Compositions including the isolated immunogens including variant gp120 polypeptides are also disclosed. In some examples, a composition further includes a carrier protein, such as a hepatitis B surface antigen or a variant thereof (natural or recombinant). Viral-like particles are also provided including any of the disclosed isolated immunogens or compositions. Also disclosed are uses of these variant gp120 polypeptides and nucleic acids encoding variant polypeptides, such as to induce an immune response to HIV-1. | 04-03-2014 |
20150079123 | LIVE, ATTENUATED RUBELLA VECTOR TO EXPRESS VACCINE ANTIGENS - Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) without an in-frame deletion, a rubella structural protein ORF, and a heterologous antigenic insert. In one example, the heterologous antigenic insert is positioned within the rubella structural protein ORF. In some examples, the heterologous antigenic insert is positioned in the rubella structural protein ORF in between a gene encoding structural protein E2 and a gene encoding structural protein E1. Exemplary antigenic inserts include HIV, SIV, RSV or hepatitis B surface antigens. In some examples, the HIV antigenic insert is a Gag antigenic insert, a gp41 antigenic insert or a gp120 antigenic insert. Also disclosed are uses of the isolated rubella viral vector, such as to induce an immune response to a particular virus, such as HIV-1, testing sensitivity to neutralizing antibodies, or screening antiviral drugs (such as protease inhibitors). | 03-19-2015 |
20150174239 | MEMBRANE PROXIMAL REGION OF HIV GP41 ANCHORED TO THE LIPID LAYER OF A VIRUS-LIKE PARTICLE VACCINE - Disclosed herein are isolated immunogens including variant hepatitis B surface antigens (HBsAgs). In an example, a variant HBsAg includes a HBsAg with one or more transmembrane domains of the HBsAg replaced with a gp41 antigenic insert. The antigenic insert can include an antigenic polypeptide fragment of gp41 including the membrane proximal region of gp41 and a transmembrane membrane region of gp41. The replacement of a membrane spanning domain of HBsAg with a membrane spanning domain of gp41 anchors gp41 into HBsAg in virtually the identical orientation as on HIV virions and correctly orients the nearby MPR on the lipid layer. Thus, the disclosed variant HBsAgs display the neutralization-sensitive MPR in association with a lipid layer, while presenting it at the most immunogenic site on HBsAg. Also disclosed are uses of these variant HBsAgs, and nucleic acids encoding variant HBsAgs, such as to induce an immune response to HIV-1. | 06-25-2015 |
Patent application number | Description | Published |
20080304619 | Modular Multi-Hole Collimators Method and System - Embodiments of the present technique relate to a modular multi-hole collimator assembly configured to have an adjustable length. Each of the two or more multi-hole collimator units has a plurality of holes therethrough. Exemplary embodiments also relate to a modular multi-hole collimator assembly that includes a base multi-hole collimator unit and one or more multi-hole collimator extension units. Each of the base multi-hole collimator unit and the one or more multi-hole collimator extension units has a plurality of holes therethrough. At least one of the plurality of holes through the base multi-hole collimator unit and at least one of the holes through the one or more multi-hole collimator extension units are axially aligned. | 12-11-2008 |
20100193696 | APPARATUS AND METHODS FOR CALIBRATING PIXELATED DETECTORS - An apparatus and methods for calibrating pixelated detectors are provided. A method includes acquiring energy response data for a plurality of pixels of the pixelated semiconductor radiation detector and performing at least one of energy calibration and sensitivity calibration on each of the plurality of pixels based on the acquired energy response data. | 08-05-2010 |
20100329418 | SYSTEM AND METHOD FOR PERFORMING NUCLEAR MAMMOGRAPHY IMAGING - A system and method for performing molecular imaging of an anatomy of interest is provided. The molecular imaging system includes a gantry, a first gamma camera coupled to the gantry, and a second gamma camera coupled to the gantry, the first and second cameras are positionable in an L-mode imaging configuration, the first and second gamma cameras are configured to immobilize an anatomy of interest therebetween in the L-mode configuration. The molecular imaging system is also configured to operate in an H-mode imaging configuration wherein the first and second gamma cameras are configured to immobilize an anatomy of interest therebetween in the H-mode configuration. | 12-30-2010 |
20100329419 | GAMMA CAMERA FOR PERFORMING NUCLEAR MAMMOGRAPHY IMAGING - A gamma camera for use in a molecular imaging system includes a housing, a cadmium zinc telluride (CZT) camera disposed within the housing, and at least one retractable wall coupled to the housing and adapted to secure an anatomy of interest in a field-of-view of the gamma camera. The gamma camera also includes a chamfered edge to enable the gamma camera to contact a second gamma camera when the gamma camera is positioned in an L-mode imaging configuration. | 12-30-2010 |
20110147574 | CALIBRATION SOURCE AND METHODS FOR CALIBRATING A NUCLEAR MEDICINE IMAGING SYSTEM - Systems and methods for calibrating a nuclear medicine (NM) imaging system are provided that include an NM calibration source. The NM calibration source includes an isotope source having an energy spectrum with at least one energy peak and a fluorescence layer adjacent the isotope source creating at least one additional energy peak in the energy spectrum. | 06-23-2011 |
20110155918 | SYSTEMS AND METHODS FOR PROVIDING A SHARED CHARGE IN PIXELATED IMAGE DETECTORS - Systems and methods for providing a shared charge in pixelated image detectors are provided. One method includes providing a plurality of pixels for a pixelated solid state photon detector in a configuration such that a charge distribution is detected by at least two pixels and obtaining charge information from the at least two pixels. The method further includes determining a position of an interaction of the charge distribution with the plurality of pixels based on the obtained charge information. | 06-30-2011 |
20110216880 | SYSTEM AND METHOD FOR MOLECULAR BREAST IMAGING - A system and method for a molecular breast imaging (MBI) are provided. One MBI system includes at least one cadmium zinc telluride (CZT) detector having a plurality of pixels and a registered parallel hole collimator coupled to a face of the CZT detector. The registered parallel hole collimator includes a plurality of collimator holes, wherein the plurality of collimator holes are aligned with the plurality of pixels, and the spatial dimensions of the plurality of holes are configured based on characteristics of the CZT detector and the registered parallel hole collimator. | 09-08-2011 |
20110220783 | METHODS AND SYSTEMS FOR CALIBRATING A NUCLEAR MEDICINE IMAGING SYSTEM - Methods and systems for calibrating a nuclear medicine imaging are provided. One method includes acquiring spatially determined non-uniform radiation flux information from a calibration scan of a calibration source using a gamma camera having an attached non-parallel-hole collimator. The method further includes determining a measured non-uniform count density profile from the acquired non-uniform radiation flux information. The method also includes creating a gamma camera uniformity correction map derived from (i) the measured non-uniform count density profile and (ii) a modeled or calculated non-uniform count density profile for calibrating the NM imaging system. | 09-15-2011 |
20120148016 | SYSTEM AND METHOD FOR MOLECULAR BREAST IMAGING - A system and method for a molecular breast imaging (MBI) are provided. One MBI system includes at least one cadmium zinc telluride (CZT) detector having a plurality of pixels and a registered parallel hole collimator coupled to a face of the CZT detector. The registered parallel hole collimator includes a plurality of collimator holes, wherein the plurality of collimator holes are aligned with the plurality of pixels, and the spatial dimensions of the plurality of holes are configured based on characteristics of the CZT detector and the registered parallel hole collimator. | 06-14-2012 |
20130193337 | SYSTEMS AND METHODS FOR PROVIDING A SHARED CHARGE IN PIXELATED IMAGE DETECTORS - Systems and methods for providing a shared charge in pixelated image detectors are provided. One method includes providing a plurality of pixels for a pixelated solid state photon detector in a configuration such that a charge distribution is detected by at least two pixels and obtaining charge information from the at least two pixels. The method further includes determining a position of an interaction of the charge distribution with the plurality of pixels based on the obtained charge information. | 08-01-2013 |
Patent application number | Description | Published |
20100030780 | IDENTIFYING RELATED OBJECTS IN A COMPUTER DATABASE - Provided are, among other things, systems, methods and techniques for identifying related objects in a computer database. In one representative implementation: (a) a feature vector that describes an existing object is obtained; (b) comparison scores are generated between the feature vector and various sample vectors; (c) a set that includes at least one designated vector is identified from among the sample vectors by evaluating the generated comparison scores; (d) a computer database is searched for matches between label(s) for the designated vector(s) and labels for representative vectors for other objects represented in the computer database; and (e) at least one related object is identified based on the identified match(es). | 02-04-2010 |
20110016520 | AUTHENTICATION SYSTEM AND METHODS - A system and methods authenticate sensitive information such as passwords. Password characters are transformed into distorted characters and distorted character groups are generated such that each distorted password character is part of a group. An image is created containing the groups and the password or other sensitive information is authenticated when groups are identified within the image that contain the password characters in an expected sequence. | 01-20-2011 |
20110184894 | GENERATING A SET OF ATOMS - An automated method comprises receiving training data representing an initial data set including text representing at least one concept embodied by the data set, using the training data in order to generate a set of atoms, each atom comprising at least one word that represents one or more concepts of the initial data set, wherein generating a set of atoms comprises minimising a cost function using an iterative process to identify one or more atoms. | 07-28-2011 |
20110185234 | SYSTEM EVENT LOGS - An automated method of processing computer system event logs comprises receiving event messages associated with one or more system event logs, each event message including event text, determining a set of message clusters, each comprising a template text, representative of the event messages across the one or more event logs, and assigning each event message to a message cluster of the set, according to a measure of similarity between the respective event text of the event message and the template text of the message cluster. | 07-28-2011 |
20120011113 | Determining Reliability of Electronic Documents Associated with Events - A method of determining reliability of electronic documents associated with an event occurring in connection with a computing device may comprise, with a processor, composing a number of search queries based on text included in an event message, searching for a number of electronic documents via a network, said searching performed based on the composed search queries, and ranking the electronic documents identified by said searching based upon an indication of reliability in addressing the event associated with the event message, in which, ranking the electronic documents comprises applying a content source ranking criteria. | 01-12-2012 |
20120016886 | DETERMINING A SEASONAL EFFECT IN TEMPORAL DATA - To determine a seasonal effect in temporal data, for each of a plurality of candidate seasons, the following is performed. An interval is defined for the corresponding candidate season. The interval is divided ( | 01-19-2012 |
20120215736 | PATTERN RECOGNITION - A method for pattern recognition performed by a physical computing system includes, with the physical computing system, structuring data as a bi-partite graph, a set of instance nodes within the graph representing instances within the data and a set of property nodes within the graph representing properties of the instances, edges between the instance nodes and the property nodes representing values of the properties, assigning a transition probability function to each of the instance nodes and to each of the property nodes, and applying a random walker to the graph, the random walker utilizing the transition probability functions. | 08-23-2012 |
20120310949 | MATCHING A USER TO A CONVERSATION - A method for matching a user to a conversation includes, for each of a plurality of documents, mapping the document to one or more of a plurality of topics. The document is associated with a user. For each user, the user is mapped to each of the plurality of topics that are mapped to documents with which the user is associated. One of the users is matched to a conversation according to the mappings of the users to those of the plurality of topics that are also mapped to the conversation. | 12-06-2012 |
20130080451 | DETERMINING SIMILARITY SCORES OF ANOMALIES - A method and system comprise abstracting configuration items (CI) in at least a first anomaly and a second anomaly based on type of CI. Further, CIs are matched of a common type between the first and second anomalies based on a cost function. Additionally, a similarity score is computed for the first and second anomalies based, at least in part, on the cost function of the matched CI's and based on topology of the first and second anomalies. | 03-28-2013 |
20130080472 | TRANSLATING NATURAL LANGUAGE QUERIES - A system and related method to process natural queries is provided. In one aspect, it is determined whether any portion of the natural language query matches one of a plurality of semantic keywords. In another aspect, the natural language query is translated into at least one database query. In a further aspect, the database query may be executed in a database arranged in accordance with the database model. | 03-28-2013 |
20130198219 | DISAMBIGUATING ASSOCIATIONS - Disclosed herein is a technique for disambiguating associations between one keyword and multiple attributes of a database model and for disambiguating associations between one attribute of a database model and multiple attribute types. | 08-01-2013 |
20130275812 | DETERMINING ROOT CAUSE - Methods, systems, and computer-readable media with executable instructions stored thereon for determining root cause are provided. A method for determining root cause can include receiving values for at least one performance metric for each of a plurality of components of an IT system to establish a normal value for each of the performance metrics, receiving an abnormal value that differs from the normal value for at least one of the plurality of components of the IT system, and determining a probability that the at least one of the plurality of components of the IT system is a root cause of the abnormal value. | 10-17-2013 |
20130275816 | IDENTIFYING A DIMENSION ASSOCIATED WITH AN ABNORMAL CONDITION - At least one value of abnormal metrics is identified as being an abnormal dimension value. A dominant dimension related to the anomaly is identified based on the identified abnormal dimension value. | 10-17-2013 |
20130282331 | DETECTING ABNORMAL BEHAVIOR - Systems, methods, and machine-readable and executable instructions are provided for detecting abnormal behavior. Detecting abnormal behavior can include receiving a mean at a previous time interval, a sum of squares at the previous time interval, and a first sample of a metric at a current time interval from a system and adjusting a first weight and a second weight at the current time interval to the first sample and a system change report. Detecting abnormal behavior can also include calculating a mean and a standard deviation of the metric at the current time interval by assigning the first sample the adjusted first weight and by assigning the mean and the sum of squares at a previous time interval the adjusted second weight and detecting abnormal behavior by comparing the first sample to an outlier value based on the mean and the standard deviation at the previous time interval. | 10-24-2013 |
20140032552 | DEFINING RELATIONSHIPS - Defining relationships are described. Defining relationships can include retrieving a number of event notifications that correspond to a number of nodes. Defining relationships can include defining a number of group patterns that correspond to the number of event notifications. Defining relationships can also include grouping the number of nodes into a number of groups that correlate with the number of group patterns, the number of groups defining a number of relationships between the number of nodes. Defining relationships can include assigning a number of weights to the number of relationships between the number of nodes, wherein the number of weights are based on a strength of the number of relationships between the number of nodes. | 01-30-2014 |
20140114713 | INCIDENT ASSIGNMENT - Systems, methods, and machine-readable and executable instructions are provided for incident assignment. Incident assignment can include selecting a number of incidents that have been resolved, wherein the number of incidents are similar to a pending incident. Incident assignment can also include identifying a first number of users that resolved the number of incidents and a number of skills associated with the first number of users. Incident assignment can include creating a target user profile based on the number of skills. Incident assignment can include computing a distance from each of a second number of users to the target user profile, wherein the distance computation does not penalize the second number of users for being over qualified. Incident assignment can also include assigning the pending incident to a selected user from the second number of users wherein the selected user is selected based on the computed distances. | 04-24-2014 |
20140165070 | RANKING AND SCHEDULING OF MONITORING TASKS - Systems, methods, and machine-readable and executable instructions are provided for dynamically ranking and scheduling monitoring tasks. Dynamically ranking and scheduling monitoring tasks can include determining an updated ranking for each of a number of monitoring tasks, where the updated ranking can include analyzing historical measurements of each of the number of monitoring tasks. An order of execution can be scheduled for each of the number of monitoring tasks based on the updated ranking for each of the number of monitoring tasks. | 06-12-2014 |
20140180635 | ADAPTIVE BASELINE BASED ON METRIC VALUES - Values of a metric are provided at irregular intervals. A forgetting factor is calculated based on a difference between the intervals, and a statistical parameter is computed using the forgetting factor that causes different weights to be placed on the corresponding values of the metric, where the statistical parameter is part of an adaptive baseline. | 06-26-2014 |
20140244642 | DATA PARTIONING BASED ON END USER BEHAVIOR - End user data partitioning can include receiving a number of data queries for a data source from a user, developing a dimension relation graph based on attributes of the number of data queries, and partitioning the data source based on the dimension relation graph. | 08-28-2014 |
20140281878 | Aligning Annotation of Fields of Documents - Methods and systems of aligning annotation of fields of documents are provided. Training information that includes first measurement information pertaining to features of each of a plurality of fields associated with training clusters for documents of a document type is accessed. A first training cluster is annotated with a first name and the second training cluster is annotated with a second name. An electronic classification model is generated based on the training information. Second measurement information for features of fields associated with new clusters of a new document is accessed. Each of the new clusters is automatically annotated based on the second measurement information using the classification model. For example, a first new cluster that has fields of the first field type is annotated with the first name and a second new cluster that has fields of the second field type is annotated with the second name. | 09-18-2014 |
20140289418 | METHODS AND SYSTEMS FOR PLANNING EXECUTION OF AN APPLICATION IN A CLOUD COMPUTING SYSTEM - Methods and systems related to planning an execution of an application in a cloud computing system are described herein. The method includes determining whether a workload causes an anomaly associated to the execution of an application. Upon determining that execution of the application under the workload causes an anomaly, an action, or a value of at least one parameter for execution of the application in the cloud computing system, is determined. The action, or the value, is for addressing the anomaly. | 09-25-2014 |
20140324409 | STOCHASTIC BASED DETERMINATION - Stochastic based determination can include accessing a sequence of a plurality of vectors, wherein each of the plurality of vectors includes a plurality of metrics that define a performance of an application. Stochastic based determination can also include querying a digital representation of a first Stochastic Model to determine a first likelihood that the sequence will terminate in an anomalous state. Stochastic based determination can include querying a digital representation of a second Stochastic Model to determine a second likelihood that the sequence will terminate in a normal state. Stochastic based determination can include determining whether the sequence will terminate in the anomalous state based on a comparison between the first likelihood and the second likelihood. | 10-30-2014 |
20150355998 | ERROR DEVELOPER ASSOCIATION - Systems, methods, and machine-readable and executable instructions are provided for error developer association. Error developer association can include Identifying a number of portions of the source code associated with a message, wherein the message is associated with an error. Error developer association can also include associating s developer with a portion of the source code of the number of portions of the source code. Error developer association can also include identifying a developer of the number of developers to resolve the error. | 12-10-2015 |
20160034835 | FUTURE CLOUD RESOURCE USAGE COST MANAGEMENT - According to an example, a history of usage and a history of utilization of resources may be accessed. A usage regression model to predict a cloud resource usage and a utilization regression model to predict a cloud resource utilization at a future time period may be developed. The usage regression model and the utilization regression model may be used to manage cloud resource usage costs. | 02-04-2016 |
Patent application number | Description | Published |
20140095145 | RESPONDING TO NATURAL LANGUAGE QUERIES - Disclosed herein are a system, non-transitory computer-readable medium, and method for responding to natural language queries. Keywords likely to appear in a natural language query are determined and each likely keyword is associated with a module. A response to a natural language query comprises information generated by each module associated with a likely keyword appearing in the natural language query. | 04-03-2014 |
20140122691 | DETERMINING ROOT CAUSES OF NETWORK ISSUES - Determining root causes of network issues includes identifying a previous network issue, comparing a first behavior of network components during the previous network issue with a second behavior of the network components during a current issue of a network, and obtaining a previous user input about a previous root cause of the previous network issue collected while diagnosing the previous issue. | 05-01-2014 |
20140372347 | METHODS AND SYSTEMS FOR IDENTIFYING ACTION FOR RESPONDING TO ANOMALY IN CLOUD COMPUTING SYSTEM - Methods performed by a physical computing system include automatically identifying, using at least one trained classifier, an action for responding to an anomaly in the execution of the application in a cloud computing system. The at least one trained classifier relates a metrics set to a result of performing an action for addressing an anomaly. Systems and computer readable media are also described herein. | 12-18-2014 |
20150347214 | Determining Suspected Root Causes of Anomalous Network Behavior - Determining suspected root causes of anomalous network behavior includes identifying anomalous components in a network exhibiting anomalous behavior from a plurality of network components, assigning a likelihood score to network components based on a scoring policy that considers recent change events affecting the anomalous components, and identifying a subset of the network components that are suspected to be root causes based on the likelihood score. | 12-03-2015 |
20160085664 | GENERATING A FINGERPRINT REPRESENTING A RESPONSE OF AN APPLICATION TO A SIMULATION OF A FAULT OF AN EXTERNAL SERVICE - Examples disclosed herein relate to generating a fingerprint representing a response of an application to a simulation of a fault of an external service. Examples include causing simulation of a fault of an external service in a simulation of the external service, and generating a testing application fingerprint representing a response of an application to the simulation of the fault of the external service during the testing of the application. | 03-24-2016 |
20160112244 | PRIORITIZING EVENT NOTICES UTILIZING PAST-PREFERENCE PAIRINGS - In one example of the disclosure, event notices are received, notice indicative of degradation of a configuration item. Configuration iter past-preference pairings are accessed. Each pairing includes a count of operator-exhibited preferences for event notices associated with a first configuration item relative to event notices associated with a second configuration item. A prioritized ordering of the received event notices is created utilizing the past-preference pairings. | 04-21-2016 |
Patent application number | Description | Published |
20080292632 | Irta2 Antibodies and Methods of Use - Antibodies that specifically bind the extracellular domain of IRTA2 are disclosed herein. In one embodiment, these antibodies do not specifically bind IRTA1, IRTA3, IRTA4, or IRTA5. In one example, the antibodies are humanized antibodies. The antibodies can be conjugated to effector molecules, including detectable labels, radionucleotides, toxins and chemotherapeutic agents. The antibodies that specifically bind IRTA2 are of use to detect B cell malignancies, such as hairy cell leukemia and non-Hodgkin's lymphoma. These antibodies that specifically bind IRTA2 are also of use to treat B cell malignancies that express IRTA2, such as hairy cell leukemia and non-Hodgkin's lymphoma. | 11-27-2008 |
20090208518 | IMMUNOGENIC PEPTIDES FOR THE TREATMENT OF PROSTATE AND BREAST CANCER - Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO: 9 and do not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO: 1. Several specific, non-limiting examples of these polypeptides are set forth as SEQ ID NOs: 3-7. Nucleic acids encoding these polypeptides, and host cells transfected with these nucleic acids, are also disclosed. Methods of using these polypeptides, and polynucleotides encoding these polypeptides, for the treatment of breast and prostate cancer are also disclosed. | 08-20-2009 |
20090280556 | Mesothelin, A Differentiation Antigen Present On Mesothelium, Mesotheliomas, and Ovarian Cancers and Methods and Kits for Targeting the Antigen - This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting and/or inhibiting the growth of cells bearing mesothelin, methods for detecting the antigen and its expression level as an indication of the presence of tumor cells, and kits for such detection. | 11-12-2009 |
20090304702 | GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE - A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer. | 12-10-2009 |
20090305411 | RECOMBINANT ANTIBODIES AND IMMUNOCONJUGATES TARGETED TO CD-22 BEARING CELLS AND TUMORS - Methods and compositions relating to anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a | 12-10-2009 |
20120107933 | ANTI-MESOTHELIN ANTIBODIES - The present invention provides monoclonal anti-mesothelin antibodies and antibody fragments and methods for their use. The antibodies can be completely human. | 05-03-2012 |
20150218286 | Methods of Treating Pediatric Acute Lymphoblastic Leukemia with an Anti-CD22 Immunotoxin - The present invention provides methods for the treatment of acute lymphoblastic leukemia (ALL) in pediatric patients using an anti-CD22 immunotoxin. The methods disclosed comprise administering to a pediatric patient in need of that treatment an effective dose of a recombinant immunotoxin comprising a variable light (V | 08-06-2015 |
Patent application number | Description | Published |
20080267909 | PHAGOCYTE ENHANCEMENT THERAPY FOR ATHEROSCLEROSIS - Compounds that increase phagocytosis of apoptotic macrophages or necrotic cells that are associated with advanced atherosclerotic lesions are useful for treating atherosclerosis. Methods are provided for identifying such compounds and for preventing or treating atherosclerosis by increasing phagocytosis of apoptotic macrophages associated with advanced atherosclerotic lesions. | 10-30-2008 |
20090010876 | VISFATIN AND USES THEREOF - The invention is directed to methods for treating, inhibiting or prevent the incidence of vascular disease in a subject or in a non-human animal by administering visfatin. Particularly, the invention provides for methods to prevent phagocyte cell death due to ER-stress by the administration of visfatin. The invention also encompasses methods for identifying a visfatin polypeptide or a visfatin nucleic acid capable of treating a vascular disease as well as pharmaceutical compositions comprising visfatin. | 01-08-2009 |
20140314789 | CaMKII, IP3R, CALCINEURIN, P38 AND MK2/3 INHIBITORS TO TREAT METABOLIC DISTURBANCES OF OBESITY - The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. Such methods include, but are not limited to, the administration to the subject of inhibitors or activators of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1, Dach2, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach2, or reduces the activity and/or activation of CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach, or activates CaMKII, IP3Rs, calcineurin, p38, MK2/3, HDAC4, Dach1 or Dach2. | 10-23-2014 |