| Patent application number | Description | Published |
|---|
| 20080206885 | Environmentally sensitive fluorophores - The present invention provides novel fluorophore compounds. | 08-28-2008 |
| 20090082577 | FLUORESCENT PROBES FOR BIOLOGICAL STUDIES - The present invention provides fluorescent compounds of formula (I) | 03-26-2009 |
| 20100168428 | ENVIRONMENTALLY SENSITIVE FLUOROPHORES - The present invention generally relates to environment-sensitive fluorophores, including environment-sensitive fluorophores for reporting protein/protein and peptide/protein interactions. In one aspect, the present invention is directed to compounds and salts thereof, compositions and methods useful in determining biological interactions. In some cases, the compounds of the present invention are environment-sensitive fluorophores that have spectroscopic behavior that may depend on factors such as the physicochemical properties of the surrounding environment. The compounds of the present invention can be used, in certain embodiments, to monitor ions, small molecules, and biological processes such as protein folding, protein-protein interactions and phosphorylation events. | 07-01-2010 |
| 20110053180 | KINASE SENSORS - The present invention generally relates to compositions and methods for determining kinase activity. In some cases, the compositions comprise a triazole heterocycle. In some embodiments, the compositions comprise a quinoline moiety. In one aspect, the present invention is directed to compositions that undergo chelation-enhanced fluorescence (CHEF). In some cases, the compositions may have fluorescence emission spectra with peak maxima greater than 490 nm. The compositions of the present invention can be used, in certain embodiments, to detect phosphorylated substrates and biological processes such as phosphorylation events. | 03-03-2011 |
