Hsieh, MA
Alex Jer-Yann Hsieh, Winchester, MA US
Patent application number | Description | Published |
---|---|---|
20150072118 | MULTI-LAYER MATRIX COMPOSITE HAVING IMPROVED ENERGY ABSORPTION, DISSIPATION AND SHOCK WAVE MITIGATION CAPABILITIES - The disclosure relates to matrix composites comprising high strain-rate sensitive elastomers in a multi-layer construct which provide ballistic-resistant material systems with enhanced protection against blast damage as well as ballistic impact. According to one embodiment, a matrix composite for impact resistance and blast mitigation formed in a multi-layer configuration may include: (a) one or more outer layers comprising poly(urethane urea) having a strain-rate sensitivity characteristic in the range of 1,000/sec to 1,000,000/sec; and (b) one or more inner layers comprising poly(urethane urea) having a strain-rate sensitivity characteristic in the range of 10,000/sec to 1,000,000/sec. | 03-12-2015 |
Chang-Tai Hsieh, Chestnut Hill, MA US
Patent application number | Description | Published |
---|---|---|
20150260664 | METHOD FOR ANALYSIS USING X-RAY FLUORESCENCE - The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker. | 09-17-2015 |
Chen-Lin Hsieh, Brighton, MA US
Patent application number | Description | Published |
---|---|---|
20140057852 | Treatment of Cancers with A-8R Peptide - The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits. | 02-27-2014 |
20140057853 | Treatment of Cancers with A-8R Peptide - The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits. | 02-27-2014 |
20140088023 | sGCalpha1 Inhibiting Compositions, and Methods of Treatment of Cancers Therewith - The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits. | 03-27-2014 |
Chung-Ming Hsieh, West Roxbury, MA US
Patent application number | Description | Published |
---|---|---|
20080311581 | FUNCTIONAL POLYMORPHISMS OF THE INTERLEUKIN-1 LOCUS AFFECTING TRANSCRIPTION AND SUSCEPTIBILITY TO INFLAMMATORY AND INFECTIOUS DISEASES - The invention provides methods and reagents for detecting a polymorphism associated with in an upstream region of the interleukin-1β (IL-B) gene (IL-1B (−3737)) that affects transcription of the gene and susceptibility to inflammatory and infectious diseases such as diffuse coronary artery disease. | 12-18-2008 |
20100279280 | FUNCTIONAL POLYMORPHISMS OF THE INTERLEUKIN-1 LOCUS AFFECTING TRANSCRIPTION AND SUSCEPTIBILITY TO INFLAMMATORY AND INFECTIOUS DISEASES - The invention provides methods and reagents for detecting a polymorphism associated with in an upstream region of the interleukin-1 beta (IL-B) gene (IL-1B (−3737)) that affects transcription of the gene and susceptibility to inflammatory and infectious diseases such as periodontal disease and Alzheimer's disease. | 11-04-2010 |
Frank Hsieh, Lexington, MA US
Patent application number | Description | Published |
---|---|---|
20100267061 | DETECTING PHOSPHOLIPIDOSIS AND DIAGNOSING LYSOSOMAL STORAGE DISORDERS - Disclosed are methods for evaluating the potential or activity of a test compound to induce phospholipidosis in a target subject, for managing patient treatment, and for diagnosing a lysosomal storage disorder in a human subject. | 10-21-2010 |
Frank Y. Hsieh, Lexington, MA US
Patent application number | Description | Published |
---|---|---|
20090325311 | Measurement methods - The invention relates to methods for measuring unconjugated molecules, e.g. antibodies, in a mixture that also includes conjugated molecules, e.g. antibodies. | 12-31-2009 |
20100273989 | ANGIOTENSIN CONVERTING ENZYME HOMOLOG AND USES THEREFOR - The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostic methods for treating blood pressure related disorders as well as various types of allergic conditions, among others. Also disclosed are screening assays for identifying compounds for treating and preventing these conditions. | 10-28-2010 |
I-Wel Andy Hsieh, Bethesda, MA US
Patent application number | Description | Published |
---|---|---|
20140205234 | VERTICAL OPTICAL COUPLER FOR PLANAR PHOTONIC CIRCUITS - Described herein are an apparatus, system, and method for providing a vertical optical coupler (VOC) for planar photonics circuits such as photonics circuits fabricated on silicon-on-insulator (SOI) wafers. In one embodiment, the VOC comprises a waveguide made from a material having refractive index in a range of 1.45 to 3.45, the waveguide comprising: a first end configured to reflect light nearly vertical by total internal reflection between the waveguide and another medium, a second end to receive the light for reflection, and a third end to output the reflected light. The VOC couples with a Si waveguide having a first region including: a first end to receive light; and an inverted tapered end in the direction of light propagation to output the received light, wherein the inverted tapered end of the Si waveguide is positioned inside the waveguide. | 07-24-2014 |
Jennifer Hsieh, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20100218105 | Method of browsing and a computer program therefor - A method of browsing a website from the Internet comprises receiving code and/or object from the website from the Internet by a first computer. The code and/or object of the website is transmitted by the first computer to a server computer. The first computer displays the code and/or object of the website at the first computer. The code and/or object of the website received by the server computer is transmitted to a second computer. The code and/or object of the website received by the second computer is displayed at the second computer. The display of the website at the first computer is substantially the same as the display of the website at the second computer. | 08-26-2010 |
Pei-Chung Hsieh, Topsfield, MA US
Patent application number | Description | Published |
---|---|---|
20090305342 | Solubilization and Purification of a Target Protein fused to a Mutant Maltose-Binding Protein - Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein. | 12-10-2009 |
20110020911 | SOLUBILIZATION AND PURIFICATION OF A TARGET PROTEIN FUSED TO A MUTANT MALTOSE-BINDING PROTEIN - Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein. | 01-27-2011 |
20110189753 | Intracellular Production of a Nuclease - Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and a truncated nuclease in a soluble form in the cytoplasm of a host cell from which it can be readily extracted. | 08-04-2011 |
20110256593 | Generation of Random Double-Strand Breaks in DNA Using Enzymes - An enzyme preparation is described that includes a non-specific nuclease and a T7 Endo I mutant in a unit ratio of less than 1:200. This enzyme preparation may be used to generate double-stranded DNA fragments of a size suitable for DNA sequencing. The ends of the fragments can be readily modified as necessary to ligate adaptors or individual nucleotides to one strand of the double-stranded DNA fragments. | 10-20-2011 |
Pen Hsieh, Andover, MA US
Patent application number | Description | Published |
---|---|---|
20130215825 | MOBILE WIDE AREA NETWORK IP TRANSLATION CONFIGURATION - A method, system and non-transitory computer storage readable medium comprise operating a Wide Area Network (WAN) device according to a first Internet protocol (IP) translation mode of operation, changing an initial connectivity status between the WAN device and a WAN and transitioning from the first IP translation mode of operation to a second IP translation mode of operation that is different from the first IP translation mode of operation based on the change in the initial connectivity status. | 08-22-2013 |
Tseh-Jen Hsieh, Rowley, MA US
Patent application number | Description | Published |
---|---|---|
20120118232 | Hydrogen COGas For Carbon Implant - A system, apparatus and method for increasing ion source lifetime in an ion implanter are provided. Oxidation of the ion source and ion source chamber poisoning resulting from a carbon and oxygen-containing source gas is controlled by utilizing a hydrogen co-gas, which reacts with free oxygen atoms to form hydroxide and water. | 05-17-2012 |
20120119113 | Implementation of CO-Gases for Germanium and Boron Ion Implants - An ion implantation system for improving performance and extending lifetime of an ion source is disclosed. A fluorine-containing dopant gas source is introduced into the ion chamber along with one or more co-gases. The one or more co-gases can include hydrogen or krypton. The co-gases mitigate the effects caused by free fluorine ions in the ion source chamber which lead to ion source failure. | 05-17-2012 |
20120190181 | CARBON IMPLANTATION PROCESS AND CARBON ION PRECURSOR COMPOSITION - Methods and carbon ion precursor compositions for implanting carbon ions generally includes vaporizing and ionizing a gas mixture including carbon oxide and methane gases in an ion source to create a plasma and produce carbon ions. The ionized carbon within the plasma is then extracted to form an ion beam. The ion beam is mass analyzed with a mass analyzer magnet to permit the ionized carbon to pass therethrough and implant into a workpiece. | 07-26-2012 |
20130140473 | Automatic Control System for Selection and Optimization of Co-Gas Flow Levels - An ion implantation system for improving performance and extending lifetime of an ion source is disclosed whereby the selection, delivery, optimization and control of the flow rate of a co-gas into an ion source chamber is automatically controlled. | 06-06-2013 |
20140319994 | Flourine and HF Resistant Seals for an Ion Source - An exemplary ion source for creating a stream of ions has a chamber body that at least partially bounds an ionization region of the arc chamber. The arc chamber body is used with a hot filament arc chamber housing that either directly or indirectly heats a cathode to sufficient temperature to cause electrons to stream through the ionization region of the arc chamber. Electrically insulating seal element(s) engaging an outer surface of the arc chamber body are provided for impeding material from exiting the chamber interior openings of the arc chamber body. The seal element(s) have a ceramic body that includes an outer wall that abuts the arc chamber body along a circumferential outer lip. The seal also has one or more radially inner channels bounded by one or more inner walls spaced inwardly from the outer wall. The electrically insulating seal element comprises a Boron Nitride (BN) material. | 10-30-2014 |
20150179393 | REDUCED TRACE METALS CONTAMINATION ION SOURCE FOR AN ION IMPLANTATION SYSTEM - An ion source chamber for ion implantation system includes a housing that at least partially bounds an ionization region through which high energy electrons move from a cathode to ionize gas molecules injected into an interior of the housing; a liner section defining one or more interior walls of the housing interior, wherein each liner section includes a interiorly facing surface exposed to the ionization region during operation the ion implantation system; a cathode shield disposed about the cathode; a repeller spaced apart from the cathode; a plate including a source aperture for discharging ions from the ion source chamber; wherein at least one of the repeller, the liner section, the cathode shield; the plate, or an insert in the plate defining the source aperture comprise silicon carbide, wherein the silicon carbide is a non-stoichiometric sintered material having excess carbon. | 06-25-2015 |
Ya-Ping Hsieh, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20110135835 | METHOD FOR DEPOSITING A CARBON NANOTUBE THIN FILM COATING ON AN ARBITRARY SUBSTRATE DIRECTLY FROM CHEMICAL VAPOR DEPOSITION SYNTHESIS - A method includes generating an aerosol comprising a plurality of catalyst particles from a precursor solution comprising a carbon source and a catalyst, transmitting the plurality of catalyst particles through a reaction zone extending along a temperature profile including at least one temperature sufficient to induce in each of the plurality of catalyst particles growth of a plurality of carbon nanotubes, and positioning at least one substrate along the temperature profile and at least partially outside of the reaction zone at a position to collect a portion of the plurality of carbon nanotubes on a surface of the at least one substrate. | 06-09-2011 |