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Huang, NC
Andrew Huang, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080281568 | Gene Expression Profiling for Identification of Prognostic Subclasses in Nasopharyngeal Carcinomas - mRNA transcript profiling can be used to formulate molecular predictors of distant metastasis for primary NPCs. The predicted results are highly correlated with short metastasis-free and overall survival. Predictions are made using 52-genes based and 12-genes based predictors. | 11-13-2008 |
Andrew T. Huang, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110085973 | Methods and Agents for the Diagnosis and Treatment of Hepatocellular Carcinoma - The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein. | 04-14-2011 |
| 20110159498 | METHODS, AGENTS AND KITS FOR THE DETECTION OF CANCER - The present invention relates to methods of diagnosing a cancer in a subject, and methods of providing a prognosis for a subject that has a cancer. The invention also relates to diagnostic and prognostic kits for cancer. | 06-30-2011 |
| 20110217297 | METHODS FOR CLASSIFYING AND TREATING BREAST CANCERS - The present invention relates to methods of treating a breast cancer in a subject, methods of identifying a subject with a breast cancer as a candidate for a therapy having efficacy for treating a breast cancer molecular subtype, and methods of selecting a therapy for a subject with a breast cancer. The methods comprise determining the molecular subtype of the breast cancer in the subject. In some embodiments, the methods further comprise administering to the subject a therapy that is effective for treating the molecular subtype of the breast cancer. | 09-08-2011 |
| 20110262349 | Methods and Agents for the Diagnosis and Treatment of Hepatocellular Carcinoma - The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins, including humanized and chimeric antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising such polypeptide antagonists. | 10-27-2011 |
Biying Huang, Apex, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20120078853 | SYSTEMS, METHODS, AND APPARATUS FOR FACILITATING CHEMICAL ANALYSES - A knowledge management platform eliminates the trial and error process for analytical chemists in, for example, identifying appropriate methodologies for separating mixtures of chemical compounds. The platform allows the analytical chemists to perform a variety of searches on data existing from previous experiments, procedures, and/or processes. The platform may be employed to make faster decisions, and ultimately decreases the time taken in selecting an appropriate separation methodology. | 03-29-2012 |
Da Huang, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110133564 | Wireless Energy Transfer with Negative Index Material - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a negative index material (NIM) arranged within the EM near-field such that the coupling is enhanced. | 06-09-2011 |
| 20110133565 | Wireless Energy Transfer with Negative Index Material - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a negative index material (NIM) arranged within the EM near-field such that the coupling is enhanced. | 06-09-2011 |
| 20110133566 | Wireless Energy Transfer with Negative Material - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a negative index material (NIM) arranged within the EM near-field such that the coupling is enhanced. | 06-09-2011 |
| 20110133567 | Wireless Energy Transfer with Negative Index Material - Embodiments of the invention disclose a system configured to exchange energy wirelessly. The system includes a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a negative index material (NIM) arranged within the EM near-field such that the coupling is enhanced. | 06-09-2011 |
| 20110156486 | Wireless Energy Transfer with Negative Index Material - Embodiments of the invention disclose a method and a system configured to exchange energy wirelessly, comprising a structure configured to exchange the energy wirelessly via a coupling of evanescent waves, wherein the structure is electromagnetic (EM) and non-radiative, and wherein the structure generates an EM near-field in response to receiving the energy; and a controller configured to tune up the structure such that the near-field is generated according a particular energy distribution pattern. | 06-30-2011 |
| 20110156487 | Wireless Energy Transfer with Energy Relays - Embodiments of the invention disclose a method and a system configured to transfer energy wirelessly, comprising a source configured to transfer the energy wirelessly to a sink via a coupling of evanescent waves, wherein the source generates an electromagnetic (EM) near-field in response to receiving the energy; and an energy relay arranged such that to increase the coupling between the source and the sink, wherein the source, the sink, and the energy relay are electromagnetic and non-radiative structures. | 06-30-2011 |
| 20110169336 | Wireless Energy Transfer to Moving Devices - Embodiments of the invention disclose a method and a system configured to transfer energy wirelessly, comprising: a source configured to generate evanescent waves, in response to receiving the energy, on at least part of a surface of the source; a sink configured to receive the energy wirelessly from the source via a coupling of the at least part of the evanescent waves; and a load configured to receive the energy from the sink, wherein the load and the sink are configured to move along the surface of the source such that the at least a part of the evanescent waves are coupled between the source and the sink within an energy transfer area. | 07-14-2011 |
Guoxiang Huang, Kernersville, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090326006 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors - The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved. | 12-31-2009 |
| 20110065713 | Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors - The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved. | 03-17-2011 |
| 20110300134 | REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF - The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6. | 12-08-2011 |
Jianhua Huang, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080305181 | Compositions and Methods for Treatment of Vascular Grafts - The present invention contemplates compositions and methods for the treatment of vascular grafts both ex vivo and in vivo. Ex vivo treatment comprises completely removing a vessel (i.e., vein or artery) from the body and treating with the compositions of the present invention. In vivo treatment comprises treating the vessel in vivo without removing the vessel completely from the body (albeit one or both ends of the vessel may be closed off in order to focus the treatment in the desired area and/or avoid systemic treatment). In one embodiment, at least a portion of the smooth muscle cells of a vessel (e.g., vein or artery) are transfected ex vivo or in vivo with a vector capable of expressing at least one phosphatase. In a preferred embodiment, smooth muscle cells are transfected with adenovirus vector comprising the gene encoding PTEN. | 12-11-2008 |
Jian-Ping Huang, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100218892 | STRUCTURAL ADHESIVES CONTAINING MALEIMIDE TERMINATED POLYIMIDES - A maleimide terminated polyimide incorporated into a two-part acrylic structural adhesive system. The maleimide terminated polyimide of the various embodiments of the present invention provide improving thermal stability, strength, and toughness. | 09-02-2010 |
Joanne Huang, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080226729 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES - The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided. | 09-18-2008 |
| 20110159047 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES - The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided. | 06-30-2011 |
Kenneth H. Huang, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20120077814 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES - The disclosure provides biologically active compounds of formula (I): | 03-29-2012 |
Kenneth He Huang, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080269193 | Tetrahydroindole and Tetrahydroindazole Derivatives - The invention provides indole and indazole compounds of Formula (I) | 10-30-2008 |
| 20090093452 | Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives - Disclosed are compounds and pharmaceutically acceptable salts of Formula I | 04-09-2009 |
Kuang-Jung Huang, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090063383 | Real-time reasoning system using natural language-like rules - A reasoning system with a reasoning engine that uses a rule set created from a rule representation language that has an English/natural language-like rule syntax and format is discussed. The reasoning system employs a real-time selection algorithm that chooses the rules used to analyze complex data (e.g.: bio-medical research, e-commerce, Customer Relationship Management (CRM), environmental research & engineering, bio-chemical research and product development, Investment and money management, anything related to research and product development) without suffering exponential performance decreases as the complexity of the analysis increases. The use of the rule representation language enables different domain users to review, create and modify rules without requiring the users to possess an advanced knowledge of programming languages. | 03-05-2009 |
Leaf Huang, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090017057 | STIMULATION OF AN IMMUNE RESPONSE BY CATIONIC LIPIDS - The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens. | 01-15-2009 |
| 20100184953 | STABLE LIPID-COMPRISING DRUG DELIVERY COMPLEXES AND METHODS FOR THEIR PRODUCTION - Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications. | 07-22-2010 |
| 20110110972 | STIMULATION OF AN IMMUNE RESPONSE BY ENANTIOMERS OF CATIONIC LIPIDS - Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids. | 05-12-2011 |
| 20110117026 | METHODS AND COMPOSITIONS FOR THE DELIVERY OF BIOACTIVE COMPOUNDS - The present invention provides compositions comprising delivery systems comprising a lipid vehicle, a bioactive compound, and a polyanionic carrier macromolecule that is not a carrier polynucleotide, wherein the lipid vehicle encapsulates the polynucleotide of interest and the polyanionic carrier macromolecule, and wherein the delivery system is essentially free of carrier polynucleotides. Compositions also include delivery systems comprising a lipid vehicle and a bioactive agent, wherein the lipid vehicle encapsulates the bioactive agent, and wherein the lipid vehicle comprises a covalent bilayer or a core supported bilayer comprising polycationic lipids. Other compositions provided herein comprise a delivery system comprising a polypeptide of interest and a means for delivering the polypeptide into a cell. Also provided herein are methods for making the delivery systems, methods for delivering bioactive compounds, methods for treating a disease or unwanted condition in a subject with the delivery systems, and methods for detecting apoptosis in a cell. | 05-19-2011 |
| 20110117141 | METHODS AND COMPOSITIONS COMPRISING NOVEL CATIONIC LIPIDS - Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention. | 05-19-2011 |
Lian-Feng Huang, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100179101 | Novel Crystalline Forms Of An Antiviral Benzimidazole Compound - The invention relates to crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H benzimidazole, pharmaceutical compositions comprising the same, processes for preparing the same, and their use in medical therapy. | 07-15-2010 |
| 20110118203 | Novel Crystalline Forms Of An Antiviral Benzimidazole Compound - The invention relates to crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1Hbenzimidazole, pharmaceutical compositions comprising the same, processes for preparing the same, and their use in medical therapy. | 05-19-2011 |
Rong Huang, Charlotte, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090290833 | Optical device including at least one replicated surface and associated methods - An optical device includes a substrate. a non-planar transparent structure on a first surface of the substrate, the non-planar transparent structure being made of a first material, and a molded refractive surface on the first surface of the substrate adjacent the non-planar transparent structure, the molded refractive surface being made of a second material, different from the first material. | 11-26-2009 |
Wensheng Huang, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090074046 | Data Structure Boundary Synchronization Between a Transmitter and Receiver - Synchronization between a transmitter and a receiver with respect to the boundary of higher-layer logical data structures is improved by considering both the statistical likelihood of the value of a transmitted boundary indicator and the quality of the channel during the transmission. A boundary indicator received under poor channel quality, that is decoded to a statistically unlikely value, is suspect and one or more retransmission is requested. A reliable value of the boundary indicator is a retransmitted boundary indicator received during good channel conditions; the value of two boundary indicators received successively, both under poor channel conditions, that decode to the same value; or a majority vote of three successive boundary indicators, the first two received under poor channel conditions. The accuracy of the received boundary indicator is increased, at a cost of one, or at most, two, retransmissions. | 03-19-2009 |
| 20100260292 | BLIND MODULATION DETECTION - In receiving a radio block comprising a plurality of bursts, burst data is saved prior to demodulating each burst using an independent preliminary modulation technique decision. When a global modulation technique decision over the radio burst is formulated, if the preliminary modulation technique decision for one or more bursts disagrees, data associated with that burst may be retrieved and demodulated using the global modulation technique decision. In one embodiment, the mismatching burst is erased and decoding over the block is attempted, with the second demodulation being performed only if a decoding metric indicates decode errors. In another embodiment, each mismatching block is re-demodulated as soon as a global modulation technique decision is formulated and a mismatch to the preliminary modulation technique decision is detected. In both embodiments, an increase in the number of soft bits improves decoder performance. | 10-14-2010 |
Xiang Huang, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100180352 | Compositions and Methods of Using RNA Interference for Control of Nematodes - The present invention relates to the use of RNA interference to inhibit expression of plant parasitic nematode target let-70 genes, and relates to the generation of plants that have increased resistance to parasitic nematodes. | 07-15-2010 |
Yangzhong Huang, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110236371 | Compositions And Methods For The Treatment Of Neurologic And Psychiatric Conditions - The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain. | 09-29-2011 |
Yen-Min Huang, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080306944 | METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR ANALOGY DETECTION AMONG ENTITIES USING RECIPROCAL SIMILARITY MEASURES - Analogies among entities may be detected by obtaining associative counts among the entities and computing similarity measures among given entities and other entities, using the associative counts. First and second entities are then identified as being analogies if the first entity has a strongest similarity measure with respect to the second entity and the second entity also has a strongest similarity measure with respect to the first entity. The similarity measures may be calculated using a normalized entropy inverted among a given entity and other entities. | 12-11-2008 |
| 20090198692 | Methods, Systems and Computer Program Products for Analogy Detection Among Entities Using Reciprocal Similarity Measures - Analogies among entities may be detected by obtaining associative counts among the entities and computing similarity measures among given entities and other entities, using the associative counts. First and second entities are then identified as being analogies if the first entity has a strongest similarity measure with respect to the second entity and the second entity also has a strongest similarity measure with respect to the first entity. The similarity measures may be calculated using a normalized entropy inverted among a given entity and other entities. | 08-06-2009 |
| 20100306227 | METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR PROVIDING A DISTRIBUTED ASSOCIATIVE MEMORY BASE - Systems, methods and computer program products are provided for a distributed associative memory base. Such methods may include providing a distributed memory base that includes a network of networks of associative memory networks. The memory base may include a network of associative memory networks, a respective associative memory network comprising associations among a respective observer entity and a plurality of observed entities that are observed by the respective observer entity. Ones of the associative memory networks are physically and/or logically independent from other ones of the associative memory networks. Methods include imagining associations from the associative memory base using a plurality of streaming queues that correspond to ones of a plurality of rows of ones of the associative memory networks. | 12-02-2010 |
Yunsheng Huang, Apex, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100273740 | Phospholipids for the Treatment of Infection by Togaviruses, Herpes Viruses and Coronaviruses - Provided are compounds, methods and pharmaceutical compositions for treating a host, especially a human, infected with a togavirus, herpes virus and/or coronavirus, and in particular SARS-CoV, cytomegalovirus or varicella-zoster virus. The method in one embodiment comprises administering to that host an effective amount of an anti-togavirus, anti-herpes virus and/or anti-coronavirus phospholipid or a pharmaceutically acceptable salt or prodrug thereof. The phospholipid compound is, e.g., a 3-alkylamido-2-alkoxypropylphosphocholine compound or salt thereof. The compound may be administered alone or in combination and/or alternation with one or more other anti-viral agents. | 10-28-2010 |