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Huang, MA
Adrian Huang, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080242700 | Methods and Compositions for Selectin Inhibition - The present teachings relate to compounds of formula I: | 10-02-2008 |
| 20080255192 | Methods and Compositions for Selectin Inhibition - The present teachings relate to novel compounds of formula I: | 10-16-2008 |
| 20090069564 | Methods and Compositions for Selectin Inhibition - The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: | 03-12-2009 |
| 20110105509 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS - Disclosed are compounds of Formula (I): | 05-05-2011 |
Bo Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080241843 | Single-cell analysis systems, methods of counting molecules in a single-cell, cylindrical fluorescence detection systems - Embodiments of the present disclosure provide for single-cell analysis systems, methods of detecting target components in a single cell, cylindrical fluorescence detection systems, and the like. | 10-02-2008 |
Cai Gu Huang, Sudbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100221338 | Coated Tablets Of 6-(5-Chloro-2-Pyridyl)-5-[(4-Methyl-1-Piperazinyl)Carbonyloxy]-7-Oxo-6,7-- Dihydro-5H-Pyrrolo[3,4-b]Pyrazine And Methods For Measuring Effectiveness Of Coating - Coated tablets of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The tablets minimize the perceived bitterness of the medicament. A method for analyzing instantaneous dissolution of sub-microgram quantities of core material is also disclosed. | 09-02-2010 |
Christene Huang, Dover, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090220995 | MULTIPLE ADMINISTRATIONS OF UMBILICUS DERIVED CELLS - A method to determine the optimal administration protocol of allogeneic donor tissue to treat a disease in a human, using an animal model of human disease. | 09-03-2009 |
Chunlei Huang, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110155171 | Cleaning and Conditioning Cloth - A cleaning and conditioning cloth for an ice skate, including hockey and speed skates, as well as other objects, includes a rectangular body, or a body selected from one of other various shapes such as circle, square, and diamond, of cut-resistant, water-absorbent fabric and an oil impregnated fabric affixed to the approximate center of the cleaning and conditioning cloth body wherein the method includes the steps of holding the cleaning and conditioning cloth in one hand and the ice skate in the other, placing the blade of the ice skate in the middle of the oil impregnated fabric, and moving the ice skate and the cleaning and conditioning cloth relative to each other, so that the blade moves from the cleaning and conditioning cloth body to the oil impregnated fabric. The body and the oil impregnated fabric may be of various sizes. | 06-30-2011 |
Chun-Wen Paul Huang, Methuen, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100140758 | Integrated Circuit with Improved Transmission Line Structure and Electromagnetic Shielding Between Radio Frequency Circuit Paths - An integrated circuit is disclosed having through silicon vias spaced apart one from another and conductors, each coupled to one or more of the through silicon vias, the conductors in aggregate in use forming a segmented conductive plane maintained at a same potential and forming an electromagnetic shield. | 06-10-2010 |
| 20100327948 | Switching Circuit - A method for controlling a switch based on transistors is disclosed. A switching circuit for switching a signal from an input port to an output port thereof is provided. A shunting circuit for switchably shunting the signal from the input port to ground is also provided. A control signal is generated for biasing a control port of the shunting circuit and an approximately complimentary control signal is generated for biasing of the switching circuit to either shunt a signal received at the input port or to switch the signal to the output port. A further bias signal for biasing a port within the switching circuit along the signal path between the input port and the output port is also provided. | 12-30-2010 |
| 20110128078 | System and Method of Prebias for Rapid Power Amplifier Response Correction - A system and method are provided for reducing dynamic EVM of an integrated circuit power amplifier (PA) used for RF communication. In a multistage PA, the largest amplification stage is biased with a high amplitude current pulse upon receipt of a Tx enable, before receipt of the RF signal data burst. The high amplitude current pulse causes a large portion of the total ICQ budget of the multistage PA to pass through the largest amplification stage causing the entire integrated circuit to rapidly approach steady-state operating conditions. A smoothing bias current is applied to the largest amplification stage after the pulse decays to compensate for transient bias current levels while standard bias circuitry is still approaching steady-state temperature. | 06-02-2011 |
| 20110254614 | System and Method of Transistor Switch Biasing in a High Power Semiconductor Switch - A system and method are provided for biasing transistor switches in a semiconductor based high power switch. Off-state Vgsd biasing for the off transistor switches is based upon acceptable levels of spurious harmonic emissions and linearity. | 10-20-2011 |
Diyun Huang, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090268999 | LOW LOSS OPTICAL POLYMER AND DEVICES MADE THEREFROM - A electro-optic composite comprising a polymer having the structure | 10-29-2009 |
Eileen Huang, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110215004 | Measuring device and methods for use therewith - The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood. | 09-08-2011 |
Eric Enyang Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090322561 | TRAFFIC SIGNALS CONTROL SYSTEM - A method of controlling traffic signals at a road intersection, which has a plurality of signal groups, each of which controls at least one direction of traffic within the intersection. The method comprises the steps of obtaining and utilising traffic data to calculate a current traffic state and the rate of change in the traffic state. The method further comprises formulating at least one action and the duration of the action in response to these calculations. Each action comprises switching at least one traffic signal. One or more policies based on the calculations and the action are resolved. A continuous decision making process is applied to evaluate a reward for the policies resolved and a policy that maximizes the reward is selected. | 12-31-2009 |
Everest Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100117727 | ASYMMETRIC MULTILEVEL OUTPHASING ARCHITECTURE FOR RF AMPLIFIERS - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 05-13-2010 |
| 20110215866 | ASYMMETRIC MULTILEVEL OUTPHASING ARCHITECTURE FOR RF AMPLIFIERS - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 09-08-2011 |
Guiqing Huang, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110114875 | ELECTROCHEMICALLY ACTIVE MATERIALS AND PRECURSORS THERETO - The invention provides unique methods and compositions useful for preparing high-quality, nano-scale powdery precursor materials that are efficiently converted to electrochemically active materials, for example those useful in rechargeable lithium-ion batteries as electrode materials and various applications. | 05-19-2011 |
Hansong Huang, Natick, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110158880 | ANISOTROPIC CTE LSM FOR SOFC CATHODE - An anisotropic coefficient of thermal expansion (CTE) cathode of a solid oxide fuel cell (SOFC) is formed by placing a layer of perovskite powder between two platens, and sintering the layer while applying pressure to the platens, thereby forming the anisotropic CTE cathode. The perovskite can be lanthanum strontium manganite (LSM). | 06-30-2011 |
Helena Huang, Boxborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100311175 | MASS TAGS FOR QUANTITATIVE ANALYSES - This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes. | 12-09-2010 |
Holly Huang, Northborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110250242 | ARFORMOTEROL AND TIOTROPIUM COMPOSITIONS AND METHODS FOR USE - Compositions and methods for the prevention and/or treatment of airway and/or respiratory disorders are provided. The compositions comprise arformoterol (the (R,R)-formoterol isomer) and tiotropium. | 10-13-2011 |
Hongbing Huang, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100087429 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 04-08-2010 |
Hua Ming Paul Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090042906 | METHODS FOR TREATING CANCERS ASSOCIATED WITH CONSTITUTIVE EGFR SIGNALING - Aspects of the invention relate to methods and compositions for treating cancers associated with constitutive EGFR signaling. Methods include inhibiting one or more components of the c-Met and/or Axl signaling pathways. Aspects of the invention also relate to methods for determining whether a subject is a candidate for treatment with an inhibitor of a c-Met and/or Axl signaling component. | 02-12-2009 |
Hui Min He Huang, Shrewsbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110071169 | Preparation of polymorphic form of lapatinib ditosylate - The present invention is directed to two novel polymorph form (Form A and Form B) of lapatinib ditosylate, wherein Form A is the hydrate ditosylate salt of lapatinib, and Form B is anhydrate ditosylate salt of lapatinib. The present invention is further directed to amorphous form of lapatinib ditosylate and its solid dispersion. The present invention further provides processes for the preparation of Form A, Form B, Amorphous form and solid dispersion of lapatinib ditosyalte, and a pharmaceutical composition comprising the said forms. Form A and Form B were characterized by X-RPD, DSC, TGA and FT-IR, and can be prepared from recrystallizing lapatinib ditosylate in a mixture of tetrahydrofuran (THF) and water. | 03-24-2011 |
Jia Huang, Medford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080293919 | Fibrous Protein Fusions and Use Thereof in the Formation of Advanced Organic/Inorganic Composite Materials - The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation. | 11-27-2008 |
| 20110275788 | FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS - The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation. | 11-10-2011 |
Jiankang Huang, Roslindale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080211491 | HIGH SENSITIVITY, PASSIVE MAGNETIC FIELD SENSOR AND METHOD OF MANUFACTURE - A magnetic field sensor comprises one or more magnetic layers of magnetostrictive material that is mechanically bonded to one or more layers of electroactive material. When a magnetic field is applied to the device, it rotates the magnetization that is present in the in the magnetostrictive material thereby generating a magnetostrictive stress in the material. The magnetostrictive stress generated by this layer, in turn, stresses the piezoelectric layer to which the magnetostrictive layer is bonded. In order to increase sensitivity, the voltage across the piezoelectric material is measured in a direction that is parallel to the plane in which the magnetization in the magnetic material rotates. | 09-04-2008 |
| 20100253089 | ENERGY HARVESTER UTILIZING EXTERNAL MAGNETIC FIELD - Apparatus and method for harvesting energy from the environment and/or other external sources and converting it to useful electrical energy. The harvester does not contain a permanent magnet or other local field source but instead relies on the earth's magnetic field of another source of a magnetic field that is external to the sensing device. One advantage of these new harvesters is that they can be made smaller and lighter than energy harvesters that contain a magnet and/or an inertial mass. | 10-07-2010 |
Jiankang Huang, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090062886 | SYSTEMS AND METHODS FOR DELIVERING ELECTRICAL ENERGY IN THE BODY - Small implantable magnetostrictive-electroactive (ME) device for delivering electrical energy to surrounding tissue. The wireless ME device is activated by a changing magnetic field from an externally applied alternating magnetic field source. The ME device provides a means for stimulating a nerve, tissue or internal organ with direct electrical current, such as relatively low-level direct current for temporary or as needed therapy. The field source (e.g. small coil antenna) may be a hand-held device or affixed to the wearer's skin, clothing or accessories. The ME implant may be configured as pellets which are small enough to be implanted through a surgical needle. In one embodiment, the wireless energy transmission system can be used for stimulating bone growth. | 03-05-2009 |
| 20100015918 | WIRELESS TRANSFER OF INFORMATION USING MAGNETO-ELECTRIC DEVICES - Apparatus and method for wireless near-field magnetic communication (NFMC) of information (e.g., voice or data) over modest distances (centimeters to a few kilometers). The transmission can proceed from an inductive coil transmitter to a magneto-electric (ME) receiving device, or between two ME devices. Electrical power may also be transmitted from and/or received using the same device. In one case, power and data are transmitted from an induction coil to a distant ME device that collects power and transmits data back to the power-transmission coil. In another case, the wireless transfer of data can be carried out between two ME devices. ME devices can be engineered to transmit or receive data and to receive electric power over a variety of frequencies by changing their dimensions, their material makeup and configuration, electrode configurations, and/or their resonance modes (longitudinal, transversal, bending, shear etc). Data rates up to and above several kilo-bits/s are possible using these methods with no limits on the frequency and duration of the communication. | 01-21-2010 |
Jianxing Huang, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090209530 | INHIBITORS OF CYCLIN-DEPENDENT KINASES, COMPOSITIONS AND USES RELATED THERETO - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation. | 08-20-2009 |
Jianxing Huang, N. Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100004207 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation. | 01-07-2010 |
Jijun Huang, Cambridge, MA US
Jinlan Huang, Wayland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090306681 | TISSUE TACK - A tissue fixation device includes a tack having at least two flexible arms on a first end of said anchor. A deployment device for deploying a tissue fixation device, wherein the deployment device is a deployment gun. | 12-10-2009 |
Jinsong Huang, Andover, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090072717 | Highly efficient polymer light-emitting diodes - An electro-optic device ( | 03-19-2009 |
Kexue Huang, Westborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100086981 | COMPOSITIONS AND METHODS FOR IMPROVED SACCHARIFICATION OF BIOMASS - Compositions and methods are provided for enhancing saccharification of biomass with one or more enzymes to enhance availability of substrates for fermentation by a microorganism. Microorganisms are also modified to enhance activity of one or more hydrolytic enzymes that are present endogenously in or are introduced heterologously into a host microorganism. | 04-08-2010 |
| 20110230682 | MICROORGANISMS WITH INACTIVATED LACTATE DEHYDROGENASE GENE (LDH) FOR CHEMICAL PRODUCTION - This invention provides systems and methods for the increased production of ethanol and other chemical compounds by recombinant | 09-22-2011 |
Lotien R. Huang, Chestnut Hill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100055758 | Magnetic Device for Isolation of Cells and Biomolecules in a Microfluidic Environment - The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the surface of the magnetic particles may then be used to bind particles, e.g., cells, or molecules of interest from complex samples, and the bound species may then be selectively released for downstream collection or further analysis. | 03-04-2010 |
Michelle Huang, Manchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100097821 | LIGHT EMITTING DIODE-BASED LAMP HAVING A VOLUME SCATTERING ELEMENT - A lamp having a candle-like appearance and using one or more light-emitting diodes (LEDs) as its light source is presented. The candle-like appearance arises because light is emitted from only a small volume at or near the center of the bulb. The heat sink and control electronics are located outside the bulb of the lamp. Inside the bulb is a set of secondary optics that guide the light from one or more LEDs to an emission point at a prescribed location in the interior of the bulb. The secondary optics include a light pipe that guides light away from the LED chip, and a volume scattering element that receives the light from the light pipe and scatters it into various directions. The volume scattering element is made from a transparent base material, and includes transparent particles of a predetermined size and refractive index. Because the lamp is typically used in an overhead position, such as in a hanging chandelier, the density of particles in the volume scattering element, the particle size and the particle refractive index are chosen to produce a scattering pattern that directs more light downward (toward the base of the bulb) than upward, while maintaining a reasonable efficiency (fraction of produced light that successfully exits the lamp). Simulation results are presented. | 04-22-2010 |
Mingdong Huang, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090264628 | CRYSTAL STRUCTURE OF HUMAN UROKINASE PLASMINOGEN ACTIVATOR AMINO TEMINAL FRAGMENT BOUND TO ITS RECEPTOR - Urokinase-type plasminogen activator (uPA) binds its cellular receptor (uPAR) with high affinity, thus localizing the generation of plasmin from plasminogen on the surface of a variety of cells. Disclosed herein is the structure of suPAR (uPAR | 10-22-2009 |
| 20090271163 | Crystal structure of human factor VIII and uses thereof - The present invention provides crystals of human Factor VIII, in particular, a B-domain deleted human Factor VIII, and its three-dimensional structure. The present invention also provides the structural information of Factor VIII, and methods for identifying compounds that modulate Factor VIII activity, for determining structures of Factor VIII homologs or analogs, and for designing drug candidates for the treatment of hemophilia based on the structural information. | 10-29-2009 |
Paul L. Huang, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090061031 | Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 03-05-2009 |
| 20110142973 | Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 06-16-2011 |
Qing Huang, Worcester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100111853 | ANTIBODIES THAT BIND TO IL-12 AND METHODS OF PURIFYING THE SAME - Anti-IL-12 antibodies are disclosed herein, including antigen-binding portions thereof. One or more methods for isolating and purifying anti-IL-12 antibodies from a sample matrix is presented. These isolated anti-IL-12 antibodies can be used in a clinical setting as well as in research and development. Pharmaceutical compositions comprising isolated anti-IL-12 antibodies are also described. | 05-06-2010 |
| 20100135987 | ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY - Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention. | 06-03-2010 |
| 20100150864 | ANTIBODIES THAT BIND TO IL-18 AND METHODS OF PURIFYING THE SAME - Anti-IL-18 antibodies are disclosed herein, including antigen-binding portions thereof. One or more methods for isolating and purifying anti-IL-18 antibodies from a sample matrix is presented. These isolated anti-IL-18 antibodies can be used in a clinical setting as well as in research and development. Pharmaceutical compositions comprising isolated anti-IL-18 antibodies are also described. | 06-17-2010 |
Qinheng Huang, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110300246 | Herbal Extracts for Treatment of Diabetic Complications and Oxidative Stress - Compositions, functional foods, methods of preparation, and their uses for the treatment of diabetic complications and oxidative stress are provided. The compositions, functional foods, and methods relate to herbal extracts from the rhizome of | 12-08-2011 |
Robin Huang, North Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110216417 | Selective Repositioning and Rotation Wavelength Beam Combining System and Method - A system and method for reconfiguring a plurality of electromagnetic beams to take advantage of various wavelength beam combining techniques. The reconfiguring of beams includes individual rotation and selective repositioning of one or more beams with respect to beam's original input position. | 09-08-2011 |
| 20110216792 | Scalable Wavelength Beam Combining System and Method - Systems and methods have been provided to increase output power, as well as spatial and/or spectral brightness when utilizing or combining a plurality of laser elements. | 09-08-2011 |
Robin K. Huang, N. Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110128982 | HIGH EFFICIENCY SLAB-COUPLED OPTICAL WAVEGUIDE LASER AND AMPLIFIER - A slab-coupled optical waveguide laser (SCOWL) is provided that includes an upper and lower waveguide region for guiding a laser mode. The upper waveguide region is positioned in the interior regions of the SCOWL. The lower waveguide region also guides the laser mode. The lower waveguide region is positioned in an area underneath the upper waveguide region. An active region is positioned between the upper waveguide region and the lower waveguide region. The active region is arranged so etching into the SCOWL is permitted to define one or more ridge structures leaving the active region unetched. | 06-02-2011 |
| 20110150010 | VERY LARGE MODE SLAB-COUPLED OPTICAL WAVEGUIDE LASER AND AMPLIFIER - A very large mode (VLM) slab-coupled optical waveguide laser (SCOWL) is provided that includes an upper waveguide region as part of the waveguide for guiding the laser mode. The upper waveguide region is positioned in the interior regions of the VLM SCOWL. A lower waveguide region also is part of the waveguide that guides the laser mode. The lower waveguide region is positioned in an area underneath the upper waveguide region. An active region is positioned between the upper waveguide region and the lower waveguide region. The active region is arranged so etching into the VLM SCOWL is permitted to define one or more ridge structures leaving the active region unetched. One or more mode control barrier layers are positioned between said upper waveguide region and said lower waveguide region. The one or more mode control barrier layers control the fundamental mode profile and prevent mode collapse of the laser mode. The mode control barrier layers also block carrier leakage from the active region. These layers are essential to obtaining VLM SCOWLs. | 06-23-2011 |
Shan Huang, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110201628 | HETEROCYCLIC JAK KINASE INHIBITORS - The present invention relates to compounds of Formula (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer. | 08-18-2011 |
Shao-Shan Carol Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100250143 | IDENTIFYING BIOLOGICAL RESPONSE PATHWAYS - A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response. | 09-30-2010 |
Shih-Min Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100267626 | METHODS AND COMPOSITIONS FOR MEASURING WNT ACTIVATION AND FOR TREATING WNT-RELATED CANCERS - The present application describes methods of regulating or modulating (e.g., antagonizing or inhibiting) Wnt signaling by administering Axin stabilizers. The application also describes methods of using Axin stabilizers described herein for the treatment, diagnosis, prevention, and/or amelioration of Wnt signaling-related disorders. | 10-21-2010 |
Shu-Wei Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110073784 | APPARATUS AND METHOD FOR GENERATING HIGH-INTENSITY OPTICAL PULSES WITH AN ENHANCEMENT CAVITY - An enhancement cavity includes a plurality of focusing mirrors, at least one of which defines a central aperture having a diameter greater than 1 mm. The mirrors are configured to form an optical pathway for closed reflection and transmission of the optical pulse within the enhancement cavity. Ring-shaped optical pulses having a peak intensity at a radius greater than 0.5 mm from a central axis are directed into the enhancement cavity. Accordingly, the peak intensity of the optical pulse is distributed so as to circumscribe the central apertures in the apertured mirrors, and the mirrors are structured to focus the pulse about the aperture toward a central spot area where the pulse is focused to a high intensity. | 03-31-2011 |
Stanley Huang, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110077958 | SYSTEMS AND METHODS FOR CLINICAL, OPERATIONAL, AND FINANCIAL BENCHMARKING AND COMPARATIVE ANALYTICS - The clinical analytics platform automates the capture, extraction, and reporting of data required for certain quality measures, provides real-time clinical surveillance, clinical dashboards, tracking lists, and alerts for specific, high-priority conditions, and offers dynamic, ad-hoc quality reporting capabilities. The clinical informatics platform may include a data extraction facility that gathers clinical data from numerous sources, a data mapping facility that identifies and maps key data elements and links data over time, a data normalization facility to normalize the clinical data and, optionally, de-identify the data, a flexible data warehouse for storing raw clinical data or longitudinal patient data, a clinical analytics facility for data mining, analytic model building, patient risk identification, benchmarking, performing quality assurance, and patient tracking, and a graphical user interface for presenting clinical analytics in an actionable format. The clinical informatics platform may enable a method of benchmarking that includes analyzing the healthcare data to obtain a data sample to compare to at least one of a clinical, operational and financial benchmark, and presenting the data sample with the benchmark as a report in a graphical user interface, wherein the report can be customized by at least one of changing at least one criterion. | 03-31-2011 |
| 20110077972 | SYSTEMS AND METHODS OF CLINICAL TRACKING - The clinical analytics platform automates the capture, extraction, and reporting of data required for certain quality measures, provides real-time clinical surveillance, clinical dashboards, tracking lists, and alerts for specific, high-priority conditions, and offers dynamic, ad-hoc quality reporting capabilities. The clinical informatics platform may include a data extraction facility that gathers clinical data from numerous sources, a data mapping facility that identifies and maps key data elements and links data over time, a data normalization facility to normalize the clinical data and, optionally, de-identify the data, a flexible data warehouse for storing raw clinical data or longitudinal patient data, a clinical analytics facility for data mining, analytic model building, patient risk identification, benchmarking, performing quality assurance, and patient tracking, and a graphical user interface for presenting clinical analytics in an actionable format. The clinical informatics platform may enable a method of clinical tracking that includes analyzing the healthcare data to obtain at least one report, and presenting the report in a graphical user interface, wherein the report can be customized based on a criterion. | 03-31-2011 |
| 20110077973 | SYSTEMS AND METHODS FOR REAL-TIME DATA INGESTION TO A CLINICAL ANALYTICS PLATFORM - The clinical analytics platform automates the capture, extraction, and reporting of data required for certain quality measures, provides real-time clinical surveillance, clinical dashboards, tracking lists, and alerts for specific, high-priority conditions, and offers dynamic, ad-hoc quality reporting capabilities. The clinical informatics platform may include a data extraction facility that gathers clinical data from numerous sources, a data mapping facility that identifies and maps key data elements and links data over time, a data normalization facility to normalize the clinical data and, optionally, de-identify the data, a flexible data warehouse for storing raw clinical data or longitudinal patient data, a clinical analytics facility for data mining, analytic model building, patient risk identification, benchmarking, performing quality assurance, and patient tracking, and a graphical user interface for presenting clinical analytics in an actionable format. | 03-31-2011 |
Sui Huang, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090322783 | Method and apparatus for displaying information - A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements. | 12-31-2009 |
Tai-Nang Huang, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100264085 | DIALYSIS DEVICE - This invention discloses dialysis devices, related housings, related membranes, related kits, and related methods. | 10-21-2010 |
Waan Jeng Huang, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100035807 | COMPOSITION AND METHOD FOR TREATMENT OF TUMORS - The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria. | 02-11-2010 |
Wei-Sheng Huang, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090149471 | Monocyclic Heterocyclic Compounds - This invention relates to compounds of the general formula: | 06-11-2009 |
| 20090156596 | Unsaturated Heterocyclic Derivatives - This invention relates to compounds of the general formula: | 06-18-2009 |
| 20090176781 | Acetylenic Heteroaryl Compounds - This invention relates to compounds of the general formula: | 07-09-2009 |
| 20110288078 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS - This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. | 11-24-2011 |
Wenhua Huang, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090035561 | Protective oxide coatings for SOFC interconnections - A dense and well adhered spinel coating such as CuMn | 02-05-2009 |
Xi Huang, Arlington, MA US
Xiangyang Huang, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080197340 | MULTIPLE-WAVELENGTH OPTO-ELECTRONIC DEVICE INCLUDING A SUPERLATTICE - A multiple-wavelength opto-electronic device may include a substrate and a plurality of active optical devices carried by the substrate and operating at different respective wavelengths. Each optical device may include a superlattice comprising a plurality of stacked groups of layers, and each group of layers may include a plurality of stacked semiconductor monolayers defining a base semiconductor portion and at least one non-semiconductor monolayer thereon. | 08-21-2008 |
| 20080197341 | METHOD FOR MAKING A MULTIPLE-WAVELENGTH OPTO-ELECTRONIC DEVICE INCLUDING A SUPERLATTICE - A method for making a multiple-wavelength opto-electronic device which may include providing a substrates and forming a plurality of active optical devices to be carried by the substrate and operating at different respective wavelengths. Moreover, each optical device may include a superlattice comprising a plurality of stacked groups of layers, and each group of layers may include a plurality of stacked semiconductor monolayers defining a base semiconductor portion and at least one non-semiconductor monolayer thereon. | 08-21-2008 |
| 20100270535 | ELECTRONIC DEVICE INCLUDING AN ELECTRICALLY POLLED SUPERLATTICE AND RELATED METHODS - A method for making an electronic device may include forming a selectively polable superlattice comprising a plurality of stacked groups of layers. Each group of layers of the selectively polable superlattice may include a plurality of stacked semiconductor monolayers defining a semiconductor base portion and at least one non-semiconductor monolayer thereon. The at least one non-semiconductor monolayer may be constrained within a crystal lattice of adjacent silicon portions, and at least some semiconductor atoms from opposing base semiconductor portions may be chemically bound together through the at least one non-semiconductor monolayer therebetween. The method may further include coupling at least one electrode to the selectively polable superlattice for selective poling thereof. | 10-28-2010 |
| 20110193063 | MULTIPLE-WAVELENGTH OPTO-ELECTRONIC DEVICE INCLUDING A SUPERLATTICE - A multiple-wavelength opto-electronic device may include a substrate and a plurality of active optical devices carried by the substrate and operating at different respective wavelengths. Each optical device may include a superlattice comprising a plurality of stacked groups of layers, and each group of layers may include a plurality of stacked semiconductor monolayers defining a base semiconductor portion and at least one non-semiconductor monolayer thereon. | 08-11-2011 |
Xiaohua Huang, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100055090 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS - The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 03-04-2010 |
| 20100130465 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS - The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 05-27-2010 |
| 20110044940 | Thiazole Carboxamide Derivatives and Their Use to Treat Cancer - The present invention relates to novel Heterocyclic Ether or Thioether Derivatives, compositions comprising the Heterocyclic Ether or Thioether Derivatives, and methods for using the Heterocyclic Ether or Thioether Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase. | 02-24-2011 |
| 20110237575 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) - The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below: (I) | 09-29-2011 |
Xiaolan Huang, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090106065 | PROCESS FOR AUTOMATICALLY HANDLING ELECTRONIC REQUESTS FOR NOTIFICATION OF UNSOLICITED COMMERCIAL EMAIL AND OTHER SERVICE DISRUPTIONS - A system and method for automatically processing and responding to large volumes of customer requests regarding Unsolicited Commercial Email (UCE) and other service disruptions. The process combines manual and automated steps, and includes routing, filtering, aggregating, validating, ticketing, custom and automated responses, tracking, analyzing, and closing each validated request. The process can be used by the Customer Support Center (CSC) of the Internet Service Provider (ISP) to insure that all complaints are handled successfully, that promotion of complaints is done correctly, that legal aspects of certain criminal or fraud related incidents are handled correctly, and that portions of the processing of complaints are handled automatically. | 04-23-2009 |
X. M. Huang, Woburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090052246 | NON-VOLATILE SHADOW LATCH USING A NANOTUBE SWITCH - A non-volatile memory cell includes a volatile storage device that stores a corresponding logic state in response to electrical stimulus; and a shadow memory device coupled to the volatile storage device. The shadow memory device receives and stores the corresponding logic state in response to electrical stimulus. The shadow memory device includes a non-volatile nanotube switch that stores the corresponding state of the shadow device. | 02-26-2009 |
X. M.h. Huang, Woburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080212361 | NONVOLATILE NANOTUBE DIODES AND NONVOLATILE NANOTUBE BLOCKS AND SYSTEMS USING SAME AND METHODS OF MAKING SAME - Under one aspect, a memory array includes word lines; bit lines; memory cells; and a memory operation circuit. Each memory cell responds to electrical stimulus on a word line and on a bit line and includes: a two-terminal non-volatile nanotube switching device having first and second terminals, a semiconductor diode element, and a nanotube fabric article capable of multiple resistance states. The semiconductor diode and nanotube article are between and in electrical communication with the first and second terminals, which are coupled to the word line bit line respectively. The operation circuit selects cells by activating bit and/or word lines, detects a resistance state of the nanotube fabric article of a selected memory cell, and adjusts electrical stimulus applied to the cell to controllably induce a selected resistance state in the nanotube fabric article. The selected resistance state corresponds to an informational state of the memory cell. | 09-04-2008 |
X. M. H. Huang, Woburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100072042 | MEMORY ELEMENTS AND CROSS POINT SWITCHES AND ARRAYS OF SAME USING NONVOLATILE NANOTUBE BLOCKS - Under one aspect, a covered nanotube switch includes: (a) a nanotube element including an unaligned plurality of nanotubes, the nanotube element having a top surface, a bottom surface, and side surfaces; (b) first and second terminals in contact with the nanotube element, wherein the first terminal is disposed on and substantially covers the entire top surface of the nanotube element, and wherein the second terminal contacts at least a portion of the bottom surface of the nanotube element; and (c) control circuitry capable of applying electrical stimulus to the first and second terminals. The nanotube element can switch between a plurality of electronic states in response to a corresponding plurality of electrical stimuli applied by the control circuitry to the first and second terminals. For each different electronic state, the nanotube element provides an electrical pathway of different resistance between the first and second terminals. | 03-25-2010 |
X. M. Henry Huang, Woburn, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090154218 | MEMORY ARRAYS USING NANOTUBE ARTICLES WITH REPROGRAMMABLE RESISTANCE - A memory array includes a plurality of memory cells, each of which receives a bit line, a first word line, and a second word line. Each memory cell includes a cell selection circuit, which allows the memory cell to be selected. Each memory cell also includes a two-terminal switching device, which includes first and second conductive terminals in electrical communication with a nanotube article. The memory array also includes a memory operation circuit, which is operably coupled to the bit line, the first word line, and the second word line of each cell. The circuit can select the cell by activating an appropriate line, and can apply appropriate electrical stimuli to an appropriate line to reprogrammably change the relative resistance of the nanotube article between the first and second terminals. The relative resistance corresponds to an informational state of the memory cell. | 06-18-2009 |
Yibing Huang, Northborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100112192 | THICK SUPERCONDUCTOR FILMS WITH IMPROVED PERFORMANCE - A method for producing a thick film includes disposing a precursor solution onto a substrate to form a precursor film. The precursor solution contains precursor components to a rare-earth/alkaline-earth-metal/transition-metal oxide including a salt of a rare earth element, a salt of an alkaline earth metal, and a salt of a transition metal in one or more solvents, wherein at least one of the salts is a fluoride-containing salt, and wherein the ratio of the transition metal to the alkaline earth metal is greater than 1.5. The precursor solution is treated to form a rare earth-alkaline earth-metal transition metal oxide superconductor film having a thickness greater than 0.8 μm. precursor solution. | 05-06-2010 |
Ying-Zong Huang, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100195488 | OPTIMIZED TRANSPORT PROTOCOL FOR DELAY-SENSITIVE DATA - Transmission delays are minimized when packets are transmitted from a source computer over a network to a destination computer. The source computer measures the network's available bandwidth, forms a sequence of output packets from a sequence of data packets, and transmits the output packets over the network to the destination computer, where the transmission rate is ramped up to the measured bandwidth. In conjunction with the transmission, the source computer monitors a transmission delay indicator which it computes using acknowledgement packets it receives from the destination computer. Whenever the indicator specifies that the transmission delay is increasing, the source computer reduces the transmission rate until the indicator specifies that the delay is unchanged. The source computer dynamically decides whether each output packet will be a forward error correction packet or a single data packet, where the decision is based on minimizing the expected transmission delays. | 08-05-2010 |
Yi-Shuian Huang, Roslindale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110294186 | DEVICES AND METHODS FOR ENRICHMENT AND ALTERATION OF CIRCULATING TUMOR CELLS AND OTHER PARTICLES - The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. | 12-01-2011 |
Yongjian Huang, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090086322 | Photonic Crystal Devices Using Negative Refraction - Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also performed for the grism. These lenses can be used in optical circuits, astronomical applications, etc. | 04-02-2009 |
Yongzhang Huang, Hamilton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080230713 | ION SOURCE ARC CHAMBER SEAL - An exemplary ion source for creating a stream of ions has a chamber body that at least partially bounds an ionization region of the arc chamber. The arc chamber body is used with a hot filament arc chamber housing that either directly or indirectly heats a cathode to sufficient temperature to cause electrons to stream through the ionization region of the arc chamber. A seals has a ceramic body having an outer wall that abuts the arc chamber body along a circumferential outer lip. The seal also has one or more radially inner channels bounded by one or more inner walls spaced inwardly from the outer wall. | 09-25-2008 |
| 20080265866 | METHOD AND SYSTEM FOR ION BEAM PROFILING - One embodiment of the invention relates to an apparatus for profiling an ion beam. The apparatus includes a current measuring device having a measurement region, wherein a cross-sectional area of the ion beam enters the measurement region. The apparatus also includes a controller configured to periodically take beam current measurements of the ion beam and to determine a two dimensional profile of the ion beam by relating the beam current measurements to sub-regions within the current measuring device. Other apparatus and methods are also disclosed. | 10-30-2008 |
| 20090236547 | EXTRACTION ELECTRODE SYSTEM FOR HIGH CURRENT ION IMPLANTER - A system and method extraction electrode system, comprising an extraction electrode, wherein the extraction electrode, further defines an aperture and forms a portion of the outside wall of the ion source and is configured to extract ions from the ion source, a suppression disk half assembly comprising two suppression electrode plate disk halves that form a variable suppression aperture, a ground disk half assembly comprising two ground electrode plate disk halves that form an variable ground aperture, wherein the suppression disk half assembly is configured between the extraction electrode and the ground disk half assembly, wherein the suppression aperture and the ground aperture variable in the direction perpendicular to the ion beam direction of travel, and wherein the extraction electrode system is used with a pendulum reciprocating drive apparatus. | 09-24-2009 |
| 20090267001 | LOW CONTAMINATION, LOW ENERGY BEAMLINE ARCHITECTURE FOR HIGH CURRENT ION IMPLANTATION - An ion implantation system comprising an ion source that generates an ion beam along a beam path, a mass analyzer component downstream of the ion source that performs mass analysis and angle correction on the ion beam, a resolving aperture electrode comprising at least one electrode downstream of the mass analyzer component and along the beam path having a size and shape according to a selected mass resolution and a beam envelope, a deflection element downstream of the resolving aperture electrode that changes the path of the ion beam exiting the deflection element, a deceleration electrode downstream of the deflection element that decelerates the ion beam, a support platform within an end station for retaining and positioning a workpiece which is implanted with charged ions, and wherein the end station is mounted approximately eight degrees counterclockwise so that the deflected ion beam is perpendicular to the workpiece. | 10-29-2009 |
| 20100243879 | High mass resolution low aberration analyzer magnet for ribbon beams and the system for ribbon beam ion implanter - The present invention provides a mass analyzing magnet which can bend a very wide charged particle ribbon beams through angles between 90 to 200 degrees. The shorter dimension of the ribbon beam is aligned with the magnetic field. The magnet can focus the longer dimension of the ribbon beam through a resolving slot inside the magnet for mass or momentum analysis. The magnet pole is shaped to increase the mass resolving power and to provide the focusing force in the direction of the shorter dimension of the ribbon beam. This magnet can achieve high mass resolving power with very small system aberrations for very wide ribbon beam. This feature is of significant value, for example, in the ion implantation industry. The ribbon beam width can be 300 mm, 450 mm and even 1000 mm. Integrated with the present invention, the ion implanter systems can be built to provide mass analyzed ribbon beams for various applications. The system will have much lower cost and much better ribbon beam quality than the ion implanters which are using conventional mass analyzing magnet. | 09-30-2010 |
Yufeng Huang, North Chelmsford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100089117 | METHOD OF CALIBRATING A WAVELENGTH-MODULATION SPECTROSCOPY APPARATUS - Several methods of calibrating a wavelength-modulation spectroscopy apparatus configured to measure a concentration of an analyte in a sample gas are disclosed. Each of the methods allows for calibration and recalibration using a relatively safe gas regardless of whether the sample gas for which the concentration of the analyte can be determined is a hazardous gas. In one embodiment of the invention, calibration that is sample-gas specific is accomplished by determining a first slope coefficient and calibration function for the sample gas, after which a scaling factor can be determined based on the first slope coefficient and a second slope coefficient for the same or a different sample gas and used in a subsequent calibration (or recalibration) to scale the calibration function. In other embodiments of the invention, calibration that is not sample-gas specific is accomplished to allow for the determination of the analyte concentration in variable gas compositions and constant gas compositions. | 04-15-2010 |
| 20100091278 | WAVELENGTH-MODULATION SPECTROSCOPY METHOD AND APPARATUS - In one embodiment of the spectroscopy method, the method comprises the steps of modulating the wavelength of a monochromatic radiation at a modulation amplitude and a modulation frequency; determining a first variable representative of an absorbance of an analyte in a sample; and demodulating by phase-sensitive detection the first variable at a harmonic of the modulation frequency to produce a harmonic spectrum of the analyte. In one embodiment of the spectroscopy apparatus, the apparatus comprises a laser diode integrated with a first photodetector configured to detect an intensity of a backward emission from the laser diode and act as a reference detector; a second photodetector configured to detect an intensity of laser radiation exiting a sample; and electronic circuitry coupled to the laser diode and the photodetectors, configured to acquire and process spectra of the sample. In another embodiment, the spectroscopy apparatus comprises a beam splitter configured to split the laser radiation into a first radiation portion and a second radiation portion and a first photodetector configured to detect the intensity of the first radiation portion. | 04-15-2010 |
| 20110181876 | METHOD OF CALIBRATING A WAVELENGTH-MODULATION SPECTROSCOPY APPARATUS - Several methods of calibrating a wavelength-modulation spectroscopy apparatus configured to measure a concentration of an analyte in a sample gas are disclosed. Each of the methods allows for calibration and recalibration using a relatively safe gas regardless of whether the sample gas for which the concentration of the analyte can be determined is a hazardous gas. In one embodiment of the invention, calibration that is sample-gas specific is accomplished by determining a first slope coefficient and calibration function for the sample gas, after which a scaling factor can be determined based on the first slope coefficient and a second slope coefficient for the same or a different sample gas and used in a subsequent calibration (or recalibration) to scale the calibration function. In other embodiments of the invention, calibration that is not sample-gas specific is accomplished to allow for the determination of the analyte concentration in variable gas compositions and constant gas compositions. | 07-28-2011 |
| 20110181877 | METHOD OF CALIBRATING A WAVELENGTH-MODULATION SPECTROSCOPY APPARATUS - Several methods of calibrating a wavelength-modulation spectroscopy apparatus configured to measure a concentration of an analyte in a sample gas are disclosed. Each of the methods allows for calibration and recalibration using a relatively safe gas regardless of whether the sample gas for which the concentration of the analyte can be determined is a hazardous gas. In one embodiment of the invention, calibration that is sample-gas specific is, accomplished by determining a first slope coefficient and calibration function for the sample gas, after which a scaling factor can be determined based on the first slope coefficient and a second slope coefficient for the same or a different sample gas and used in a subsequent calibration (or recalibration) to scale the calibration function. In other embodiments of the invention, calibration that is not sample-gas specific is accomplished to allow for the determination of the analyte concentration in variable gas compositions and constant gas compositions. | 07-28-2011 |
Yumei Huang, North Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090275142 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY - The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes. | 11-05-2009 |
| 20100159446 | Detection Assays and Use Thereof - The invention provides compositions and methods for the detection and/or quantification of biological targets (e.g., nucleic acids and proteins) by the nucleic acid-templated creation of one or more reaction products, for example, epitopes, enzyme substrates, enzyme activators, and ligands. The reaction products can be detected and/or quantitated after signal amplification using an amplification system. | 06-24-2010 |
| 20100159455 | RECEPTOR FAMILY PROFILING - The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics. | 06-24-2010 |
| 20110059458 | COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY - The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications. | 03-10-2011 |