Huxley
Alice Huxley, Binningen CH
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20100173919 | PHARMACEUTICAL COMPOSITION USING ALISKIREN AND AVOSENTAN - The present invention relates to a pharmaceutical composition and method of achieving a therapeutic effect including, but not limited to, the treatment of hypertension, kidney or heart disease in an animal, preferably a mammal including a human subject, using (i) SPP100/aliskiren or a pharmaceutically acceptable salt thereof in combination with (ii) SPP301/avosentan or a pharmaceutically acceptable salt thereof and (iii) a pharmaceutically acceptable carrier. | 07-08-2010 |
20140296129 | REGULATION OF RECEPTOR EXPRESSION THROUGH DELIVERY OF ARTIFICIAL TRANSCRIPTION FACTORS - The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a receptor gene promoter fused to an inhibitory or activatory protein domain, a nuclear localization sequence, and a protein transduction domain. In particular examples these receptor gene promoters regulate the expression of the endothelin receptor A, the endothelin receptor B, the Toll-like receptor 4 or the high-affinity IgE receptor. Artificial transcription factors directed to the endothelin A or B receptors are useful in the treatment of diseases modulated by endothelin, such as cardiovascular diseases, and, in particular, eye diseases, e.g. retinal vein occlusion, retinal artery occlusion, macular edema, optic neuropathy, central serous chorioretinopathy, retinitis pigmentosa, Leber's hereditary optic neuropathy, and the like. Artificial transcription factors directed to the Toll-like receptor 4 or the IgE receptor are useful for the treatment of autoimmune disorders, and the like, and allergic disorders, respectively. | 10-02-2014 |
Anthony Huxley, Harlow GB
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20110039833 | 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS - The present invention relates to novel diazepanyl derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders. | 02-17-2011 |
Iain Huxley, Sunnyvale, CA US
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20130013699 | Online Photosession - Methods, systems and computer readable medium with program instructions for sharing documents with other users in an online document sharing session include identifying a set of documents to share with viewing users at a document sharing website. The set of documents may have been uploaded onto the document sharing website by a sharing user and selected for sharing in an online document sharing session. One or more viewing users are selected for sharing the documents of the online document sharing session and access information to access the identified documents are provided. The access provides uniform level of control to both the viewing users and the sharing user so as to interact and manage the documents in the online document sharing session. The viewing users and the sharing user access, view and interact with the documents equally and the interactions are gathered and propagated to all the viewing the sharing users in substantial real-time. | 01-10-2013 |
Iain Andrew Huxley, Sunnyvale, CA US
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20120264427 | SMS-INITIATED MOBILE REGISTRATION - Embodiments are directed towards SMS-initiated mobile registration. A mobile device sends an SMS message to a mobile registration device. In response, the mobile registration device generates a random identifier and associates it with the mobile device identifier of the mobile device. Then, the mobile registration device sends a response SMS message to the mobile device, the response SMS message containing a Uniform Resource Identifier (URI) to a mobile registration web page, where the URI contains the generated random identifier. The mobile device uses the URI to navigate to the mobile registration web page, where additional registration information is provided. The mobile registration device associates the additional registration information with the mobile device based on the generated random identifier included in the URI, and creates a user account based on the mobile number from which the SMS message was received and the additional registration information. | 10-18-2012 |
Justin Robert Huxley, West Pymble AU
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20140094238 | Card Game - A card game is described in which two hands of cards are dealt, and players are invited to wager on whether one hand or the other will win, or whether the hands will tie. The hands may initially be formed from two cards each, and further cards may be added to the hands on the basis of a predetermined dealing tableau. Determination of the winner may be on the basis of a modified blackjack scoring system which provides for a winner even if both hands have totals over 21. In an alternative embodiment, the initial hands are formed from five cards each and the winning hand is determined by determining ascribing a rank value to the five-card combination and determining that the winning hand is the hand with the higher rank value. In some embodiments, the rank value may represent the highest-ranking poker hand which can be formed from the cards of each hand, and the winner will be the hand from which the higher-ranking poker hand can be formed. Rank values may be ascribed to 5-card combinations on the basis of other criteria or characteristics of the five-card combination. | 04-03-2014 |
Martin Huxley, St. Johns, Isle Of Man GB
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20100148983 | ELECTRICAL SUPPLY DEVICES - A mains electrical supply outlet comprising: signal-receiving means to receive an encoded wireless signal; a socket, connectable, in use, to an electricity-consuming device, to supply mains electricity thereto; a controller, powered by mains electricity, to decode said received encoded signal and, in response to said signal, to control switching of electrical power to said socket; and a connection sensor, to sense the connection of an electricity-consuming device to said socket and to disconnect power from said controller in the absence of such a connection. The invention also provides an electrical light switch assembly comprising: a manually operable light switch to control the supply of power to a lighting circuit; a manually operable remote power switch to actuate the transmission of an encoded wireless signal to the aforementioned mains electrical supply outlet. The invention further provides an electrical transmission assembly comprising: a plug suitable for receiving mains electricity; a socket suitable for conveying mains electricity received by the plug; and a manually operable remote power switch to actuate the transmission of an encoded wireless signal to the aforementioned mains electrical supply outlet. | 06-17-2010 |
Philip Huxley, Freeland GB
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20100168180 | Novel Compounds - A compound for use in the treatment of proliferative disorders, such as cancer, having the following formula: | 07-01-2010 |
20110092497 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES - Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: | 04-21-2011 |
20110218178 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES - Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: | 09-08-2011 |
20130023567 | Novel Compounds - A compound for use in the treatment of proliferative disorders, such as cancer, having the following formula: | 01-24-2013 |
Philip Huxley, Oxon GB
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20150057443 | Cycloalkyl Amine Compounds - Cycloalkyl amine compounds of Formula (I), | 02-26-2015 |
Stewart Huxley, Cambridge GB
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20110056494 | Blister Strip Coil Forming - A method of coiling a strip of blisters for insertion into an inhalation device is disclosed. The method includes the steps of taking a preformed strip of blisters in which each blister contains a dose of medicament for inhalation by a user, manipulating the strip to impart a continuous curvature or a series of discrete creases to the strip; that allow the strip to form into a coiled shape. A strip which has been coiled according to the method is also disclosed, as is an inhalation device incorporating means for coiling a strip of blisters according to the invention. | 03-10-2011 |
Stewart Leonard Huxley, Cambridge GB
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20090154298 | CLOCK - A clock comprising concentric rings of slots slits for indicating time by fully illuminating an appropriate one of the slots. Full illumination is propagated from one slot to an adjacent slot by causing all of the slots in a ring of slots to briefly light up sequentially, thus causing a flash of light to propagate around the ring of slots, thus more clearly showing passage of a second, a minute et as the illumination was switched from the one slot to the adjacent slot. | 06-18-2009 |