Huang, CT
Angela Huang, New Haven, CT US
Bo Huang, New London, CT US
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20120213793 | CANCER TREATMENT - The present invention relates to methods of treating cancer, such as melanoma, by administering a CTLA4 antagonist to a subject with a serum C-Reactive Protein (CRP) concentration that is less than or equal to some amount. The invention further relates to methods of treating cancer by determining the level of serum CRP concentration in a subject, and then administering a CTLA4 antagonist if the CRP concentration is less than or equal to a certain amount. The invention further relates to, among other things, the use of serum CRP concentration as a predictive factor for a subjects response to a cancer treatment. | 08-23-2012 |
20130209479 | CANCER TREATMENT - The present invention relates to methods of treating cancer, such as melanoma, by administering a CTLA4 antagonist to a subject with a serum C-Reactive Protein (CRP) concentration that is less than or equal to some amount. The invention further relates to methods of treating cancer by determining the level of serum CRP concentration in a subject, and then administering a CTLA4 antagonist if the CRP concentration is less than or equal to a certain amount. The invention further relates to, among other things, the use of serum CRP concentration as a predictive factor for a subject's response to a cancer treatment. | 08-15-2013 |
Fang Huang, New Haven, CT US
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20160044255 | TECHNIQUES FOR PROCESSING IMAGING DATA HAVING SENSOR-DEPENDENT NOISE - Techniques for processing imaging data contaminated by sensor-dependent noise. An imaging method is described. In the imaging method, imaging data corresponding to an imaged region and acquired by at least first and second sensor elements is obtained. A parameterized model is fitted to the imaging data. The parameterized model includes a first sensor-dependent model of noise generated by the first sensor element in a first portion of the imaging data acquired by the first sensor element, and a second sensor-dependent model of noise generated by a second sensor element in a second portion of the imaging data acquired by the second sensor element. The first sensor-dependent noise model differs, at least in part, from the second sensor-dependent noise model. | 02-11-2016 |
Henry Huang, Darien, CT US
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20110282731 | Systems and Methods for Optimizing Marketing Investments - Systems and methods for optimizing marketing investments are provided. The system includes a computer system in electronic communication with a business over a first communications link, means for electronically receiving marketing expenditure information from the business using the first communications link. The system executes an optimization algorithm which processes the marketing expenditure information and estimates at least one optimized future marketing expenditure for the business based upon the marketing expenditure information. the system electronically transmits the at least one optimized future marketing expenditure to a user using a second communications link, for subsequent display of the at least one optimized future marketing expenditure to the user. | 11-17-2011 |
Henry Huang, Madison, CT US
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20110117094 | Reactivation of Axon Growth and Recovery in Chronic Spinal Cord Injury - Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, and polynucleotides. Also disclosed are methods of noninvasively monitoring axonal growth during and after treatment with an axonal growth promoting agent. | 05-19-2011 |
Hong Huang, Durham, CT US
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20120283264 | Oxazolidinones as Modulators of MGLUR5 - The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system. | 11-08-2012 |
Jianbing Huang, Norwalk, CT US
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20130101938 | ON-PRESS DEVELOPABLE LITHOGRAPHIC PRINTING PLATE PRECURSORS - A negative-working lithographic printing plate precursor is designed for improved printout or contrast between exposed and non-exposed regions in its imageable layer. The imaged precursor can be developed on-press. The improvement in printout is achieved by using a combination of at least two infrared radiation absorbing cyanine dyes. At least one of these cyanine dyes comprises a methine chain substituent that comprises a group represented by Structure (I): | 04-25-2013 |
Jiangzhong Huang, Storrs, CT US
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20140146413 | Systems and Methods for Enhanced Servo Data Processing - Systems and method relating generally to detecting information, and more particularly without limitation to systems and methods for synchronizing to a data stream. | 05-29-2014 |
Jianming Huang, Old Lyme, CT US
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20150330305 | ANTI-ICING INTERNAL MANIFOLD - A manifold for a gas turbine engine includes oppositely facing first and second walls that extend from an annular wall. An undulating wall oppositely faces the annular wall and couples the first wall to the second wall. The walls collectively form a plurality of first chambers in fluid communication with a plurality of second chambers so that each of the second chambers intersperse adjacent first chambers. Each first chamber has a first volume that is greater that a second volume of each second chamber. | 11-19-2015 |
20150345327 | Heated Inlet Guide Vane - A heated inlet guide vane is disclosed. The disclosed guide vane may include a body having an inlet cavity disposed alongside of an outlet cavity wherein the outlet cavity is disposed alongside the leading edge of the vane. The inlet cavity is in communication with a source of heated air. The inlet cavity is in communication with the outlet cavity by way of a plurality of impingement holes spaced along the inner wall disposed between the two cavities. Bleed holes are spaced along the length of the outlet cavity. Fresh, heated air enters the outlet cavity along the entire length of the outlet cavity and quickly exits the outlet cavity with minimal cooling so that a uniform d-icing capability is provided along the entire leading edge of the inlet guide vane. | 12-03-2015 |
Jianzhong Huang, Storrs, CT US
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20140268400 | Systems and Methods for Loop Feedback - The present inventions are related to systems and methods for data processing, and more particularly to systems and methods for performing loop feedback in a data processing system. | 09-18-2014 |
Jiewen Huang, New Haven, CT US
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20120310916 | Query Execution Systems and Methods - System, method and computer program product for processing a query are disclosed. Query processing includes partitioning the stored data into a plurality of partitions based on at least one vertex in the plurality of vertexes, storing at least another triple in the plurality of triples on the at least one node, assigning, based on the triple containing the at least one vertex, at least one partition in the plurality of partitions corresponding to the triple to at least one node in the plurality of nodes, and processing, based on the assigning, the query by processing the plurality of partitions. | 12-06-2012 |
20130159317 | HIGH PRECISION SET EXPANSION FOR LARGE CONCEPTS - A set expansion system is described herein that improves precision, recall, and performance of prior set expansion methods for large sets of data. The system maintains high precision and recall by 1) identifying the qualify of particular lists and applying that quality through a weight, 2) allowing for the specification or negative examples in a set of seeds to reduce the introduction of bad entities into the set, and 3) applying a cutoff to eliminate lists that include a low number of positive matches. The system may perform multiple passes to first generate a good candidate result set and then refine the set to find a set with highest quality. The system may also apply Map Reduce or other distributed processing techniques to allow calculation in parallel. Thus, the system efficiently expands large concept sets from a potentially small set of initial seeds from readily available web data. | 06-20-2013 |
John Huang, Hamden, CT US
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20100261646 | SUSTAINED INTRAOCULAR DELIVERY OF DRUGS FROM BIODEGRADABLE POLYMERIC MICROPARTICLES - Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (TOP) in the eye. In one embodiment, the microspheres are formed from polylactide-co-glycolide (“PLGA”); in another embodiment, the microspheres are formed from a blend PLGA and poly lactic acid (“PLA”). Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time. The combination of drug loading and release rate, as well as the minimization of initial burst release, result in prolonged release of a higher amount of drug. | 10-14-2010 |
John J. Huang, Hamden, CT US
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20110206773 | SUSTAINED DELIVERY OF DRUGS FROM BIODEGRADABLE POLYMERIC MICROPARTICLES - Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (TOP) in the eye. | 08-25-2011 |
Liwei Huang, Farmington, CT US
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20150060364 | Thin Film Composite Membrane Structures - Provided are thin film composite membrane structures comprising: a selective membrane layer for ion rejection attached to a support layer, the support layer comprising a multi-zone microfiltration membrane comprising: a porous support material; and at least two microfiltration zones, where a first zone comprises a first membrane and a second zone that is attached to the first zone and that coats at least a portion of the porous support material. Thin film composite membrane structures may be provided in reverse osmosis systems or nanofiltration systems. Also, thin film composite membrane structures may be provided in direct osmotic concentration systems, forward osmosis systems, or pressure retarded osmosis systems. | 03-05-2015 |
Qiaojian Huang, Rocky Hill, CT US
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20150265154 | SYSTEMS AND METHODS FOR A MULTI-ELEMENT MEDICAL SENSOR - Various methods and systems for the use of multi-element photoacoustic sensors within medical devices configured for photoacoustic spectroscopy techniques are provided. The photoacoustic sensor includes two or more acoustic detectors spatially configured to increase the probability of a clinician properly placing at least one of the acoustic detectors on the measurement site over the blood vessels of interest. Further, the photoacoustic sensor includes a light delivery system configured to provide multiple light sources to the measurement site, such that each acoustic detector has an adequate light supply within close proximity. The present techniques additionally provide methods for processing each acoustic signal measured at the two or more acoustic detectors to calculate one or more physiological parameters of interest, such as cardiac output. | 09-24-2015 |
Rui Huang, Glastonbury, CT US
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20110213739 | NON-INTRUSIVE LOAD MONITORING SYSTEM AND METHOD - In accordance with one embodiment, a system for non-intrusive load monitoring includes an output device, a data storage device including program instructions stored therein, a sensing device operably connected to a common source for a plurality of electrical devices, and an estimator operably connected to the output device, the data storage device, and the sensing device, the estimator configured to execute the program instructions to obtain data associated with a sensed state of the common source from the sensing device, obtain at least one model of each of the plurality of electrical devices, solve a Mixed Integer Programming problem for the at least one models over a fixed time horizon using the obtained data to determine a combination of operational stages of the plurality of electrical devices, and store operational data based on the solved Mixed Integer Programming problem. | 09-01-2011 |
Ruoshuang Huang, Farmington, CT US
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20150075760 | ALUMINUM ALLOY TUBE-FIN HEAT EXCHANGER - A heat exchanger includes | 03-19-2015 |
Samuel Jien-Shek Huang, Mystic, CT US
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20120040907 | Method of Use of Bioactive Materials - A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair. | 02-16-2012 |
Shengqiang Huang, West Simsbury, CT US
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20120024260 | COMBINED ENGINE BRAKING AND POSITIVE POWER ENGINE LOST MOTION VALVE ACTUATION SYSTEM - A system for actuating one or more engine valves for positive power operation and engine braking operation is disclosed. In a preferred embodiment, an exhaust valve bridge and intake valve bridge each receive valve actuations from two sets of rocker arms. Each valve bridge includes a sliding pin for actuating a single engine valve and an outer plunger disposed in the center of the valve bridge to actuate two engine valves through the bridge. The outer plunger of each valve bridge may be selectively locked to its valve bridge to provide positive power valve actuation. During engine braking, application of hydraulic pressure to the outer plungers may cause the respective valve bridges and outer plungers to unlock so that all engine braking valve actuations are provided from a rocker arm acting on one engine valve through the sliding pin. | 02-02-2012 |
20140245992 | COMBINED ENGINE BRAKING AND POSITIVE POWER ENGINE LOST MOTION VALVE ACTUATION SYSTEM - A system for actuating one or more engine valves for positive power operation and engine braking operation is disclosed. In a preferred embodiment, an exhaust valve bridge and intake valve bridge each receive valve actuations from two sets of rocker arms. Each valve bridge includes a sliding pin for actuating a single engine valve and an outer plunger disposed in the center of the valve bridge to actuate two engine valves through the bridge. The outer plunger of each valve bridge may be selectively locked to its valve bridge to provide positive power valve actuation. During engine braking, application of hydraulic pressure to the outer plungers may cause the respective valve bridges and outer plungers to unlock so that all engine braking valve actuations are provided from a rocker arm acting on one engine valve through the sliding pin. | 09-04-2014 |
20140251266 | Auxiliary Valve Motions Employing Disablement of Main Valve Events and/or Coupling of Adjacent Rocker Arms - In controlling valve motions of an internal combustion engine, after determining that engine braking operation has been initiated, a deactivation mechanism disposed within a main valve train is activated thereby disabling conveyance of main valve events from a main valve motion source to a valve via the main valve train. Engine braking valve events are enabled for the valve, which may include two-stroke engine braking. Coupling mechanisms, including one-way coupling mechanisms, between adjacent rocker arms may be used in this manner. | 09-11-2014 |
Sun-Yi Huang, Stamford, CT US
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20090048142 | Improved Biodegradability of Antiscalant Formulations - Anionic polymers comprising. organic counterfoils exhibit improved biodegradability. The anionic polymers are useful as antiscalants. The biodegradability of an anionic polymer may be improved by replacing inorganic counterions with organic counterions. | 02-19-2009 |
Xiaojie Huang, New Haven, CT US
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20150235360 | Sparse Appearance Learning-based Segmentation - The coronary sinus or other vessel is segmented by finding a centerline and then using the centerline to locate the boundary of the vessel. For finding the centerline, a refinement process uses multi-scale sparse appearance learning. For locating the boundary, the lumen is segmented as a graph cut problem. | 08-20-2015 |
Yazhong Huang, Branford, CT US
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20110207749 | Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase - The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity. | 08-25-2011 |
20110207772 | Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase - The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity. | 08-25-2011 |
Yingqun Huang, East Haven, CT US
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20090258424 | Cellular Delivery of siRNA - The invention provides a method for delivering a nucleic acid to a cell using a targeting molecule that is bound non-covalently to the nucleic acid. Compositions and kits are also provided. | 10-15-2009 |