| Patent application number | Description | Published |
|---|
| 20080267989 | Hiv Gp-41-Membrane Proximal Region Arrayed On Hepatitis B Surface Antigen Particles as Novel Antigens - Recombinant HBsAg-gp120 has been used to present approximately amino acids 1-500 gp120. However, this presentation of gp120 in this form has not successfully been used to produce neutralizing antibodies. The use of the immunogenic Hepatitis B surface antigen (HBsAg) particulate platform to array specific epitopes from the conserved, neutralization-sensitive membrane proximal region (MPR) of HIV-1, and the use of these monomeric fusion proteins, polymeric forms of these fusion proteins, and nucleic acids encoding these fusion proteins to induce an immune response to HIV-1 are disclosed. | 10-30-2008 |
| 20100215682 | DELETION OF THE BETA 20-21 LOOP IN HIV GP120 EXPOSES THE CD4 BINDING SITE FOR IMPROVED ANTIBODY BINDING AND ANTIBODY INDUCTION - Disclosed herein are isolated immunogens including variant gp120 polypeptides. In an example, a variant gp120 polypeptide includes a deletion of at least 8 consecutive residues of the fourth conserved loop (C4) between residues 419 and 434 of gp120 according to HXB2 numbering. Also provided are isolated nucleic acid molecules encoding the disclosed isolated immunogens. In an example, an isolated nucleic acid molecule further includes a nucleic acid molecule encoding a hepatitis B surface antigen or a variant thereof. Compositions including the isolated immunogens including variant gp120 polypeptides are also disclosed. In some examples, a composition further includes a carrier protein, such as a hepatitis B surface antigen or a variant thereof (natural or recombinant). Viral-like particles are also provided including any of the disclosed isolated immunogens or compositions. Also disclosed are uses of these variant gp120 polypeptides and nucleic acids encoding variant polypeptides, such as to induce an immune response to HIV-1. | 08-26-2010 |
| 20110142869 | MEMBRANE PROXIMAL REGION OF HIV GP41 ANCHORED TO THE LIPID LAYER OF A VIRUS-LIKE PARTICLE VACCINE - Disclosed herein are isolated immunogens including variant hepatitis B surface antigens (HBsAgs). In an example, a variant HBsAg includes a HBsAg with one or more transmembrane domains of the HBsAg replaced with a gp41 antigenic insert. The antigenic insert can include an antigenic polypeptide fragment of gp41 including the membrane proximal region of gp41 and a transmembrane membrane region of gp41. The replacement of a membrane spanning domain of HBsAg with a membrane spanning domain of gp41 anchors gp41 into HBsAg in virtually the identical orientation as on HIV virions and correctly orients the nearby MPR on the lipid layer. Thus, the disclosed variant HBsAgs display the neutralization-sensitive MPR in association with a lipid layer, while presenting it at the most immunogenic site on HBsAg. Also disclosed are uses of these variant HBsAgs, and nucleic acids encoding variant HBsAgs, such as to induce an immune response to HIV-1. | 06-16-2011 |
| Patent application number | Description | Published |
|---|
| 20080304619 | Modular Multi-Hole Collimators Method and System - Embodiments of the present technique relate to a modular multi-hole collimator assembly configured to have an adjustable length. Each of the two or more multi-hole collimator units has a plurality of holes therethrough. Exemplary embodiments also relate to a modular multi-hole collimator assembly that includes a base multi-hole collimator unit and one or more multi-hole collimator extension units. Each of the base multi-hole collimator unit and the one or more multi-hole collimator extension units has a plurality of holes therethrough. At least one of the plurality of holes through the base multi-hole collimator unit and at least one of the holes through the one or more multi-hole collimator extension units are axially aligned. | 12-11-2008 |
| 20100193696 | APPARATUS AND METHODS FOR CALIBRATING PIXELATED DETECTORS - An apparatus and methods for calibrating pixelated detectors are provided. A method includes acquiring energy response data for a plurality of pixels of the pixelated semiconductor radiation detector and performing at least one of energy calibration and sensitivity calibration on each of the plurality of pixels based on the acquired energy response data. | 08-05-2010 |
| 20100329418 | SYSTEM AND METHOD FOR PERFORMING NUCLEAR MAMMOGRAPHY IMAGING - A system and method for performing molecular imaging of an anatomy of interest is provided. The molecular imaging system includes a gantry, a first gamma camera coupled to the gantry, and a second gamma camera coupled to the gantry, the first and second cameras are positionable in an L-mode imaging configuration, the first and second gamma cameras are configured to immobilize an anatomy of interest therebetween in the L-mode configuration. The molecular imaging system is also configured to operate in an H-mode imaging configuration wherein the first and second gamma cameras are configured to immobilize an anatomy of interest therebetween in the H-mode configuration. | 12-30-2010 |
| 20100329419 | GAMMA CAMERA FOR PERFORMING NUCLEAR MAMMOGRAPHY IMAGING - A gamma camera for use in a molecular imaging system includes a housing, a cadmium zinc telluride (CZT) camera disposed within the housing, and at least one retractable wall coupled to the housing and adapted to secure an anatomy of interest in a field-of-view of the gamma camera. The gamma camera also includes a chamfered edge to enable the gamma camera to contact a second gamma camera when the gamma camera is positioned in an L-mode imaging configuration. | 12-30-2010 |
| 20110147574 | CALIBRATION SOURCE AND METHODS FOR CALIBRATING A NUCLEAR MEDICINE IMAGING SYSTEM - Systems and methods for calibrating a nuclear medicine (NM) imaging system are provided that include an NM calibration source. The NM calibration source includes an isotope source having an energy spectrum with at least one energy peak and a fluorescence layer adjacent the isotope source creating at least one additional energy peak in the energy spectrum. | 06-23-2011 |
| 20110155918 | SYSTEMS AND METHODS FOR PROVIDING A SHARED CHARGE IN PIXELATED IMAGE DETECTORS - Systems and methods for providing a shared charge in pixelated image detectors are provided. One method includes providing a plurality of pixels for a pixelated solid state photon detector in a configuration such that a charge distribution is detected by at least two pixels and obtaining charge information from the at least two pixels. The method further includes determining a position of an interaction of the charge distribution with the plurality of pixels based on the obtained charge information. | 06-30-2011 |
| 20110216880 | SYSTEM AND METHOD FOR MOLECULAR BREAST IMAGING - A system and method for a molecular breast imaging (MBI) are provided. One MBI system includes at least one cadmium zinc telluride (CZT) detector having a plurality of pixels and a registered parallel hole collimator coupled to a face of the CZT detector. The registered parallel hole collimator includes a plurality of collimator holes, wherein the plurality of collimator holes are aligned with the plurality of pixels, and the spatial dimensions of the plurality of holes are configured based on characteristics of the CZT detector and the registered parallel hole collimator. | 09-08-2011 |
| 20110220783 | METHODS AND SYSTEMS FOR CALIBRATING A NUCLEAR MEDICINE IMAGING SYSTEM - Methods and systems for calibrating a nuclear medicine imaging are provided. One method includes acquiring spatially determined non-uniform radiation flux information from a calibration scan of a calibration source using a gamma camera having an attached non-parallel-hole collimator. The method further includes determining a measured non-uniform count density profile from the acquired non-uniform radiation flux information. The method also includes creating a gamma camera uniformity correction map derived from (i) the measured non-uniform count density profile and (ii) a modeled or calculated non-uniform count density profile for calibrating the NM imaging system. | 09-15-2011 |
| Patent application number | Description | Published |
|---|
| 20100086137 | INTEGRATED AMBIENT AUDIO TRANSFORMATION DEVICE - A method and device for transforming ambient audio are provided. Example embodiments may include monitoring ambient audio proximate to a sound processing device located in an environment. The device may access memory to obtain transformation audio and generate output transformation audio based on the transformation audio and the ambient audio to provide modified output audio for propagation into the environment. The device may at least reduce feedback of the modified output audio received by the sound processing device from the environment. | 04-08-2010 |
| 20100086138 | AMBIENT AUDIO TRANSFORMATION MODES - A method and device for transforming ambient audio are provided. Example embodiments may include monitoring ambient audio proximate to a sound processing device located in an environment. The device may receive a selection from a user interface. The selection may comprise one of a number of available first selections, each available first selection identifying one of multiple transformation modes. The device may access memory to obtain transformation audio and process the transformation audio, based on the ambient audio and the selection. The device may also use the transformation audio to provide modified output audio for propagation into the environment. | 04-08-2010 |
| 20100086139 | ADAPTIVE AMBIENT AUDIO TRANSFORMATION - A method and device for transforming ambient audio are provided. Example embodiments may include monitoring ambient audio proximate to a sound processing device located in an environment. The device may sense environmental conditions associated with the environment. Memory may be accessed to obtain transformation audio. The device may generate output transformation audio based on the transformation audio, the ambient audio, and the environmental conditions to provide modified output audio for propagation into the environment | 04-08-2010 |
| 20100086141 | AMBIENT AUDIO TRANSFORMATION USING TRANSFORMATION AUDIO - A method and device for transforming ambient audio are provided. Example embodiments may include monitoring ambient audio proximate to a sound processing device located in an environment. The device may analyze the ambient audio to derive one or more first characteristics. Memory may be accessed to obtain at least one transformation audio from a number of stored transformation audio. Each stored transformation audio may have one or more associated characteristics. A characteristic associated with the transformation audio may match one or more of the first characteristics. The device may generate output transformation audio based on the one or more transformation audio to provide modified output audio for propagation into the environment. | 04-08-2010 |
| Patent application number | Description | Published |
|---|
| 20100030780 | IDENTIFYING RELATED OBJECTS IN A COMPUTER DATABASE - Provided are, among other things, systems, methods and techniques for identifying related objects in a computer database. In one representative implementation: (a) a feature vector that describes an existing object is obtained; (b) comparison scores are generated between the feature vector and various sample vectors; (c) a set that includes at least one designated vector is identified from among the sample vectors by evaluating the generated comparison scores; (d) a computer database is searched for matches between label(s) for the designated vector(s) and labels for representative vectors for other objects represented in the computer database; and (e) at least one related object is identified based on the identified match(es). | 02-04-2010 |
| 20110016520 | AUTHENTICATION SYSTEM AND METHODS - A system and methods authenticate sensitive information such as passwords. Password characters are transformed into distorted characters and distorted character groups are generated such that each distorted password character is part of a group. An image is created containing the groups and the password or other sensitive information is authenticated when groups are identified within the image that contain the password characters in an expected sequence. | 01-20-2011 |
| 20110184894 | GENERATING A SET OF ATOMS - An automated method comprises receiving training data representing an initial data set including text representing at least one concept embodied by the data set, using the training data in order to generate a set of atoms, each atom comprising at least one word that represents one or more concepts of the initial data set, wherein generating a set of atoms comprises minimising a cost function using an iterative process to identify one or more atoms. | 07-28-2011 |
| 20110185234 | SYSTEM EVENT LOGS - An automated method of processing computer system event logs comprises receiving event messages associated with one or more system event logs, each event message including event text, determining a set of message clusters, each comprising a template text, representative of the event messages across the one or more event logs, and assigning each event message to a message cluster of the set, according to a measure of similarity between the respective event text of the event message and the template text of the message cluster. | 07-28-2011 |
| Patent application number | Description | Published |
|---|
| 20090145900 | FOOD CONTAINER SYSTEM WITH HANDLE STRAP - The food container system can comprise a lid, tray, and strap. The strap can comprise signage, a handle, and two attachment ends on the sides of the handle. The signage can convey information to a user concerning certain product information and/or other information. | 06-11-2009 |
| 20090145916 | FOOD CONTAINER SYSTEM WITH HANDLE STRAP - The food container system can comprise a lid, tray, and strap. The strap can comprise signage, a handle, and two attachment ends on the sides of the handle. The signage can convey information to a user concerning certain product information and/or other information. | 06-11-2009 |
| 20090211941 | Display and Storage Container - A container comprises a clamshell-like shape. The container includes a hinge positioned low on a viewing face and opens high on the rear end. The interior of the container is shaped so as to present its contents at a desirable viewing angle, the container intended to provide an unobstructed view through the viewing face. The container may comprise a closing mechanism at the rear end to hold the container closed. The container can contain products for sale, including cookies, slices of pound cake, other baked goods, and other products. | 08-27-2009 |
| 20100155402 | DISPLAY AND STORAGE CONTAINER - A container can have a viewing end, a rear end, a top section, and a bottom section. The bottom section can be configured such that the top and bottom sections come together at a border and be attached by a hinge along one portion of the border at the viewing end. The border can be configured such that it is higher at the rear end and lower at the viewing end. Additionally, the hinge can be tearable and the border can form a seam that makes a free rim of the top section unavailable. | 06-24-2010 |
| Patent application number | Description | Published |
|---|
| 20080292632 | Irta2 Antibodies and Methods of Use - Antibodies that specifically bind the extracellular domain of IRTA2 are disclosed herein. In one embodiment, these antibodies do not specifically bind IRTA1, IRTA3, IRTA4, or IRTA5. In one example, the antibodies are humanized antibodies. The antibodies can be conjugated to effector molecules, including detectable labels, radionucleotides, toxins and chemotherapeutic agents. The antibodies that specifically bind IRTA2 are of use to detect B cell malignancies, such as hairy cell leukemia and non-Hodgkin's lymphoma. These antibodies that specifically bind IRTA2 are also of use to treat B cell malignancies that express IRTA2, such as hairy cell leukemia and non-Hodgkin's lymphoma. | 11-27-2008 |
| 20090208518 | IMMUNOGENIC PEPTIDES FOR THE TREATMENT OF PROSTATE AND BREAST CANCER - Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO: 9 and do not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO: 1. Several specific, non-limiting examples of these polypeptides are set forth as SEQ ID NOs: 3-7. Nucleic acids encoding these polypeptides, and host cells transfected with these nucleic acids, are also disclosed. Methods of using these polypeptides, and polynucleotides encoding these polypeptides, for the treatment of breast and prostate cancer are also disclosed. | 08-20-2009 |
| 20090280556 | Mesothelin, A Differentiation Antigen Present On Mesothelium, Mesotheliomas, and Ovarian Cancers and Methods and Kits for Targeting the Antigen - This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting and/or inhibiting the growth of cells bearing mesothelin, methods for detecting the antigen and its expression level as an indication of the presence of tumor cells, and kits for such detection. | 11-12-2009 |
| 20090304702 | GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE - A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer. | 12-10-2009 |
| 20090305411 | RECOMBINANT ANTIBODIES AND IMMUNOCONJUGATES TARGETED TO CD-22 BEARING CELLS AND TUMORS - Methods and compositions relating to anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a | 12-10-2009 |
