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Huang, MD
Alex Huang, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090304596 | Methods for Predicting Psychotropic Drugs Which Elicit Weight Gain - The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase (AMPK), an action abolished in mice with deletion of histamine H1 receptors. These findings afford a means of developing better therapeutic agents and provide insight into the hypothalamic regulation of food intake. | 12-10-2009 |
Austin B. Huang, N. Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090304794 | CONTROLLED RELEASE FORMULATIONS OF PRAMIPEXOLE - A controlled release formulation of pramipexole for once-a-day administration to a mammalian subject, which formulation releases pramipexole along a pre-determined release profile, is provided. | 12-10-2009 |
| 20110244042 | STABILIZED FORMULATIONS OF CNS COMPOUNDS - Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone. | 10-06-2011 |
Huapeng Huang, Ellicott City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110038457 | X-RAY DIFFRACTION APPARATUS AND TECHNIQUE FOR MEASURING GRAIN ORIENTATION USING X-RAY FOCUSING OPTIC - An x-ray diffraction apparatus for measuring crystal orientation of a multiple grain sample. An x-ray excitation path is provided having a focusing optic for collecting x-rays from an x-ray source and redirecting the collected x-rays into an x-ray beam converging on a single grain of the multiple grain sample. At least one point detector and the sample are rotated relative to each other; and a grain orientation is obtained based upon diffraction patterns collected from first and second grain crystal planes within the apparatus. | 02-17-2011 |
Jiaqi Huang, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110256155 | METHODS TO MOLECULARLY CHARACTERIZE CIRCULATING TUMOR CELLS - The invention relates to a rapid, sensitive method to obtain a gene expression profile from a target cell population in a blood sample. The target cells can be circulating tumor cells. Disclosed are methods and kits for obtaining such profiles. | 10-20-2011 |
Lanqing Huang, Ellicott City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110293608 | ANNEXIN A2 AS IMMUNOLOGICAL TARGET - AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. AnnexinA2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane AnnexinA2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. The cytoplasmic to cell surface translocation of AnnexinA2 expression is critical for pancreatic cancer cell invasion. In addition, phosphorylation of AnnexinA2 at Tyrosine 23 is important for its localization to the cell surface and for the invasion of pancreatic cancer cells. Finally, loss of AnnexinA2 leads to the loss of the Epithelial-Mesenchymal Transition. | 12-01-2011 |
Lan-Qing Huang, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090209034 | TUMOUR REJECTION ANTIGENS - Polypeptides comprising an unbroken sequence of amino acids from SEQ. ID. NO. 1 or 2, with an ability to complex with a major histocompatibility complex molecule type HLA-A2, and preferably HLA-A2.1. | 08-20-2009 |
Lucas K. Huang, Columbia, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080261192 | SYNCHRONOUS MULTI-MEDIA RECORDING AND PLAYBACK WITH END USER CONTROL OF TIME, DATA, AND EVENT VISUALIZATION FOR PLAYBACK CONTROL OVER A NETWORK - A system and system are provided for providing synchronous multimedia recording and playback. Aspects the exemplary embodiment include in response to a training session is being conducted, synchronously recording in real-time simulator data from a simulator captured by a simulator capture tool, and video of the training session captured by a plurality of A/V sources; encoding each of the videos captured by the plurality of A/V sources as respective digital media files formatted as streaming media; and transmitting both the simulator data and the video media files from a server to a client over a network, such that when the client receives the simulator data and the stream, the respective videos are synchronously played back with the simulator data on the client | 10-23-2008 |
Mingjun Huang, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080207760 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv - The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test compounds for the ability to induce the formation of replicase complex defects are also described. Also included are methods of inhibition of HCV replication by replicase complex defect inducers. | 08-28-2008 |
| 20090081636 | Pharmaceutical compositions for and methods of inhibiting HCV replication - The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test compounds for the ability to induce the formation of replicase complex defects are also described. Also included are methods of inhibition of HCV replication by replicase complex defect inducers. | 03-26-2009 |
| 20100029652 | Combination Therapy For Treating Hepatitis C Infections - The invention provides a method of treating hepatitis C, by providing compound of Formula I (shown below) in combination with a second active agent to a patient infected with the hepatitis C virus. Also provided herein are pharmaceutical combinations comprising a compound of Formula I and a second active agent. The pharmaceutical combination may be a unit dosage form or a packaged pharmaceutical composition. Packaged pharmaceutical combinations include a compound of Formula I and a second active agent in a package with instructions for using the formulation to treat a hepatitis C infection. | 02-04-2010 |
| 20100093018 | CELLS EXPRESSING CHIMERIC PROTEINS AND ASSAYS USING SUCH CELLS - Cells expressing chimeric hepatitis C virus NS4A protein are disclosed, as are vectors and methods for preparing such cells and methods of using the cells and the chimeric proteins therein in screening assays for detecting compounds that alter the associative characteristics of NS4A proteins. Disclosed screening assays are suitable for use in high throughput screening of compound libraries to identify compounds with a exhibiting specific anti-viral activity against hepatitis C virus. | 04-15-2010 |
Ru Chih Huang, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080207532 | Use of Nordihydroguaiaretic Acid Derivatives in the Treatment of Drug Resistant Cancer, Viral and Microbial Infection - Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections. | 08-28-2008 |
| 20110014192 | SUPPRESSION OF CANCER GROWTH AND METASTASIS USING NORDIHYDROGUAIARETIC ACID DERIVATIVES WITH METABOLIC MODULATORS - Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two metabolic modulators. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis. | 01-20-2011 |
Ru Chih C. Huang, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100173861 | COMBINATIONAL PARADIGM COMBATING HIV, HIV/HSV, OR HIV/HPV INFECTIONS IN HUMANS USING SMALL MOLECULAR WEIGHT COMPOUNDS FROM PLANTS - Compounds, compositions and methods for the treatment of HIV/HSP/HPV, in particular, compositions and methods for a 3 part combination therapy for HIV/HSV/HPV, comprising a viral attachment inhibitor, a viral sequence integration inhibitor, and a proviral transcription inhibitor. The therapy is advantageous for the treatment of HIV infection, and is also effective for HSV and HPV infection. Also disclosed are novel viral attachment inhibitors and methods of use. | 07-08-2010 |
| 20110135711 | Methods and Compositions for Delivery of Catecholic Butanes for Treatment of Tumors - The present invention provides kits, methods and compositions for the treatment of diseases such as cancers. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues. | 06-09-2011 |
Ruili Huang, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110112079 | PHOSPHODIESTERASE INHIBITORS - The invention related to compounds for formula I useful for inhibiting phosphodiesterase-4. | 05-12-2011 |
Ruilli Huang, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100041617 | Modulating mxa expression - The invention provides compositions and methods for inhibiting cell motility, metastatic cancer and viral infections in a mammal that involve increasing the activity or expression of MxA. | 02-18-2010 |
Steve Chien-Wen Huang, Germantown, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080260707 | Isolated homozygous stem cells, differentiated cells derived therefrom and materials and methods for making and using same - The present invention discloses and describes pluripotent homozygous stem (HS) cells, and methods and materials for making same. The present invention also provides methods for differentiation of HS cells into progenitor (multipotent) cells or other desired cells, groups of cells or tissues. Further, the applications of the HS cells disclosed herein, include (but are not limited to) the diagnosis and treatment of various diseases (for example, genetic diseases, neurodegenerative diseases, endocrine-related disorders and cancer), traumatic injuries, cosmetic or therapeutic transplantation, gene therapy and cell replacement therapy. | 10-23-2008 |
Wei-Hao Huang, College Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090072191 | Nor-Seco-Bis-Nor-Seco, Tris-Nor-Seco, and Higher Nor-Seco-Cucurbit[n]Uril Compounds - Nor-seco-type cucurbit[n]uril compounds and methylene bridged glycoluril oligomers are produced by reacting glycoluril and formaldehyde in strong organic or mineral acid at a temperature adequate to condense the reactants. These compounds are characterized by lacking —CH | 03-19-2009 |
Wenwei Huang, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110195018 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder. | 08-11-2011 |
Yue Huang, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080286306 | HIV vaccines based on Env of multiple clades of HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 11-20-2008 |
| 20090175910 | Modifications of HIV Env, Gag, and Pol enhance immunogenicity for genetic immunization - Modified HIV Env, Gag, Pol, or Nef DNA with improved ability to elicit antibody and CTL responses to HIV antigens have been identified as prototype immunogens for the treatment and prevention of HIV infections. | 07-09-2009 |
| 20100111998 | HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single Glade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 05-06-2010 |
| 20110274721 | HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 11-10-2011 |
Yue Huang, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090214588 | Vaccines against aids comprising cmv/r-nucleic acid constructs - The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided. | 08-27-2009 |
| 20110200636 | METHOD FOR IMPROVING THE BREADTH OF THE IMMUNE RESPONSE TO DIVERSE STRAINS AND CLADES OF HIV - The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided. | 08-18-2011 |
Yunhan Huang, College Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120017978 | Energy harvesting using RF MEMS - Described herein is an energy harvesting device and a method for its fabrication for the harvesting of solar energy. Solar energy is absorbed using a photosensitive material which is coated upon a flexible membrane, which is suspended over a metal signal line of an RF MEMS structure. By controlling the discharge sequence the stored electrical charge can be transferred as high voltage pulses to an external load or rechargeable batteries. The output voltage can be adjusted by controlling the on/off frequency of operation of the switch. | 01-26-2012 |
| 20120018514 | MEMS barcode device for monitoring medical systems at point of care - This invention relates to a novel wireless barcode MEMS canary which can be embedded in electronic systems that can be monitored at any time for their degradation over a period of time until they fail. By establishing the relationship between the healthy state of the barcode and its degradation to that of the electronic system and the components, the residual life of the system can be established and preventive measures can be taken before part failure. | 01-26-2012 |
| 20120019386 | Wireless biosensor network for point of care preparedness for critical patients - A biodegradable, bio-compatible material is described for use in wireless biosensors for point-of-care applications. The biosensor made from this biomaterial is capable of sensing environmental effects and as well as presence of bio-logical entities in the environment of concern simultaneously. Such a sensor can be used for evaluating point-of-care environmental preparedness for a specific patient through continuous monitoring of patient health performance due to environmental exposure. A two-tier network architecture is established for real-time monitoring (static case) that also provides warning of accumulated exposure. Wavelet analysis can be used to identify anomalies in the sensed data to initiate a warning. | 01-26-2012 |
Zhuhui Huang, College Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120064112 | RECOMBINANT NEWCASTLE DISEASE VIRUSES USEFUL AS VACCINES OR VACCINE VECTORS - The present invention concerns an antigenomic RNA of Newcastle Disease virus (NDV) carrying one or more foreign genes inserted before NP gene, between P and M genes, and/or between HN and L genes. The invention is also directed toward a cDNA encoding a recombinant antigenomic RNA having one or more foreign genes inserted according to the invention, a cell containing the cDNA, a plasmid comprising the cDNA, a cell containing the plasmid, a cell containing the recombinant antigenomic RNA, and a recombinant NDV containing the recombinant antigenomic RNA of the invention, such as a recombinant NDV carrying one or more foreign genes recovered from transcription of the cDNA or the plasmid in a competent cell. The recombinant NDV carrying the one or more foreign genes can be used as a vaccine or vaccine vector. | 03-15-2012 |