Hotchkiss, US
Adam R. Hotchkiss, Richardson, TX US
Patent application number | Description | Published |
---|---|---|
20090103926 | SYSTEMS AND METHODS FOR THE INTEGRATION OF FRAMING, OAM&P, AND FORWARD ERROR CORRECTION IN SFP OPTICAL TRANSCEIVER DEVICES - The present invention provides systems and methods for integrated framing functionality; optical layer operations, administration, maintenance, and provisioning (OAM&P); forward error correction (FEC); data encapsulation; and performance enhancement support in SFP optical transceiver modules. An SFP pluggable transceiver is configured to frame a client signal and to provide OAM&P functionality, such as with G.709 framing. The SFP pluggable transceiver operates within existing multi-source agreement (MSA) specifications for SFP. Accordingly, the pluggable transceiver can operate in any customer device compliant to the MSA specifications. | 04-23-2009 |
20090317073 | SYSTEMS AND METHODS FOR ETHERNET EXTENSION AND DEMARCATION - The present invention provides Ethernet extension and demarcation functionality through a Multi-Source Agreement (MSA) pluggable transceiver in a customer or remote device. The pluggable transceiver is configured to frame an Ethernet client signal and to provide OAM&P functionality, such as with G.709 framing. The pluggable transceiver operates within existing multi-source agreement (MSA) specifications. Accordingly, the pluggable transceiver can operate in any customer device compliant to the MSA specifications. Additionally, the framing and OAM&P functionality are transparent to the customer device, but instead utilized by a service provider for demarcation functionality, eliminating the requirements for external demarcation equipment and for external transponders. | 12-24-2009 |
20110135312 | 40G/100G OPTICAL TRANSCEIVERS WITH INTEGRATED FRAMING AND FORWARD ERROR CORRECTION - The present disclosure provides integrated performance monitoring (PM); optical layer operations, administration, maintenance, and provisioning (OAM&P); and alarming in optical transceivers, such as multi-source agreement (MSA)-defined modules. The present disclosure includes an optical transceiver defined by an MSA agreement with integrated PM and alarming for carrier-grade operation. The integration preserves the existing MSA specifications allowing the optical transceiver to operate with any compliant MSA host device. Further, the host device can be configured through software to retrieve the PM and alarming from the optical transceiver. The optical transceiver can include CFP and variants thereof (e.g., future CFP2, CDFP, CXP), OIF-MSA-100GLH-EM-01.0, CCRx (Compact Coherent Receiver), Quad Small Form-factor Pluggable (QSFP) and variants thereof (e.g., future QSFP+, QSFP2), 10×10 MSA, XFP, XPAK, XENPAK, X2, XFP-E, SFP, SFP+, 300-pin, and the like. | 06-09-2011 |
20130136445 | OPTICAL TRANSCEIVER PERFORMANCE MONITORING AND ALARMING SYSTEMS AND METHODS - Performance monitoring (PM); optical layer operations, administration, maintenance, and provisioning (OAM&P); and alarming are provided in optical transceivers, such as multi-source agreement (MSA)-defined modules. The present disclosure provides an optical transceiver defined by an MSA agreement with integrated PM and alarming for carrier-grade operation. The integration preserves the existing MSA specifications allowing the optical transceiver to operate with any compliant MSA host device. Further, the host device can be configured through software to retrieve the PM and alarming from the optical transceiver. The optical transceiver can include XFP, XPAK, XENPAK, X2, XFP-E, SFP, SFP+, 300-pin, and the like. The optical transceiver is configured to frame incoming signals to provide overhead and FEC. The transceiver provides access to all alarms in ITU-T G.709, all Tandem Connection Monitoring (TCM) bytes in G.709, far end monitoring as specified in G.709, loopbacks, historical and real-time PM values, and the like. | 05-30-2013 |
20130136446 | VIRTUALIZED OPTICAL TRANSPORT NETWORK SYSTEMS AND METHODS - The present disclosure provides an optical transceiver, method of mapping, and method of management utilizing a plurality of Optical Channel Transport Unit layer k (OTUk) links to form an aggregate signal, such as, for example, 10 OTU2s to provide a single 100 Gigabit Ethernet (100 GbE) signal. Specifically, the present invention enables use of existing circuitry and methods at lower speed signals, e.g. 10 G, to support higher speed aggregate signals, e.g. 100 G. The present invention may be utilized to support carrier-grade OTN applications with optical transceivers such as, for example, pluggable optical transceivers. In an exemplary embodiment, the present invention includes a method which receives a plurality of signals, frames each of the plurality of signals into an OTUk frame, and manages/monitors each of the plurality of signals in an OTUk frame in the aggregate. | 05-30-2013 |
20130177309 | 40G/100G MSA-COMPLIANT OPTICAL TRANSCEIVERS WITH ADVANCED FUNCTIONALITY - Integrated performance monitoring (PM); optical layer operations, administration, maintenance, and provisioning (OAM&P); alarming; amplification, and the like is described in optical transceivers, such as multi-source agreement (MSA)-defined modules. An optical transceiver defined by an MSA agreement can include advanced integrated functions for carrier-grade operation which preserves the existing MSA specifications allowing the optical transceiver to operate with any compliant MSA host device with advanced features and functionality. The optical transceiver can include CFP and variants thereof (e.g., CFP2, CDFP, CXP), OIF-MSA-100GLH-EM-01.0, CCRx (Compact Coherent Receiver), Quad Small Form-factor Pluggable (QSFP) and variants thereof (e.g., QSFP+, QSFP2), 10X10 MSA, XFP, XPAK, XENPAK, X2, XFP-E, SFP, SFP+, 300-pin, and the like. | 07-11-2013 |
20140056594 | EXTENDED REACH XFP TRANSCEIVER WITH INTEGRATED FORWARD ERROR CORRECTION - Integrated performance monitoring (PM); optical layer operations, administration, maintenance, and provisioning (OAM&P); alarming; amplification, or the like is described in optical transceivers, such as multi-source agreement (MSA)-defined modules. An optical transceiver defined by an MSA agreement can include advanced integrated functions for carrier-grade operation which preserves the existing MSA specifications allowing the optical transceiver to operate with any compliant MSA host device with advanced features and functionality. An XFP module can include integrated circuitry configured to provide forward error correction encoding and decoding; a transmitter communicatively coupled to the integrated circuit; a receiver communicatively coupled to the integrated circuit; and a module housing in which the integrated circuitry, the transmitter, and the receiver are disposed, wherein the module housing is pluggable in a host device configured to operate the pluggable optical transceiver, and wherein the forward error correction encoding and decoding is performed transparently to the host device. | 02-27-2014 |
20140369001 | HIGH-DENSITY RACK UNIT SYSTEMS AND METHODS - High-density rack unit systems and methods are described for telecommunication and data communication systems that utilize novel airflow mechanisms thereby enabling modularity and high-density in small-form factor units. The high-density rack unit systems and methods offer novel airflow mechanisms via right-angle backplane connectors to enable more airflow in a rack unit as well as novel field replaceable fans in these high-density rack units. Further, the high-density rack unit systems and methods include a baffle structure to keep power-supply-related airflow separate from the airflow over other components in the 1U or 2U rack unit. In this manner, the high-density rack unit systems and methods enable system vendors and network operators to realize significant density improvements. | 12-18-2014 |
20150125158 | 40G/100G/200G/400G PLUGGABLE OPTICAL TRANSCEIVERS WITH ADVANCED FUNCTIONALITY - Integrated performance monitoring (PM); optical layer operations, administration, maintenance, and provisioning (OAM&P); alarming; amplification, and the like is described in optical transceivers, such as multi-source agreement (MSA)-defined modules. A pluggable optical transceiver defined by an MSA agreement can include advanced integrated functions for carrier-grade operation which preserves the existing MSA specifications allowing the pluggable optical transceiver to operate with any compliant MSA host device with advanced features and functionality, such as Forward Error Correction (FEC), framing, and OAM&P directly on the pluggable optical transceiver. The advanced integrated can be implemented by the pluggable optical transceiver separate and independent from the host device. | 05-07-2015 |
20160006513 | PLUGGABLE OPTICAL TRANSCEIVERS WITH INTEGRATED ELECTRONIC DISPERSION COMPENSATION - Integrated performance monitoring (PM); optical layer operations, administration, maintenance, and provisioning (OAM&P); alarming; amplification, and the like is described in optical transceivers, such as multi-source agreement (MSA)-defined modules. A pluggable optical transceiver defined by an MSA agreement can include advanced integrated functions for carrier-grade operation which preserves the existing MSA specifications allowing the pluggable optical transceiver to operate with any compliant MSA host device with advanced features and functionality, such as Forward Error Correction (FEC), framing, and OAM&P directly on the pluggable optical transceiver. The advanced integrated can be implemented by the pluggable optical transceiver separate and independent from the host device. | 01-07-2016 |
Arland T. Hotchkiss, Ambler, PA US
Patent application number | Description | Published |
---|---|---|
20100316766 | Methods of Promoting the Growth of Beneficial Bacteria in the Gut - A method of promoting the growth of beneficial bacteria in the gut of a human in need thereof, which involves administering to a human a composition containing an effective amount of Ara-(1-5)-(Ara) | 12-16-2010 |
20130316025 | Cranberry Xyloglucan Oligosaccharide Composition - A composition prepared from a cranberry hull enzyme-treated composition which reduces or inhibits the adhesion of microorganisms to cells having α-Gal-(1-4)-Gal terminal oligosaccharide receptors for adhesion. | 11-28-2013 |
David Hotchkiss, Oconomowoc, WI US
Patent application number | Description | Published |
---|---|---|
20120100313 | VERTICAL LASER CLADDING SYSTEM - A vertical laser cladding system is particularly effective for the interior surfaces of tube-like structures. The vertical cladding process works from bottom to top, so that previously clad layers form a shelf for subsequent application of cladding powder. This system is also particularly effective for handling double-bore plasticating barrels. | 04-26-2012 |
Glen Hotchkiss, Montgomery, TX US
Patent application number | Description | Published |
---|---|---|
20110126843 | Limb Support Device - One embodiment comprises a limb support device that includes a vertical support, a base connected to a lower end of the vertical support and a head portion connected to an upper end of the vertical support. In this embodiment, the base includes a set of foldable legs that can be positioned upward, where each leg is substantially parallel to the vertical support, or downward, where each leg is substantially perpendicular to the vertical support so that the vertical support is held upright. The head portion has a generally concave saddle that can hold a limitation above the vertical support. The saddle can be pivoted so that it can be positioned at a variable angle with respect to the vertical support. The vertical support itself is adjustable in length. | 06-02-2011 |
Gregory Barton Hotchkiss, Richardson, TX US
Patent application number | Description | Published |
---|---|---|
20090166810 | Semiconductor Device Crack-Deflecting Structure and Method - The invention relates to microelectronic semiconductor devices, and to mass-production of the same on semiconductor wafers with novel crack-deflecting structures and methods. According to the invention, a semiconductor device includes an active circuit area surrounded by an inactive area and circumscribed with a bulwark having a crack-deflecting face oriented toward the periphery of the device. Embodiments of the invention are disclosed, in which a semiconductor device, or multiple devices on a wafer, include bulwarks having series of minor arcs with their chords oriented toward the peripheries of the devices. Additional embodiments of the invention described include bulwarks having series of right angles oriented toward the peripheries of the devices. Examples of the invention also include preferred embodiments wherein the bulwarks further comprise series of discrete pickets, parallel bulwarks, and bulwarks in combination with scribe seals. | 07-02-2009 |
Jay Hotchkiss, Denver, CO US
Patent application number | Description | Published |
---|---|---|
20090060839 | Gold Nanoparticle Conjugates and Uses Thereof - The disclosure generally relates to formation of polymers grafted to or polymerized from the surface of gold nanoparticles. The polymers are functionalized to include therapeutic agents and/or targeting agents at their surface, thereby allowing both therapeutic and targeting compounds to be directed to specific cells in a patient. | 03-05-2009 |
Jay Robert Hotchkiss, Brookings, SD US
Patent application number | Description | Published |
---|---|---|
20140059713 | Maize Variety Hybrid X95A926 - A novel maize variety designated X95A926 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X95A926 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X95A926 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X95A926, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X95A926. This invention further relates to methods for producing maize varieties derived from maize variety X95A926. | 02-27-2014 |
Jay W. Hotchkiss, Rochester Hills, MI US
Patent application number | Description | Published |
---|---|---|
20160132112 | SUSPENSION COMPONENT FOR A HAPTIC TOUCH PANEL ASSEMBLY - A suspension component for coupling a touch panel to a substrate in a haptic touch panel assembly. The suspension component includes a flexible connector that extends between a first end adapted for attachment to the touch panel and a second end adapted for attachment to the substrate. The flexible connector includes a concave section, an axial side wall, and a mobility gap and is shaped to allow the touch panel to move with respect to the substrate with three or more degrees of freedom, thereby facilitating more accurate and dynamic haptic feedback. | 05-12-2016 |
20160132113 | HAPTIC TOUCH PANEL ASSEMBLY FOR A VEHICLE - A haptic touch panel assembly for a vehicle. The haptic touch panel assembly includes a haptic touch panel, a support substrate, and a suspension component to couple the haptic touch panel to the support substrate. More accurate and dynamic haptic feedback for various vehicle interior components may be provided through the use of a suspension component that allows for three or more degrees of freedom movement or two or more haptic actuators that facilitate movement in two or more different directions. | 05-12-2016 |
Joe Hotchkiss, East Lansing, MI US
Patent application number | Description | Published |
---|---|---|
20140120627 | METHOD FOR LABELING NANOCLAY FOR TRACKING THEM WITHIN DIFFERENT SOLID AND LIQUID MATERIAL - A method of monitoring a location of a nanoparticle within a material is described herein. The method includes the steps of providing at least one nanoclay particle, attaching a fluorescent tag to the at least one nanoclay particle, and determining a fluorescence of the fluorescent-labeled nanoclay particle. The method also includes forming the material including the at least one fluorescent-labeled nanoclay particle, depositing the material in an aqueous solution, and detecting a movement of the fluorescent-labeled nanoclay particle from the material to the aqueous solution. | 05-01-2014 |
John G. Hotchkiss, Duluth, GA US
Patent application number | Description | Published |
---|---|---|
20090173774 | Partition Insert - A partition insert ( | 07-09-2009 |
Joseph H. Hotchkiss, Ithaca, NY US
Patent application number | Description | Published |
---|---|---|
20100196985 | METHOD AND SYSTEM FOR LACTOSE-FREE OR LACTOSE-REDUCED MILK AND ASSOCIATED PRODUCTS, PRODUCTION THEREOF, AND ASSOCIATED PROCESSES - A system and method capable of hydrolyzing lactose, where the system includes a support formed from a functionalized hydrophobic polymer that is covalently linked to a hydrophilic molecule covalently that is, in turn, covalently linked to an enzyme such as lactose. The method includes the steps of functionalizing a hydrophobic polymer support, covalently linking a hydrophilic molecule to said functionalized polymer support, and covalently linking an enzyme such as lactase to said hydrophilic molecule. The system and method generally relate to the field of food science and engineering and, more particularly to dairy-based food products and their production including solutions to problems associated with lactose intolerance such as product processing methods and products produced by these methods. | 08-05-2010 |
20110151099 | Extended Shelf Life and Bulk Transport of Perishable Organic Liquids with Low Pressure Carbon Dioxide - Carbon dioxide is dissolved in liquid dairy products loaded and transported in bulk containers so as to improve product shelf life, thereby providing options for more economical shipment, as by rail and ocean vessels and for extended transport by truck and to facilitate extended storage of perishable products and to avoid the necessity of multiple treatments for pathogen reduction. | 06-23-2011 |
Lynette I. Hotchkiss, Lake Forest, CA US
Patent application number | Description | Published |
---|---|---|
20090177664 | System and Method for Regulatory Rules Repository Generation and Maintenance - A system and method for deriving compliance requirements from statutes, regulations, case law, official interpretations, attorney general opinions, determination and other interpretive letters, administrative agency regulations, and sources prescribing and interpreting compliance requirements for a jurisdiction, preparing compliance rules documentation that reflect these regulatory requirements, creating computer-encoded compliance rules from the compliance rules documentation, and storing these computer-encoded compliance rules in a compliance rules repository within a regulatory compliance computer system. The jurisdiction may be Federal, state or local authority. The regulatory compliance computer system makes use of the computer-encoded compliance rules by extracting compliance review data from a institution's data system and archiving the institution's data file in a compliance review file database, comparing the compliance review file against the applicable computer-encoded compliance rules in the rules repository, and preparing a regulatory compliance results file that captures noncompliant data in the institution's data system. | 07-09-2009 |
Michelle Hotchkiss, Eden Prairie, MN US
Patent application number | Description | Published |
---|---|---|
20150024348 | SYSTEM TO VISUALLY DISPLAY AND DEMONSTRATE HEARING ASSISTANCE DEVICE FEATURES - A method to playback media of a feature of a hearing aid may include establishing a communication link between a computing device and a hearing assistance device; obtaining, over the communications link, a parameter of a feature of the hearing assistance device; querying from the computing device, using the obtained parameter as an input, a storage device external to the computing device for media associated with the feature; receiving the media associated with the feature from the storage device external to the computing device; and presenting the media received in response to the query to a user of the computing device. | 01-22-2015 |
Peter Hotchkiss, Washington, DC US
Patent application number | Description | Published |
---|---|---|
20120114974 | ELECTRONIC DEVICES COMPRISING NOVEL PHOSPHONIC ACID SURFACE MODIFIERS - In some embodiments, the inventions described herein relate to a composition of matter comprising a molecule having the structure: wherein: independently at each occurrence, R | 05-10-2012 |
Peter Hotchkiss, Albuquerque, NM US
Patent application number | Description | Published |
---|---|---|
20110114935 | Stable electrodes with modified work functions and methods for organic electronic devices - One embodiment is a method, comprising: depositing a molecule on an electrode, wherein the electrode has a surface and the molecule has a binding group (e.g., an anchoring group) that binds to the surface, thereby providing a work function that is stable for at least 100 hours under ambient conditions. | 05-19-2011 |
Peter Hotchkiss, Atlanta, GA US
Patent application number | Description | Published |
---|---|---|
20100027192 | COATED METAL OXIDE NANOPARTICLES AND METHODS FOR PRODUCING SAME - Disclosed are coated metal oxide nanoparticles comprising a metal oxide nanoparticle having a surface; and ligands attached to the metal oxide nanoparticle surface. Also disclosed are phosphonic acid compounds comprising the structure Gn-R-Xn, wherein G is a terminal group; wherein R is a bridging group; wherein X is a phosphonic acid group; and wherein each n is, independently, 1, 2, or 3. Also disclosed are methods for preparing and using coated metal oxide nanoparticles. Also disclosed are nanocomposite compositions comprising a polymer; and a coated metal oxide nanoparticle dispersed within the polymer. Also disclosed are articles, films, and capacitors comprising a coated metal oxide nanoparticle or a nanocomposite composition. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-04-2010 |
20100051917 | PRINTABLE THIN-FILM TRANSISTORS WITH HIGH DIELECTRIC CONSTANT GATE INSULATORS AND METHODS FOR PRODUCING SAME - Disclosed are embodiments of organic thin-film transistors (OTFT) with a gate insulator layer comprised of nanocomposites incorporating metal oxide nanoparticles coated by organic ligands and methods of fabricating such OTFTs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 03-04-2010 |
Peter J. Hotchkiss, Albuquerque, NM US
Patent application number | Description | Published |
---|---|---|
20150062576 | TRACE DETECTION OF ANALYTES USING PORTABLE RAMAN SYSTEMS - Apparatuses and methods for in situ detection of a trace amount of an analyte are disclosed herein. In a general embodiment, the present disclosure provides a surface-enhanced Raman spectroscopy (SERS) insert including a passageway therethrough, where the passageway has a SERS surface positioned therein. The SERS surface is configured to adsorb molecules of an analyte of interest. A concentrated sample is caused to flow over the SERS surface. The SERS insert is then provided to a portable Raman spectroscopy system, where it is analyzed for the analyte of interest. | 03-05-2015 |
Richard Hotchkiss, Chesterfield, MO US
Patent application number | Description | Published |
---|---|---|
20090012025 | Methods and Compositions for Treatment of Sepsis - Methods of treatment of sepsis are disclosed. These methods comprise administering to a subject a composition comprising at least one siRNA directed against at least one gene encoding a pro-apoptotic polypeptide. The pro-apoptotic polypeptide, in some aspects, can be other than Fas or caspase-8. In some embodiments, an siRNA can be directed against a pro-apoptotic component of the mitochondrial pathway, such as a pro-apoptotic bcl-2 protein. In some aspects, an siRNA can be directed against a BH3-only bcl-2 protein, while in other aspects, siRNAs can be directed against multi BH domain Bcl-2 family members such as bax and bak. In some embodiments, an siRNA can be directed against a death receptor pathway molecule such as FADD. In various configurations, a composition can also comprise a cationic lipid such as DOTAP, or nanoparticles comprising a cyclodextrin-containing polycation and a polymer such as a poly(ethylene glycol). | 01-08-2009 |
20100048614 | THERAPEUTIC USES OF BICYCLIC LIGANDS OF SIGMA 2 RECEPTOR - A series of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs are disclosed, as well as methods of their preparation. Their affinities for sigma (σ1 and σ2) receptors are described. Two new compounds, N-(9-(4-aminobutyl)-9-azabicyclo[3.3.1]nonan-3α-yl)-N′-(2-methoxy-5-methylphenyl)carbamate and N-(9-(6-aminohexyl)-9-azabicyclo[3.3.1]nonan-3α-yl)-N′-(2-methoxy-5-methylphenyl)carbamate, are shown to have a high affinity and selectivity for σ2 versus σ1 receptors. Among the disclosed compounds are biotinylated and fluorescent analogs. These compounds can serve as probes to the σ2 receptor. In addition, some disclosed compounds can induce apoptotic cell death by both caspase-dependent and caspase-independent mechanisms, and are effective for treatment of tumors. The compounds can be used as chemotherapeutics or chemosensitizers in the treatment of a wide variety of solid tumors. | 02-25-2010 |
20100121031 | MEMBRANE-PERMEANT PEPTIDE COMPLEXES FOR TREATMENT OF SEPSIS - Methods and compositions for treating sepsis and diseases and conditions involving cellular apoptosis using cell membrane-permeant peptide conjugates of a cell membrane permeant peptide together with anti-apoptotic domains of the TCL1 protein are provided. | 05-13-2010 |
Richard A. Hotchkiss, Chesterfield, MO US
Patent application number | Description | Published |
---|---|---|
20090176705 | MODULAR PLATFORM FOR TARGETED THERAPEUTIC DELIVERY - Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free form, binds a cell receptor with a dissociation constant K | 07-09-2009 |
Richard L. Hotchkiss, Greenwood, SC US
Patent application number | Description | Published |
---|---|---|
20090050457 | NETWORK PROTECTOR RETROFIT HANDLE ASSEMBLY - A retrofit operating handle assembly structured to allow a CM22 type circuit breaker to be operatively coupled to a MG 8 or 9 type circuit breaker tank is provided. The operating handle assembly includes a tank assembly, which is coupled to the MG 8 or 9 type circuit breaker tank, and a circuit breaker, which is coupled to the CM22 type circuit breaker. | 02-26-2009 |
Richard Lyle Hotchkiss, Greenwood, SC US
Patent application number | Description | Published |
---|---|---|
20130250539 | Electrical Disconnect Apparatus - An improved electrical disconnect apparatus includes a set of spaced apart conductors and a removable conductive element that is structured to extend between the conductors and to complete at least a portion of an electrical circuit that includes the conductors. The electrical disconnect apparatus is situated between an electrical network and a network protector. The conductors and the conductive element which extends therebetween are situated within the interior of a support that is sealed in order to permit the electrical disconnect apparatus to be in a submerged environment during use. The conductive element is retained by a key interlock wherein the key that enables removal of the conductive element is stored on the network protector and is only made available to the technician when the network protector has been switched to an OFF condition. | 09-26-2013 |
Richard S. Hotchkiss, Chesterfield, MO US
Patent application number | Description | Published |
---|---|---|
20110300629 | TRAIL trimers, methods and uses therefor - Disclosed are TNF-related apoptosis-inducing ligand (TRAIL) trimers (TR3) and nucleic acids encoding covalently linked TRAIL trimers. A TRAIL trimer can have greater stability compared to native TRAIL, and can retain the native killing ability of TRAIL. Target specificity of a TR3 can be shown by blocking its activity with soluble death receptor 5 (DR5-Fc). Also disclosed are modified TRAIL trimers and nucleic acids encoding them. These modifications include additional functional domains, such as antibody fragments (scFvs). A TR3 comprising an additional functional domain can allow for cell-specific delivery of the TR3. In some configurations, a modification such as the addition of a functional domain can be stoichiometrically controlled. In some configurations, a modification can be inconsequential with regard to the bioactivity of TRAIL. In various embodiments, a TR3, including a modified TR3, can be a cancer-selective drug. In some configurations, a TR3 that comprises an additional biologically active moiety such as a functional domain of a protein can have fewer off-target toxicities compared to TRAIL alone. In some configurations, a TR3 that comprises an additional biologically active moiety such as a functional domain of a protein can have enhanced killing capacities compared to the moiety alone. In some aspects, TR3 activity can be targeted to an RBC membrane. The inventors disclose TR3-decorated RBCs that target cell killing in a model of pancreatic cancer. | 12-08-2011 |
Robert N. Hotchkiss, Riverside, CT US
Patent application number | Description | Published |
---|---|---|
20100249779 | EXTERNAL FIXATION DEVICES AND METHODS OF USE - External fixation devices and methods of use are provided. A device for external fixation of a joint includes a first pin block for connection to a first skeletal element and a second pin block for connection to a second skeletal element. The device includes a connection assembly that is releasably attached to at least one of the pin blocks. The device is locked in an original position when the connection assembly is attached to both of the pin blocks, and is unlocked when the connection assembly is detached from at least one of the pin blocks. | 09-30-2010 |
20110125274 | ELBOW REPLACEMENT APPARATUS AND METHODS - Apparatus and methods for total elbow replacement are provided to allow a surgeon to intraoperatively select a linked or unlinked constraint by utilizing a connection located on the body of the ulnar and/or humeral stem. Additional modularity also allows the selection of a cemented or cementless stem as described herein. The modularity and adjustability provides a number of advantages. | 05-26-2011 |
20110238016 | DRUG DELIVERY TO A JOINT - A drug delivery device may include a base to be percutaneously affixable in an attachment zone of a synovial joint and a sustained-release drug carrier coupled to the base. The drug delivery device may also include an access device to provide access to the attachment zone. The attachment zone may comprise a non-articulating portion of a bone and/or cartilage with the synovial joint and the drug carrier may elute the drug into the synovial fluid sufficient to sustain a therapeutically effective concentration of the drug in the synovial fluid for at least 8 hours. | 09-29-2011 |
20140142712 | ELBOW REPLACEMENT APPARATUS AND METHODS - Apparatus and methods for total elbow replacement are provided to allow a surgeon to intraoperatively select a linked or unlinked constraint by utilizing a connection located on the body of the ulnar and/or humeral stem. Additional modularity also allows the selection of a cemented or cementless stem as described herein. The modularity and adjustability provides a number of advantages. | 05-22-2014 |
Ronald Hotchkiss, Brooksville, FL US
Patent application number | Description | Published |
---|---|---|
20080304200 | INSULATED SURGE SUPPRESSION CIRCUIT - A potted electrical circuit is enclosed within a housing and has a first and second fiberglass layer that is laid upon a top surface of the potted electrical circuit. A lid of the housing seals the electrical circuit there within and an opening formed in a side wall allows circuitry wiring to extend there from out. The first fiberglass layer is a woven layer while the second fiberglass layer is a padding-like layer. Circuitry wiring pushes through the woven first fiberglass layer before extending out through the opening in the housing. The first fiberglass layer is tucked in and around the electrical circuit and adheres to the inside of the housing by attaching to the potting material while it hardens. In a preferred embodiment, the electrical circuit in combination with the insulation material is used within a transient voltage surge suppression device. | 12-11-2008 |
Ronald Hotchkiss, Destin, FL US
Patent application number | Description | Published |
---|---|---|
20100033885 | POTTED ELECTRICAL CIRCUIT WITH PROTECTIVE INSULATION - A potted electrical circuit is enclosed within a housing and has a first and second fiberglass layer that is laid upon a top surface of the potted electrical circuit. A lid of the housing seals the electrical circuit there within and an opening formed in a side wall allows circuitry wiring to extend there from out. The first fiberglass layer is a woven layer while the second fiberglass layer is a padding-like layer. Circuitry wiring pushes through the woven first fiberglass layer before extending out through the opening in the housing. The first fiberglass layer is tucked in and around the electrical circuit and adheres to the inside of the housing by attaching to the potting material while it hardens. In a preferred embodiment, the electrical circuit in combination with the insulation material is used within a transient voltage surge suppression device. | 02-11-2010 |
Samuel Hotchkiss, Alburquerque, NM US
Patent application number | Description | Published |
---|---|---|
20150288715 | Systems And Methods For Protecting Websites From Botnet Attacks - A computer-implemented method for preventing an unauthorized login attempt includes the steps of: (i) receiving, at a central server in communication with a plurality of servers in a distributed computing network, a first communication comprising a security key and an IP address associated with an entity attempting to login to a website hosted by a server; (ii) comparing, by the central server, the received security key to a stored list of security keys; (iii) authenticating the first communication if the received security key matches one of the stored security keys; (iv) comparing, by the central server, the received IP address to blacklisted IP addresses; (v) determining whether the received IP address is one of the blacklisted IP addresses; and (vi) providing, to the server, an indication of whether the IP address is one of the blacklisted IP addresses. | 10-08-2015 |