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Insel
Olaf Insel, Rothemuhle DE
| Patent application number | Description | Published |
|---|---|---|
| 20110109105 | ENERGY ABSORBER WITH LOBES PROVIDING UNIFORM PEDESTRIAN IMPACT - A bumper system includes an injection molded energy absorber of polymeric material having hollow longitudinally-spaced lobes configured to crush and absorb energy during a pedestrian impact, and straps interconnecting adjacent lobes. The lobes are particularly sized and dimensioned, including potentially external ribs and/or apertures in corners, to provide a relatively uniform impact energy absorption during an impact stroke during crush of the shear walls of the lobes, such as within +/−30% or more preferably within +/−20% of a desired amount regardless of a specific location of impact, along a selected center portion of the energy absorber. A reason for the uniformity is to promote pedestrian safety regardless of the specific location where a pedestrian's leg strikes the energy absorber. | 05-12-2011 |
Paul A. Insel, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090131353 | Diagnosis and Treatment of Chronic Lymphocytic Leukemia (CLL) - The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided. | 05-21-2009 |
Paul A. Insel, Atlanta, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110117562 | Diagnosis and Treatment of Chronic Lymphocytic Leukemia (CLL) - The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL, particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided. | 05-19-2011 |