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| 20080205982 | Gating Impact Attenuator - The present invention relates primarily to highway safety devices, secondarily to on-board vehicle mounted safety devices and more particularly to enhancing the performance of such devices when occupants of vehicles are subjected to severe deceleration forces. | 08-28-2008 |
| 20080295522 | THERMO-ENERGY-MANAGEMENT OF SOLID-STATE DEVICES - The present invention reduces to practice discoveries made by the present inventors during their investigations into present-art-perceived-difficulties in thermal-management applications of solid-state devices. | 12-04-2008 |
| 20110250417 | Dimensional Lumber Structural Substitute - Dimensional lumber subjected to structural load regimes, where moment is the dominate load condition, usually fail structurally by initial localized compressive failure located at or near the maximum compressive extreme fiber. Said localized compressive failure, exhibited by buckling failure of maximum compressive fiber, results in an overall increase of section-modulus. The increase in section modulus, due to onset of structural failure, allows the lumber element in question to provide post-structural-failure increase in load-carrying-capacity with the trade-off of an increase in load-vs-deflection ratio. Said increase in load-carrying-capacity due to the increase in section-modulus, or thickening of the lumber element continues as an applied load is increased until the lumber element's tensile extreme fiber's capacity is exceeded, at which event the lumber element structurally fails catastrophically. The present invention, unlike previously disclosed compositions, unexpectedly mimics the stiffness and failure-mode structural characteristics of traditional dimensional lumber. A comparison of test data shows the present invention possesses unexpected improved properties that the present art does not have. | 10-13-2011 |
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| 20090151845 | PNEUMATIC TIRE - A pneumatic radial tire has a chipper in place of a traditional apex, the chipper located between a carcass main portion and turnup portion. The chipper layer may be composed of a chopped carbon fiber and aramid composite reinforced elastomeric layer. The tire sidewalls have a radial height SH and a section width SW located within a range of 0.4 to 0.44 of the sidewall radial height SH measured from the bead core. The section width SW may further be located within a range of 0.1″ to 0.3″ inches from a radially outward end of the chipper layer in a radial direction. The tread may of a dual layer construction, having a radially inward first layer formed of a relatively low rolling resistance compound and a radially outward second layer formed of a compound containing silica. | 06-18-2009 |
| 20100018618 | TIRE WITH TREAD HAVING A TWO-PLY TREAD CAP LAYER - The invention relates to a tire with a tread of a cap/base construction comprised of a two-ply (dual layered) tread cap rubber layer comprised of a combination of an outer tread cap layer and an inner tread cap layer together with an underlying tread base rubber layer which underlies the two-ply tread cap layer. The tread cap layer is of a lug and groove configuration with at least a portion of the grooves extending through the outer tread cap layer into the inner tread cap layer without extending to the tread base rubber layer. The outer tread cap rubber layer is comprised of a carbon black-rich rubber composition to promote dry traction for the tread running surface. The inner tread cap layer is comprised of a softer silica-rich rubber composition to promote wet traction for tread running surface as the outer tread cap layer wears away to expose the softer inner tread cap layer. | 01-28-2010 |
| 20110114240 | PNEUMATIC TIRE - A pneumatic radial tire having a circumferentially extending equatorial plane of the tire, the tire comprising a carcass, a tread radially outward of the carcass, the carcass comprising at least one carcass reinforcing ply, opposing bead portions, and opposing sidewalls, the carcass reinforcing ply having a main portion extending between the opposing bead portions and a pair of turnup portions, each turnup portion extending from one end of the main portion, each bead portion having a bead core, and a reinforcement cavity outward of each bead core, the cavity located between the main portion and one turnup portion of the at least one reinforcing ply, the tire characterized by:
| 05-19-2011 |
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| 20120071361 | Substrate Preparation Process - The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays. | 03-22-2012 |
| 20120173158 | TIME-WARPED BACKGROUND SIGNAL FOR SEQUENCING-BY-SYNTHESIS OPERATIONS - Methods for analyzing signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the method comprises formulating a function that models the output signal of a representative empty well of a reactor array. A time transformation is applied to the empty well function to obtain a time-warped empty well function. The time-warped empty well function is fitted to an output signal from the loaded well representative of a flow that results in a non-incorporation event in the loaded well. The fitted time-warped empty well function can then be used to analyze output signals from the loaded well for other flows. | 07-05-2012 |
| 20120264621 | PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS - A method for nucleic acid sequencing includes disposing template polynucleotide strands in defined spaces on a sensor array, at least some of the template polynucleotide strands having a sequencing primer and a polymerase operably bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed according to a predetermined ordering; and determining, for each of the series of flows of nucleotide species, how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands, wherein the predetermined ordering (a) is not a series of consecutive repetitions of a 4-flow permutation of four different nucleotide species, (b) is not specifically tailored to a particular combination of a particular template polynucleotide strand to be sequenced and a particular sequencing primer to be used, and (c) comprises a phase-protecting flow ordering. | 10-18-2012 |
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| 20080232657 | Feature Intensity Reconstruction of Biological Probe Array - The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data. | 09-25-2008 |
| 20080287308 | SYSTEM, METHOD, AND COMPUTER SOFTWARE PRODUCT FOR GENOTYPE DETERMINATION USING PROBE ARRAY DATA - An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate. | 11-20-2008 |
| 20110160092 | Methods for Selecting a Collection of Single Nucleotide Polymorphisms - The invention relates to the selection of a collection of relevant single nucleotide polymorphisms across a genome to design a nucleic acid probe array. As such, the invention relates to diverse fields impacted by the nature of genetics, including biology, medicine, and medical diagnostics. | 06-30-2011 |
| 20110274328 | Feature Intensity Reconstruction of Biological Probe Array - The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data. | 11-10-2011 |
| 20110281772 | Methods, systems and computer software for designing and synthesizing sequence arrays - Embodiments of the invention provides methods, computer software products and systems for arranging polymers during combinatorial polymer synthesis so that the border or edge between synthesis site is minimized. In one embodiment, travelling salesman algorithm is used to minimize the edges. In another embodiment, a locally greedy optimization method is provided. In addition, methods and software products are provided for solving the robust arrangement problem for multi-probe gene expression arrays. | 11-17-2011 |
| 20120221255 | System, Method, and Computer Software Product for Genotype Determination Using Probe Array Data - An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate. | 08-30-2012 |
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| 20100205027 | Business Driven Learning Solution Particularly Suitable for Sales-Oriented Organizations - Disclosed is a business driven learning solution and related methods for managing the learning and training needs of a sales-oriented organization in a manner that is responsive to dynamic business needs. The invention employs modules of interrelated and interdependent business processes for the identification and prioritization of learning needs, the selection of learning approaches, the development of learning content, the coordination and delivery of learning instruction, and the overall management and administration learning efforts. Embodiments of the inventions disclosed include sales training objects to provide a template for sales training that is focused on a solution, and how to position and sell the solution, rather than on the products that make up the solution. As a result, the sales force is educated, understands the customers' business requirements, and is able to craft specific value propositions to a given customer with respect to that solution. Thus, the training is customer-centric as opposed to product-centric. | 08-12-2010 |
| 20110264481 | BUSINESS DRIVEN LEARNING SOLUTION PARTICULARLY SUITABLE FOR SALES-ORIENTED ORGANIZATIONS - Disclosed is a business driven learning solution and related methods for managing the learning and training needs of a sales-oriented organization in a manner that is in responsive to dynamic business needs. The invention employs modules of interrelated and interdependent business processes for the identification and prioritization of learning needs, the selection of learning approaches, the development of learning content, the coordination and delivery of learning instruction, and the overall management and administration learning efforts. Embodiments of the inventions disclosed include sales training objects to provide a template for sales training that is focused on a solution, and how to position and sell the solution, rather than on the products that make up the solution. As a result, the sales force is educated, understands the customers' business requirements, and is able to craft specific value propositions to a given customer with respect to that solution. Thus, the training is customer-centric as opposed to product-centric. | 10-27-2011 |
