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| 20120022139 | Short Interfering Ribonucleic Acid (siRNA) for Oral Administration - Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification. | 01-26-2012 |
| 20120029052 | Short Interfering Ribonucleic Acid (siRNA) for Oral Administration - Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification. | 02-02-2012 |
| 20120029053 | Short Interfering Ribonucleic Acid (siRNA) for Oral Administration - Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification. | 02-02-2012 |
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| 20100145459 | ZERO-PROFILE INTERBODY SPACER AND COUPLED PLATE ASSEMBLY - An implant for insertion into a disc space between vertebrae, wherein the implant includes a spacer portion, a plate portion coupled to the spacer portion, two bone fixation elements for engaging the vertebrae and a retention mechanism for preventing the bone fixation elements from postoperatively backing-out of the plate portion. The retention mechanism may be in the form of a spring biased snapper element that is biased into communication with the bone fixation elements so that once the bone fixation element advances past the snapper element, the snapper element is biased back to its initial position in which the snapper element interfaces with the bone fixation elements. Alternatively, the retention mechanism may be in the form of a propeller rotatable between a first position in which the bone fixation elements are insertable to a second position where the bone fixation elements are prevented from backing-out. | 06-10-2010 |
| 20100145460 | ZERO-PROFILE INTERBODY SPACER AND COUPLED PLATE ASSEMBLY - An implant for insertion into the disc space between vertebrae. The implant including a spacer portion, a plate portion coupled to the spacer portion, a plurality of bone fixation elements for engaging the vertebrae and a retention mechanism for preventing the bone fixation elements from postoperatively uncoupling from the implant. | 06-10-2010 |
| 20100305704 | INTERVERTEBRAL IMPLANT WITH FIXATION GEOMETRY - An intervertebral spacer implant ( | 12-02-2010 |
| 20100312346 | LOW PROFILE INTERVERTEBRAL IMPLANT - The present invention is directed to a low profile intervertebral implant ( | 12-09-2010 |
| 20110137347 | NON-FUSION SCOLIOSIS EXPANDABLE SPINAL ROD - A growing rod for mounting between attachment mechanisms that are secured to anatomical structures of a patient having scoliosis. The growing rod includes a base rod having an attachment end, an extendable rod that is translatable relative to the base rod along a longitudinal axis and a housing enclosing at least a portion of the extendable rod therein. A magnet is rotatably mounted within the housing and is enclosed by a top magnet cover and a bottom magnet cover. The magnet includes a first pole and a second pole. A gear reduction mechanism is associated with the magnet and the extendable rod. The gear reduction mechanism reduces an output rotation to the extendable rod relative to an input rotation from the magnet. | 06-09-2011 |
| 20110172710 | MINIMALLY INVASIVE INTERSPINOUS PROCESS SPACER IMPLANTS AND METHODS - An interspinous process spacer for implantation in an interspinous space between a superior spinous process and an inferior spinous process includes a balloon-like body, a first deployable protrusion and a second deployable protrusion. The body has a distal end, a proximal end and a longitudinal axis extending between the proximal and distal ends. The spacer is arrangeable in an unexpanded configuration and an expanded configuration. The first deployable protrusion is mounted proximate the proximal end and the second deployable protrusion is mounted proximate the distal end. The first and second deployable protrusions are oriented generally parallel to the longitudinal axis in the unexpanded configuration and generally perpendicular to the longitudinal axis in the expanded configuration. | 07-14-2011 |
| 20110190817 | MINIMALLY INVASIVE INTERSPINOUS PROCESS SPACER IMPLANTS AND METHODS - An interspinous process spacer for implantation in an interspinous space between a superior spinous process and an inferior spinous process includes a balloon-like body, a first deployable protrusion and a second deployable protrusion. The body has a distal end, a proximal end and a longitudinal axis extending between the proximal and distal ends. The spacer is arrangeable in an unexpanded configuration and an expanded configuration. The first deployable protrusion is mounted proximate the proximal end and the second deployable protrusion is mounted proximate the distal end. The first and second deployable protrusions are oriented generally parallel to the longitudinal axis in the unexpanded configuration and generally perpendicular to the longitudinal axis in the expanded configuration. | 08-04-2011 |
| 20120004692 | Remotely Adjustable Tissue Displacement Device - The invention relates to an apparatus for displacing tissue within the body, wherein the apparatus includes two or more attachment members selectively displaceable with respect to each other via a driving member. The driving member preferably is rotatable and is caused to rotate by a magnetic actuator that can be activated by a magnetic field from outside the body. | 01-05-2012 |
| 20120130428 | NON-FUSION SCOLIOSIS EXPANDABLE SPINAL ROD - A growing rod for mounting between attachment mechanisms that are secured to anatomical structures of a patient having scoliosis. The growing rod includes an outer housing and an inner housing disposed within the outer housing. The inner housing includes a magnet assembly including a magnet having a first pole and a second pole and a gear reduction mechanism coupled to the magnet. A first rod is secured to the inner housing and a second rod is secured to the outer housing. The gear reduction mechanism reduces an output rotation of the magnet to rotate a driver that operates to move the inner housing along a longitudinal axis with respect to the outer housing. | 05-24-2012 |
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| 20100120948 | PROCESS FOR GRINDING AN AN AQUEOUS MEDIUM OF MINERAL MATTER AND BINDERS USING A REVERSE EMULSION OF A POLYMER ACRYLAMIDE WITH AN ACRYLIC MONOMER - The invention consists of a process for preparation of self-binding pigmentary particles, dry or in aqueous suspension or dispersion, using in a particular stage of the process a reverse emulsion formed from a dispersion in an oily phase of water particles and of at least one polymer of acrylamide with an acrylic monomer. | 05-13-2010 |
| 20100222484 | Process of Manufacture of Particles With a Natural Calcium Carbonate and Ethylene Acrylic Acid Salts Base, Suspensions and Dry Pigments Obtained, Their Uses - The present invention consists of a process of preparation of at least one mineral matter and/or of at least one pigment, including a calcium carbonate made at once partially organophilic and partially hydrophilic, in which the carbonate is blended and/or ground and/or concentrated in an aqueous medium, in the presence of at least one salt of ethylene acrylic acid, one dispersing agent and/or one grinding aid agent, which is introduced before and/or during this treatment stage. | 09-02-2010 |
| 20120016061 | PROCESS TO PREPARE SELF-BINDING PIGMENT PARTICLES IMPLEMENTING ACRYLIC COMB COPOLYMERS WITH HYDROPHOBIC GROUPS AS COUPLING AGENTS, SELF BINDING PIGMENT PARTICLES AND USES THEREOF - The present invention relates to a process to prepare self-binding pigment particles comprising at least one step a) of grinding one or more binders and one or more mineral materials in an aqueous environment to obtain a suspension, characterised in that, prior to and/or during step a), a copolymer is added in the form of an aqueous solution, said copolymer resulting from the polymerisation of: 2.1) at least one anionic monomer that is an alkene; 2.2) at least one oxyalkylated monomer that is an alkene, wherein the oxyalkyl group has a terminal hydrophobic alkyl, aryl, alkyl aryl or aryl alkyl group having 10 to 32 carbon atoms; 2.3) optionally, at least one other monomer that is an acrylic ester, a preferred acrylic ester being ethyl acrylate, and/or an unsaturated amide, a preferred unsaturated amide being acrylamide, as well as to the products obtained by this process, and uses of these products. | 01-19-2012 |
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| 20090232791 | METHODS AND COMPOSITIONS FOR TISSUE REGENERATION - Disclosed is a kit comprising a first component comprising fibrinogen, aprotinin, and a buffered solution, and a second component comprising, fibroblasts, keratinocytes, thrombin, glycerol, human serum albumin, and a buffered solution, wherein the first and second components are comprised in separate sterile containers. | 09-17-2009 |
| 20090257986 | EPIDERMAL AND DERMAL EQUIVALENTS - The present invention relates to the treatment of skin defects by organotypically-cultured autologous keratinocytes isolated from the outer root sheath of anagen or growing hair. Methods for primary, as well as subsequent organotypic cultures (i.e., epidermal equivalents) in fully-defined media supplemented by autologous human serum and substances isolated form blood components, with minimal allogeneic biological supplements, are disclosed herein. Techniques to prepare epidermal equivalents for transplantation by use of a biocompatible glue are also disclosed herein. | 10-15-2009 |
| 20100068281 | METHODS AND COMPOSITIONS FOR TISSUE REGENERATION - Disclosed is a composition comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ, angiopoietin, EGF, IL-Iβ, IL-6, IL-8, TGFα, and TNFα and an extracellular matrix comprising alginate, wherein the cells are allogeneic and mitotically inactive. | 03-18-2010 |
| 20100310526 | COSMETIC METHOD FOR INCREASING THE PIGMENTATION OF SKIN USING MELANOCYTE PRECURSOR CELLS - The present invention proposes a cosmetic method for increasing the pigmentation of skin with the steps application of melanocyte precursor cells from root sheaths collected from a first area of skin of a donor to a second area of skin of a recipient. Furthermore, the use of melanocyte precursor cells for increasing the pigmentation of skin as well as a method for producing a suspension having precursor cells from the root sheath is proposed. | 12-09-2010 |
| 20110083987 | METHODS AND COMPOSITIONS FOR TISSUE REGENERATION - A kit is disclosed that includes a first component comprising alginate, wherein the first component is comprised in a first sterile vial, and a second component comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ, angiopoietin, EGF, IL-Iβ, IL-6, IL-8, TGFα, and TNFα, wherein the cells are allogeneic and mitotically inactive, a buffered solution, and human serum albumin or a cryoprotectant, wherein the second component is comprised in a second sterile vial. | 04-14-2011 |
| 20120064049 | USE OF STEM CELLS FROM HAIR ROOT SHEATHS AND KERATINOCYTE PRECURSOR CELLS FOR THE REGENERATION OF AGED SKIN - The present invention relates to the use of stem cells from hair root sheaths and/or keratinocyte precursor cells for the regeneration of aged but otherwise healthy and non-injured skin for the cosmetic purposes and for the prevention of skin diseases. In addition, the invention is directed to a cosmetic method for the regeneration of aged skin. | 03-15-2012 |
| 20120134962 | METHODS AND COMPOSITIONS FOR TISSUE REGENERATION - Disclosed is a method of treating a wound comprising applying a composition to a wound site on a patient in need of wound treatment, wherein the composition comprises mitotically inactive allogeneic cells that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ, angiopoietin, EGF, IL-Iβ, IL-6, IL-8, TGFα, and TNFα, and wherein the cells are keratinocytes or fibroblasts, or mixtures thereof. | 05-31-2012 |
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| 20100035373 | Method for manufacturing a sensor device with a stress relief layer - A method for packaging a sensor device having a sensitive structure integrated on a semiconductor chip is provided. When molding the device package, an inward extending section of the mold maintains an access opening to the sensor. A buffer layer is arranged on the chip between the inward extending section and the sensitive structure. The buffer layer protects the sensitive structure from damage by the inward extending section and acts as a seal while casting the housing. The buffer layer also covers at least part of the semiconductor electronic components of the circuitry integrated onto the chip. By covering these components, mechanical stress, as it is e.g. caused by different thermal expansion coefficients of the packaging and the chip, can be reduced. | 02-11-2010 |
| 20100117185 | Temperature sensor with buffer layer - A temperature sensor with a bandgap circuit is provided. The bandgap circuit is covered by a buffer layer of photoresist. The device is packaged in a housing. By providing the buffer layer, mechanical stress in the bandgap circuit, as it is e.g. caused by different thermal expansion coefficients of the packaging and the chip, can be reduced. This improves the accuracy of the device. | 05-13-2010 |
| 20100212433 | Sensor in a moulded package and a method for manufacturing the same - The flow sensor or other type of sensor comprises a package having a cylindrical section arranged between an anchor section and a head section. The diameter of the anchor section is typically larger than the diameter of the cylindrical section, which in turn is typically larger than the diameter of the head section. A sensor chip is embedded partially into the package, with a sensitive area being exposed to the surroundings. The sensor can e.g. be inserted into a bore having a diameter matching the one of the cylindrical section. | 08-26-2010 |
| 20120217593 | SENSOR MOUNTED IN FLIP-CHIP TECHNOLOGY AT A SUBSTRATE EDGE - The sensor assembly comprises a substrate ( | 08-30-2012 |
