Patent application number | Description | Published |
20090203025 | BRANCHED AND MULTI-CHAIN NUCLEIC ACID SWITCHES FOR SENSING AND SCREENING - Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and a tether that holds P and C together and a signaling apparatus. Some embodiments include a toggle strand (T) where now the tether holds P, C, T, and the signaling apparatus together. As the switch changes between the first and second conformations; the signaling apparatus reports the state of the switch. The signaling entity is typically a lumiphore and a quencher located along the switching framework. Nucleic acid switches have applications in real time assays for diverse agents including infectious agents, environmental toxins, and terrorist agents, as well as screening methods for such agents. Further applications are found for nanoelectronics, nanofabrication and nanomachines. | 08-13-2009 |
20110059555 | BRANCHED AND MULTI-CHAIN NUCLEIC ACID SWITCHES FOR SENSING AND SCREENING - Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and a tether that holds P and C together and a signaling apparatus. Some embodiments include a toggle strand (T) where now the tether holds P, C, T, and the signaling apparatus together. As the switch changes between the first and second conformations; the signaling apparatus reports the state of the switch. The signaling entity is typically a lumiphore and a quencher located along the switching framework. Nucleic acid switches have applications in real time assays for diverse agents including infectious agents, environmental toxins, and terrorist agents, as well as screening methods for such agents. Further applications are found for nanoelectronics, nanofabrication and nanomachines. | 03-10-2011 |
20110068064 | METHOD AND APPARATUS FOR SEPARATION OF PHARMACEUTICAL MATERIALS ON THE BASIS OF THEIR DENSITY - Systems and methods for separating particles of pharmaceutically active materials, based on differences in density. | 03-24-2011 |
Patent application number | Description | Published |
20100052549 | Illuminated Bollard for Loading Dock - A combination dock light and bollard serves the purposes of both, without having any sensitive structure projecting out from the bollard into the traffic lane at the loading dock. A lamp assembly within the bollard projects out a window cutout at an upper end of the tubular metal body of the bollard. The lamp assembly rests on a sub-plate welded into the bollard below the cutout. The lamp holder is mounted on compression springs held in place with machine screw, to permit adjustment of the lamp beam direction. A photo eye turns the lamp on when the loading dock door is opened, and off when the dock door is closed. | 03-04-2010 |
20100320918 | Illuminated Bollard with Safety Light for Loading Dock - A combination dock light, safety light, and bollard serves the purposes of all three, without having any sensitive structure projecting out from the bollard into the traffic lane at the loading dock. A trailer lamp assembly within the bollard projects out a window cutout at an upper end of the tubular metal body of the bollard. A red/green safety light is visible through an elongated cutout on the proximal side of the bollard. A photo eye turns the lamp on when the loading dock door is opened, and off when the dock door is closed, and also switches the safety light to green or to red depending on whether the dock door is opened or closed. | 12-23-2010 |
20130056995 | Sliding Pin Lock Mechanism for Overhead Door - A door lock mechanism for an overhead door employs a sliding pin or rod that passes into the path of the rollers in the track, and obstructs the roller from movement in the direction to open the door. A spring in the door lock frame biases the sliding pin towards a proximal open position. The sliding pin has an arm that extends radially from its proximal end, and which engages retaining structure at the proximal end of the door lock frame. The arm is rotated out of engagement with the retaining structure to release the pin so it may slide proximally to an unlocked position. The pin may slide into a receiver housing mounted on a door panel. | 03-07-2013 |
20150061300 | Sliding Pin Lock Mechanism for Overhead Door with Microswitch - A door lock mechanism for an overhead door employs a sliding pin or rod that passes into the path of the rollers in the track, and obstructs the roller from movement in the direction to open the door. A spring in the door lock frame biases the sliding pin towards a proximal open position. The sliding pin has a swing arm that extends radially from the pin's proximal end, and which engages retaining structure at the proximal end of the door lock frame. In the lock position the distal end of the sliding pin blocks movement of wheels or rollers in the vertical track. The arm is rotated out of engagement with the retaining structure to release the pin so it may slide proximally to an unlocked position. A microswitch in the interior of the lock switches on when the sliding pin is moved to the locked position and turns off when the pin is returned to its unlocked position. A sleeve disposed over the proximal part of the spring engages the actuator of the microswitch. | 03-05-2015 |