Patent application number | Description | Published |
20080269466 | Modified Antibody Fragments - The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region. | 10-30-2008 |
20090239263 | Expression Control Using Antibody Expression Optimisation Sequences - The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream cistron contains DNA coding for the corresponding heavy chain, characterised in that the dicistronic message comprises a sequence selected from AEOS1 (SEQ ID NO:1), AEOS2 (SEQ ID NO:2), AEOS3 (SEQ ID NO:3), AEOS4 (SEQ ID NO: 4), AEOS5 (SEQ ID NO:5), AEOS6 (SEQ ID NO:6), AEOS7 (SEQ ID NO:7), AEOS8 (SEQ ID NO:8), AEOS9 (SEQ ID NO:9), AEOS1O (SEQ ID NO:10) and AEOS1 1 (SEQ ID NO:11). | 09-24-2009 |
20100093977 | Altered Antibodies - This invention relates to engineering of antibodies and more specifically provides altered antibodies of the IgG class to which one or more effector molecules are attached. The invention further relates to methods for the production of such conjugated antibodies. | 04-15-2010 |
20100239582 | Dual Specificity Antibody Fusions - The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab′ fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest. | 09-23-2010 |
20130108622 | DISULFIDE STABILIZED ANTIBODIES AND FRAGMENTS THEREOF | 05-02-2013 |
20130323236 | Antibodies of the Class IGG4 - The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a C | 12-05-2013 |
20150274810 | Disulfide Stabilised Antibodies and Fragments Thereof - The present disclosure provides an antibody or antibody fragment comprising at least one Fab molecule, wherein the light chain variable region, V | 10-01-2015 |
Patent application number | Description | Published |
20120258492 | BACTERIAL HOST STRAIN - A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest. | 10-11-2012 |
20120288894 | BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC AND HAVING REDUCED TSP ACTIVITY - The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding DsbC and has reduced Tsp protein activity compared to a wild-type cell. | 11-15-2012 |
20120295309 | BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND HAVING REDUCED TSP ACTIVITY - The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell. | 11-22-2012 |
20120301920 | BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND A WILD-TYPE TSP GENE - The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non-recombinant wild-type chromosomal Tsp gene. | 11-29-2012 |
20130243772 | ANTIBODY MOLECULES HAVING SPECIFICITY FOR HUMAN OX40 - The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules. | 09-19-2013 |
20130302336 | DISULFIDE STABILIZED DVD-IG MOLECULES - A re-epoxidized polyfunctional epoxy resin composition comprising the reaction product of: (I) an epoxidized polyfunctional epoxy resin oligomeric composition comprising a polyfunctional aliphatic or cycloaliphatic epoxy resin which has been isolated from an epoxy resin product formed as a result of an epoxidation process comprising the reaction of: (i) an aliphatic or cycloaliphatic hydroxyl-containing material; (ii) an epihalohydrin, (iii) a basic-acting substance, in the presence of (iv) a non-Lewis acid catalyst; and (v) optionally, one or more solvents; (II) an epihalohydrin; (III) a basic acting substance; in the presence of (IV) a non-Lewis acid catalyst; and (V) optionally, one or more solvents. A curable epoxy resin composition of the re-epoxidized polyfunctional epoxy resin composition and a thermoset of the curable composition is also disclosed. | 11-14-2013 |
20140141468 | BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DSBC - The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector, comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to CD154. | 05-22-2014 |
20140194596 | Dual Specificity Antibody Fusions - The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab′ fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest. | 07-10-2014 |
20140302033 | ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF - A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same. | 10-09-2014 |
20140348844 | NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXINS TCDA AND TCDB OF CLOSTRIDIUM DIFFICILE - This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of | 11-27-2014 |
20150017169 | Sequence Asymmetric Modified IgG4 Bispecific Antibodies - The present disclosure provides an asymmetric mixed antibody comprising two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a CH1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, and wherein the second heavy chain or fragment thereof is characterised in that part or all of the chain has a different amino acid sequence to said first heavy chain in at least the region outside the variable region (for example the constant region), formulations comprising the same, therapeutic used of both of the above, and processes for preparing the antibodies and formulation. | 01-15-2015 |
20150018529 | Sequence Symmetric Modified IgG4 Bispecific Antibodies - The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain: the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations. | 01-15-2015 |
20150111249 | Recombinant Bacterial Host Cell for Protein Expression - The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti Fc Rn antibodies and proteins made by the methods described herein. | 04-23-2015 |
20150132828 | BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND HAVING REDUCED TSP ACTIVITY - The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell. | 05-14-2015 |
Patent application number | Description | Published |
20090314544 | Well Drilling and Production Using a Surface Blowout Preventer - Production and drilling may be achieved by a system which uses a rotating head coupled to surface blowout preventer stack for fluid flow control. A casing connects these surface components to a subsea shutoff assembly with a pair of ram shear devices to cut off the string to the wellhead. Both the casing and an alternate line may be latched so that they may be released if necessary. The rotating head may include a rubber packer to prevent upward flow of drilling fluid and production hydrocarbons and, at the same time, provide rotation to the drill string. Managed pressure drilling or under balanced drilling may be used in some embodiments. | 12-24-2009 |
20100098498 | Anchor system for offshore dynamically positioned drilling platform - An anchor system may reduce stress on anchor cables when an offshore drilling platform weathervanes. The anchor system may hold the platform in a set position above the sea floor during drilling operations. The anchor system includes anchor cables that pass through a split bearing. Clamps may be connected to the bearing to hold the anchor cables in tension. | 04-22-2010 |
20110127040 | ASSEMBLY AND METHOD FOR SUBSEA WELL DRILLING AND INTERVENTION - An assembly suitable for subsea drilling and intervention operations includes a dual blow out preventer system having an upper blow out preventer located between a drill floor and a riser string, and a lower blow out preventer located below the riser string and above a wellhead. The dual BOP system is adapted to enable advanced drilling and intervention operations such as Managed Pressure Drilling (“MPD”), Underbalanced Drilling (“UBD”), or Through Tubing Rotary Drilling (“TTRD”) in an offshore deepwater environment. | 06-02-2011 |
20110247827 | Dual Drilling Activity Drilling Ship - A single drilling ship may be equipped with two drilling centers, each capable of running risers. Each drilling center has a set of tubulars stored for use in association with that drilling center, those tubulars including risers. However, the risers for one drilling center are of a smaller diameter than the risers for the other drilling center. In the event that a main drilling center drilled well fails, a relief well can then be drilled from the same ship using a secondary drilling center. | 10-13-2011 |
20120055678 | DUAL ACTIVITY DRILLING SHIP - Dual gradient drilling may be performed by anchoring drilling tubulars from a drilling ship on the seabed. The drilling tubulars may include an inline pump for pumping mud through another set of tubulars that actually drill the well. Then dual gradient drilling may be instituted by controlling the pressure by controlling the operation of the pump. | 03-08-2012 |
20120291684 | Ice Breaking Drilling Vessel With Stowable Mast - A drilling vessel may function both as an ice breaker and, if needed, as a drilling platform for drilling a relief well. The vessel may be provided with a mast that may be stowed when drilling operations are not being conducted. | 11-22-2012 |
20140144646 | Well Safety Equipment - An independently operable disconnect device remotely disconnectable from an LMRP to reveal a riser profile compatible with a capping device connecter. A capping device including a capping device connector to be coupled to said riser profile. The capping device includes at least one blow-out preventer operable to stop the overflow of petroleum products from a well. Thus, a drilling marine riser may be fully disconnected from an LMRP in an emergency. Then the well may be subsequently capped. | 05-29-2014 |
20140209004 | Ice Breaking Drilling Vessel With Stowable Mast - A drilling vessel may function both as an ice breaker and, if needed, as a drilling platform for drilling a relief well. The vessel may be provided with a mast that may be stowed when drilling operations are not being conducted. | 07-31-2014 |
20150083432 | Triple Activity Drilling Ship - A triple activity drilling ship may be provided with two separate drilling centers, each including drilling apparatus. In addition, a trolley that is capable of supporting tubulars may be positioned between a first position within one of said drilling centers and a second position outside that drilling center. As a result, the trolley may be used to hold assembled tubulars while other activities are ongoing in one or more of the drilling centers. | 03-26-2015 |
20150267482 | Triple Activity Drilling Ship - A triple activity drilling ship may be provided with two separate drilling centers, each including drilling apparatus. In addition, a trolley that is capable of supporting tubulars may be positioned between a first position within one of said drilling centers and a second position outside that drilling center. As a result, the trolley may be used to hold assembled tubulars while other activities are ongoing in one or more of the drilling centers. | 09-24-2015 |